• Journal of Biomedical Engineering Research
• /
• v.28 no.6
• /
• pp.750-755
• /
• 2007

The linear SEF (Spectral Edge Frequency) parameter and spectrum analysis method can not reflect the non-linear of EEG. This method can not contribute to acquire real time analysis and obtain a high confidence in the clinic due to low discrimination. To solve the problems, the development of a new index is carried out using the bispectrum analyzing the EEG including the non-linear characteristic. At the bispectrum analysis of the 2 dimension, the most significant's power spectrum density peaks appeared much at the specific area in awake and anesthesia state. Because many peaks are showed at the specific area in the frequency coordinate, these points are used to create the new index. Range of the index is 0-100. At the anesthesia, the index is 20-50 and at the awake, the index is 90-60. New index can discriminate the awake and anesthesia state.

• BMB Reports
• /
• v.44 no.2
• /
• pp.118-122
• /
• 2011

Most widely used secondary structure assignment methods such as DSSP identify structural elements based on N-H and C=O hydrogen bonding patterns from X-ray or NMR-determined coordinates. Secondary structure assignment algorithms using limited $C{\alpha}$ information have been under development as well, but their accuracy is only ~80% compared to DSSP. We have hereby developed SABA (Secondary Structure Assignment Program Based on only Alpha Carbons) with ~90% accuracy. SABA defines a novel geometrical parameter, termed a pseudo center, which is the midpoint of two continuous $C{\alpha}s$. SABA is capable of identifying $\alpha$-helices, $3_{10}$-helices, and $\beta$-strands with high accuracy by using cut-off criteria on distances and dihedral angles between two or more pseudo centers. In addition to assigning secondary structures to $C{\alpha}$-only structures, algorithms using limited $C{\alpha}$ information with high accuracy have the potential to enhance the speed of calculations for high capacity structure comparison.

• Journal of Biomedical Engineering Research
• /
• v.31 no.1
• /
• pp.14-19
• /
• 2010

Baroreflex sensitivity (BRS) is a parameter of the cardiovascular system that is reflected in changes in pulse interval (PD and systolic blood pressure (SBP). BRS contains information about how the autonomic nervous system regulates hemodynamic homeostasis. Normally the beat-to-beat SBP measurement and the pulse interval measured from the electrocardiogram (ECG) are required to estimate the BRS. We investigated the possibility of measuring BRS in the absence of a beat-to-beat SBP measurement device. Pulse arrival time (PAT), defined as the time between the R-peak of the ECG and a single characteristic point on the pulse wave recorded from any arterial location was measured by photoplethysmography. By comparing the BRS obtained from conventional measurements with our method during controlled breathing, we confirmed again that PAT and SBP are closely correlated, with a correlation coefficient of -0.82 to -0.95. The coherence between SBP and PI at a respiration frequency of 0.07-0.12 Hz was similar to the coherence between PAT and PI. Although the ranges and units of measurement are different (ms/mmHg vs. ms/ms) for BRS measured conventionally and by our method, the correlation is very strong. Following further investigation under various conditions, BRS can be reliably estimated without the inconvenient and expensive beat-to-beat SBP measurement.

• Journal of Biomedical Engineering Research
• /
• v.30 no.3
• /
• pp.241-246
• /
• 2009

Since inappropriate muscle forces mean that people cannot perform some activities related to roles of the muscle, muscle forces have been considered as an important parameter in clinic. Therefore, many methods have been introduced to estimate muscle forces indirectly. One of the methods is muscle tissue dynamics and it is widely used in commercial softwares including musculoskeletal model, such as SIMM. They, however, need motion data captured from 3-dimensional motion analysis system. In this study, we introduced an algorithm to estimate muscle forces in real-time by using joint angles. The heel-rise movements were performed for a normal with 3-dimensional motion analysis system, EMG measurement system, and electrogoniometers. Joint angles obtained from electrogoniometers and EMG signals were used to estimate muscle forces. Simulation was performed to find muscle forces using motion data which was imported into musculoskeletal software. As the results, muscle lengths and forces from the developed algorithm were similar to those from commercial software in pattern. Results of this study would be helpful to implement a tool to calculate reasonable muscle forces in real-time.

