• Korean Journal of Ecology and Environment
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• v.41 no.1
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• pp.73-80
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• 2008

Present study aims to investigate the effect of muddy water on the gill and the kidney tissues of Zacco koreanus under high turbidity rearing condition. The gill of Z. koreanus showed abnormal shapes in its secondary lamellae and a rough surface with impure debris in the high level of turbidity and the longer raising period condition. In addition, the gills showed the edema, the exfoliation of epithelial cell, and the fusion of the secondary lamellae. In case of kidney tissue, the atrophied glomerulus was observed, and the empty space in Bowman's capsule was wider. The SOD activities in both gill and kidney tissues were increased in proportion to the high level of turbidity. On the while, CAT and GPX activities were shown constant level in the gill, but were increased in the kidney in the high turbid muddy water. These results indicate that the harmful radicals which generate by high level of turbidity could be removed partly by antioxidant enzymes in the kidney. The concentrations of micro heavy metal ions accumulated in the gill increased drastically at the 1,000 NTU. Based on the above results, it is considered that the exposure to the high level of turbidity for long period may affect on the structures of tissues, and change the enzymatic balance in Z. koreanus, causing the fatal disease.

• Animal cells and systems
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• v.16 no.5
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• pp.357-365
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• 2012

We have examined the effect of circadian disturbances induced by night shifts (NSs) on the phenotypes of the tibiae and abdominal adipose tissues (ADTs) in a mouse model by using in vivo micro-computed tomography (micro-CT). We found that the volumes of total and visceral ADTs in the night-shifted group of mice were significantly larger (69 and 92%, respectively) than those in the control. The mean polar moment of inertia, cross-sectional thickness, and bone mineral density of the cortical bone in the night-shifted group of mice were less (13, 5, and 3%, respectively) than those in the control. Moreover, the volume and the thickness of growth plates (GPs) of the tibiae in the night-shifted mice were significantly smaller (22 and 20%, respectively) than those in the control. Taken together, our results indicate that disturbances in the mouse circadian rhythms induced by NSs affect the morphological characteristics of cortical bone, the volume and the thickness of GPs, and the volume of ADTs.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.18 no.2
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• pp.77-105
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• 2014

Medical imaging techniques have evolved to expand our ability to visualize new contrast information of electrical, optical, and mechanical properties of tissues in the human body using noninvasive measurement methods. In particular, electrical tissue property imaging techniques have received considerable attention for the last few decades since electrical properties of biological tissues and organs change with their physiological functions and pathological states. We can express the electrical tissue properties as the frequency-dependent admittivity, which can be measured in a macroscopic scale by assessing the relation between the time-harmonic electric field and current density. The main issue is to reconstruct spectroscopic admittivity images from 10 Hz to 1 MHz, for example, with reasonably high spatial and temporal resolutions. It requires a solution of a nonlinear inverse problem involving Maxwell's equations. To solve the inverse problem with practical significance, we need deep knowledge on its mathematical formulation of underlying physical phenomena, implementation of image reconstruction algorithms, and practical limitations associated with the measurement sensitivity, specificity, noise, and data acquisition time. This paper discusses a number of issues in electrical tissue property imaging modalities and their future directions.

• Analytical Science and Technology
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• v.32 no.3
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• pp.88-95
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• 2019

This study was conducted to establish the analytical method for the determination of cyanide in blood, urine, lung and skin tissues in rats. In order to detect or quantify the sodium cyanide in above biological matrixes, it was derivatized to Pentafluorobenzyl cyanide (PFB-CN) using pentafluorobenzyl bromide (PFB-Br) and then reaction substance was analyzed using gas chromatography mass spectrometer (GC/MS)-SIM (selected ion monitoring) mode. The analytical method for cyanide determination was validated with respect to parameters such as selectivity, system suitability, linearity, accuracy and precision. No interference peak was observed for the determination of cyanide in blank samples, zero samples and lower limit of quantification (LLOQ) samples. The lowest limit detection (LOD) for cyanide was $10{\mu}M$. The linear dynamic range was from 10 to $200{\mu}M$ for cyanide with correlation coefficients higher than 0.99. For quality control samples at four different concentrations including LLOQ that were analyzed in quintuplicate, on six separate occasions, the accuracy and precision range from -14.1 % to 14.5% and 2.7 % to 18.3 %, respectively. The GC/MS-based method of analysis established in this study could be applied to the toxicokinetic study of cyanide on biological matrix substrates such as blood, urine, lung and skin tissues.

• Journal of Biomedical Engineering Research
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• v.22 no.3
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• pp.303-309
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• 2001

It is well known that the electrical impedance of biological tissues is very sensitive to their temperature. In this paper, we have analyzed the effects of temperature change on the phase of magnetic resonance images obtained with external current injection. It has been found that the local phase in the current injected magnetic resonance image can be changed noticeably when local temperature change appears at a part of the tissue. At the experiments with a 0.3 Tesla MRI system, we observed the local phase changes at the phantom images when the phantom temperature was varied between 25 -45$^{\circ}C$. We think that the current injection MRI technique can be used for in-vivo monitoring of the temperature inside biiological tissues if the relation between the local temperature and phase can be quantified.

• Journal of Biomedical Engineering Research
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• v.27 no.6
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• pp.310-317
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• 2006

Extensive research with polarimetry and Mueller matrix has been done for chemical measurements and possible cancer detection. However, the effect of thermally denatured biological tissue on polarization changes is not well known. The purpose of this study is to characterize polarization changes in collagen due to thermal denaturation. The variations in polarized state caused by thermal damage were investigated by obtaining the Mueller matrix elements of collagen sample at multiple thermal damage levels. The changes in birefringence of denatured collagen were also investigated. This information could be used to determine the extent of thermal damage level of clinically heat treated tissues.

• Advances in materials Research
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• v.13 no.4
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• pp.321-334
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• 2024

The paper is a study on the biothermoelastic analysis in viscoelastic biological tissues in the presence of thermal relaxation times. Using Laplace transforms and related methodologies, we explore how living tissue responds to an exponentially decaying pulse of heat flux at the boundary. The Laplace transformations are reversed using the numerical method. The Tzuo technique was used to measure the reversal. Temperature, displacement, and stress distributions are affected by single-phase and delay relaxation coefficients as well as volume rheological factors, are provided with numerical findings and graphically depicted. In addition, we carry out a parametric analysis to provide assistance in choosing the design variables that are the most successful, which finally results in an improvement in the accuracy of hyperthermia treatments.

• Proceedings of the Optical Society of Korea Conference
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• 2003.02a
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• pp.286-287
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• 2003

Polarization-sensitive optical coherence tomography (PS-OCT) was developed to image highly scattering tissues with accounting for polarization effects in the sample. These polarization-sensitive images can provide additional information on the structure of the tissue because of a polarization state of the light is changed at its interaction with biological tissues. The scattering and birefringence are two phenomena, which change the polarization state of light passing through medium. (omitted)

• Proceedings of the KOSOMBE Conference
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• v.1990 no.11
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• pp.92-95
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• 1990

• Proceedings of the Zoological Society Korea Conference
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• 2003.08a
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• pp.158.4-158
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• 2003

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