• Title/Summary/Keyword: Biomedical optics

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Cerebral Oxygenation Monitoring during a Variation of Isoflurane Concentration in a Minimally Invasive Rat Model

  • Choi, Dong-Hyuk;Kim, Sungchul;Shin, Teo Jeon;Kim, Seonghyun;Kim, Jae Gwan
    • Current Optics and Photonics
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    • v.6 no.5
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    • pp.489-496
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    • 2022
  • Our previous study on monitoring cerebral oxygenation with a variation of isoflurane concentration in a rat model showed that near-infrared spectroscopy (NIRS) signals have potential as a new depth of anesthesia (DOA) index. However, that study obtained results from the brain in a completely invasive way, which is inappropriate for clinical application. Therefore, in this follow-up study, it was investigated whether the NIRS signals measured in a minimally invasive model including the skull and cerebrospinal fluid layer (CSFL) are similar to the previous study used as a gold standard. The experimental method was the same as the previous study, and only the subject model was different. We continuously collected NIRS signals before, during, and after isoflurane anesthesia. The isoflurane concentration started at 2.5% (v/v) and decreased to 1.0% by 0.5% every 5 min. The results showed a positive linear correlation between isoflurane concentration and ratio of reflectance intensity (RRI) increase, which is based on NIRS signals. This indicates that the quality of NIRS signals passed through the skull and CSFL in the minimally invasive model is as good as the signal obtained directly from the brain. Therefore, we believe that the results of this study can be easily applied to clinics as a potential indicator to monitor DOA.

Sol-gel Derived-highly Transparent c-axis Oriented ZnO Thin Films (졸-겔법에 의한 c-축 배향성을 가진 고투과율 ZnO 박막의 제조)

  • Lee, Young-Hwan;Jeong, Ju-Hyun;Jeon, Young-Sun;Hwang, Kyu-Seog
    • Journal of Korean Ophthalmic Optics Society
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    • v.13 no.1
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    • pp.71-76
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    • 2008
  • Purpose: A simple and efficient method to prepare nanocrystalline ZnO thin film with pure strong UV emission on soda-lime-silica glass substrates by low-temperature annealing was improved. Methods: Crystal structural, surface morphological, and optical characteristics of nanocrystalline ZnO thin films deposited on soda-lime-silica glass substrates by prefiring final annealing process at 300$^{\circ}C$ were investigated by using X-ray diffraction analysis, field emission-scanning electron microscope, scanning probe microscope, ultraviolet-visible-near infrared spectrophotometer, and photoluminescence. Results: Highly c-axis-oriented ZnO films were obtained by prefiring at 300$^{\circ}C$. A high transmittance in the visible spectra range and clear absorption edge in the ultra violet range of the film was observed. The PL spectrum of ZnO thin film with a deep near band edge emission was observed while the defect-related broad green emission was nearly quenched. Conclusions: Our work will be possibly adopted to cheaply and easily fabricate ZnO-based optoelectronic devices at low temperature, below 300$^{\circ}C$, in the future.

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Evaluation of Transparent Amorphous $V_2O_5$ Thin Film Prepared by Thermal Evaporation (진공증착법으로 제조한 투명 비정질 $V_2O_5$박막의 특성평가)

  • Hwang, Kyu-Seog;Jeong, Seol-Hee;Jeong, Ju-Hyun
    • Journal of Korean Ophthalmic Optics Society
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    • v.13 no.1
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    • pp.27-30
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    • 2008
  • Purpose: This research is that $V_2O_5$ cathode's composition is possible in low temperature. Methods: Transparent in visible spectra range and crystallographically amorphous $V_2O_5$ thin films were prepared by simple vacuum thermal evaporation on soda-lime-silica slide glass substrate. After annealing at 100$^{\circ}C$, 150$^{\circ}C$ and 200$^{\circ}C$ for 10 minutes in air, the surface morphology and the fracture-cross section of the films were investigated by field emission - scanning electron microscope. Transmittance in visible spectra range and surface roughness of the films were analyzed by ultra violet - visible spectrophotometer and scanning probe microscope, respectively. Results: As the increase of annealing temperature from 100$^{\circ}C$ to 150$^{\circ}C$ and 200$^{\circ}C$, transmittance of the $V_2O_5$ films decreased. Optical properties will be fully discussed on the basis of the surface morphological results. Conclusions: Optical transmissivity was superior in case of 100$^{\circ}C$, and could make amorphous $V_2O_5$ thin film that surface quality of thin film did homogeneity.

