• 한국농공학회논문집
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• 제61권6호
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• pp.1-8
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• 2019

Carbon dioxide is one of the major driving forces causing climate changes, and many countries have been trying to reduce carbon dioxide emissions from various sources. Soil stores more carbon dioxide(two to three times) amounts than atmosphere indicating that soil organic carbon emission management are a pivotal issue. In this study, we developed a Soil Organic Carbon(SOC) storage estimation model to predict SOC storage amounts in soils. Also, SOC storage values were assessed based on the carbon emission price provided from Republic Of Korea(ROK). Here, the SOC model calculated the soil hydraulic properties based on the soil physical and chemical information. Base on the calculated the soil hydraulic properties and the soil physical chemical information, SOC storage amounts were estimated. In validation, the estimated SOC storage amounts were 486,696 tons($3.526kg/m^2$) in Jindo-gun and shown similarly compared to the previous literature review. These results supported the robustness of our SOC model in estimating SOC storage amounts. The total SOC storage amount in ROK was 305 Mt, and the SOC amount at Gyeongsangbuk-do were relatively higher than other regions. But the SOC storage amount(per unit) was highest in Jeju island indicating that volcanic ashes might influence on the relatively higher SOC amount. Based on these results, the SOC storage value was shown as 8.4 trillion won in ROK. Even though our SOC model was not fully validated due to lacks of measured SOC data, our approach can be useful for policy-makers in reducing soil organic carbon emission from soils against climate changes.

• 수산경영론집
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• 제51권4호
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• pp.19-45
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• 2020

This study is to evaluate economic effect of the creation project of snow crab, Chionoecetes opilio, spawning and habitat ground in Uljin and Youngdeok county. The main results of this study are summarized as follows: first, 14,400 million won was invested in the creation project cost of Chionoecetes opilio spawning and habitat ground of Uljin and Youngdeok County from 2015 to 2020. Second, the creation project of Chionoecetes opilio spawning and habitat ground directly provides fishing benefits, festival benefits, research and development benefits and employment benefits. Third, on the basis of above benefits, the creation project of Chionoecetes opilio spawning and habitat ground has net present value of 29,900.53 million won, internal rate of return 16.9%, and benefit-cost of 2.91 under a 4.5% social discount rate. Also, the creation project creates 195 jobs. This indicates that the creation project of Chionoecetes opilio spawning and habitat ground not only contributes to the increase in the income of coastal fishery and fishing villages but also to the job making. The result of this study provides useful information to policy makers or project managers as it shows that the project to create spawning and habitat ground should be carried out in consideration of the resource and biological characteristics of individual fish and that economic assessment logic should also be developed based on this. Also, it proves that the project to create a snow crab spawning and habitat ground is a national and local infrastructure project that increases the actual fishing income in the region. At the same time, it maintains the reproducibility function of most fish species, along with enhancing the people's benefits such as fishing village tourism and marine product consumption. Moreover, it provides useful information on budgeting for the continuous development of snow crab spawning and habitat ground in the mid to long-term.

• 한국물환경학회지
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• 제36권6호
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• pp.621-635
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• 2020

Water quality models are scientific tools that simulate and interpret the relationship between physical, chemical and biological reactions to external pollutant loads in water systems. They are actively used as a key technology in environmental water management. With recent advances in computational power, water quality modeling technology has evolved into a coupled three-dimensional modeling of hydrodynamics, water quality, and ecological inputs. However, there is uncertainty in the simulated results due to the increasing model complexity, knowledge gaps in simulating complex aquatic ecosystem, and the distrust of stakeholders due to nontransparent modeling processes. These issues have become difficult obstacles for the practical use of water quality models in the water management decision process. The objectives of this paper were to review the theoretical background, needs, and development status of water quality modeling technology. Additionally, we present the potential future directions of water quality modeling technology as a scientific tool for national environmental water management. The main development directions can be summarized as follows: quantification of parameter sensitivities and model uncertainty, acquisition and use of high frequency and high resolution data based on IoT sensor technology, conjunctive use of mechanistic models and data-driven models, and securing transparency in the water quality modeling process. These advances in the field of water quality modeling warrant joint research with modeling experts, statisticians, and ecologists, combined with active communication between policy makers and stakeholders.

