• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.341.3-342
• /
• 2002

The interest in polyhydroxyamines is based in their biological activity as enzyme inhibitors. and as starting materials in the synthesis of more complex compounds. Polyhydroxyamines is that amine group is continuing structurally with hydroxy groups and has become important target of the synthesis strategy because of the chirality control of amine group and each hydroxy groups. (omitted)

• Bulletin of the Korean Chemical Society
• /
• v.30 no.1
• /
• pp.43-48
• /
• 2009

The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.

• Proceedings of the PSK Conference
• /
• 2003.04a
• /
• pp.238.2-238.2
• /
• 2003

The synthesis of a new series of 1${\beta}$-methylcarbapenems having the substituted aminoethyl-carbamoylpyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. In particular. the compound 11 g having piperazinyl urea moiety showed the most potent antibacterial activity.

• Proceedings of the PSK Conference
• /
• 2003.10b
• /
• pp.175.1-175.1
• /
• 2003

Galactosyl ceramides paly important roles in biological system as immunomodulator and essential constituents of membranes and cell walls. An efficient synthesis of $\alpha$-galactosyl ceramide, KRN 7000, derived from marine sponge Agelas mauritianus as accomplished via a short reaction involving the coupling ceramide moiety and trichloroacetimidate as glycosylation donor. We could synthesize $\alpha$-galactosyl ceramide stereoselectivity without $\beta$-anomer formation on a multigram scale.

• Proceedings of the PSK Conference
• /
• 2003.10b
• /
• pp.188.1-188.1
• /
• 2003

The antiparasitic agent apicidin, which was recently isolated from cultures of Fusarium Pallidoroseum, belongs to a rare group of cyclictetrapeptide fungal metabolites. Apicidin inhibits protozoal HDAC and is orally active against Plasmodium berghei malaria in mice. The biological activity of apicidin appears to be attributable to inhibition of apicomplexan HDAC at low nanomolar concentrations. In the present, we have worked about the synthesis of new apicidin derivatives and discovered that apicidin and some derivatives have mild antitumor activity. (omiited)

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.342.2-342.2
• /
• 2002

The ${\beta}$-turn has been implicated as an important conformation for biological recognition of peptides or proteins. Benzodiazepine classes have been known as one of the non peptide ${\beta}$-turn mimic scaffolds. We have developed an efficient approach for the synthesis and derivatization of a scaffold of hydroxytetrahydrodizepinone class in order to screen compound library in various protein targets for new lead generations as well as for structure activity relationships of the scaffold. (omitted)

• Journal of the Korean Institute of Gas
• /
• v.18 no.4
• /
• pp.63-67
• /
• 2014

Fischer-Tropsch synthesis mainly produces a wax which is a viscous liquid for long carbon chain. When a catalytic fixed-bed reactor is used for Fischer-Tropsch synthesis, the wax generated on a catalyst surface can keep adsorbing on the catalyst surface. This liquid hold-up causes significant pressure drop and clogging problems through the reactor. Thus, the model for liquid hold-up is required to design the size of reactor and catalyst particles. In this study, the liquid hold-up model considering structural and operational conditions was proposed based on empirical equations for convective mass transfer between the syngas flow and the wax-adsorbed catalyst. The developed model was validated by comparing with the experimental data from Knochen's work (2010). The influence of reactor length and coross section on the wax hold-up in reactor were analyzed and the optimal reactor size were proposed.

• Bulletin of the Korean Chemical Society
• /
• v.28 no.9
• /
• pp.1562-1566
• /
• 2007

1-Alkenyl-2,3-dimethylimidazolium tetrafluoroborate ionic liquids having an olefinic substituent were synthesized and characterized. Among them, [AMMIm]BF4 with an allyl group showed lower viscosity, higher ionic conductivity, and a wider electrochemical window compared with its analogue having a saturated alkyl substituent. An EDLC with [AMMIm]BF4 showed better performance than that with [PMMIm]BF4, too.

• Biotechnology and Bioprocess Engineering:BBE
• /
• v.7 no.5
• /
• pp.263-267
• /
• 2002

Our purpose is to develop an efficient synthetic method of obtaining oligosaccharide unit in sufficient amounts to study functions of glycans. Many exoglycosidases have been used as tools for the oligosaccharide synthesis. In contrast, a limited number of reports are available on the utilization of endoglycosidases. We describe herewith the efficient synthetic method of useful oligosaccharides and derivatives as biomaterials utilizing lysozyme, cellulase, and lacto-N-biosidase-mediated transglycosyltions.

• Journal of Applied Biological Chemistry
• /
• v.55 no.3
• /
• pp.191-194
• /
• 2012

Novel pyrazolinecarbothioamide (5) was synthesized from chalcone (3) which was prepared from 2'-hydroxy-1'-acetonaphthone (1) and 2-methoxy benzaldehyde (2). Treatment of pyrazolinecarbothioamide (5) on HCT116 cancer cell showed upregulation of p21 and downregulation of cyclin D1 protein. Flowcytometer analysis revealed that pyrazolinecarbothioamide (5) controls the expression of cell cycle regulatory proteins, which blocks cell cycle progression of HCT116 cancer cell at the G1 phase.