• Proceedings of the PSK Conference
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• 2001.10a
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• pp.292.1-292.1
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• 2001

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.544-544
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• 2003

We investigated the inhibitory effect of whitening materials with growth factor or alone on melanomas derived from Human (B-16) and mouse (SK-MEL-31) using melanin content. Melanin content was determined by the absorbance value at 470nm per cells. we used the growth factors known as activators of Adenylate cyclase, Protein kinase C and tyrosine kinase pathway separately. In addition, we compared the action of UV-induced with non-biological growth factor with whitening materials in melanomas derived from Human and mouse. The results showed that the aspect of inhibitory effect of whitening materials on B16 and SK-MEL-31 was not different. And, the action of each growth factor involved in the differentiation and proliferation of melanoma on the inhibition of melanogenesis in B-16 and SK-MEL-31 using whitening agents showed no difference. Also, The action of UV -induced and non-biological growth factors didn't exhibit different pattern on the effect of whitening agent in B-16 and SK-MEL-31.

• Applied Biological Chemistry
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• v.20 no.3
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• pp.270-278
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• 1977

In case of sensory evaluation with multi-samples and long-period, in spite of using method with good sensitivity, quality differences among samples could net be detected well because of panel's fatigue and tiredness. So new method to reduce panel's sense of psychological and physiological responsibility, "Trio Paired Comparison", is designed, and New Modified Scheffe's Method 2 as the statistical method for a test of "Trio Paired Comparison" is proposed. And also in this paper problems and countermeasures in applicating "Trio Paired Comparison" are considered.

• Archives of Pharmacal Research
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• v.28 no.6
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• pp.648-651
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• 2005

Synthesis and biological evaluation of a series of $C_4$-modified acanthoic acid analogs are reported. Among them, the analog 7 and 10 exhibit potent cellular inhibitory activity in NO inhibition assay.

• Proceedings of the Korean Fiber Society Conference
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• 2007.11a
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• pp.443-444
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• 2007

• Journal of Environmental Science International
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• v.4 no.2
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• pp.201-214
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• 1995

Design approach of upflow Anaerobic Sludge Blanket(UASB) process based on the biological kinetic parameters are known to be very difficult since the characteristics of the granular slut비e depends on the type of wastewater and size distribution of the granular sludge also depends on the upflow velocity in the UASB reactors. Furthermore, industrial wastewater containing toxic substances has been treated by UASB process without the clear knowledge of toxic effects on the granular slut형e. Hence, the present research was aimed on the intensive evaluation of biological kinetic parameters of the granular sludge in UASB reactor with and without toxic substance of 2, 4-dichlorophenol in order to present the basic design measures for UASB process design. The results could be summarized as follows. The biological kinetic parameters(k and Ks) considerably varied with the granular size of the sludge. Generally, 연e k and ks values of the granular sludge increased with the particle size of the granule. The biological kinetic parameters(k and Ks) of the granular sludge obtained from batch test were not applicable to design purpose of UASB process due to substrate diffusional limitation into the granular sludge in the completely mixed UASB reactors. The toxic effects on k and Ks greatly varied with the granular sixte. And as the toxicant concentration increased, the k value decreased while the Ks value increased. Inhibition constant(hi) for k with the toxicant of 2, 4-dichlorophenol varied from 0.5 to 2.3 depending on the granular sizes while the inhibition constant(Ki) for Ks varied from 20.7 to 80.1, showing the mixed inhibition.

• Journal of Korea Water Resources Association
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• v.38 no.1
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• pp.49-57
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• 2005

The investigation and evaluation of river naturalness was conducted for sample rivers-Hongchungang, Mihochun, Naesungchun - using the method from previous paper 'The Evaluation of River Naturalness for Habitat Restoration : I. Proposal of Evaluation Method'. As a result, Hongchungang and Naesungchun, Mihochun showed 2$^{nd}$ Grades with averaged point 1.92, 1.43, and 2.31. Also comparison and examination of the relationship between water quality and river naturalness shows a little relation with coefficient of correlation 0.575. This result means that the evaluation of river naturalness can be possibly used as index to evaluate river ecology, from a different standpoint with water quality.oint with water quality.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7409-7414
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• 2015