• Proceedings of the KOSOMBE Conference
• /
• v.1996 no.05
• /
• pp.77-81
• /
• 1996

To emulate tri-phasic pulsatile flow of human circulatary system, we have selected control parameters and examined the changing effect of each parameter by using Doppler ultrasound. In this experiment, it was shown that the distal complaince and the break time were the major factors to form tri-phasic flow.

• International Journal of Vascular Biomedical Engineering
• /
• v.1 no.2
• /
• pp.20-29
• /
• 2003

A new treatment for coronary artery occlusive disease is being developed in which a shunt or conduit is placed directly connecting the left ventricle with the diseased artery at a point distal to the obstruction. To aid in assessing and optimizing its benefit, a computational model of the cardiovascular system was developed and used to explore various design conditions. Simulation results indicate that in complete LAD occlusion, flow can be returned to approximately 65% of normal if the conduit resistance is equal for forward and reverse flow, increasing to 80% in the limit in which backflow resistance is infinite. Increases in flow rate produced by asymmetric flow resistance are considerably enhanced in the case of a partial LAD obstruction since the primary effect of resistance asymmetry is to prevent leakage back into the ventricle("steal") during diastole. Increased arterial compliance has little effect on net flow with a symmetric shunt, but leads to considerable augmentation when the resistance is asymmetric. These results suggest that an LV-LAD conduit will be beneficial when stenosis resistance(Rst) > 27 PRU if resistance is symmetric.

• Proceedings of the KIEE Conference
• /
• 2009.07a
• /
• pp.1978_1979
• /
• 2009

Heart rate may be a very important parameter in human health. To extract heart rate, the electrocardiogram(ECG) is commonly used. But the ECG acquisition procedure is somewhat complex. On the other hand, the acquisition of pulse wave or photoplethysmogram(PPG) is very easy. However, the peak of PPG is not so sharp as ECG. This study tries to enhance the performance of period detection in PPG signal. The method uses the average slopes around the main peak. The crossing point of the increasing and the decreasing slopes is selected as the peak point of heart rate period. The proposed method showed smoothed heart rate graph and reduced irregularity in heart rate values.

• Journal of Biomedical Engineering Research
• /
• v.31 no.3
• /
• pp.194-198
• /
• 2010

The effective Young’s modulus of a microfibril surrounded by water may be simply calculated by using the upper (Voigt) and lower (Reuss) bounds, which is one way to estimate the Young’s modulus in composite materials. The Steered Molecular Dynamics (SMD) has been used for estimating the Young’s modulus of a microfibril surrounded by water. In this paper, the result estimated by the upper (Voigt) and lower (Reuss) bounds shows 9.2% to 21.8% discrepancy from the result estimated by SMD, but introducing “efficiency of reinforcement parameter” removes the discrepancy and shows good agreement with the result estimated by SMD. We found the best fit for the Young’s modulus against the size of the gap between microfibrils. Also the steps using these bounds are much simpler than SMD.

• Proceedings of the KIEE Conference
• /
• 1987.07b
• /
• pp.1317-1321
• /
• 1987

A new type of motor-driven Total Artificial Heart(TAH) system with rolling cylinder mechanism has been developed. Brushless DC motor was chosen as energy converter and controlled by PI controller according to the given velocity profile under the highly time-varying load. Computer simulation was also performed to calculate the optimal gains of PI controller which minimize the input power, one of the most important parameter in artificial heart system.

• International Journal of Vascular Biomedical Engineering
• /
• v.4 no.1
• /
• pp.17-26
• /
• 2006

Diabetes mellitus (DM) is a metabolic disorder, characterized by varying or persistent hyperglycemia, which induces several changes in the erythrocyte membrane and its cytoplasm, leading to alteration in the deformability. Techniques applied to measure this are based on filtration of erythrocyte suspension through a membrane and to obtain diffraction pattern under sheared conditions. Ektacytometry requiring less quantity of blood with disposable flow chamber used to measure the deformability of erythrocytes obtained from patients with diabetes and also associated with nephropathy and retinopathy. A decreasing trend of deformability in these patients is observed. The shape parameter form factor, as determined by image processing procedure, increases with the increased of blood glucose levels and shows a pattern similar to filtration time of erythrocyte suspensions through cellulose membranes. Further work is suggested to detect micro-level changes in cell membrane in diabetic patients