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The Change in Binocular Function and Sensory Anomaly After vision Training on Intermittent Exotropia and Recurrent Intermittent Exotropia Patients After Surgical Correction (간헐성 외사시 및 외사시 재발환자에 대한 시기능 훈련 후 양안시 기능 및 감각이상 변화)

  • Lee, Chang-Seon;Kim, Jong-Ki;Shin, Jeong-Hoon;Kim, Dae-Nyoun;Lee, Hyun Mee;Kim, Ki-Hong
    • Journal of Korean Ophthalmic Optics Society
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    • v.16 no.3
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    • pp.345-350
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    • 2011
  • Purpose: This was a study of the effects of the vision training on binocular function and sensory anomaly for intermittent exotropia and recurrent intermittent exotropia patients. Mehtods: The change was examined weekly at the clinic during the 8 week vision training. The sample group of 17 patients, intermittent exotropia and recurrent intermittent exotropia patients without amblyopia, were chosen from the patients with the short and the long-distance deviation angle p=0.558 and p=0.338, and also greater than 10${\Delta}$, respectively. Results: The longdistance deviation angle was reduced by 67.9(${\pm}$32.7)%, and the short-distance deviation angle by 75.4(${\pm}$32.9)% after the vision training. There is an improvement on the binocular function and sensory anomaly according to the fusion reverse and Worth 4 dot tests. Conclusions: This study shows that the vision training is effective for phoria, function and sensory anomalyon of the intermittent extropia and recurrent intermittent exotropia patients.

Development of Dot Sight with Prism Beam Splitter (빔분리프리즘 도트사이트 장치의 개발)

  • Lee, Dong-Hee;Jung, Bo-Seon;Park, Seung-Hwan
    • Journal of Korean Ophthalmic Optics Society
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    • v.18 no.4
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    • pp.519-524
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    • 2013
  • Purpose: This study relates to the development of dot-sight device, whose length is reduced, with a prism beam splitter. Methods: We developed a new dot-sight device whose length was reduced by eliminating the optical axis tilt of the doublet reflector to reduce the occurrence of the parallax and by redesigning the doublet reflector to use a prism beam splitter. Results: We could develop the new type dot-sight device having a prism beam splitter and the dot reticle generator and the doublet reflector, of which optical axises showed a T-letter type with the optical axis of the observer's eye. Conclusions: In this study, we designed and developed a new type dot sight employing a prism beam splitter that could be able to further enhance the accuracy of the fire in comparison with the traditional dot sight, thereby reducing the overall optical length of system. The new designed dot sight was able to be reduced 2.2 times on the overall optical length, and could be improved more than three times on the accuracy of shooting in the horizontal direction, than the traditional dot sight.

Preparation of ZnO Thin Films with UV Emission by Spin Coating and Low-temperature Heat-treatment (스핀코팅 및 저온열처리에 의한 자외선 발광특성을 갖는 산화아연 박막의 제조)

  • Kang, Bo-An;Jeong, Ju-Hyun
    • Journal of Korean Ophthalmic Optics Society
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    • v.13 no.3
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    • pp.73-77
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    • 2008
  • Purpose: This research is that prepare amorphous or crystalline ZnO thin films with pure strong UV emission on soda-lime-silica glass (SLSG) substrates by low-temperature annealing. Methods: Growth characteristic and optical properties of the amorphous or nano-crystalline ZnO thin films prepared on soda - lime - silica glass substrates by chemical solution deposition at 100, 150, 200, 250 and $300^{\circ}C$ were investigated using X-ray diffraction analysis, ultraviolet - visible - near infrared spectrophotometer, and photoluminescence. Results: The films exhibited an amorphous pattern even when finally annealed at $100^{\circ}C{\sim}200^{\circ}C$ for 60 min, while crystalline ZnO was obtained by prefiring at 250 and $300^{\circ}C$. The photoluminescence spectrum of amorphous ZnO films shows a strong NBE emission, while the visible emission is nearly quenched. Conclusions: These results indicate it should be possible to cheaply and easily fabricate ZnO-based optoelectronic devices at low temperature, below $200^{\circ}C$, in the future.

