• Journal of Biomedical Engineering Research
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• v.22 no.1
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• pp.81-90
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• 2001

본 연구에서는 디지털 영상 뇌파계(digital video electroencephalogram, Digital VEEG)에서 비디오 영상과 뇌전도 파형의 동기화된 편집 시스템을 구성한다. 이 시스템은 기존 아날로그 영상 뇌파계(analog video electroencephalogram)의 동기화 문제와 디지털 영상 시스템에서의 영상편집 문제를 해결하기 위하여 MPEG-I(이하 MPEG) 고압축 기술을 이용한 MPEG 인코딩 보드(encoding board)와 MPEG 편집 엔진(editing engine)을 각각 사용하였다. 시스템은 디지털 영상뇌파계모듈과 디지털 편집 모듈로 구성되며, 뇌전도모듈에서는 환자에게 연결된 전극을 통해 들어온 뇌파를 생체신호증폭기를 이용하여 증폭한 후 AD 보드(analog to digital board)를 이용 디지털화한다. 디지털 카메라로 촬영된 환자영상의 아날로그 영상신호(NTSC 신호)는 MPEG 인코딩 보드를 이용하여 고압축 디지털화한다. 이후 디지털화된 뇌전도신호와 MPEG 형식의 영상을 시간 동기화하여 두 개의 모니터에 각각보여준다. 편집 모듈에서는 영상신호와 뇌파신호를 어느 부분이든 간단한 조작으로 오려 붙이기(cut and paste) 기능을 이용할 수 있다. 본 시스템은 사용된 데이터 모두 디지털 기술을 이용하여 영상과 뇌파신호의 정확한 동기화 및 각각의 데이터의 오려 붙이기 기능을 가능케 하였으며, 이는 환자의 데이터를 관리 및 보관하는데 있어, 임상의에게 의미 있는 자료만을 모아서 효율적으로 관리할 수 있게 해준다. 이와 같은 장점을 갖는 디지 영상뇌파계 편집시스템을 구현하였다.

• Biomedical Engineering Letters
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• v.8 no.4
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• pp.373-382
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• 2018

Since epileptic seizure is unpredictable and paroxysmal, an automatic system for seizure detecting could be of great significance and assistance to patients and medical staff. In this paper, a novel method is proposed for multichannel patient-specific seizure detection applying the earth mover's distance (EMD) in scalp EEG. Firstly, the wavelet decomposition is executed to the original EEGs with five scales, the scale 3, 4 and 5 are selected and transformed into histograms and afterwards the distances between histograms in pairs are computed applying the earth mover's distance as effective features. Then, the EMD features are sent to the classifier based on the Bayesian linear discriminant analysis (BLDA) for classification, and an efficient postprocessing procedure is applied to improve the detection system precision, finally. To evaluate the performance of the proposed method, the CHB-MIT scalp EEG database with 958 h EEG recordings from 23 epileptic patients is used and a relatively satisfactory detection rate is achieved with the average sensitivity of 95.65% and false detection rate of 0.68/h. The good performance of this algorithm indicates the potential application for seizure monitoring in clinical practice.

• Biomedical Engineering Letters
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• v.8 no.4
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• pp.345-353
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• 2018

This study suggested a new EMG-signal-based evaluation method for knee rehabilitation that provides not only fragmentary information like muscle power but also in-depth information like muscle fatigue in the field of rehabilitation which it has not been applied to. In our experiment, nine healthy subjects performed straight leg raise exercises which are widely performed for knee rehabilitation. During the exercises, we recorded the joint angle of the leg and EMG signals from four prime movers of the leg: rectus femoris (RFM), vastus lateralis, vastus medialis, and biceps femoris (BFLH). We extracted two parameters to estimate muscle fatigue from the EMG signals, the zero-crossing rate (ZCR) and amplitude of muscle tension (AMT) that can quantitatively assess muscle fatigue from EMG signals. We found a decrease in the ZCR for the RFM and the BFLH in the muscle fatigue condition for most of the subjects. Also, we found increases in the AMT for the RFM and the BFLH. Based on the results, we quantitatively confirmed that in the state of muscle fatigue, the ZCR shows a decreasing trend whereas the AMT shows an increasing trend. Our results show that both the ZCR and AMT are useful parameters for characterizing the EMG signals in the muscle fatigue condition. In addition, our proposed methods are expected to be useful for developing a navigation system for knee rehabilitation exercises by evaluating the two parameters in two-dimensional parameter space.

