• Journal of Biomedical Engineering Research
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• v.43 no.2
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• pp.94-101
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• 2022

Recent advancement of micro/nano technology enables the development of diverse micro/nano particle-based delivery systems. Due to the multi-functionality and engineerability, particle-based delivery system are expected to be a promising method for delivery to the target cell. Since the particle-based delivery system should be delivered to the various kinds of target cell, including the cardiovascular system, cancer cell etc., it is frequently decorated with multiple kinds of targeting molecule(s) to induce specific interaction to the target cell. The surface decorated molecules interact with the cell surface expressed molecule(s) to specifically form a firm adhesion. Thus, in this study, the probability of adhesion is estimated to predict the possibility to form a firm adhesion for the multi-ligand decorated particle-based delivery system.

• International Journal of Stem Cells
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• v.17 no.1
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• pp.1-14
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• 2024

The clustered regularly interspaced short palindromic repeats (CRISPR) system, a rapidly advancing genome editing technology, allows DNA alterations into the genome of organisms. Gene editing using the CRISPR system enables more precise and diverse editing, such as single nucleotide conversion, precise knock-in of target sequences or genes, chromosomal rearrangement, or gene disruption by simple cutting. Moreover, CRISPR systems comprising transcriptional activators/repressors can be used for epigenetic regulation without DNA damage. Stem cell DNA engineering based on gene editing tools has enormous potential to provide clues regarding the pathogenesis of diseases and to study the mechanisms and treatments of incurable diseases. Here, we review the latest trends in stem cell research using various CRISPR/Cas technologies and discuss their future prospects in treating various diseases.

• Molecules and Cells
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• v.39 no.5
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• pp.389-394
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• 2016

Dovitinib (TKI258) is a small molecule multi-kinase inhibitor currently in clinical phase I/II/III development for the treatment of various types of cancers. This drug has a safe and effective pharmacokinetic/pharmacodynamic profile. Although dovitinib can bind several kinases at nanomolar concentrations, there are no reports relating to osteoporosis or osteoblast differentiation. Herein, we investigated the effect of dovitinib on human recombinant bone morphogenetic protein (BMP)-2-induced osteoblast differentiation in a cell culture model. Dovitinib enhanced the BMP-2-induced alkaline phosphatase (ALP) induction, which is a representative marker of osteoblast differentiation. Dovitinib also stimulated the translocation of phosphorylated Smad1/5/8 into the nucleus and phosphorylation of mitogen-activated protein kinases, including ERK1/2 and p38. In addition, the mRNA expression of BMP-4, BMP-7, ALP, and OCN increased with dovitinib treatment. Our results suggest that dovitinib has a potent stimulating effect on BMP-2-induced osteoblast differentiation and this existing drug has potential for repositioning in the treatment of bone-related disorders.

• Proceedings of the IEEK Conference
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• 2005.11a
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• pp.1185-1188
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• 2005

Recently, ubiquitous computing and sensor networks are making a rapid development. These technology can enable a new way of biomedical signal processing and healthcare. that is, they can improve care giving by a more flexible acquisition of relevant vital sign data, and by providing more convenience for patients. In this paper, we realize the biomedical sensor networks by applying IEEE 802.15.4/Zigbee networks to some various biomedical sensing unit. For address this, we developed minimized zigbee module and set-up procedure using PDA. The main advantages that we achieve are interference-free operation of different body sensor networks in the vicinity, as well as intuitive usage by the nontechnical personnel.

• Journal of Biomedical Engineering Research
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• v.41 no.2
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• pp.75-83
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• 2020

In large-scale hospitals, the department of biomedical engineering should always provide quick repair service for damaged medical devices to guarantee continuous patient treatment. However, in actual circumstances, there are so many time-consuming issues that delays device repair for weeks or even months; therefore, it is required to prepare alternative ways for quick repair service. In this study, we first mentioned about the regulation issues in Korea about the 3D printing-based medical device repair, and then introduced the results of our preliminary study that evaluated the feasibility of 3D printing-based medical device repair before real-field application. Results of the study demonstrated that, in all of the 23 cases, parts for repair that were manufactured by 3D-printing were successfully fixed and connected to the main body of the original device, and showed sufficient rigidity for protecting internal parts of the device. Considering the experimental results, medical device repair by applying 3D printing technology can be a promising alternative in cases when regular repair process is not available or takes too much time.