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The Change After Visual Training of Forced Vergence Fixation Disparity Curve (강제vergence 주시시차곡선의 시기능훈련 후의 변화)

  • Choi, Sun-Mi;Lee, Ki-Young;Park, Hyun-Ju
    • Journal of Korean Ophthalmic Optics Society
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    • v.19 no.4
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    • pp.539-550
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    • 2014
  • Purpose: This research was designed to figure out if there are changes based on types of vergence fixation disparity curve after optical correction and vision training to for people with steep slope of forced vergence fixation disparity curve and symptoms. Methods: For 30 subjects out of 91 subjects, who have steep slopes of fixation disparity curve examined with Wesson Fixation Disparity Card and symptoms about steep slope of fixation disparity curve, proper vision training was offered for 5 weeks. Results: After Vision training for 30 people with the symptoms of type I, II, III, IV for 5 weeks, slope of fixation disparity curve was significantly changed (p=0.013), and the results of binocular vision test and subjective symptoms were also significantly improved. Conclusions: Vision training can not only affect the change of fixation disparity curve, but also relieve the symptoms. Fixation disparity curve has lots of visual function information of the subject and can be suggested as a guideline for prescribing.

Study on the Functionality and Application of Natural-polymer with Biocompatibility (생체적합성을 가진 천연고분자의 응용 및 기능성에 관한 연구)

  • Kim, Tae-Hun;Kim, Doo-Eon;Sung, A-Young
    • Journal of the Korean Chemical Society
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    • v.53 no.5
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    • pp.547-552
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    • 2009
  • Chitosan, a natural polymer, has been importantly considered as biomedical materials due to its good biocompatibility and various bio-active characteristes. Water soluble chitosan was then copolymerized EGDMA(ethylene glycol dimethacrylate; used as a cross-linking agent for the free-radical copolymerization), MMA (methylmethacrylate), MA (methacrylic acid) in the presence of AIBN (azobisisobutyronitrile) as a radical initiator. The water content and visible transmissibility, ultimate strength of copolymerized ophthalmic polymer were measured to be 24$\sim$59%, 88$\sim$89% and 0.1$\sim$2.4 Kgf, respectively. And also, we tested for antimicrobial activities against staphylococcus aureus, Pseudomonas aeruginosa. They showed that in case of antimicrobial activities, the values including chitosan were much higher than that of the polymers of no including chitosan, suggesting that the copolymer can be used as a novel ophthalmic material of high performance.

Delayed Luminescence Characteristics of Human Hands (사람 손의 지연발광 특성)

  • Yang, Joon-Mo;Choi, Chun-Ho;Soh, Kwang-Sup;Lim, Woo-Taek;Lee, Han-Sang;Chae, Seung-Byung;Yoon, Se-Yeol;Lee, Kyung-Il;Shin, Eun-Seok;Choi, Sun-Mi
    • Korean Journal of Optics and Photonics
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    • v.17 no.1
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    • pp.81-88
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    • 2006
  • Delayed luminescence from human hands after illumination by light at different wavelength bands was studied. A delayed luminescence measurement system equipped with photomultiplier tube (PMT), fiber optics and automatic mechanical shutter system was developed. Three spectrum band-pass filters, fer which transmissions are on 350${\~}$450 nm, 450${\~}$550 nm and 550${\~}$650 nm, were used to select irradiation wavelength, and 150W metal-halide lamp was used as an illumination source. Six volunteers put their palms (dorsa) onto the measurement system, and after light illumination, delayed luminescence were measured for 10 minutes. The results show that delayed luminescence after shorter wavelength illumination was higher than that a(ter longer wavelength one. These results indicate the existence of accepters in human skin which can be excited at short wavelengths. Furthermore, each subjects showed different delayed luminescence curve patterns. Reactive oxygen species (ROS) are known to have important roles on delayed luminescence, and this research suggests that ROS concentration can be measured noninvasively with optical methods.

Gold Colored Coating of TiO2 thin film on Nickel-Silver by Sol-Gel Process (양백에 코팅된 비정질 TiO2 박막의 특성에 관한 연구)

  • Lim, Yongmu;Kim, Sangmoon;Shim, Moonsik;Jang, Heejin;Shin, Jongyoon;Hwang, Kyuseog
    • Journal of Korean Ophthalmic Optics Society
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    • v.4 no.1
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    • pp.51-56
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    • 1999
  • $TiO_2$ thin films were spin coated on commercial Nickel-Silver with 2%Ti-naphthanate toluene solution by sol-gel process. The thin films were heat-treated at $500^{\circ}C$ for 2min and then decorative-protective coating was obtained. The conditions for gold colored coating, and the morphology, microstructure and color of the coating surface were have been characterized by Optical microscope, Photospectrometer and XRD. The heating temperature of colored-$TiO_2$ coating was $500^{\circ}C$ and was preferable. The average thickness of 1 time coating was $0.24{\mu}m$ and the total thickness increased linearly as a function of the coating time. The color of amorphous colored-$TiO_2$ coating was changed from gold to dark redish gold with coating time. 'L' as lightness and 'b' were decreased to red, but 'a' was decreased to blue after increase with coating time.

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