• Genomics & Informatics
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• 제21권3호
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• pp.31.1-31.8
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• 2023

Multiple myeloma (MM) is a hematological malignancy. It is widely believed that genetic factors play a significant role in the development of MM, as investigated in numerous studies. However, the application of genomic information for clinical purposes, including diagnostic and prognostic biomarkers, remains largely confined to research. In this study, we utilized genetic information from the Genomic-Driven Clinical Implementation for Multiple Myeloma database, which is dedicated to clinical trial studies on MM. This genetic information was sourced from the genome-wide association studies catalog database. We prioritized genes with the potential to cause MM based on established annotations, as well as biological risk genes for MM, as potential drug target candidates. The DrugBank database was employed to identify drug candidates targeting these genes. Our research led to the discovery of 14 MM biological risk genes and the identification of 10 drugs that target three of these genes. Notably, only one of these 10 drugs, panobinostat, has been approved for use in MM. The two most promising genes, calcium signal-modulating cyclophilin ligand (CAMLG) and histone deacetylase 2 (HDAC2), were targeted by four drugs (cyclosporine, belinostat, vorinostat, and romidepsin), all of which have clinical evidence supporting their use in the treatment of MM. Interestingly, five of the 10 drugs have been approved for other indications than MM, but they may also be effective in treating MM. Therefore, this study aimed to clarify the genomic variants involved in the pathogenesis of MM and highlight the potential benefits of these genomic variants in drug discovery.

• 전자공학회논문지CI
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• 제49권3호
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• pp.34-45
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• 2012

본 논문은 생물학적 바이러스의 특성과 감염 경로 및 감염 절차를 이용한 전염성 정보은닉(infectious information hiding, IIH) 기술 기반의 비디오 콘텐츠 보호 시스템을 제안한다. 제안한 IIH 시스템에서는 비디오 콘텐츠 보호에 필요한 중요 정보들을 전염성 바이러스로 간주하며, 콘텐츠 및 코덱을 숙주 및 감염 매개체로 하는 새로운 패러다임의 비디오 콘텐츠 보호 기술을 제시하였다. 전염성 정보로써 병원체, 돌연변이 및 감염체 바이러스를 모델링 하였으며, 주요 기술도구로써 전염성 정보 인증, 커널 기반 IIH, 콘텐츠 기반 IIH 및 전염성 정보 생성 기술도구들을 정의하였다. 마지막으로 기존의 간단한 정보은닉 알고리즘들을 각각 커널기반 IIH 및 콘텐츠 기반 IIH로 간주하여 시뮬레이션 함으로써 제안한 IIH 시스템의 가능성을 검증하였다.

• 지식정보인프라
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• 통권10호
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• pp.70-75
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• 2002

우리나라는 생물다양성협약(CBD, Convention on Biological Diversity)의 당사국뿐만 아니라 2001년 5월 국제생물다양성정보기구(GBIF, Global Biodiversity Information Facility)에 투표회원국으로 가입하게됨으로써 국가적 차원의 생물다양성정보 전담기구(National Node)의 지정이 표면화되었고 국내 산재한 관련 DB의 통합, 관련 연구에 집중 및 범세계적 차원으로 대응해야하는 의무가 부여되었다.

• 기술사
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• 제34권3호
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• pp.10-15
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• 2001

The biotechnology is the study of biochemical and biological processes in living things. Since 1990's biotechnology has developed more repidly than all of the life technical industries, through the use of extremly sensitive analytical instruments, computers, and radioactive tracers. The biotechnician has been able to gain an understanding of the mechanisms and information on biotechnology, enables the biologist and biochemist to fine farther information about DNA techniques and human beings.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1995년도 추계학술대회
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• pp.269-272
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• 1995

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1995년도 춘계학술대회
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• pp.230-232
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• 1995

• Genomics & Informatics
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• 제7권3호
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• pp.168-170
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• 2009

The explosion in biological data resulting from high-throughput experiments requires new software tools to manipulate and display pathways in a way that can integrate disparate sources of information. A visual Java-based CAD tool for drawing and annotating biological pathways with semiautomatic image-processing features is described in this paper. The result of the image-editing process is an XML file for the appropriate links. This tool integrates the pathway images and XML file sources. The system has facilities for linking graphical objects to external databases and is capable of reproducing existing visual representations of pathway maps.

• BMB Reports
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• 제37권1호
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• pp.35-44
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• 2004

Recently produced information on post-translational modifications makes it possible to interpret their biological regulation with new insights. Various protein modifications finely tune the cellular functions of each protein. Understanding the relationship between post-translational modifications and functional changes ("post-translatomics") is another enormous project, not unlike the human genome project. Proteomics, combined with separation technology and mass spectrometry, makes it possible to dissect and characterize the individual parts of post-translational modifications and provide a systemic analysis. Systemic analysis of post-translational modifications in various signaling pathways has been applied to illustrate the kinetics of modifications. Availability will advance new technologies that improve sensitivity and peptide coverage. The progress of "post-translatomics", novel analytical technologies that are rapidly emerging, offer a great potential for determining the details of the modification sites.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.430-433
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• 1997

We present the preliminary algorithms for automatic sleep scoring. According to the Rechtschaffen & Kales[3]'s critera, we developed six events detectors and eight parameters which contain the background information of signals, such as EEG, EMG, EOG. With the calculated parameters, we scored each epoch by IF-THEN rules, ANFIS for REM preiods, and finally Neural Network for unobvious epochs. The typical point of this algorithm is that the epoch which had good data sets were calculated in the first stage, and unobvious epochs were postponed until the final stage. After staging the good epochs, we classified unobvious epochs by the dominant stage of previous and posterior epochs.

• Journal of Species Research
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• 제5권3호
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• pp.477-482
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• 2016

Mite of the genus Hypoaspis of family Laelapidae are free-living soil predators mostly observed on the open grass field. Five species in the genus Hypoaspis were listed in Korean Catalog (NIBR, 2013) without detail information. Recent series of soil acarine biodiversity survey in Gyeongbuk and Gangwon provinces during 2009-2015 recovered a new record of Hypoaspis sardous (Canestrini, 1884) to Korean inventory from apple orchard and riparian grass land. Detailed description and morphological comparison with the related species, H. aculeifer which is well known biological control agent of horticultural crop pests were provided with identification keys.