Archives of Pharmacal Research
- Volume 13 Issue 4
- /
- Pages.306-309
- /
- 1990
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Synthesis and Biological Effects of Some 5-Heterocyclicmethyl-2'-deoxyurdines
- Kwak, In-Young (Organic Chemistry Laboratory, Korea Research Institute of Chemical Technology) ;
- Ryu, Eung K. (Organic Chemistry Laboratory, Korea Research Institute of Chemical Technology)
- Published : 1990.12.01
Abstract
The synthesis of 5-hyterocyclimethyl-2'-deoxyuridines (4a-f) has been accomplished by displacement reaction of 5-(bromomethyl)-3', 5'-di-O-acetyl-2'-deoxyuridine with heterocyclic compounds, followed by removal of acetyl protecting group with methanolic ammonia. The compoudns synthesized were evaluated the inhibitory effects on L1210 cell probiferation and antiviral activities against Herpes simplex virus type 1 (HSV-1) None of the compounds exhibited sufficient biological activities.