• Environmental Engineering Research
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• v.22 no.4
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• pp.356-362
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• 2017

This study investigates the use of methyl-esterified eggshell membranes (MESM) for the harvesting of microalgae species under various conditions. Eggshell membranes were esterified with HCl to impact polycationic characteristics. After methyl esterification, the negative surface charge property of eggshell membrane was changed from negative to positive for all pH values to improve microalgae sorption capacity. The harvesting efficiency of microalgae by MESM reached 78-99% for all pH ranges evaluated. In addition, a 150 mesh particle size and $10mg\;L^{-1}$ MESM dose were found to yield up to 98% microalgae harvesting. These results indicate that the high cationic charge of MESM strongly adsorbs the negatively-charged microalgae. MESM is biocompatible and can be applied to the harvest of microalgae.

• Journal of Biomedical Engineering Research
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• v.10 no.3
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• pp.237-242
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• 1989

The physical properties and drug release behaviours of polyethylene glycol grafted poly ${\gamma}$- benzyl L-glutamate (PEG- g- PBLG), polyethylene glycol crosslinked poly ${\gamma}$-benzyl L- glutamate(PEG-c-PBLG), and PBLG homopolymer are compared. PBLG containing PEG segements showed higher wettability and larger enlongation than PBLG homoplymer, but lower elastic modulus. The release rate of rhodamine is strongly influenced by the wettability of the polymer. Rhodamine is more rapidly released from PEG-c-PBLG membrane having a larger water contact angle than from other polymer having a lower water contact angle. The surfaces of PBLG derivative membranes are modified by substitution reaction using hydroxyalkylamine. The resulting polymer membranes showed hider wettability and swelling ratio than virgin membranes.

• Korean Chemical Engineering Research
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• v.54 no.3
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• pp.285-292
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• 2016

Three-dimensional (3D) printing is driving major innovation in various areas including engineering, manufacturing, art, education and biosciences such as biochemical engineering, tissue engineering and regenerative medicine. Recent advances have enabled 3D printing of biocompatible materials, cells and supporting components into complex 3D functional tissues. Compared with non-biological printing, 3D bioprinting involves additional complexities which require the integration of technologies from the fields of biochemical engineering, biomaterial sciences, cell biology, physics, pharmaceutics and medical science.

• Proceedings of the Materials Research Society of Korea Conference
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• 2011.05a
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• pp.17.1-17.1
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• 2011

Inorganic III-V light emitting diodes (LEDs) have superior characteristics, such as long-term stability, high efficiency, and strong brightness compared to conventional incandescent lamps and OLED. However, due to the brittle property of bulk inorganic semiconductor materials, III-V LED limits its applications in the field of high performance flexible electronics. This seminar introduces the first flexible and implantable GaN LED on plastic substrates that is transferred from bulk GaN on Si substrates. The superb properties of the flexible GaN thin film in terms of its wide band gap and high efficiency enable the dramatic extension of not only consumer electronic applications but also the biosensing scale. The flexible white LEDs are demonstrated for the feasibility of using a white light source for future flexible BLU devices. Finally a water-resist and a biocompatible PTFE-coated flexible LED biosensor can detect PSA at a detection limit of 1 ng/mL. These results show that the nitride-based flexible LED can be used as a type of implantable LED biosensor and as a therapy tool.

• Journal of Korean Vacuum Science & Technology
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• v.6 no.1
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• pp.16-21
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• 2002

Ti-0 film is a kind of biocompatible surface materials. In this paper, a new method, glow discharge plasma oxidizing, has been used in synthesizing Ti-O gradient films on Ti6A14V substrates. The effects of ion bombardment and process parameters on the structures of titanium oxide layers have been investigated. The results demonstrate that DC glow plasma oxidizing is more efficient in preparation of dense, hard, and high adhesive Ti-O biomedical films on titanium and its alloys. Samples treated by this method show higher hardness values than by others. Especially, in the condition of hollow cathode discharge, the ion bombardment enhances ionization of oxygen, promotes the oxygen permeation and facilitates the formation of the oxide of low valence states of titanium.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2001.09a
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• pp.103-106
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• 2001