• Journal of Korean Neurosurgical Society
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• 제65권2호
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• pp.236-244
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• 2022

Objective : To evaluate the interactions among differentially expressed autophagy and mitophagy markers in subarachnoid hemorrhage (SAH) patients with delayed cerebral ischemia (DCI). Methods : The expression data of autophagy and mitophagy-related makers in the cerebrospinal fluid (CSF) cells was analyzed by real-time reverse transcription-polymerase chain reaction and Western blotting. The markers included death-associated protein kinase (DAPK)-1, BCL2 interacting protein 3 like (BNIP3L), Bcl-1 antagonist X, phosphatase and tensin homolog-induced kinase (PINK), Unc-51 like autophagy activating kinase 1, nuclear dot protein 52, and p62. In silico functional analyses including gene ontology enrichment and the protein-protein interaction network were performed. Results : A total of 56 SAH patients were included and 22 (38.6%) of them experienced DCI. The DCI patients had significantly increased mRNA levels of DAPK1, BNIP3L, and PINK1, and increased expression of BECN1 compared to the non-DCI patients. The most enriched biological process was the positive regulation of autophagy, followed by the response to mitochondrial depolarization. The molecular functions ubiquitin-like protein ligase binding and ubiquitin-protein ligase binding were enriched. In the cluster of cellular components, Lewy bodies and the phagophore assembly site were enriched. BECN1 was the most connected gene among the differentially expressed markers related to autophagy and mitophagy in the development of DCI. Conclusion : Our study may provide novel insight into mitochondrial dysfunction in DCI pathogenesis.

• Parasites, Hosts and Diseases
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• 제59권6호
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• pp.595-605
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• 2021

An understanding of the knowledges, attitudes and perceptions of different populations is key for public health policy makers. Here, a survey was performed on knowledge, attitudes, and perceptions about malaria diagnosis, prevention, control, and treatment. The 407 survey participants included both uninfected inhabitants and patients from 2 cities (Gimpo- and Paju-si) of Northern Gyeonggi-do, known as high-risk areas for vivax malaria. We used community-based study design and non-probability sampling method using the primary data. Association between variables were tested using χ²-tests. In general, the information on malaria reported by the participants in this study was unsystematic and included inaccurate details. The knowledge of malaria symptoms, identified as headache, chills and fever, was high, but the surveyed community lacks knowledge of the specific medications used for malaria treatment, with a large number of respondents having no knowledge of any form of medication. Survey questions with high correct answer rates included questions about easy treatment of malaria in Korea, the high daytime activity of malaria-borne mosquitoes, and the infection risk posed by outdoor activities. However, a large portion of the respondents was unable to provide simple medical and biological information about the disease. This study aimed to comprehensively evaluate the knowledge, attitude, and practical behavior of the surveyed community with respect to malaria and the implications reported here could be applicable to other malaria endemic areas in Korea.

• Journal of Ecology and Environment
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• 제47권4호
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• pp.219-227
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• 2023

