• Journal of Microbiology and Biotechnology
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• v.22 no.4
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• pp.571-573
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• 2012

Glyceraldehyde-3-phosphate (G-3-P), the substrate of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), is a key intermediate in several metabolic pathways. Recently, we reported that G-3-P directly inhibits caspase-3 activity in a reversible noncompetitive mode, suggesting the intracellular G-3-P level as a cell fate decision factor. It has been known that apoptotic stimuli induce the generation of NO, and NO S-nitrosylates GAPDH at the catalytic cysteine residue, which confers GAPDH the ability to bind to Siah-1, an E3 ubiquitin ligase. The GAPDH-Siah-1 complex is translocated into the nucleus and subsequently triggers the apoptotic process. Here, we clearly showed that intracellular G-3-P protects GAPDH from S-nitrosylation at above a certain level, and consequently maintains the cell survival. In case G-3-P drops below a certain level as a result of exposure to specific stimuli, G-3-P cannot inhibit S-nitrosylation of GAPDH anymore, and consequently GAPDH translocates with Siah-1 into the nucleus. Based on these results, we suggest that G-3-P functions as a molecule switch between cell survival and apoptosis by regulating S-nitrosylation of GAPDH.

• Science of Emotion and Sensibility
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• v.20 no.4
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• pp.89-100
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• 2017

Since smart devices are able to efficiently provide information without barriers of time and location, they are widely utilized with advent of the hyper-connected society. Especially, the smart devices have been developed in the form of wearable devices for mutual interaction between human and objects. Smart clothing, which embeds smart devices within clothes, measures and obtains a variety of bio-signals as it is in close contact with the human bodies. Conventional smart clothing generated wearers' discomfort because they were developed by simple attachment of electronic devices to clothes. Therefore, it is highly recommended to develop novel smart clothing based on smart textiles which integrate electronic devices as parts of textiles. As smart watches are currently the most available wearable devices in the market, smart watch users were selected in this study, for the purpose of investigating core needs of wearable smart device users based on the user experience and user's sensibility. Qualitative research was performed through semi-structured interview in order to obtain detailed answers about user sensibility based on smart watch user experience. After the in-depth interview, the user's sensibility was categorized into four aspects; functional, aesthetic, social, and empirical. Sensibility adjectives and key words were assigned to each aspect and their frequency was analyzed. It was the functional aspect of sensibility that the wearable device users require the most. The results of this study will be utilized as a fundamental data to develop the smart textiles required for the next generation of smart clothing which is attracting as a future wearable device.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.135-145
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• 2017

The purpose of this study is to present meaningful information and policy implications concerning the determinants of royalties to the government-funded research centers and agencies. These groups are responsible for policies encouraging technology transfer from the public sector to the private sector. To identify key determinants of royalties in technology transfer, this study conducted AHP survey analysis (Survey period: 01/10~31/10, 2016) of 85 companies which were participants of the R&D project "Next Generation BioGreen21" of R.D.A in the "N"center from 2011 to 2015. Research results show that the critical factors include: 1)Technical considerations for determining the profitability of the technologies, 2)The interest and willingness of the management group, 3)Necessity and urgency of technology transfer. These findings suggest three main policy implications. First, the government-funded research centers and agencies should develop technologies that help companies improve their commercialization as well as the profitability in the near future. Second, government-funded research centers and agencies should consider reducing the administrative burden of the royalty payment for private companies. Third, public R&D projects should reflect the proper research schedule for technology development on the basis of the R&D time span of companies which transfer technology.

• Journal of Ecology and Environment
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• v.31 no.1
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• pp.45-67
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• 2008

