• Title/Summary/Keyword: Biological Synthesis

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Synthesis and Cardiovascular Activities of 1,4-Dihydropyridine Derivatives (1,4-Dihydropyridine 유도체들의 합성 및 혈압강하 효과)

  • Shim, Young-Key;Chun, Jae-Sang;Kim, Wan-Joo
    • YAKHAK HOEJI
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    • v.32 no.3
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    • pp.157-163
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    • 1988
  • 4-Aryl-1, 4-dihydropyridines(DHP) derived from Hantsch type condensation of aromatic aldehydes with aminocrotonates and acetoacetic esters are studied as calcium channel blocking drugs. New DHP derivatives containing alkenyl ester show fairly good cardiovascular activity in mice. Preparation of the DHP derivatives and their major biological activity are presented along with their physical data.

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Synthesis and Biological Activity of Benzoxazole Containing Thiazolidinedione Derivatives

  • Jeon, Ra-Ok;Park, So-Yeon
    • Archives of Pharmacal Research
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    • v.27 no.11
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    • pp.1099-1105
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    • 2004
  • The peroxisome proliferator-activated receptors (PPARs) are a primary regulator of lipid metabolism. Potency for activation of PPAR$\gamma$, one of a subfamily of PPARs, particularly mirrors glucose lowering activity. We prepared thiazolidinediones featuring benzoxazole moiety for subtype selective PPAR$\gamma$ activators. 5-[4-[2-(Benzoxazol-2-yl-alkylamino)ethoxy]benzyl]thiazolidine-2,4-diones have been prepared by Mitsunobu reaction of benzoxazolylalkylaminoethanol 8 and hydroxybenzylthiazolidinedione 6 and their activities were evaluated. Most compounds tested were identified as potent PPAR$\gamma$ agonists.

Purification and Characterization of $\beta$-Glucosidase and $\alpha$-Arabinofuranosidase Metabolizing Ginsenoside Rc from Bifidobacterium K-103

  • Park, Sun-Young;Kim, Dong-Hyun
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.224.2-225
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    • 2003
  • Ginsenoside, major components of ginseng have been reported to show various biological activities including an increase of cholesterol metabolism. stimulation of serum protein synthesis, immunomodulatory effects. To explain these pharmacological actions, it is thought that ginseng saponins should be metabolized by human intestinal bacteria after they are orally administered. (omitted)

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