• Journal of Oral Medicine and Pain
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• v.24 no.1
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• pp.37-47
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• 1999

This study was performed to investigate the factors related to vibration of temporomandibular joint during mandibular opening movement. For this study, 144 patients with temporomandibular disorders were randomly selected. Angle's classification, lateral guidance pattern, range of maximal mouth opening, preferred chewing side, and affected side were investigated clinically. Mandibular torque rotational movement during opening was recorded with $BioEGN^{(R)}$ and vibration of temporomandibular joint during opening was recorded with $Sonopak^{(R)}$. After clinical diagnosis was made, visual analogue scale(VAS) was used for evaluation of clinical progress of the subject's chief complaints. The author calculated VAS treatment index(VAS Ti) from the record of VAS. The more VAS Ti was, the less remission of subjective symptom was, The data were analyzed with SAS/Stat program and the results of this study were as follows: 1. There were no significant difference in all the variables of joint vibration by age and sex. 2. Integral and peak amplitude in patients of Angle's class I were higher than those of class II or III patients. Integral in patients of group function was higher than that in patients of canine guidance or other types of lateral excursion. 3. As to Angle's classification or lateral guidance type, there were almost not significant difference between subgroup of same class or type and subgroup of different class or type on both sides. And there were also almost not difference between one side and the other side related to preferred chewing side or affected side. 4. Patients with disk displacement with reduction showed higher value of integral and peak amplitude than any other patients. 5. Joint vibration variables significantly correlated with VAS Ti of pain. with clinical range of mouth opening, and with ingredients of mandibular torque rotational movement.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.146.2-146.2
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• 2014

KIST 6MV 가속기는 이온빔 분석 그리고 가속기 질량 분석법(Accelerator mass spectrometry)으로 활용된다. 이온빔 분석으로는 RBS, TOF ERD, PIXE. ${\mu}$-Probe을 할 수 있으며 AMS(Accelerator mass spectrometry)는 액체섬광측정법(LSC)과 비교할때 민감도는 1,000배 정도로 3H, 14C, 26Al,41Ca 을 10-21 ~ 10-18 mole/mg 까지 검출 가능하여. 응용분야로는 BAMS(Biological AMS), 전통과학, 지구과학, 환경과학에 활용되고 있다. 이중 AMS의 생-의학분야(BAMS)의 응용은 최근 매우 중요하게 연구되고 있다. BAMS의 활용 연구에 사용하는 핵종으로는 주로 3H, 14C, 41Ca, 36Cl를 사용하며, 14C 화합물은 쉽게 구할 수 있고, 자연방사선 이하의 낮은 14C labeled drug 사용하기 때문에 1948년 이후 생물학 연구에 혁신적으로 활용되고 있다. 주 활용분야로는 (1) 신약개발은 임상실험 전(Phase 0) 이용되며, 14C로 표지된 bio-molecule을 자연수준의 방사선 농도에서 추적자로 사용하여 질량을 측정하는 방법을 활용. (2) 의과학분야는 인체 내에서의 추적자 연구수행 (3) 항암제 연구는 암조직 중 약물농도와 암효과의 상관성을 연구 (4) 바이오 기술 분야에서는 생약 유효물질의 체내 대사연구 등을 할 수 있어 전세계적으로 활발히 연구가 진행되고 있다. KIST에서는 6MV가속기를 BAMS 연구에 활용하기 위하여 전처리 단계의 Combustion, Gas transfer, Reduction 등을 자체 제작하여 테스트 중에 있으며, BAMS 샘플의 Gas는 호기중의 성분, 대기 성분이 있으며, Liquid는 혈액(혈장,혈청,적혈구), Solid는 DNA, 세포, 장기 뼈, 피부, 식물조직, 사료, Drug 및 그 대사 류가 있다. AMS 측정 결과는 14C/12C 비율로 나타나며 그 결과를 농도로 환산하여 분석하게 된다. 또한 분석 데이터 신뢰를 확보하기 위하여 표준시료 및 품질관리용 시료를 사용하여 BAMS분석법에 대한 검증을 실시하였다.