Ocean climate variables ($1900{\sim}2005$), time series of catches ($1910{\sim}2005$) and body size data were used to assess the year-to-year and decadal scale fluctuations in abundance of the fish populations (Japanese sardine, anchovy, jack mackerel, chub mackerel, Pacific saury and common squid) that have spawning grounds in the East China Sea and its adjacent regions. A negative correlation between the abundance of pelagic fishes (e.g. jack mackerel) in the Tsushima Warm Current (TWC) region and the Kuroshio-Oyashio Current (KOC) region was attributed to the climatic modulation of larval transport and recruitment, which depends on the winter monsoon-induced drift, current systems, and spawning season and site. The changes in abundance and alternation of dominant fish populations in the two regions in the 1930s, 1970s, and late 1980s mirrored changes in the climate indices (ALPI, AOI and MOI). Oscillations in the decadal climate shifts between the two regions led to zonal differences in larval transport and recruitment, and hence differences in the abundance of the pelagic fish populations. During deep Aleutian Lows, as in the 1980s, larval transport from the East China Sea to the KOC region increases in association with the strong winter Asian monsoon, cool regime and increased volume transport of the Kuroshio Current systems, whereas during a weak Aleutian Low (as in the 1990s), larval transport to the TWC region increased in association with a weak winter Asian monsoon, a warm regime, and increased volume transport of the Tsushima current system. We postulate that the increased chub mackerel abundance in the TWC region and the decreased abundance in the KOC region in the 1990s are partly attributed to changes in recruitment and availability to the fishing fleets under the warm regime in the spawning and nursery grounds in the East China Sea in association with the quasi-steady state of mild winter monsoon in the 1990s. The fluctuations in chub mackerel and jack mackerel abundance are under the environment-dependant growth form, although the tropicalization was identified in the TWC region. The density-dependant growth form was found in Japanese sardine populations, but no tropicalization by fishing was identified in the long ($10{\sim}15$ year) periods of abundance despite their short ($3{\sim}4$ year) generation time, suggesting that the environment-dependant growth form drove the changes in abundance. Year-to-year and decadal scale variations in abundance and population structure of the Pacific saury responded to climate regime shifts (1976/1977, 1988/1989), suggesting that the fish is a key bio-indicators for changes in the ecosystem.

• Journal of Korea Technology Innovation Society
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• v.20 no.2
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• pp.430-457
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• 2017

The purpose of this study is to present meaningful information and policy implications concerning the determinants of royalties of technology transfer to stakeholder. To identify key determinants of royalties in technology transfer, this study conducted AHP survey analysis (Survey period: 01/09~31/10, 2016) of 96 government-funded research centers and 85 companies which were participants of the R&D project "Next Generation BioGreen21" of R.D.A in the "N" center from 2011 to 2015. Research results show that both parties acknowledge 'Technical considerations for determining the profitability of the technologies' and 'The interest and willingness of the management group' as critical factors for the determinants of royalties. The difference of each party is that private companies acknowledge 'Available budget plan' as a critical factor while the government-funded research centers value 'Market competitiveness'. These findings suggest four main policy implications which are the investigation of technological demands reflecting specific needs of industrial sites, the diversification of royalty payments for private companies, the differentiated research evaluation system for the purpose of technology transfer and the planning of public R&D project reflecting research time span of private companies.

• Journal of Life Science
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• v.22 no.12
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• pp.1688-1696
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• 2012

Oenanthe javanica has been used as a food source and also in traditional folk medicine for its detoxifying properties and anti-microbial effects since ancient times. In this study, we evaluated the effect and mechanism of O. javanica seed methanol extract (OJSE) on adipocyte differentiation by 3T3-L1 preadipocytes. Under non-toxic conditions, OJSE treatment resulted in a dose-dependent inhibition of lipid droplet generation and triglyceride accumulation by suppressing adipocyte differentiation, which are associated with the decreased expression of key proadipogenic transcription factors including CCAAR/enhancer binding protein ${\alpha}$, ${\beta}$ ($C/EBP{\alpha}$, $C/EBP{\beta}$) and peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$). OJSE also significantly inhibited proliferation and differentiation of 3T3-L1 preadipocytes through G1-phase arrest, indicating that OJSE blocked mitotic clonal expansion during adipocyte differentiation. Investigation of the alteration of G1 phase arrest-related proteins indicated a dose-dependent increase in the expression of p21 and reduction in expression of cyclin E, Cdk2, E2F-1 and phospho-Rb by OSJE. Taken together, these results suggest that OJSE inhibits adipocyte differentiation by blocking the mitotic clonal expansion, which is accompanied by preadipocyte cell cycle arrest.