• Biomedical Science Letters
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• v.17 no.3
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• pp.185-190
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• 2011

Adenovirus type 5 (Ad5) vectors have been used for gene transfer to a wide variety of cell types in vivo and in vitro. The advantages of adenovirus vectors include the high titer of virus readily obtained in large scale preparations, their ability to transduce dividing and non dividing cells, and the high level of transgene expression. Since adenovirus vectors do not integrate in host cell DNA, there is a lack of insertional mutagenesis. However, many human tumor cells lack expression of the adenovirus 5 receptors and contain areas of hypoxia. In order to identify the pattern of replication and gene expression of oncolytic adenovirus in hypoxic condition, multiple different fiber modified Ads (Ad5F/S11, Ad5F/S35, Ad5F/K7, Ad5F/K21, and Ad5F/RGD) was compared. The replication of all fiber modified adenovirus was inhibited in hypoxic condition in HEK 293 cells, but gene expression has variety on different tumor cell lines and the level of coxackievirus and adenovirus receptor (CAR) expression. These data suggest that CAR expression pattern and hypoxic condition of tumor are considered for optimal oncolytic adenovirus application.

• Journal of Biomedical Engineering Research
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• v.26 no.5
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• pp.283-294
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• 2005

The Center for Imaging Human Structures (CIH) was established in December 2002 to develop new diagnostic imaging techniques and to make them available to the greater community of biomedical and clinical researchers at Sungkyunkwan University. CIH has been involved in 5 specific activities to provide solutions for early diagnosis and improved treatment of human diseases. The five area goals include: 1) development of a digital mammography system with computer aided diagnosis (CAD); 2) development of digital radiological imaging techniques; 3) development of unified medical solutions using 3D image fusion; 4) development of multi-purpose digital endoscopy; and, 5) evaluation of new imaging systems for clinical application

• Proceedings of the KOSOMBE Conference
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• v.1994 no.05
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• pp.60-62
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• 1994

In this paper, we present a signal analysis workstation in which the user can scrutinize and quantify biological signals, observe the effects of various signal processing algorithms on them, and eventually get some interpretation of clinical use. Within the system, the user can also access all the information in the central data base, such as patient personal information, biological signal information, and insert his interpretation results obtained into the data base after his careful observation. The software system is designed in an object-oriented paradigm, and written in C++ as a window-based application program.

• Journal of Biomedical Engineering Research
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• v.3 no.1
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• pp.35-42
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• 1982

The objective of this phantom study is to develop a digital method for improving the lateral resolution of B-scan ultrasonographic images irs medical application of ultrasound. By utilizing a discrete state-space modeling approach and Kalman-Buch method for analysis of the transducer's beam profile and the measurement and sampling noise, a stable recursive restoration of the object image was obtained for improved lateral resolution. The point spread function (PSF) was measured for the reflective signals after scanning the small pins located along the depth of interest. One major advantage of the present recursive scheme over the transform method is in its applicability for the space-variant imaging, such as in the case of the rotational movement of transducer.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.11
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• pp.239-241
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• 1995

There has presently been made impressional progress in the data communications and communication equipment market throughout the industry. Especially the CALS(Commerce At Light Speed) that is currently rising domestically, clearly shows the changes In the communication market in the near future. This will also apply to medical equipments where there will be significant progress in communications between medical equipments or through present network system. We will show how these communication equipments can be applied to the equipments we are designing, and how these application can be used.

• Journal of Biomedical Engineering Research
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• v.27 no.6
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• pp.357-364
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• 2006

Microwave Radiometry is the spectral measurement of eleclromagnetic radiation at frequency bands in the microwave region. One particular application of Microwave Radiometry is for analyzing temperature difffrentials of inside of human body to detect and diagnose pathologic conditions in which the temperature differentials are related with the symptoms of certain diseases. To accomplish this aim, we propose a new calibration method for estimating subcutaneous temperature by Microwave Radiometer and we also suggest a tumor-imitator phantom structure for simulating heat diffusion propagated by tissues around tumors to evaluate the discernment of brighuless temperature difffrentials.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.263-266
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• 1997

The purpose of this paper is the development of Integrated Bio-signal Management System. (IBMS) using the network. IBMS is the system to manage the medical signals that measured from the each independent medical measurement system module. Each has a LAN Card. We developed the Network Application using Socket Library. Also, we developed the Graphic User Interface software for IBMS using Visual C++ on Windows 95.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2006.08a
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• pp.107-107
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• 2006

• Biomedical Science Letters
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• v.26 no.3
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• pp.136-148
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• 2020

A bispecific antibody (BsAb) is an artificial protein containing two kinds of specific antigen binding sites. BsAb can connect target cells to functional cells or molecules, and thus stimulate a directed immune response. Last several decades a wide variety of bsAb formats and production technologies have been developed. BsAbs are constructed either chemically or biologically, exploiting techniques like cell fusion and recombinant DNA technologies. There are over 100 different formats of bsAb so far developed, but they could be classified into the two main categories such as Fc-based (with a Fc region) bsAbs and fragment-based (without a Fc region) bsAbs. BsAb has a broad application prospect in tumor immunotherapy and drug delivery. Here, we present a brief introduction to the structure of antibody, pharmacological mechanisms of antibodies and the trend in the production technologies of therapeutic antibodies. In addition, we address a review on the current status of various bsAb format development and their production technologies together with global situation in the clinical studies of bsAb.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.183-184
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• 1998

Respiration monitoring is important in many clinical situations due to its relationship to vitality. But present commercial monitoring systems are bulky and expensive, so they are inadequate to be used for long term recording or out-patients application. We have developed a low cost, low power, handhold respiration monitoring system based on airflow measurement. Respiration flow is indirectly detected using a thermister or a themocouple sensor. Real time recording of respiration rate, abnormality detection and apnea alarming are available.