• The Korean Journal of Ceramics
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• 제3권2호
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• pp.129-133
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• 1997

Fine powder of $\alpha$-tricalcium phosphate, tetracalcium phosphate and dicalcium phosphate were mixed together to prepare self-setting cements which form hydroxyapatite, one of the well-known biocompatible materials, as the end of products of hydration. Hardening behaviour of the cements was examined at the temperature range of 37~$70^{\circ}C$ and 150~$250^{\circ}C$ under the normal and hydrothermal condition respectively. The conversion of cements into hydroxyapatite was significantly improved ast elevated temperature and the paste was strengtheed by interlocking of hydroxyapatite crystals, indicating that the strength is determined by microtexture rather the amount of conversion of cements into hydroxyapatite.

• 한국염색가공학회지
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• 제6권4호
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• pp.40-45
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• 1994

To improve the blood compatibility of cellulose membrane, 2-(methacryloyloxy)ethyl-2-(trimethylammonium)ethyl phosphate(MTP), which is a methacrylate with phospholipid polar group, and glycidyl methacrylate(GMA) were grafted simultaneously on the surface of membrane and the biocompatibility of grafted membrane was investigated. There was no difference of permeability between the MTP and GMA-grafted and the original cellulose membrane. The permeation pathway for a solute whose molecular weight was above 10$^{4}$ is maintained after grafting on the surface of membrane. The cellulose membrane grafted with MTP and GMA effectively suppressed thrombogenicity for the rabbit blood. This effect became more clear with increasing the surface distribution of phospholipid polar groups.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2008년도 추계학술대회논문집
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• pp.203-204
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• 2008

Bacterial Cellulose Actuator with biocompatible and biodegradable properties was newly developed as an electro-active biopolymer under water. The performance of the BC actuator was improved through Li treatment. The mechanical and chemical properties of BC membranes were measured such as the tensile test, proton conductivity. The surface morphology of the bacterial cellulose was observed by using SEM. The electromechanical bending responses under both direct current and alternating current excitations were investigated. In voltage-current test,the power consumption under dynamic excitation increases with increasing voltage. Present results show that the bacterial cellulose actuator can be a promising smart material and may possibly have diverse applications under water.

• 한국염색가공학회지
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• 제14권6호
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• pp.313-318
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• 2002

Chitosan is known to be an excellent biocompatible natural polymer. Recently, with a growing interest of health and environment, chitosan which is good in no harmful effect on human body and environment, has been watched as the finish treatment of hygiene and pleasantness. The purpose of this study is to develop multi functional fabrics by chitosan added on acrylic acid grafted cotton fabrics. Therefore physical properties such as moisture regain, air permeability, whiteness, static voltage and tensile strength of chitosan added on acrylic acid grafted cotton fabrics were investigated. The results are as follows ; According to increased chitosan's concentration, grafting yield was decreased. Therefore thickness of film by treated chitosan added on acrylic acid grafted cotton fabric became thin. FT R spectra of chitosan add on acrylic acid grafted cotton fabric clearly showed peaks of COOH and $NH_2$, Moisture regain, static voltage of chitosan add on acrylic acid grafted cotton fabrics were increased than control. Air permeability, whiteness and tensile strength were decreased than control.

• Journal of Korean Neurosurgical Society
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• 제49권6호
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• pp.317-322
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• 2011

The prevalence of osteoporosis has been increasing globally. Recently surgical indications for elderly patients with osteoporosis have been increasing. However, only few strategies are available for osteoporotic patients who need spinal fusion. Osteoporosis is a result of negative bone remodeling from enhanced function of the osteoclasts. Because bone formation is the result of coupling between osteoblasts and osteoclasts, anti-resorptive agents that induce osteoclast apoptosis may not be effective in spinal fusion surgery, necessitating new bone formation. Therefore, anabolic agents may be more suitable for osteoporotic patients who undergo spinal fusion surgery. The instrumentations and techniques with increased pullout strength may increase fusion rate through rigid fixation. Studies on new osteoinductive materials, methods to increase osteogenic cells, strengthened and biocompatible osteoconductive scaffolds are necessary to enable osteoporotic patients to undergo spinal fusion. When osteoporotic patients undergo spinal fusion, surgeons should consider appropriate osteoporosis medication, instrumentation and technique.

