• Title/Summary/Keyword: Biological variable

Search Result 381, Processing Time 0.034 seconds

Wide phenotypic variations in Charcot-Marie-Tooth 1A neuropathy with rare copy number variations on 17p12

  • Kanwal, Sumaira;Choi, Byung-Ok;Kim, Sang-Beom;Koo, Hea-Soo;Kim, Jee-Young;Hyun, Young-Se;Lee, Hye-Jin;Chung, Ki-Wha
    • Animal cells and systems
    • /
    • v.15 no.4
    • /
    • pp.301-309
    • /
    • 2011
  • Charcot-Marie-Tooth disease (CMT) is clinically heterogeneous hereditary motor and sensory neuropathies with genetic heterogeneity, age-dependent penetrance, and variable expressivity. Rare copy number variations by nonrecurrent rearrangements have recently been suggested to be associated with Charcot-Marie-Tooth 1A (CMT1A) neuropathy. In our previous study, we found three Korean CMT1A families with rare copy number variations (CNVs) on 17p12 by nonrecurrent rearrangement. Careful clinical examinations were performed in all the affected individuals with rare CNVs (n=19), which may be the first full study of a subject from a large CMT1A family with nonrecurrent rearrangement. The clinical phenotype showed no significant difference compared with common CMT1A patients, but with variable phenotypes. In particular, a broad intrafamilial phenotypic spectrum was observed within the same family, which may suggest the existence of a genetic modifier. This study may broaden the understanding of the role of CNVs in the pathogenesis of CMT.

Solubility of Ibuprofen in Supercritical Carbon Dioxide (초임계 이산화탄소를 이용한 Ibuprofen의 용해도 측정)

  • Kim, Young Ae;Chu, Junho;Lim, Jong Sung;Kim, Hwayoung;Lee, Youn-Woo
    • Clean Technology
    • /
    • v.11 no.3
    • /
    • pp.147-152
    • /
    • 2005
  • For estblishing the best technique for the micronization of Ibuprofen using supercritical fluids, the solubility should be known. The solubility of Ibuprofen in supercritical carbon dioxide was measured by observing the cloud point. The cloud point was observed using high pressure equipment equipped a variable volume view cell between temperature of 35, 40 and $45^{\circ}C$. The solubility data was correlated by the Peng-Robinson equation of state Solute physical properties, such as critical temperature (Tc), critical pressure (Pc) and acentric factor (${\omega}$) were estimated by the some group contribution method. As pressure was increased, the solubility increased at constant temperature. The retrograde phenomenon by a solute vapor pressure and a density of solvent was observed at the pressure of around 150bar. It was found that $CO_2$ can be used as a supercritical solvent in micronization of ibuprofen by RESS.

  • PDF

Development of Blood Pressure Estimation Algorithm Using Variable Characteristic Ratios on Oscillometric Method (진동법에서 가변 특성 비를 이용한 혈압 추정 알고리즘의 개발)

  • Shin, Joon
    • Journal of Biomedical Engineering Research
    • /
    • v.30 no.6
    • /
    • pp.510-515
    • /
    • 2009
  • In this paper, variable characteristic ratio algorithm based on oscillometric method is proposed to enhance the accuracy of blood pressure measurement. We combined the slope-based approach and fuzzy inference technique to change the characteristic ratios of height-based method. The proposed algorithm was assessed on 255 measurements from 85 subjects and compared with the conventional height-based algorithm. The testing results showed that the developed algorithm achieved an overall grade A for both systolic and diastolic blood pressures according to the BHS protocol. And, mean standard deviation between the observers and the developed algorithm were 5.71mmHg and 6.29mmHg for systolic and diastolic pressures respectively, which also fulfilled the AAMI criteria. In conclusion, this algorithm was successfully developed and recommended for further clinical trials with the wider adult population.

Removal of Hydrogen Sulfide using Reticulated Polyurethan Carrier in Biofilter (망상구조 폴리우레탄 담체를 이용한 황화수소 제거)

  • Jeong, Gwi-Taek;Lee, Gwang-Yeon;Cha, Jin-Myoung;Park, Don-Hee
    • Korean Chemical Engineering Research
    • /
    • v.45 no.4
    • /
    • pp.372-377
    • /
    • 2007
  • In order to assess its capability as biofilter bed material under variable conditions of two parameters (inlet gas concentration and inlet gas flow rate), reticulated polyurethan was applied to remove hydrogen sulfide via a biological process. We detected a maximal elimination capacity (critical loading rate) of $488.3(330.1)g-H_2S/m^3{\cdot}hr$, when reticulated polyurethane was employed as supporting material of biofilter. This study show that the application of reticulated polyurethane carrier might be a favorable choice as a packing material in biofilter for the biological removal of hydrogen sulfide.

Study of Boron Doping Feasibility with Atmospheric Pressure Plasma for p-n Junction Formation on Silicon Wafer for Semiconductor (p-n 접합 형성을 위한 반도체 실리콘 웨이퍼 대기압 플라즈마 붕소 확산 가능성 연구)

  • Kim, Woo Jae;Lee, Hwan Hee;Kwon, Hee Tae;Shin, Gi Won;Yang, Chang Sil;Kwon, Gi-Chung
    • Journal of the Semiconductor & Display Technology
    • /
    • v.16 no.4
    • /
    • pp.20-24
    • /
    • 2017
  • Currently, techniques mainly used in semiconductor impurity diffusion processes include furnace thermal diffusion, ion implantation, and vacuum plasma doping. However, there is a disadvantage that the process equipment and the unit cost are expensive. In this study, boron diffusion process using relatively inexpensive atmospheric plasma was conducted to solve this problem. With controlling parameters of Boron diffusion process, the doping characteristics were analyzed by using secondary ion mass spectrometry. As a result, the influence of each variable in the doping process was analyzed and the feasibility of atmospheric plasma doping was confirmed.