• Parasites, Hosts and Diseases
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• v.59 no.3
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• pp.319-324
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• 2021

Incidence of tsutsugamushi disease (scrub typhus) caused by Orientia tsutsugamushi, is steadily increasing. It is a mite-borne disease transmitted by chigger mites. In this study, the chigger mites were collected from field small mammals in Hwaseong-si (city), Gyeonggi-do (province), Korea, 2019 and 2020. The field small mammals captured were 56 Apodemus agrarius (94.9%) and 3 Crocidura lasiura (5.1%). A total of 7,531 chigger mites were collected from the captured small mammals. Using PCR test, 153 chigger mite pools were examined and 17 pools were reported positive for O. tsutsugamushi. The O. tsutsugamushi were identified to 5 strains; Jecheon strain was most prevalent, followed by Boryong strain. The other strains were OI011, Taguchi, and Shimokoshi. Collectively, these results provide essential regional information on mite-borne tsutsugamushi disease in the Hwaseong-si, and further contribute to bring awareness and rapid diagnosis for the tsutsugamushi disease.

• Tuberculosis and Respiratory Diseases
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• v.85 no.2
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• pp.111-121
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• 2022

Multidrug-resistant tuberculosis (MDR-TB) is caused by an organism that is resistant to both rifampicin and isoniazid. Extensively drug-resistant TB, a rare type of MDR-TB, is caused by an organism that is resistant to quinolone and one of group A TB drugs (i.e., linezolid and bedaquiline). In 2018, the World Health Organization revised the groupings of TB medicines and reclassified linezolid as a group A drug for the treatment of MDR-TB. Linezolid is a synthetic antimicrobial agent in the oxazolidinone class. Although linezolid has a good efficacy, it can cause substantial adverse events, especially hematologic toxicity. In both TB infection and linezolid mechanism of action, mitochondrial dysfunction plays an important role. In this concise review, characteristics of linezolid as an anti-TB drug are summarized, including its efficacy, pathogenesis of hematologic toxicity highlighting mitochondrial dysfunction, and the monitoring and management of hematologic toxicity.

• Proceedings of the Korean Society of Computer Information Conference
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• 2021.01a
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• pp.45-46
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• 2021

의료영상이란 의료영상장비로부터 DICOM이라는 의료영상표준에 따라 저장되며, 의료영상관리 시스템인 PACS를 통해 관리된다. 이러한, 의료영상장비 ICT기술이 융합되어 급격하게 발전되고 있으며 다양한 의료영상장치가 개발되어지고 있다. 하지만, 기술력은 높아지고 있으나 개발된 의료영상장비로부터 촬영된 영상품질관리에 대한 문제점이 제기되고 있다. 이와 관련하여 다기관의 의료영상장비 개발과 해당 기기로부터 수집된 의료영상에 대한 품질을 관리할 필요성이 증가하고 있다. 따라서 코로나 19와 같은 상황에서 의료기기 개발 지원과 관리를 비대면 관리서비스 시스템 개발과 의료영상장치 개발 정도를 관리할 수 있을 뿐만 아니라 의료영상에 대한 품질까지 모니터링하여 및 개선 할 수 있는 시스템을 제안하고자 한다.

• Annual Conference of KIPS
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• 2023.11a
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• pp.662-664
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• 2023

해양 식물플랑크톤의 성장은 유해적인 적조를 유발할 수 있으며, 이는 여러 국가의 생태계에 피해를 주는 상황이다. 적조를 모니터링하는 것은 식물플랑크톤 미생물의 증가를 예방하고 통제하기 위해 중요하다. 그러나 현재의 적조 모니터링 기술은 날씨, 시간 제약 및 실시간 모니터링에 대한 어려움으로 인해 측정 정확도에 영향을 미치는 한계가 있다. 본 연구는 특히 적조 발생을 감지하기 위한 목적으로 개발된 자동 실시간 모니터링 시스템의 성공적인 개발을 보여준다. 개발한 시스템은 음향 반사파 데이터 처리를 통해 합성곱 신경망(Convolutional neural networks, CNN)을 활용하여 식물플랑크톤 농도를 정확하게 구별할 수 있다. 특히, 이 CNN 모델은 음향 신호의 변환된 주파수 스펙트럼과 Cochlodinium polykrikoides (C. polykrikoides)의 농도 간의 상관 관계를 수립하는 데 뛰어난 효과를 나타냈다. 이 CNN 은 C. polykrikoides 를 감지하는 데 0.90 의 정확도를 보여준다. 이러한 모니터링과 CNN 분류의 활용은 실시간 측정의 중요한 잠재력을 보여주며, 추가적인 절차가 필요 없는 자동 모니터링 시스템을 구축할 수 있을 것으로 예상된다.

