• Proceedings of the Korean Institute of Interior Design Conference
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• 2006.05a
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• pp.278-283
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• 2006

For the company, the office space is the expensive resource next to human resource. Employees are under the influence of physical characters of the office space. Among them lighting is the most effective factor in physical, biological and psychological for employees. Although there are lots of investments in architectural aspect of the office space, there is almost no investment and consideration about the lighting environment. Therefore this study was trying to find out these things as follow. First, evaluate lighting environment of people who works in the office spaces. Second, find out which factors are more affective in evaluation of lighting environment. And then with these findings this study found what should be considered as important in lighting planning of the office space. As the result of this study, however the majority of the employees are satisfied with current lighting conditions, they are not satisfied with individual operation of lighting. And in office space work type and position changes by age can affect in a large degree more than other factors. Therefore when planning lighting of the office space, it is necessary to figure out work features of Individual and group exactly and accept the difference by positions appropriately.

• Biomolecules & Therapeutics
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• v.25 no.1
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• pp.69-79
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• 2017

Viruses continue to evolve a new strategy to take advantage of every aspect of host cells in order to maximize their survival. Due to their central roles in transducing a variety of transmembrane signals, GPCRs seem to be a prime target for viruses to pirate for their own use. Incorporation of GPCR functionality into the genome of herpesviruses has been demonstrated to be essential for pathogenesis of many herpesviruses-induced diseases. Here, we introduce US28 of human cytomegalovirus (HCMV) as the best-studied example of virally-encoded GPCRs to manipulate host GPCR signaling. In this review, we wish to summarize a number of US28-related topics including its regulation of host signaling pathways, its constitutive internalization, its structural and functional analysis, its roles in HCMV biology and pathogenesis, its proliferative activities and role in oncogenesis, and pharmacological modulation of its biological activities. This review will aid in our understanding of how pathogenic viruses usurp the host GPCR signaling for successful viral infection. This kind of knowledge will enable us to build a better strategy to control viral infection by normalizing the virally-dysregulated host GPCR signaling.

• Journal of Environmental Health Sciences
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• v.38 no.1
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• pp.1-7
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• 2012

Carbon nanotubes (CNTs) stand at the frontier of nanotechnology and are destined to stimulate the next industrial revolution. Rapid increase in their production and use in the technology industry have led to concerns over the effects of CNT on human health and the environment. The prominent use of CNTs in biomedical applications also increases the possibility of human exposure, while properties such as their high aspect ratio (fiber-like shape) and large surface area raise safety concerns for human health if exposure does occur. It is crucial to develop viable alternatives to in vivo tests in order to evaluate the toxicity of engineered CNTs and develop validated experimental models capable of identifying CNTs' toxic effects and predicting their level of toxicity in the human respiratory system. Human lung epithelial cells serve as a barrier at the interface between the surrounding air and lung tissues in response to exogenous particles such as air-pollutants, including CNTs. Monolayer culture of the key individual cell types has provided abundant fundamental information on the response of these cells to external perturbations. However, such systems are limited by the absence of cell-cell interactions and their dynamic nature, which are both present in vivo. In this review, we suggested two viable alternatives to in vivo tests to evaluate the health risk of human exposure to CNTs.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.26 no.3
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• pp.285-291
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• 2017

Micro-needles are used as transferring devices for sampling of tiny constitute substances from biological bodies. Typically, nickel is used as a coating to improve the rigidity of micro-needles. This study introduces the methodology to manufacture a WC needle with very high hardness and toughness. Micro-EDM technology was used to manufacture micro-needles with holes $130{\mu}m$ in diameter and $2300{\mu}m$ in length. A micro-needle was aligned to the micro-EDM electrode using a custom two degree-of-freedom alignment system. A three-step manufacturing technique was developed to drill a micro-hole using a WC electrode. In the first process, an electrode $105{\mu}m$ in diameter was used to make a hole. Electrodes of 90 and $105{\mu}m$ diameters were used in the second and third process, respectively. Consequently, a WC micro-needle with an inner hole of $135{\mu}m$ diameter, length of $2300{\mu}m$, and outer diameter of $300{\mu}m$ was developed.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.395-398
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• 1997

Human pulse represents the physical characteristics of heart and cardiovascular system. Therefore, malfunctions and errors of heart and cardiovascular system can be determined by using an automatic diagnosis system that can detect the pulse signal. Not only will the computerised system preclude the possibilities of observational errors by giving an accurate measurement with great stability, but minimize the possibilities of misinterpretation by using an automated diagnostic logic. A new combinational fiber-optic sensor, which has a detecting part and a transmitting part was used to acquire radial pulse signal noninvasively. The development of P-5 transducer makes it possible to obtain more effective detection and obvious display of pulse signals in the aspect of reliability. Using P-5 transducer in the field of plethysomography and MAC- JIN, one of our diagnoses in Korean traditional medicine, it is expected that we can ontain quantitative and valuable information or the diagnosis of human pulses.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.164-167
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• 1997

The treatment setup of patients during irradiation is an important aspect in relation to the success of radiotherapy. Imaging with the treatment beam is a widely used method or verification of the radiation field position relative to the target area, prior to or during irradiation. In this paper, Real time digital radiography system was implemented or verification of local error between simulation plan and radiation therapy machine. Portal image can be acquired by CCD camera, image board and pentium PC after therapy Radiation was converted into light by a metal/fluorescent Screen. The resulting image quality is comparable to film, so the imaging system represents a promising alternative to film as a method of verifying patient positioning in radiotherapy. Edge detection and field size measurement were also implemented and detected automatically for verification of treatment position. Field edge was added to the original image or checking the anatomical treatment verification by therapy technicians. By means of therapy efficiency improvement and decrease of Radiation side effects with these techniques, Exact Radiation treatments are expected.