The US National Science Foundation's National Ecological Observatory Network (NEON) is a continental-scale program intended to provide open data, samples, and infrastructure to understand changing ecosystems for a period of 30 years. NEON collects co-located measurements of drivers of environmental change and biological responses, using standardized methods at 81 field sites to systematically sample variability and trends to enable inferences at regional to continental scales. Alongside key atmospheric and environmental variables, NEON measures the biodiversity of many taxa, including microbes, plants, and animals, and collects samples from these organisms for long-term archiving and research use. Here we review the composition and use of NEON resources to date as a whole and specific to biodiversity as an exemplar of the potential of national research infrastructure to contribute to globally relevant outcomes. Since NEON initiated full operations in 2019, NEON has produced, on average, 1.4 M records and over 32 TB of data per year across more than 180 data products, with 85 products that include taxonomic or other organismal information relevant to biodiversity science. NEON has also collected and curated more than 503,000 samples and specimens spanning all taxonomic domains of life, with up to 100,000 more to be added annually. Various metrics of use, including web portal visitation, data download and sample use requests, and scientific publications, reveal substantial interest from the global community in NEON. More than 47,000 unique IP addresses from around the world visit NEON's web portals each month, requesting on average 1.8 TB of data, and over 200 researchers have engaged in sample use requests from the NEON Biorepository. Through its many global partnerships, particularly with the Global Biodiversity Information Facility, NEON resources have been used in more than 900 scientific publications to date, with many using biodiversity data and samples. These outcomes demonstrate that the data and samples provided by NEON, situated in a broader network of national research infrastructures, are critical to scientists, conservation practitioners, and policy makers. They enable effective approaches to meeting global targets, such as those captured in the Kunming-Montreal Global Biodiversity Framework.

• Journal of Applied Biological Chemistry
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• 제59권4호
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• pp.365-372
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• 2016

본 연구에서는 150 mM HCl/60 % ethanol로 급성 위염을 유발한 마우스에서 증숙 시간에 따른 홍삼의 위염 보효 효과에 대해 살펴보고자 하였다. 백삼과 홍삼의 증숙 시간에 따른 성분을 분석한 결과 사포닌, total polyphenol과 total flavonoid의 총 함량이 증숙 시간에 따라 증가하였고 6시간 증숙한 홍삼에서 가장 높은 함량을 보였다. 또한 1,1-diphenyl-2-picrylhydrazyl와 2,2'-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid radical 소거능 실험을 통해 항산화 활성을 측정한 결과 RG 6에서 가장 높은 활성을 나타냈다. In vitro 실험 결과를 바탕으로 시료를 선택하였고 in vivo 실험을 진행하였다. 급성 위염 마우스 모델에 백삼과 6시간 증숙한 홍삼을 투여하였을 때, RG 6에서 위 점막 손상의 개선을 육안적으로 확인할 수 있었으며, 혈액에서 측정한 ROS 수치도 대조군에 비해 유의적인 감소를 보였다. 또한 염증성 사이토카인을 확인한 결과 대조군에 비해 RG6에서 감소하는 경향을 보였다. 이러한 결과들을 종합해 볼 때 증숙 시간에 따른 홍삼은 급성 위염 유발 마우스 모델에서 위염 보호 효과가 있는 것으로 사료된다.

• 환경영향평가
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• 제19권3호
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• pp.271-279
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• 2010

We conducted a quantitative human health risk assessment with respect to inhalation of heavy metals for residents of housing developments in "new towns" where an incinerator will be operated within the area scheduled for construction thereof. To assess potential human health risk we calculated the amount of heavy metals emitted from the incinerator, and then forecasted the potential health impact on adjoining areas where new housing is to be developed (i.e. "new towns") at different altitudes by a using SCREEN-3 model. We assessed Cancer Risk (CR) caused by known carcinogens using the Inhalation Unit Risk criteria developed by the US Environmental Protection Agency. Notably, we assessed risk by determining concentrations of heavy metals on a floor by floor basis, as apartment buildings are to be constructed near the incinerator according to a pre-devised plan. Results indicated that cancer risk for most carcinogens exceeded US EPA standards for the highest locations at each collection point. This result indicates that construction of high buildings in areas adjoining incinerators is undesirable, and that measures to lower carcinogens are needed. The results of this study, which assessed health risk from exposure to heavy metals emitted from a nearby incinerator, can be useful in land use planning with respect to the location of housing developments in new towns, as well as the heights of any buildings constructed. Furthermore, the methodology deployed herein with respect to risk assessment can be helpful for policy makers and the general public in the event of conflicts regarding incinerator projects in the future. The results herein may also be of merit in determining priorities when establishing harm reduction measures for carcinogens at incinerators. However, the study does contain several limitations. The SCREEN-3 model, a kind of screening model that provides conservative results, can provide higher forecasted concentrations of air pollutants than other models. Moreover, although the incinerator in question is set to be a thermoselect type, domestic data for emissions from these incinerators is not available, and assumptions were based on a stoker type incinerator. Insufficient domestic data likewise compelled the use of data of USA, resulting in possible errors in results. Continued research will thus be required to develop systematic methodologies that address the foregoing factors and produce more reliable outcomes.

