• Bioinformatics and Biosystems
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• v.1 no.2
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• pp.89-94
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• 2006

Mass spectrometry (MS) is widely applied for high throughput proteomics analysis. When large-scale proteome analysis experiments are performed, it generates massive amount of data. To search these proteomics data against protein databases, fully automated database search algorithms, such as Mascot and SEQUEST are routinely employed. At present, it is critical to reduce false positives and false negatives during such analysis. In this review we have focused on aspects of automated protein identification using tandem mass spectrometry (MS/MS) spectra and validation of the protein identifications of two most common automated protein identification algorithms Mascot and SEQUEST.

• International Journal of Control, Automation, and Systems
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• v.6 no.6
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• pp.828-835
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• 2008

We present a novel method for eye location by means of a two-level classifier scheme. Locating the eye by machine-inspection of an image or video is an important problem for Computer Vision and is of particular value to applications in biomedical imaging. Our method aims to overcome the significant challenge of an eye-location that is able to maintain high accuracy by disregarding highly variable changes in the environment. A first level of computational analysis processes this image context. This is followed by object detection by means of a two-class discrimination classifier(second algorithmic level).We have tested our eye location system using FERET and BioID database. We compare the performance of two-level classifier with that of non-level classifier, and found it's better performance.

• 한국약용작물학회:학술대회논문집
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• 2008.11a
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• pp.431-432
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• 2008

• Journal of Biomedical Engineering Research
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• v.26 no.5
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• pp.271-282
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• 2005

There are strong demands for accurate, fast, and inexpensive devices in the medical diagnostic laboratories, such as biosensors and chemical sensors. Biosensors can provide the reliable and accurate informations on the desired biochemical parameters, which is an essential prerequisite for a patient before going for a treatment. They can be used for continuous measurements of metabolites, blood cations, gases, etc. Of these, electrochemical biosensors play an important role in the improvement of public health, because rapid detection, high sensitivity, small size, and specificity are achievable for clinical diagnostics. In this paper, the clinical applications with electrochemical biosensors are reviewed. An attempt is also made to highlight some of the trends that govern the research and developments of the important biosensors that are associated to clinical diagnosis.

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2559-2562
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• 2014

• BMB Reports
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• v.43 no.9
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• pp.609-613
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• 2010

The Dvl and Axin proteins, which are involved in the Wnt signaling pathway, each contain a conserved DIX domain in their sequences. The DIX domain mediates interaction between Dvl and Axin, which together play an important role in signal transduction. However, the extremely low production of DIX domain fragments in E. coli has prevented more widespread functional and structural studies. In this study, we demonstrate that the DIX domains of Dvl and Axin are expressed noticeably in a multi-cistronic system but not in a mono-cistronic system. Formation of the $DIX_{Dvl1}-DIX_{Axin1}$ complex was investigated by affinity chromatography, SEC and crystallization studies. Unstable DIX domains were stabilized by complexing with counterpart DIX domains. The results of the preliminary crystallization and diffraction of the $DIX_{Dvl1}-DIX_{Axin1}$ complex may prove useful for further crystallographic studies.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.323-326
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• 1996

Dental implant is increasingly used to recover the mastication function of tooth. Several types of implant were designed to give an optimal stress distribution in surrounding bony regions. In this study, six types of implant were investigated using finite element method and it was studied i) how the variation of cortical bone thickness affects the stress distribution in surrounding bony regions depending upon implant types, ii) which type gives the best characteristics in the sence of stress distribution and stability. The hybrid-type implant with cylinder and screw gave the optimum properties in view of stability and response to the variation of cortical bone thickness.

• Journal of Biomedical Engineering Research
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• v.29 no.1
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• pp.1-7
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• 2008

Recent a few decades, the microtechnology has been progressed so rapidly and applied in diverse areas. Especially, this technology was focused on the field of biotechnology and medicine because of its size and simple fabrication process. In this paper, the current status of microtechnology is briefly introduced from the aspect of material, process and device and the application of this technology in biotechnology and medicine is also described. The microtechnology will be more broadly applied in future in the biotechnology and medicine area and the biomedical engineer should have continuous interests in this technology.

• Journal of Chest Surgery
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• v.49 no.1
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• pp.70-72
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• 2016

The single-suture neochorda-folding plasty technique is a modification of existing mitral valve repair techniques. In the authors' experience, its simplicity, reliability, and versatility make it a useful technique for mitral valve repair, especially when a minimally invasive approach is used.

• Journal of the Semiconductor & Display Technology
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• v.17 no.4
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• pp.62-65
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• 2018

We will provides a micro-pump infusion injector with the cloud networking for remote control. The existing infusion injector with controlled manually have an uncomfortable to use it inconveniently. The proposed remote control infusion, infusion system enables the identification and control of injected amount through the IOT function on th WEB. The micro-pump used is a piezo electric pump manufactured by using MEMS technology, and the amount of charge is varied depending on the frequency magnitude through the micro-controller. The micro-pump can adjust the speed of the fluid depending on the frequency and can be from 0.1ml / min to 7ml / min when the frequency is from 3 to 110Hz.