• Journal of Pharmaceutical Investigation
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• 제22권3호spc1호
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• pp.17-34
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• 1992

A novel drug delivery system, detergent-phospholipid mixed micelles as proliposomes, for water-insoluble compounds was developed by investigating (i) spontaneous formation of small unilamellar vesicles (SUV) from bile salt-egg phosphatidylcholine mixed micelles, (ii) the molecular mechanism of micelle-to-vesicle transition in aqueous mixtures of detergent-phospholipid, (iii) preparation and screening of a suitable liposomal formulation for a lipophilic drug: solubilization of the drug within the lipid bilayer, evaluation of the solubility limit, and characterization of the resulting product with respect to the physical properties and stability of the drug in the system, and (iv) testing antitumor activity in vitro. The results showed that the new carrier had a strong possibility to be a biocompatible universal formulation for water-insoluble drugs.

• Archives of Plastic Surgery
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• 제47권5호
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• pp.392-403
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• 2020

Severe cartilage defects and congenital anomalies affect millions of people and involve considerable medical expenses. Tissue engineering offers many advantages over conventional treatments, as therapy can be tailored to specific defects using abundant bioengineered resources. This article introduces the basic concepts of cartilage tissue engineering and reviews recent progress in the field, with a focus on craniofacial reconstruction and facial aesthetics. The basic concepts of tissue engineering consist of cells, scaffolds, and stimuli. Generally, the cartilage tissue engineering process includes the following steps: harvesting autologous chondrogenic cells, cell expansion, redifferentiation, in vitro incubation with a scaffold, and transfer to patients. Despite the promising prospects of cartilage tissue engineering, problems and challenges still exist due to certain limitations. The limited proliferation of chondrocytes and their tendency to dedifferentiate necessitate further developments in stem cell technology and chondrocyte molecular biology. Progress should be made in designing fully biocompatible scaffolds with a minimal immune response to regenerate tissue effectively

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.1259-1264
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• 2007

Microstereolithography technology has potential capability for fabrication of 3D microstructures. It evolved from conventional SLA which is one of the RP processes. In a microstereolithography process, 3D microstructures can be easily fabricated by continuously stacking 2D layer which is photopolymerized using a liquid prepolymer. Combination between biocompatible/biodegradable photocurable prepolymer and 3D complex fabrication in microstereolithography makes broad application areas such as medical, pharmaceutic, and bio devices. In particular, a 3D microneedle for transdermal drug delivery and a scaffold for tissue engineering are fabricated using this technology. In this paper, the authors address development of microstereolithography system adapted to large surface and fabrication of various microstructures. In addition, to apply human body we suggest a biodegradable 3D microneedle and a scaffold using biodegradable photocurable prepolymer.

• Journal of Microbiology and Biotechnology
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• 제14권5호
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• pp.932-937
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• 2004

In situ extraction by organic solvent was studied in order to improve the recovery yield of hydrocarbon from the culture of Botryococcus braunii, a green colonial microalga. When the solvent mixture of octanol as an extractive solvent and n-octane as a biocompatible solvent was added to a two-phase column, the algal growth was seriously inhibited, even at a low concentration of polar octanol. Therefore, a two-stage cell-recycle extraction process was proposed to improve the contact area between the organic phase and the aqueous phase. The hydrocarbon recovery with in situ cell-recycle extraction showed a three-fold increase (57% of cell) in yield over that with two-phase extraction. In addition, over 60% of the hydrocarbon could be recovered without serious cell damage by downstream separation when this process was applied to the culture broth after batch fermentation.

• 한국분말재료학회지
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• 제21권1호
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• pp.1-6
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• 2014

Medical technologies are gaining in importance because of scientific and technical progress in medicine and the increasing average lifetime of people. This has opened up a huge market for medical devices, where complex-shaped metallic parts made from biocompatible materials are in great demand. Today many of these components are already being manufactured by powder metallurgy technologies. This includes mass production of standard products and also customized components. In this paper some aspects related to metal injection molding of Ti and its alloys as well as modifications of microstructure and surface finish were discussed. The process chain of additive manufacturing (AM) was described and the current state of the art of AM processes like Selective Laser Melting and electron beam melting for medical applications was presented.