• 생물정신의학
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• 제20권4호
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• pp.129-135
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• 2013

Aggression can be defined as 'behavior intended to harm another' which can be seen both from humans and animals. However, trying to understand aggression in a simplistic view may make it difficult to develop an integrated approach. So, we tried to explain aggression in a multidisciplinary approach, affected by various factors such as neuroanatomical structures, neurotransmitter, genes, and sex hormone. Parallel with animal models, human aggression can be understood with two phenomena, offensive aggression and defensive aggression. Neurobiological model of aggression give a chance to explain aggression with an imbalance between prefrontal regulatory influences and hyper-reactivity of the subcortical areas involved in affective evaluation, finally in an aspect of brain organization. Serotonin and GABA usually inhibit aggression and norepinephrine while glutamate and dopamine precipitate aggressive behavior. As there is no one gene which has been identified as a cause of aggression, functions between gene to gene interaction and gene to environment interaction are being magnified. Contributions of sex hormone to aggression, especially molecular biologic interaction of testosterone and regulation of estrogen receptor have been emphasized during the research on aggression. This multidisciplinary approach on aggression with types, neurochemical bases, and animal models can bring integrated interpretation on aggression.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2017년도 춘계학술대회 논문집
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• pp.3-23
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• 2017

The achievement of tissue engineering can be highly depending on the capability to generate complicated, cell seeded three dimensional (3D) micro/nano-structures. So, various fabrication techniques that can be used to precisely design the architecture and topography of scaffolding materials will signify a key aspect of multi-functional tissue engineering. Previous methods for obtaining scaffolds based on top-down are often not satisfactory to produce complex micro/nano-structures due to the lack of control on scaffold architecture, porosity, and cellular interactions. However, a bioprinting method can be used to design sophisticated 3D tissue scaffolds that can be engineered to mimic the tissue architecture using computer aided approach. Also, in recent, the method has been modified and optimized to fabricate scaffolds using various natural biopolymers (collagen, alginate, and chitosan etc.). Variation of the topological structure and polymer concentration allowed tailoring the physical and biological properties of the scaffolds. In this presentation, the 3D bioprinting supplemented with a newly designed plasma treatment for attaining highly bioactive and functional scaffolds for tissue engineering applications will be introduced. Moreover, various in vivo and in vitro results will show that the fabricated scaffolds can carry out their structural and biological functionality.

• 한국의류학회지
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• 제29권6호
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• pp.745-752
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• 2005

Green tea has various medical effects. It was selected as new natural dyes guessing the effects of the biological activities are still appeared on dyeing. It was examined whether they have the function of Uv-blocker or not. Cotton, linen & Hanji were dyed with Green tea. Al, Cr, Cu, Fe and Sn were selected as the mordant and the UV blocking rate of dyed samples was measured. The results of this study as follows; 1 . The color of dyed samples with Green tea changed yellowish red except Hanji and linen mordanted with Fe. 2. K/S values of dyed samples with Green tea increased by the number of dyeing treatment(p<.01). 3. UVA and UVB blocking rate increased by the number of dyes. Cotton and Linen could block the UV radiation over $93\%$ and Hanji could block over $95\%$ after three times of dyeing. These results suggest that Hanji has possibility far various practical uses of clothing material in beautiful and functional aspect. It could have the biological effects when we put on dyed clothing material with Green tea.

• Journal of Korean Biological Nursing Science
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• 제12권3호
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• pp.157-165
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• 2010

Purpose: The purpose of this study was to examine the effects of recreation combined exercise program on body composition, physical fitness and depression in elderly women in rural district over a three-month follow-up period. Methods: Recreation combined exercise program (RCEP) was composed of resistance exercise, walking and recreation activity twice a week. The subjects were 52 divided in to experimental group (n=28) and control group (n=24). Arm curl, chair stand, 2 min step test, back scratch, chair sit and reach were measured as pre- or post-test data. Also, Depression was expressed using geriatric depression scale as pre- or post-test data. $X^2$ test, paired t-test and t-test were performed using SAS program. Results: Arm curl (p=.023), 2 minute step test (p<.001), back scratch (p=.004) and chair sit and reach (p=.024) showed the significant difference in the comparison between groups. Depression showed the significant difference in the comparison between groups (p=.008). Conclusion: These findings indicated the RCEP has positive influence upon increasing the physical fitness and improving the depression level. In conclusion, the regular RCEP will contribute to the improving physical and psychologic aspect in elderly women over the long period.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.544-544
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• 2003

We investigated the inhibitory effect of whitening materials with growth factor or alone on melanomas derived from Human (B-16) and mouse (SK-MEL-31) using melanin content. Melanin content was determined by the absorbance value at 470nm per cells. we used the growth factors known as activators of Adenylate cyclase, Protein kinase C and tyrosine kinase pathway separately. In addition, we compared the action of UV-induced with non-biological growth factor with whitening materials in melanomas derived from Human and mouse. The results showed that the aspect of inhibitory effect of whitening materials on B16 and SK-MEL-31 was not different. And, the action of each growth factor involved in the differentiation and proliferation of melanoma on the inhibition of melanogenesis in B-16 and SK-MEL-31 using whitening agents showed no difference. Also, The action of UV -induced and non-biological growth factors didn't exhibit different pattern on the effect of whitening agent in B-16 and SK-MEL-31.

