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http://dx.doi.org/10.3839/jabc.2012.030

Synthesis of Novel Pyrazolinecarbothioamide and Evaluation of Its Anti-Cancer Activity  

Koh, Dongsoo (Dept. of Applied Chemistry, Dongduk Women's University)
Publication Information
Journal of Applied Biological Chemistry / v.55, no.3, 2012 , pp. 191-194 More about this Journal
Abstract
Novel pyrazolinecarbothioamide (5) was synthesized from chalcone (3) which was prepared from 2'-hydroxy-1'-acetonaphthone (1) and 2-methoxy benzaldehyde (2). Treatment of pyrazolinecarbothioamide (5) on HCT116 cancer cell showed upregulation of p21 and downregulation of cyclin D1 protein. Flowcytometer analysis revealed that pyrazolinecarbothioamide (5) controls the expression of cell cycle regulatory proteins, which blocks cell cycle progression of HCT116 cancer cell at the G1 phase.
Keywords
anti-cancer; cell cycle; chalcone; cyclin D1; pyrazolinecarbothioamide;
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