• Preventive Nutrition and Food Science
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• v.10 no.3
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• pp.279-284
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• 2005

Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis, and has been implicated in the pathogenesis of obesity and metabolic disorders. The aim of this study was to estimate the effects of A-3826G polymorphism of UCP-1 gene on body fat distribution. Two hundred forty eight Korean female overweight subjects with BMI more than 25 kgfm2 participated in this study. The areas of abdominal subcutaneous and visceral fat of all subjects were measured from computed tomography cross sectional pictures of the umbilical region. Subcutaneous fat areas of upper and lower thigh were also measured. Body composition was measured by bio-impedance analysis, and serum concentrations of biochemical parameters, such as glucose, triglyceride, cholesterol etc, were also measured. Genotype of UCP-1 was analyzed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. The frequencies of UCP-1 genotypes were AA type; $27.8\%,\;AG\;type;\;51.2\%\;and\;GG\;type;\;21.0\%,$ and the frequency of G allele was 0.47. Body weight, BMI, WHR, SBP, DBP and body compositions were not significantly different by UCP-1 genotype. Abdominal visceral fat area was significantly higher in AG and GG type compared with AA type (p=0.009), but subcutaneous fat areas were not significantly different by UCP-1 genotype. Among biochemical parameters, LDL cholesterol level was significantly higher in GG type compared with AA and AG types (p=0.033). Among all subjects, 121 subjects finished 1 month weight loss program containing hypocaloric diet and exercise. The reduction of body weight and BMI were lower in GG type compared with AA/AG type even though statistical significances were not found (p > 0.05). These results suggest that UCP-1 genotype has a significant effect on visceral fat accumulation among Korean female overweight subjects with BMI more than $25\;kg/m^2$.

• Journal of the Korea Society of Computer and Information
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• v.20 no.5
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• pp.91-98
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• 2015

In this paper, we introduce PMS's main function and main effect which implemented medium and large scale software development project site, and we propose importance and improvement nacessity of PMS implementation. PMS's main functions are developed based on best practices which CMMI model and PMBOK. Also, each PMS has specialized unique function according to it's target industry area or related I.T solutions which has infra dependency. The effectiveness of PMS implementation on project site is seperated two types, one is qualitative effect, the other quantitative effect. Representative qualitative effects are improvement of enterprise's image and competency. Also representative quantitative effect is reduction of project management cost as a financial effect. As far as project size is increase, PMS's needs and necessariness will be increase, so we need to improve PMS;s function according to project management's global trend and software customer's requisition.

• Journal of environmental and Sanitary engineering
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• v.6 no.2
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• pp.109-121
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• 1991

For the analysis of mercury in blood and urine, many literatures have been reffered and many kinds of reducing agents for mercury reduction and many acids for pretreatmr are known to be varied. $So HNO_{3}$ and $H_{2}SO_{4}$ among acids and $SnCl_{2}$ and $NaBH_{4}$ as a reducing agent being chosen for the establishment of more efficient and less erroneous analysis, and comparing the absorbance by using vapor generator, the results are followings. 1. The difference of absorbance from concentration of $HNO_{3}$ and $H_{2} SO_{4}$ was not nearly found when mercury reduced by $NaBH_{4}$ after pretreatment. But for more precise analysis, conc acid treatment need to be used. 2. Higher absorbance was shown by using conto acid treatment (P<0.005) when mercury reduced by $NaBH_{4}$ after treating acid primer. And sample which has 99.5% reliability in T-test, treated by conc $H_{2}SO_{4}$(P<0.005) was shown higher absorbance than treat by CORC $HNO_{3}$. 3. The difference of absorbance was not in the slightest in higher 0.1 w/v% $NaBH_{4}$ proved by uruskal-wallis H-Test 4. Some difference of absorbance in $SnCl_{2}$(P<0.005) having 99.5% reliability was found but there was no difference in these 20 w/v% , 25 w/v% and 30 w/v% SnCl$_{2}$ by the experiment of T-test. 5. According to these test results, organic materials were much affect the absorballce when reducing mercury by using $SnCl_{2}$ rather than by $NaBH_{4}$. For bio sample which is contained various organic substances, reduclng agent $NaBH_{4}$ is a lot more efficient to reduce the error then $SnCl_{2}$. 6. analytic method for this study is as following. 7. As the recovery test was done by this, the rate of recovery was shown form 94% to 100.7% .