A remediation technology consisting of biodegradation and a modified Fenton reaction was developed to degrade mixtures of polycyclic aromatic hydrocarbons (PAHs) at a former manufactured gas plant (MGP) site. The original Fenton reaction (i.e., $H_2O$$_2$ + Fe$^{2+}$) was modified to be biocompatible by using ferric ions and chelating agents such as catechol and gallic acid. The modified reaction was effective in degrading PAHs at near neutral pH and thus was compatible with biodegradation. By the combined treatment of the modified Fenton reaction and biodegradation, more than 98% of 2- or 3-ring hydrocarbons and between 70 and 85% of 4- or 5-ring compounds were degraded in the MGP soil, while maintaining its pH about 6.6.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.6
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• pp.540-545
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• 2005

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate), poly(3HB-co-3HV), copolyesters, with 3-hydroxyvalerate (3HV) contents ranging from 17 to 60 mol%, were produced by Alcaligenes sp. MT-16, and their biocompatibility evaluated by the growth of Chinese hamster ovary (CHO) cells and the adsorption of blood proteins and platelets onto their film surfaces. The number of CHO cells that adhered to and grew on these films was higher with increasing 3HV content. In contrast, the tendency for blood proteins and platelets to adhere to the copolyester surfaces significantly decreased with increasing 3HV content. Examination of the surface morphology using atomic force microscopy revealed that the surface roughness was an important factor in determining the biocompatibility of theses copolyesters. The results obtained in this study suggest that poly(3HB-co-3HV) copolyesters, with >30 mol% 3HV, may be useful in biocompatible biomedical applications.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.816-820
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• 2005

Polysaccharide-based dressings have increasingly become viable alternatives to somewhat less biocompatible and often problematic cotton or viscose gauzes traditionally used for wound dressings. Polysaccharide which is particularly abundunt in Agaricus blazei Murill is known as the bioactive materials. Polysaccharide extracted from Agaricus blazei Murill enhances the recovery of the damaged epidermal tissue and the production of epithelial cell growth factors which are necessary to heal the burn and wound on the epidermal tissue. In this study, the biopolymer delivery system of polysaccharide extracted from Agaricus blazei Murill into epidermal tissue was elucidated using the skin permeating enhancer in vitro. The enhancing effects of various penetration enhancers and some other enhancers on the permeation of ${\beta}-glucan$ were evaluated using Franz diffusion cell. Permeation of polysaccharide in nomal and burn skin was compared. Polysaccharide was studied for the burn and wound healing activity in the epidermal tissue on rats.

• Journal of the Korean Ceramic Society
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• v.53 no.2
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• pp.222-226
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• 2016

The synthesis of pure calcium carbonate nanocrystals was achieved using a simultaneous injection method to produce nano particles of uniform size. These were characterized using scanning electron microscopy and powder X-ray diffraction. The nano particles were needle-shaped aragonite polymorphs, approximately 100-200 nm in length. The aragonite polymorph of calcium carbonate was prepared using aqueous solutions of $CaCl_2$ and $Na_2CO_3$, which were injected simultaneously into double distilled water at $50^{\circ}C$ and then allowed to react for 1.5 h. The resulting whisker-type nano aragonite with high aspect ratio (30) is biocompatible and potentially suitable for applications in light weight plastics, as well as in the medical, pharmaceutical, cosmetic and paint industries.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4237-4240
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• 2016

Drugs processed using nanobiotechnology may be more biocompatible, with sustainable and stabilised release or action. L-asparaginase produced from fungi has many advantages for treatment of lymphocytic leukemia with lesser side effect. In the present work, maghemite nanobiocomposites of fungal asparaginase were produced using glutaraldehyde-pretreated colloidal magnetic nanoparticles. Formation of nanobiocomposites was observed using laser light scattering and confirmed by UV-visible spectrophotometry with the absorption peak at 497 nm. The specific asparaginase activity was increased from 320 U/mg with crude asparaginase to 481.5 U/mg. FTIR analysis confirmed that primary amines are the functional groups involved in binding of asparaginase on magnetic nanoparticles. The average size of the produced nanobiocomposite was found in the range of 30 nm to 40 nm using histogram analysis. The magnetic nanobiocomposite of asparaginase synthesised using glutaraldehyde showed 90.75% cytotoxicity against human colon adenocarcinoma cell lines. Hence it can be used as an active anticancer drug with an augmented level of bioavailability.