• 수산경영론집
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• 제18권1호
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• pp.59-97
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• 1987

Tuna and tuna fishing extend over most of the tropical waters of the world oceans, especially, this study of the Indian Ocean and the fish and the fishing vessels are highly mobile. No country can deal in isolation with the problems of its tuna fishery and of any tuna fishery in its waters, without collaborating with other countries. This cooperation is often best established through some formal international mechanism. The essential requirements are for information-on the resources, the fishery, the trade-and to identify where management actions are needed to consore the resources or to maintain the economic or social function of the fishery. These will also usually require some form of international mechanism. With the changes in the Law of the Sea, the siuuation in respect of management of tuna-considered among the highly migratory species, requirng special treatment-has also changed. At present there are both uncertainty regarding tuna management and political arguments as to how such management can be best implemented. Bearing this in mind, together with the fact that only few tuna stocks have shown clear evidence of serious depletion through over-exploitation, present emphasis will be placed on information requirements. This study included compiling the data necessary to review the state of stoks in the Indian Ocean tuna fishing grounds. Information on the resources-where the fish are, their quantity, their movements, etc. is important, whether in planning development of new fisheries, or considering the need for collaboration with other countries (in ascertaining to what extent their catches may affect catches of the natoinal fleet) or for conservation measures. A major source of information is the statistics of for conservation measures. A major source of information is the statistics of catch and fishing effort from existing commercial vessels. These need to be assembled for all fisheries on the same stock on an oceanwide basis. The statistical data also need to be analysed and intepreted, and combined with biological data(e.g., on growth, mortality and migration rates) to provide information that is intelligible and useful for administrators and other decision-makers. This must also be undertaken on a resource-wide or ocean-wide basis. Finally, because of the world-wide similarities in the methods of datching, processing and marketing fish, there is a particular tut not exclusive need in those countries just beginning to develop their tuna fisheries-to have ready access to a syntheis of information on tuna, tuna biology and tuna fisheries and tuna fisheries economics and management on the Indian Ocean.

• Molecular & Cellular Toxicology
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• 제2권4호
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• pp.236-243
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• 2006

Microarray analysis of gene expression has become a powerful approach for exploring the biological effects of drugs, particularly at the stage of toxicology and safety assessment. Acetaminophen (APAP) has been known to induce necrosis in liver, but the molecular mechanism involved has not been fully understood. In this study, we investigated gene expression changes of APAP using microarray technology. APAP was orally administered with a single dose of 50 mg/kg or 500 mg/kg into ICR mice and the animals were sacrificed at 6, 24 and 72 h of APAP administration. Serum biochemical markers for liver toxicity were measured to estimate the maximal toxic time and hepatic gene expression was assessed using high-density oligonucleotide microarrays capable of determining the expression profile of >30,000 well-substantiated mouse genes. Significant alterations in gene expression were noted in the liver of APAP-administered mice. The most notable changes in APAP-administered mice were the expression of genes involved in apoptosis, cell cycle, and calcium signaling pathway, cystein metabolism, glutatione metabolism, and MAPK pathway. The majority of the genes upregulated included insulin-like growth factor binding protein 1, heme oxygenase 1, metallothionein 1, S100 calcium binding protein, caspase 4, and P21. The upregulation of apoptosis and cell cycle-related genes were paralleled to response to APAP. Most of the affected gene expressions were returned to control levels after 72 hr. In conclusion, we identified potential hepatotoxicity makers, and these expressions profiling lead to a better understanding of the molecular basis of APAP-induced hapatotoxicity.