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.562-562
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• 2012

Recently, graphene and graphene-based materials such as graphene oxide (GO) or reduced graphene oxide (R-GO) draws a great attention for electronic devices due to their structures of one atomic layer of carbon hexagon that have excellent mechanical, electrical, thermal, optical properties and very high specific surface area that can be high potential for chemical functionalization. R-GO is a promising candidate because it can be prepared with low-cost from solution process by chemical oxidation and exfoliation using strong acids and oxidants to produce graphene oxide (GO) and its subsequent reduction. R-GO has been used as semiconductor or conductor materials as well as sensing layer for bio-molecules or ions. In this work, reduced graphene oxide field-effect transistor (R-GO FET) has been fabricated with ITO extended gate structure that has sensing area on ITO extended gate part. R-GO FET device was encapsulated by tetratetracontane (TTC) layer using thermal evaporation. A thermal annealing process was carried out at $140^{\circ}C$ for 4 hours in the same thermal vacuum chamber to remove defects in R-GO film before deposition of TTC at $50^{\circ}C$ with thickness of 200 nm. As a result of this process, R-GO FET device has a very high stability and durability for months to serve as a transducer for sensing applications.

• Journal of Environmental Impact Assessment
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• v.20 no.2
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• pp.207-215
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• 2011

In order to establish fundamental data for stream restoration and environmental flow, we investigated physical habitat conditions of Korean chub (Zacco koreanus) in the typical streams of Han River. Field monitoring including fish sampling was conducted from September 2008 to April 2010. A total number of fish caught in the 8 sites was 3,421 representing 8 families 31 species, and 17 species (54.8%) including Korean shinner (Coreoleuciscus splendidus) and Z. koreanus were Korean endemic species during the study period. The most frequently found species in number was pale chub (Z. platypus, 25.7%) followed by Z. koreanus (22.8%) and Microphysogobio longidorsalis (16.8%). Numbers of Z. Koreanus ranged from 8 to 10 cm of total length were the highest in size distribution of their population in all sites. They were widely found in ranges of flow velocity (0.2~0.9 m/sec, 89.6%), water depth (0.3~0.9 m, 91.6%), and different types of substrates except for silt, and they tended to prefer run (58.1%) and riffle (33.7%) with cobble bed (47.0%) microhabitat. Most of upper streams in Korea consist of riffles and runs that are repeatedly followed by another one. However, stream channelization and leveling have caused reduction of habitat diversity. Therefore, it is necessary to make an effort on stream rehabilitation with evaluation of physical habitat condition by indicator species in order to maintain biodiversity and perform ecological restoration.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.11 no.3
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• pp.39-49
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• 2008

A study was carried out on the physico-chemical properties of soil and content of heavy metals and benzo(a)pyrene that might have been introduced through by-product fertilizers or air pollution to growing turfgrass at natural turfgrass playgrounds in elementary schools located at the western coast and eastern mountain areas in Jeollabuk-do, Korea. The soil of turfgrass playgrounds is composed of loamy sand, and the CEC and organic matters were very low. Compared to agricultural land in Korea, the concentrations of nitrogen, phosphorus and potassium were very low, requiring control in terms of nutrients. The contents of total and fraction heavy metals in soil were found to be background level. The reason may lie in the fact that unpolluted sand soil or sand was used to construct the foundation for the natural grass playground in the first place. However, any change in oxidation-reduction conditions or acceleration of decomposition of organic compounds may release some heavy metals from the soil and be transformed into forms that may be easily absorbed by plants or grass. It is believed that sustained monitoring and environment impact assessments should be carried out. The contents of benzo(a)pyrene in soil showed an average 0.60ng/g with a range between 0.06 to 1.47ng/g. The detected contents were found as background level.

