• Archives of Pharmacal Research
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• v.13 no.4
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• pp.306-309
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• 1990

The synthesis of 5-hyterocyclimethyl-2'-deoxyuridines (4a-f) has been accomplished by displacement reaction of 5-(bromomethyl)-3', 5'-di-O-acetyl-2'-deoxyuridine with heterocyclic compounds, followed by removal of acetyl protecting group with methanolic ammonia. The compoudns synthesized were evaluated the inhibitory effects on L1210 cell probiferation and antiviral activities against Herpes simplex virus type 1 (HSV-1) None of the compounds exhibited sufficient biological activities.

• Bulletin of the Korean Chemical Society
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• v.24 no.7
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• pp.1017-1020
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• 2003

• Journal of Microbiology and Biotechnology
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• v.17 no.10
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• pp.1598-1606
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• 2007

A new series comprising 7 analogs of N-(sulfanyl ethanoyl)-L-HSL derivatives, 2 analogs of N-(fluoroalkanoyl)-$_L$-HSL derivatives, N-(fluorosulfonyl)-L-HSL, and 2,2-dimethyl butanoyl HSL were synthesized using a solid-phase organic synthesis method. Each of the 11 synthesized compounds was analyzed using NMR and mass spectroscopies, and molecular modeling studies of the 11 ligands were performed using SYBYL packages. Thereafter, a bacterial test was designed to identify their quorum-sensing inhibition activity and antifouling efficacy. Most of the synthesized compounds were found to be effective as quorum-sensing antagonists, where antagonist screening revealed that 10 among the 11 synthesized ligands were able to antagonize the quorum sensing of A. tumefaciens.

• Applied Biological Chemistry
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• v.35 no.6
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• pp.470-474
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• 1992

For the further development of thelepin analog as antibiotic agents, we undertook the synthesis of spirobenzopyranone derivative ${\underline{5}}$ as thelepin analog by oxidative phenol coupling. The spirobenzopyranone analog ${\underline{5}}$ showed high activity against Bacillus subtilis (IFO 3108) in $5\;{\mu}g/disc$.

• Applied Biological Chemistry
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• v.41 no.6
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• pp.483-485
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• 1998

• Journal of Applied Biological Chemistry
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• v.50 no.4
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• pp.296-300
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• 2007

• Applied Biological Chemistry
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• v.5
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• pp.1-5
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• 1964

• Proceedings of the Korean Society of Life Science Conference
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• 2002.03a
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• pp.49-49
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• 2002

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2003.10a
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• pp.103-103
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• 2003

• Journal of Applied Biological Chemistry
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• v.44 no.1
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• pp.35-38
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• 2001