• Journal of Plant Biology
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• 제39권4호
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• pp.265-271
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• 1996

Full-length cDNA for RNA2 of cucumber mosaic virus strian Kor (Kor-CMV) was cloned downstream of synthetic T7 promoter by reverse transcriptase-polymerase chain reaction (RT-PCR). The clone could generate a full-length transcript corresponding to RNA1 in size when synthesized by T7 RNA polymerase. The complete nucleotide sequence has shown that the RNA2 is composed of 3,049 nucleotides and contains one functional open reading frame (ORF) of 2,574 nucleotides encoding 2a protein. The deduced translation product of the 2,574 nucleotides contains GDD motif which is a characteristic of RNA-dependent RNA polymerase (RdRp). The amino acid sequence analysis of the 2a protein has shown that the homology is found in decreasing order with O-CMV (98.8%), Y-CMV (98.7%), Fny-CMV (98.3%), KCMV (94.9%), Ix-CMV (91.9%), and Q-CMV (74.9%). Kor-CMV is suggested to belong to subgroup Ⅰ in the aspect of nucleotide sequence homology of RNA2.

• 한국BIM학회 논문집
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• 제8권4호
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• pp.72-79
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• 2018

Rapid developments around the world have resulted in urban expansion, habitat destruction, habitat fragmentation, and pollution problems, which are the main reasons for the decline in biological diversity. The United Nations warns that many animals and plants will die out in the near future if this continues. This study was performed to propose a map of eco-corridor suitability analysis of Korean water deer(Hydropotes Inermis) to enhance biodiversity in Chuncheon city. Eight factors affecting habitat suitability were elevation, aspect, slope, forest type, distance to the road, distance to the stream, land use and green connectivity. Previous study analysis on the mobility behaviour of the Korean water deer(Hydropotes Inermis) produced a habitat suitability map by determining the threshold and assigning a value between 0 and 1 depending on the habitat suitability using the fuzzy function. A method of analysis was proposed for a number of eco-corridor through comparative analysis of the data from the produced habitat suitability map and the road-kill point. The previous studies were focused on Backdudaegan region and national parks except for urban cities. The potential habitat map of Korean water deer could be helpful as a way to prevent habitat disconnection and increase species diversity in urban areas.

• Biomolecules & Therapeutics
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• 제29권3호
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• pp.290-294
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• 2021

Extracellular beta amyloid (Aβ) plaques are the neuropathological hallmarks of Alzheimer's disease (AD). Accordingly, reducing Aβ levels is considered a promising strategy for AD prevention. 3'-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-D-xylopryranoside significantly decreased the Aβ production and this effect was accompanied with reduced sAPPβ production known as a soluble ectodomain APP fragment through β-secretases in HeLa cells overexpressing amyloid precursor proteins (APPs). This compound also increased the level of sAPPα, which is a proteolytic fragment of APP by α-secretases. In addition, 3'-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-D-xylopryranoside decreased the protein level of β-secretases, but the protein levels of A disintegrin and metalloproteinase (ADAM) family, especially ADAM10 and ADAM17, are increased. Thus, 3'-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-D-xylopryranoside could be useful in the development of AD treatment in the aspect of amyloid pathology.

• Korean Chemical Engineering Research
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• 제50권5호
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• pp.900-907
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• 2012

연구개발은 더욱 다양한 형태를 보이고, 결과물도 급격한 증가 추세에 있으며 기술경쟁은 점차 심화되고 있다. 본 연구는 빠르게 변하고 있는 연구개발의 향상을 위한 필요성과 연구생산성 도출을 위한 대안을 제시하는데 목적이 있다. 이를 위해 특허와 논문분석이라는 두 가지 기법을 활용하여 정삼투막 기술 분석을 하였다. 지금까지 출원된 기술에 대한 객관적이고 광범위한 정보를 포함하고 있는 특허데이터를 정량적으로 분석하여 정삼투막에 대한 기술적 예측에 필요한 특허분석 방법을 제안한다. 1990~2011년 동안의 한국, 미국, 일본, 중국 및 유럽에서 출원된 특허에 대하여 출원국별, 출원인별, 연도별, 세부기술 분야로 분류하여 비교함으로써 기술개발 현황을 분석하였다.

• 한국수소및신에너지학회논문집
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• 제13권1호
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• pp.3-12
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• 2002

In this study, it achieved life cycle assessment to estimate environmental performance for naphtha steam reforming that account for the production over 50% of total hydrogen output. Although hydrogen dosen't emit air emissions, especially, $CO_2$, a large of $CO_2$ is emitted in hydrogen production process. In the result of this study, it ascertained the truth that $CO_2$ is emitted at the rate of $6.3kg/kgH_2$ and that result from steam reforming reaction and use of fossil fuel in hydrogen manufacturing process. Above all, 57% of total $CO_2$ emissions is emitted in process of steam reforming of naphtha and so it knew that the principle of steam reforming is key issue in aspect to environment. Also, it compared hydrogen by fuel of fuel cell vehicle with gasoline fuel of general gasoline vehicle to analyze relative environment of hydrogen for fossil fuel during the life cycle. As the result, it might be difficult in improvement of environment because $CO_2$ emissions during the hydrogen manufacturing process is nearly the same with that during the use of gasoline.