• The Journal of Korean Medicine
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• v.36 no.3
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• pp.135-143
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• 2015

Objectives: Recently lactic acid formulation was known as the adjuvant therapy on atopic dermatitis(AD) symptoms because of little side effects. In this study, it was studied that Lactobacillus mixed culture appliment was effective on not on AD symptoms. Methods: The case-photos 30-40 times of AD symptoms from case were observed with literatures. The case-photos were acquired with environmental AD dermatitis experience program which is conducted in SUNCHANG RESERCH INSTITUTE OF HEALTH AND LONGEVITY from 2014.01 to 2014.08. Experience applicants were limited the oral administration and chemical external administration. Results: Lactobacillus mixed culture appliment was effective because of the mitigation or disappearance of AD primary symptoms like pruritus, erythema, edema, effusion, dry skin, scaly, scab etc. AD symptom degree was dependent on lactobacillus mixed culture appliment times, and classified as Reaction Period (RAP), Reduction Period (RDP), Efection Period (EP), Reproduction Period (RPP) on a single mixed culture appliment time. And AD symptoms which were appeared in RPP were classified as Rebound Period (RBP), Effection Period (EP), Subclinical Period (SCP). Conclusions: Lactobacillus mixed culture appliment is considered to be useful for AD symptoms and is estimated to be effective by different mechanism with oral administration or steroid ointment application. Lactobacillus mixed culture appliment is expected to induce a synergistic effects on AD symptom reliefs with the other oral administration.

• Korean Journal of Acupuncture
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• v.28 no.2
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• pp.23-36
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• 2011

목적 : 이 연구는 관절 및 심혈관계 질환 치료에 사용되는 송절(松節)(Pinus densiflora Gnarl)을 약침용 시료로 조제하여 본 약물의 항산화 효능을 규명하고자 하였으며 이를 다양한 시스템에서 검토하였다. 방법 : $FeCl_2$-ascorbic acid system에서 흰쥐 간조직의 지질과산화 반응을 관찰하였고, Fenton reaction system에서 자유기에 의한 plasmid DNA 분절을 유도하였다. 또한 deoxyribose assay를 통해 hydroxyl radical 소거능을 관찰하였고, NBT reduction assay로 superoxide radical 소거능을 검토하였다. 또한 human low-density lipoprotein(LDL)의 산화를 유도하기 위해 $CuSO_4$와 AAPH를 사용하였으며 relative electrophoretic mobility (REM) assay로 LDL 산화 억제 효능을 대조 항산화물질과 비교 검토하였다. 결과 : 송절 약침액은 자유기에 의한 간조직의 지질과산화(p < 0.01)및 DNA 분절을 현저하게 억제하였으며, hydroxyl radical, superoxide radical (p < 0.01), nitric oxide 및 peroxynitrite를 강하게 소거하였다. 또한 $CuSO_4$ ($IC_{50}=9.2{\pm}0.2\;{\mu}g/ml$)와 AAPH ($IC_{50}=34.8{\pm}5.1\;{\mu}g/ml$)에 의해 유도된 human LDL의 산화를 억제하였고, REM assay에서도 산화 억제 효능을 재확인할 수 있었다. 결론 : 송절 약침액은 활성산소종 및 활성질소종를 소거하였고, 지질과산화를 억제하였으며, 특히 human LDL의 산화적 손상을 방어하였다. 이에 본 약물은 자유기에 의한 심혈관의 산화적 손상을 효과적으로 보호할 것으로 판단된다.