• Journal of the Korean Ceramic Society
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• v.55 no.6
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• pp.597-607
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• 2018

In this study, a wet chemical method was used to synthesize nanostructured hydroxyapatite for biomedical applications. Diammonium hydrogen phosphate and calcium nitrate 4-hydrate were used as starting materials with a sodium hydroxide solution as an agent for pH adjustment. Scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, differential thermal analysis, thermal gravimetric analysis, atomic absorption spectroscopy, and ethylenediaminetetraacetic acid (EDTA) titration analysis were used to characterize the synthesized powders. Having been uniaxially pressed, the powders formed a disk-like shape. The sinterability and electrical properties of the samples were examined, and the three-point bending test allowed for the measurement of their mechanical properties. Sedimentation analysis was used to analyze the slurry ability of hydroxyapatite. As in-vitro biological properties of the samples, biocompatibility and cytotoxicity were assessed using osteoblast-like cells and the L929 cell line, respectively. Solubility was assessed by employing a simulated body fluid.

• Molecular & Cellular Toxicology
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• v.4 no.2
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• pp.100-105
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• 2008

Biochips are a powerful emerging technology for biomedical, environmental applications. Especially, making use of bioseonors in the evaluation of toxicity becomes increasingly important. For biosensor as a toxicity detection, biomolecules like antibodies or aptamers have been developed to specifically capture the toxic target molecules. In addition, the development of optimal chip materials capable of maintaining the activity of embedded biomolecules such as proteins or aptamers has proven challenging. Here, using sol-gel materials, new chip material, whose ability for immobilizing the embedded aptamers and maintaining the ability of embedded aptamers is optimal, was searched. We used sol-gel formulation screening methods previously developed and found the best formulation which shows high sensitive and specific interactions of aptamers. This study results will support the technological advancement for diagnosis and environmental sensor.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.1794-1795
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• 2011

본 연구에서는 가속도 센서의 값을 디지털 신호 처리 과정을 통하여 저역통과 필터(low pass filter), 벡터의 크기(vector magnitude), 롤(roll) 그리고 피치(pitch)를 계산하는 알고리즘을 적용하였다. 필터의 경우 IIR(Infinite Impulse Response)을 이용하였으며 차수는 9차로 하였다. 피험자의 연령은 $25{\pm}5$세의 10명을 기준으로 실험하였으며 앞, 뒤, 좌, 우 방향으로 직각 낙하하도록 하였고 센서 모듈은 오른쪽 허리의 정중앙에 착용하도록 하여 피험자간의 오차가 발생하지 않도록 하였다. 환자의 낙상을 검출하기 위해서 벡터의 크기를 사용하였고 롤과 피치를 이용하여 환자의 낙상 방향을 검출하였다. 결과적으로 피험자 10명의 경우 낙상의 검출률은 100% 였으며 낙상 방향에 따른 앞, 뒤, 좌, 우 판별 정확도는 95% 정도이다. 낙상 방향의 판별은 사고 후 환자를 다룰 때의 주의할 신체부위를 참고하며 재활 운동 시 하체의 어느 쪽이 낙상의 주요인인지 분석하는 보조 자료가 될 수 있다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2003.05a
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• pp.84-89
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• 2003

The virtual reality(VR) technology can provide various stimuli, including, visual and auditory stimuli, simultaneously in the virtual environment and encourage the user to interact. Virtual reality is a set of computer technologies, which when combined, provide an interactive interface to a computer generated world. In this world the subject can see, hear and navigate in a dynamically changing environment in which he participates as an active player, by modifying the environment according to his will. Moreover, the subject can get a feeling for the virtual environment in much the same way as one feels real life situations. In the real world, a plethora of information from various modalities may be in conflict, and modulate each other to form an illusion. In this study we investigated whether a tactile illusion on a real hand could be evoked by a virtual stimulus, the time required to generate this illusion and its duration. This study shows that the illusion occurred, and that was correlated with presence score in the virtual environment.

• Journal of Biomedical Engineering Research
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• v.36 no.5
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• pp.162-168
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• 2015

In this study, we suggested the performance and safety testing guideline for low intensity pulsed ultrasound (LIPUS) represented by the ultrasound fracture treatment device and cartilage treatment device and low intensity focused ultrasound (LIFU) represented by ultrasonic face lifting device. For these study, the international standards and management regulations of Korea, Japan and United State were analyzed. And the usefulness and applicability were evaluated by testing with commercial equipment and reflecting the views of the industry and experts. As a result of this study, the safety and performance test guidelines for low intensity therapeutic ultrasound device were proposed by presenting the 10 items for LIPUS and 12 items for LIFU. The suggested guidelines are considered a high utilization in the domestic testing and approval authorities. And they are also thought to be useful to new technology development.