Loop-mediated isothermal amplification (LAMP) developed by Notomi et al. (2000) has made it possible to amplify DNA with high specificity, efficiency and rapidity under isothermal conditions. The ultimate products of LAMP are stem-loop structures with several inverted repeats of the target sequence and cauliflower-like patterns with multiple loops shaped by annealing between every other inverted repeats of the amplified target in the similar strand. Because the amplification process in LAMP is achieved by using four to six distinct primers, it is expected to amplify the target region with high selectivity. However, evaluation of reaction accuracy or quantitative inspection make it necessary to append other procedures to scrutinize the amplified products. Hitherto, various techniques such as turbidity assessment in the reaction vessel, post-reaction agarose gel electrophoresis, use of intercalating fluorescent dyes, real-time turbidimetry, addition of cationic polymers to the reaction mixture, polyacrylamide gel-based microchambers, lateral flow dipsticks, fluorescence resonance energy transfer (FRET), enzyme-linked immunosorbent assays and nanoparticle-based colorimetric tests have been utilized for this purpose. In this paper, we reviewed the best-known techniques for evaluation of LAMP amplicons and their applications in molecular biology beside their advantages and deficiencies. Regarding the properties of each technique, the development of innovative prompt, cost-effective and precise molecular detection methods for application in the broad field of cancer research may be feasible.

• Journal of Environmental Science International
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• v.32 no.2
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• pp.99-120
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• 2023

The community structure of benthic macroinvertebrates in Upo wetland was identified, and the biological water quality was evaluated. In addition, through statistical analysis of current and literature data, ecological changes over time were evaluated for each wetland. Benthos were quantitatively collected in March, June, and September of 2020 and 2021, and 4 phyla, 5 classes, 16 orders, 42 families, 81 species and 3,406 individuals were identified. In the functional feeding group of Upo wetland, predators were dominant with 34 species (45.95%) and 1,504 individuals (41.84%). In the habitual dwelling group, sprawlers and swimmers showed the highest proportion in the number of species and individuals. Average biological indices in Mokpo and Upo were the highest and lowest, respectively, and it is considered that Mokpo maintains the healthy ecosystem for benthic macroinvertebrates. Community stability was high in Upo, and other wetlands are thought to be stabilizing. The ecological score of benthic macroinvertebrate community is considered to be more suitable index among three biological water quality evaluation indices for the environmental evaluation of Upo wetland. The evaluation results on changes in environmental quality showed that Upo has stable ecosystem without significant change, Mokpo and Sajipo have significant increases in some indices.

• Journal of Environmental Science International
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• v.25 no.5
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• pp.655-671
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• 2016

The distribution characteristics of functional feeding groups and biological evaluation of water quality with benthic macroinvertebrates were investigated from 2013 to 2014 in the mountain streams of Jirisan National Park. Both quantitative and qualitative collection had been performed six times during study periods in twelve sites located at upstream, midstream and downstream of four valleys, Chilsungol, Baemsagol, Daesunggol and Piagol of freshwater ecosystem in Jirisan National Park. As results, the total collected benthic macroinvertebrates were 3 phyla, 4 classes, 11 orders, 37 families, 107 species and 4,028 individuals. In 2013, 3 phyla, 4 classes, 10 orders, 32 families, 89 species and 1,829 individuals were collected. And in 2014, 3 phyla, 4 classes, 9 orders, 31 families, 80 species and 2,199 individuals were identified. The total dominant species was Ecdyonurus kibumensis, and EPT groups occupied 80.39% of total species number. Biotic indices were also compared to site and to season. The dominant index (DI) was highest at the downstream of Baemsagol in the spring of 2013, and the evenness index (J') was highest at the downstream of Daesunggol in the summer of 2013. Both diversity index (H') and richness index (RI) were highest at the upstream of Baemsagol in the summer of 2014. The correlation between altitude above sea level and functional feeding groups of benthic macroinvertebrates was also researched in this study. As a result, the species number of shredders and predators have significantly increased according to the increase of the altitude of their habitat. On the other hand, individuals of gathering collectors have increased according to the increase of altitude. The biological water quality was evaluated and compared with several methods in this study, and we suggest that ESB and GPI are more appropriate than KSI and BMI to evaluate biological water quality of mountain stream water.