• Journal of Industrial Technology
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• v.43 no.1
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• pp.25-31
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• 2023

Stretchable and flexible electronics that comply with dynamic movements and micromotion of the human tissues can enable real-time monitoring of physiologic signals onto the human skin and in the brain, respectively. Especially, gallium based liquid metal stretchable electronics can offer human-interactive biosensors to monitor various physiologic parameters. However, the liquid-like nature, surface oxidation and contamination by organic materials, and low biostability of the liquid metals have still limited the long-term use as bioelectronics. Here we introduced electrochemical deposition without oxidation pathways to overcome these practical challenges in liquid metal bioelectronics. CNT/PDDA composite with reduction way and PEDOT:BF₄ with oxidation way under organic solvent are suggested as rationally designed material engineering approaches. We confirmed that the structures with the soft, flexible, and stretchable liquid metal platform can successfully detect dopamine with a high sensitivity and selectivity, record neural signals including action potentials without scar formation, and monitor physiologic signals such as EMG and ECG.

• Analytical Science and Technology
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• v.37 no.4
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• pp.201-210
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• 2024

Surface-enhanced Raman scattering (SERS) has emerged as a powerful technique for detecting and analyzing chemical and biological molecules at ultra-low concentrations. The effectiveness of SERS largely depends on structures with sub-10 nm gaps, prompting the proposal of various nanostructures as efficient SERS-active platforms. Among these, single-crystalline gold nanowires (AuNWs) are particularly promising due to their large dielectric constants, well-defined geometries, atomically smooth surfaces, and surface plasmon resonance across the visible spectrum, which produce strong SERS enhancements. This review comprehensively explores the synthesis, functionalization, and application of Au NWs in SERS. We discuss various methods for synthesizing AuNWs, including the vapor transport method, which influences their morphological and optical properties. We also review practical applications in chemical and biosensing, showcasing the adaptability of Au NWs-based SERS platforms in detecting a range of analytes, from environmental pollutants to biological markers. The review concludes with a discussion on future perspectives that aim to enhance sensor performance and broaden application domains, highlighting the potential of these sensors to revolutionize diagnostics and environmental monitoring. This review underscores the transformative impact of AuNW-based SERS sensors in analytical chemistry, environmental science, and biomedical diagnostics, paving the way for next-generation sensing technologies.

• YAKHAK HOEJI
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• v.51 no.2
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• pp.96-102
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• 2007

Measurement of globotriaosylceramide (Gb3, ceramide trihexoside) in urine has clinical importance for monitoring after enzyme replacement therapy in Fabry disease patients. The disease is an X-linked lipid storage disorder that results from a deficiency of the enzyme ${\alpha}$-galactosidase A (${\alpha}$-Gal A). The lack of ${\alpha}$-Gal A causes an intracellular accumulation of glycosphingolipids, mainly Gb3. A simple, rapid, and highly sensitive analytical method for Gb3 in urine was developed without labor-extensive pre-treatment by electrospray ionization MS/MS (ESI-MS/MS). Only simple 5-fold dilution of urine is necessary for the extraction and isolation of Gb3 in urine. Gb3 in diluted urine was dissolved in dioxane containing C17:0 Gb3 as an internal standard. After centrifugation it was directly injected and analyzed through guard column by in combination with multiple reaction monitoring mode of ESI-MS/MS. Eight isoforms of Gb3 were completely resolved from urine matrix. C24:0 Gb3 occupied 50% of total Gb3 as a major component in urine. Linear relationship for Gb3 isoforms was found in the range of 0.005${\sim}$5.0 ${\mu}$g/ml. The limit of detection (S/N=5) was 0.005 ${\mu}$g/ml and limit of quantification was 0.05 ${\mu}$g/ml for C24:0 Gb3 with acceptable precision and accuracy. Correlation coefficient of calibration curves for 8 Gb3 isoforms ranged from 0.9598 to 0.9975. This method could be useful for rapid and sensitive 1st line Fabry disease screening, monitoring and/or diagnostic tool for Fabry disease.