• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.71-72
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• 2005

• Proceedings of the Korea Information Processing Society Conference
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• 2005.05a
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• pp.585-588
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• 2005

연구자들이 국외 생명과학관련 문헌정보를 찾으려면 PubMed와 같은 세계적인 문헌정보서비스를 많이 이용하며, 국내 생명과학관련 문헌정보를 찾으려면 KISTI 학회마을, KoreaMed 등 여러 사이트를 방문해야 한다. 이에 생명과학관련 연구를 원활히 수행할 수 있도록 생명정보 데이터베이스와 분석도구를 서비스하고 있는 KISTI 바이오인포매틱스센터(CCBB) 홈페이지에서 인터넷상의 Open Access 문헌정보와 국내 학회정보를 수집하여 메타 데이터베이스를 구축하여 서비스하고자 한다. 또한 생명과학 관련 주제별 Open Archiving 커뮤니티의 구성과 운영을 통한 연구자간의 정보교환을 유도하고, 더불어 논문뿐만 아니라 세미나, 연구노트 등의 최신의 연구정보를 공유할 수 있도록 본 프로토타입 시스템을 설계하였다.

• Proceedings of the Korea Information Processing Society Conference
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• 2006.11a
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• pp.381-384
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• 2006

센서 네트워크 환경에서 스트림 데이터를 모니터링 하기 위해서는 스트림 데이터에 대한 연속적인 질의들을 효과적으로 처리하는 것이 필요하다. 이러한 연속적인 질의를 빠르게 검색하고 처리하기 위하여 낮은 저장 비용과 빠른 탐색 성능을 가진 질의 색인 기법이 많이 활용되고 있다. 기존 연구들은 사전에 삽입될 Interval 을 알고 트리를 구성하므로 동적인 삽입, 삭제가 불가능하거나 삽입된 Interval 수와 Interval 의 범위에 따라 높은 저장 비용이나 상대적으로 느린 탐색 속도를 보인다. 따라서 이 논문에서는 연속적인 질의 처리를 효율적으로 하기 위하여 Hashed Multiple Lists 를 제안한다. 제안된 기법은 빠른 선형 탐색 성능과 낮은 저장 비용을 요구하며 삽입, 삭제가 용이하고 다양한 범위를 표현할 수 있는 장점이 있다. 제안된 색인 기법은 센서 네트워크를 응용한 시스템과 상황 인식 시스템 등에서 연속적인 질의를 처리하는데 활용할 수 있다.

• Genomics & Informatics
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• v.21 no.3
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• pp.37.1-37.11
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• 2023

Systemic lupus erythematosus (SLE) is an inflammatory-autoimmune disease with a complex multi-organ pathogenesis, and it is known to be associated with significant morbidity and mortality. Various genetic, immunological, endocrine, and environmental factors contribute to SLE. Genomic variants have been identified as potential contributors to SLE susceptibility across multiple continents. However, the specific pathogenic variants that drive SLE remain largely undefined. In this study, we sought to identify these pathogenic variants across various continents using genomic and bioinformatic-based methodologies. We found that the variants rs35677470, rs34536443, rs17849502, and rs13306575 are likely damaging in SLE. Furthermore, these four variants appear to affect the gene expression of NCF2, TYK2, and DNASE1L3 in whole blood tissue. Our findings suggest that these genomic variants warrant further research for validation in functional studies and clinical trials involving SLE patients. We conclude that the integration of genomic and bioinformatic-based databases could enhance our understanding of disease susceptibility, including that of SLE.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.301-305
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• 2002

Bioinformatics can beexplained as the science of developing algorithms, applicatiou tools, and computer databases and so on, for the purpose of supporting and enhancing biological research. Bioinformatic information systems (BIS) typically handle large data sets and the amount of the data goes up exponentially. Another impediment to easy extraction and retrieval of genomic data in BIS is the need to access different sites for similar information. Recently. there has been some attempts to integrate bioinformatics data in the World Wide Web (WWW) among the bioinformatics community by the internet computing technology. However, the work to integrate bioinformatics data on a universal platform has some problems because of the lack of standard, terminologies, semantics, and ontologies about bioinformatics. In this paper, an XML-based BIS architecture is proposed as an integrated BIS framework. The XML and related technologies allow the creation of meaningful information tags to exchange data between various databases as a standard format, and to create more simple interfaces. This integrated BIS framework has bioinformatic architectural components which is used in the Corporate Information Factory (CIF) method.

• Proceedings of the Zoological Society Korea Conference
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• 1998.10a
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• pp.54-66
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• 1998

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.5
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• pp.451-461
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• 2005

The effect of carbon dioxide on yeast growth was investigated during the cultivation of pH 5.0 and pH 6.8. by replacing the nitrogen part with carbon dioxide under aerobic conditions. The values of the specific growth rate under pH 5.0 and pH 6.8 conditions became 64.0% and 46.9%, respectively, compared to those before the change in gas composition. This suggests that the effect of carton dioxide was greater pronounced in pH 6.8 than in pH 5.0. The genome-wide transcriptional response to elevated carbon dioxide was examined using a DNA microarray. As for upregulated genes, it was noteworthy that 3 genes were induced upon entry into a stationary phase and 6 genes were involved in stress response. Of 53 downregulated genes, 22 genes were involved in the ribosomal biogenesis and assembly and 5 genes were involved in the lipid metabolism. These facts suggest that carbon dioxide could bring the cell conditions partially to a stationary phase. The ALD6 gene encoding for cytosolic acetaldehyde dehydrogenase was downregulated, which would lead to a lack of cell components for the growth. The downregulation of ALD6 was greater in pH 6.8 than in pH 5.0. consistent with physiological response. This suggests that it might be the most effective factor for growth inhibition.

• Proceedings of the Korea Contents Association Conference
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• 2005.11a
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• pp.428-432
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• 2005

This paper has studied the concept and technical factors of e-Learning system to which we intend to apply domestic biodiversity information. This article describes how we analyzed and designed the e-learning system to serve biodiversity information as e-Learning contents. It would be useful for the public and students if this information are organized and provided as e-learning contents especially in our country which has well-established network infrastructure considering the limited land space. It is expected that the establishment of e-Learning system based on this proposed design will help students and public to access and team biodiversity on cyber space.

• Proceedings of the Microbiological Society of Korea Conference
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• 2005.05a
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• pp.89-92
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• 2005

• Proceedings of the Microbiological Society of Korea Conference
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• 2008.05a
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• pp.141-143
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• 2008