• 제목/요약/키워드: Biological Synthesis

검색결과 1,240건 처리시간 0.023초

Synthesis and Biological Effects of Some 5-Heterocyclicmethyl-2'-deoxyurdines

  • Kwak, In-Young;Ryu, Eung K.
    • Archives of Pharmacal Research
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    • 제13권4호
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    • pp.306-309
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    • 1990

  • The synthesis of 5-hyterocyclimethyl-2'-deoxyuridines (4a-f) has been accomplished by displacement reaction of 5-(bromomethyl)-3', 5'-di-O-acetyl-2'-deoxyuridine with heterocyclic compounds, followed by removal of acetyl protecting group with methanolic ammonia. The compoudns synthesized were evaluated the inhibitory effects on L1210 cell probiferation and antiviral activities against Herpes simplex virus type 1 (HSV-1) None of the compounds exhibited sufficient biological activities.

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Molecular Modeling, Synthesis, and Screening of New Bacterial Quorum-sensing Antagonists

  • Kim, Cheol-Jin;Kim, Jae-Eun;Park, Hyung-Yeon;Mclean, Robert J.C.;Kim, Chan-Kyung;Jeon, Jong-Ho;Yi, Song-Se;Kim, Young-Gyu;Lee, Yoon-Sik;Yoon, Je-Yong
    • Journal of Microbiology and Biotechnology
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    • 제17권10호
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    • pp.1598-1606
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    • 2007

  • A new series comprising 7 analogs of N-(sulfanyl ethanoyl)-L-HSL derivatives, 2 analogs of N-(fluoroalkanoyl)-$_L$-HSL derivatives, N-(fluorosulfonyl)-L-HSL, and 2,2-dimethyl butanoyl HSL were synthesized using a solid-phase organic synthesis method. Each of the 11 synthesized compounds was analyzed using NMR and mass spectroscopies, and molecular modeling studies of the 11 ligands were performed using SYBYL packages. Thereafter, a bacterial test was designed to identify their quorum-sensing inhibition activity and antifouling efficacy. Most of the synthesized compounds were found to be effective as quorum-sensing antagonists, where antagonist screening revealed that 10 among the 11 synthesized ligands were able to antagonize the quorum sensing of A. tumefaciens.

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항균성물질 thelepin의 spirobenzopyranone 유도체의 합성과 생물활성 (Synthesis and biological activity of spirobenzopyranone derivative as analogs of thelepin, isolated from the marine annelid Thelepus setosus)

  • 고병섭;절곡륭지
    • Applied Biological Chemistry
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    • 제35권6호
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    • pp.470-474
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    • 1992

  • 해양환형동물 thelepus setosus로부터 분리된 thelepin ${\underline{2}}$의 항균활성에 착안하여 새로운 항균성 선도구조를 찾아내고자, B 환구조를 coumaran형에서 chroman-4-one형으로 전환하고 생물활성을 조사하였다. Thelepin의 spirobenzopyranone 유도체를 산화적분자내에 환반응을 이용하여 합성하였으며 진균 2종과 박테리아 2종을 대상으로 paper disc법으로 생물활성을 조사한 결과 gram-positive 박테리아인 Bacillus subtilis에 대하여 $5\;{\mu}g/disc$ 수준에서 억제 활성을 보였다.

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