  • PDF

Cost Analysis Model according to Mortality in Land-based Aquaculture (육상수조 어류양식 생존율에 따른 비용분석모형)

  • Eh, Youn-Yang
    • The Journal of Fisheries Business Administration
    • /
    • v.47 no.4
    • /
    • pp.1-13
    • /
    • 2016
  • Fish mortality is the most important success factor in aquaculture management. To analyze the effect of mortality considering biological and economic condition is a important problem in land-based aquaculture. This study is aimed to analyze the effect of mortality for duration of cultivation in land-based aquaculture. This study builds the mathematical model that finds the value of decision variable to minimize cost that sums up the water pool usage cost, sorting cost, fingerling cost and feeding cost under critical standing corp constraint. The proposed mathematical model involves many aspects, both biological and economical: (1) number of fingerlings (2) timing and number of batch splitting event, based on (3) fish growth rate, (4) mortality, and (5) several farming expense. Numerical simulation model presented here in. The objective of numerical simulation is to provide for decision makers to analyse and comprehend the proposed model. When extensive biological and cost data become available, the proposed model can be widely applied to yield more accurate results.

Monitoring of Biological Processes by 2-dimensional Fluorescence Sensor (2차원 형광센서에 의한 생물공정의 모니터링)

  • 이종일;정상윤;서국화
    • KSBB Journal
    • /
    • v.16 no.5
    • /
    • pp.493-499
    • /
    • 2001
  • This work presented the monitoring technique of biological processes by a 2-dimensional fluorescence sensor. The 2-dimensional fluorescence sensor can be used to monitor some important variable during cultivation processes simultaneously. In this study we have monitored fermentation processes of a few microorganisms such as recombinant E.coli, A. terreus and T. vulgaris. and investigated the change of the fluorescence spectra in the fermentation processes qualitatively. The 2-dimensional fluorescence sensor can be also used to monitor biochemical reactions and separation processes and applied for the optimization of biological processes.

  • PDF

Enhancement of UV-induced nucleotide excision repair activity upon forskolin treatment is cell growth-dependent

  • Lee, Jeong-Min;Park, Jeong-Min;Kang, Tae-Hong
    • BMB Reports
    • /
    • v.49 no.10
    • /
    • pp.566-571
    • /
    • 2016
  • Forskolin (FSK), an adenylyl cyclase activator, has recently been shown to enhance nucleotide excision repair (NER) upon UV exposure. However, our study revealed that this effect was detected in human skin epithelial ARPE19 cells only in growing cells, but not in non-cycling cells. When the cells were grown at low density (70% confluence), FSK was capable of stimulating cAMP responsive element binding (CREB) phosphorylation, a marker for FSK-stimulated PKA activation, and resulted in a significant increase of NER activity compared to control treatment. However, cells grown under 100% confluent conditions showed neither FSK-induced CREB phosphorylation nor the resulting NER enhancement. These findings indicate that cellular growth is critical for FSK-induced NER enhancement and suggest that cellular growth conditions should be considered as a variable while evaluating a reagent's pharmacotherapeutic efficacy.

DEVELOPMENT OF A 3-DOF ROBOT FOR HARVESTING LETTUCE USING MACHINE: VISION AND FUZZY LOGIC CONTROL

  • S. I. Cho;S. J. Chang;Kim, Y. Y.
    • Proceedings of the Korean Society for Agricultural Machinery Conference
    • /
    • 2000.11b
    • /
    • pp.354-362
    • /
    • 2000
  • In Korea, researches on year-round leaf vegetables production system are in progress, most of them focused on environmental control. Therefore, automation technologies for harvesting, transporting, and grading are in great demand. A robot system for harvesting lettuces, composed of a 3-DOF (degree of freedom) manipulator, an end-effector, a lettuce feeding conveyor, an air blower, a machine vision system, six photoelectric sensors, and a fuzzy logic controller, was developed. A fuzzy logic control was applied to determine appropriate grip force on lettuce. Leaf area index and height were used as input variables and voltage as an output variable for the fuzzy logic controller. Success rate of the lettuce harvesting was 94.12%, and average harvesting time was approximately 5 seconds per lettuce.

  • PDF

Molecular phylogeny of Daucus (Apiaceae): Evidence from nuclear ribosomal DNA ITS sequences

  • Lee, Byoung Yoon;Park, Chong-Wook
    • Journal of Species Research
    • /
    • v.3 no.1
    • /
    • pp.39-52
    • /
    • 2014
  • The Apiaceae genus Daucus consists of approximately 25 species (including carrots) which are characterized by the presence of bracts in pedunculate umbels, dorsally compressed mericarps, hairs on primary ridges, and uniseriately arranged spines on the secondary ridges of the fruit. Taxonomically, Daucus has been considered to be one of the most problematic genera in the Apiaceae due to the highly variable fruit morphology. Despite taxonomic controversy and economic importance of the genus, no rigorously constructed estimate of phylogenetic relationships exists. To examine generic limit and relationships among species of Daucus and its putatively related taxa, phylogenetic analyses of characters derived from nuclear ribosomal DNA ITS sequences were conducted. Two major clades emerged within Daucus, but neither of them have been previously recognized using morphological characters. The phylogeny also provides taxonomic status of recently reported new species of Daucus, D. arcanus and D. conchitae.