• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2003.06a
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• pp.185-191
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• 2003

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.713-714
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• 2005

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.369-370
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• 2005

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.4
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• pp.275-287
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• 2000

Fermentation strategies for recombinant protein production in Pichia pastoris have been investigated and are reviewed here. Characteristics of the expression system, such as phenotypes and carbon utilization, are summarized. Recently reported results such as growth model establishment, app58lication of a methanol sensor, optimization of substrate feeding strategy, DOstat controller design, mixed feed technology, and perfusion and continuous culture are discussed in detail.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.203-204
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• 1998

ECG analysis is main techniques for diagnosing heart disease. In recent, some studies have been performed about detection of QT interval. But, it's difficult to detect QT interval because T wave is evasive. In this paper, we have detected peak point and end point of T wave and calculated QT interval. And the result has been compared with the other algorithm after detection of QT interval.

• Proceedings of the Korean Society of Rheology Conference
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• 2006.06a
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• pp.89-92
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• 2006

• Proceedings of the Korean Society of Rheology Conference
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• 2006.06a
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• pp.37-40
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• 2006

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2002.10a
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• pp.94-94
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• 2002

No Abstract, See Full Text

• Proceedings of the Korean Vacuum Society Conference
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• 2006.08a
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• pp.188-188
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• 2006

• Journal of the Korean Chemical Society
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• v.60 no.2
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• pp.125-130
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• 2016

With the goal of developing Alzheimer’s disease therapeutics, we have designed and synthesized new triazole linked decursinol derivatives having potency inhibitory activities against cholinesterase [acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)]. Since inhibition of cholinesterase (ChE) is still considered to be one of the most effective targets to treat AD patients, many new classes of ChE inhibitors have been synthesized. In an effort of identifying new type of cholinergic drug, decursinol derivatives 11-17 have been synthesized between decursinol and other biological interesting compounds such as lipoic acid, polyphenols, etc by using the click reaction and then evaluated their biological activities. Compound 12 (IC₅₀ = 5.89 ± 0.31 mM against BuChE) showed more effective inhibitory activity against BuChE than galantamine (IC₅₀ = 9.4 ± 2.5 mM). Decursinol derivatives can be considered a new class inhibitor for BuChE and can be applied to be a novel drug candidate to treat AD patients.