• Ocean Science Journal
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• v.42 no.3
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• pp.135-152
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• 2007

The ecological aspect of meiofaunal communities in Can Gio mangrove forest, Ho Chi Minh city, Vietnam has not been investigated before. The composition, distribution, density and biodiversity of meiofaunal communities were studied along an intertidal transect at the Khe Nhan mudflat. Each time, three replicate samples were collected in four stations along a transect following the water line from low tide level up to the mangrove forest edge. In total, 18 meiofaunal taxa were found with the dominant taxa belonging to Nematoda, Copepoda, Sarcomastigophora and Polychaeta. The densities of meiofauna ranged from $1156inds/10cm^2$ to $2082inds/10cm^2$. The increase in densities from the mangrove forest edge towards the low water line was significant Along the mudflat transect, the biodiversity (expressed by different indices) was relatively high at different taxonomic levels but did not vary significantly along the mudflat except for taxa richness. Eighty nematode genera belonging to 24 families with Comesomatidae having the highest abundance 33.8 % were found. Theristus and Neochromadora decreased in densities from the lower water line towards the mangrove forest edge, while Paracomesoma and Hopperia are typical and more abundant at the middle of the mudflat. Halalaimus increased from high on the mudflat to the low water line.

• Journal of the Korean Wood Science and Technology
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• v.29 no.3
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• pp.59-67
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• 2001

Rice husk flours were analyzed by chemical composition and thermogravimetric methods in nitrogen atmosphere to discuss its feasibility as a raw material for manufacturing agricultural lignocellulosic fiber-thermoplastic polymer composite. It was revealed in the chemical composition analysis that rice husk flour was composed of moisture, 5.0%; lignin, 21.6%; holocellulose, 60.8%; ash, 12.6%. In the thermogravimetric analysis (TGA), thermal decomposition behavior of rice husk flour from room temperature to $350^{\circ}C$ was similar to that of wood flour, but rice husk flour was more thermally stable from 350 to $800^{\circ}C$ than wood flour because of higher silica content in the rice husk flour and smaller particle size of rice husk flour. The activation energy of thermal decomposition was evaluated using Flynn & Wall expression. As the thermal decomposition proceeded in rice husk flour, the activation energy of thermal decomposition appeared almost constant up to ${\alpha}=0.25$, but thereafter increased. Activation energy of thermal decomposition in wood flour, however, decreased steeply up to ${\alpha}=0.3$, but thereafter remained almost constant. From the results, rice husk flour was thought be a substitute for wood flour in manufacturing agricultural lignocellulosic fiber-thermoplastic polymer composite in the aspect of thermal decomposition.

• Journal of fish pathology
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• v.1 no.2
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• pp.123-130
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• 1988

General anaesthetics have been usually used for a long time because handling and transportation of live fish constitutes an important aspect in fisheries science. Numerous investigations, however, have shown that the majority of fish anaesthetics cause strong toxic effect to marine fishes. Therefore, less toxic and more effective anaesthetics are essential for marine fishes. Lidocaine belongs to a group of anaesthetics which are used as a local anaesthetic in human medicine. This chemical was tested for 11 commercially important marine fishes. Anaesthetic effects were clearly dose dependent and acute or chronic toxicities were not observed within clinical doses. The recovery time in the tested fish after anaesthetization was 3 to 4 minutes.

• The Journal of Korean Medicine
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• v.18 no.1
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• pp.157-168
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• 1997

The purpose of this study is the separation of biologically active ingredients from Coptidis Rhizoma which has been widely used as one of oriental herbal medicine for body fever. In this study, berberine-type alkaloids were tested on their biological activities in the aspect of antibacterial, antitumor, anti-herpetic and anti-HIV activity. Contents of five major alkaloids for the various origin of Coptidis Rhizoma were assayed by HPLC. As the results, the content of berberine from Coptis chinensis and Coptis japonica were 6.78% and 7.09%, respectively. The contents of coptisine, jatrorrhizine, berberastine from Coptis chinensis were higher than those of Coptis japonica. The amount of palmatine from both species were almost the same. Surprisingly for antitumor experiment, all compounds have been shown remarkable activity, especially against SNU-l(human stomach cancer) cell line. Among the compounds purified through column chromatography, palmatine, coptisine, and jatrorrhizine inhibited the growth of K-562(human chronic myelogenous leukemia) cell line whereas jatrorrhizine has been shown the effective inhibition of A-549 (human lung) cell line at the same time.