• Genomics & Informatics
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• 제13권2호
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• pp.40-44
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• 2015

DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chromatin opening is tightly coupled with gene transcription. To understand how these two processes are genetically regulated and associated with each other, we examined the changes of chromatin accessibility and gene expression in response to genetic variation by means of quantitative trait loci mapping. Regulatory patterns commonly observed in yeast and human across different technical platforms and experimental designs suggest a higher genetic complexity of transcription regulation in contrast to a more robust genetic architecture of chromatin regulation.

• 전기학회논문지
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• 제66권1호
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• pp.107-113
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• 2017

Unlike regular images, there is no ground truth for bio surface images. Result of biosurface imaging is not only significantly affected by the environment and the condition of the bio surface, it requires more detailed expression than regular images. Therefore, unlike algorithms tested on regular images, studies on bio surface images requires a highly precise optimization process. We aim to optimize the graph cut algorithm, known to be the most outstanding among the stereo visions, by considering baseline, lambda, and disparity range. Optimal results were in the range of 1~10 for lambda. The disparity ranged from -30 to -50, indicating an optimal value in a slightly higher range. Furthermore, we verified the tested optimization data using SIFT.

• Archives of Pharmacal Research
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• 제29권7호
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• pp.582-586
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• 2006

Due to consumer reluctance to take synthetic drugs for nematode infections and the appearance of resistance to anthelminthic drugs, new drugs from natural products must be developed. Caenorhabditis elegans is one of the freely living nematodes and serves as a good model system for screening anthelminthic drugs. In this study, thirteen flavonoid derivatives were tested for anthelminthic activity and the relationships between their activities and structures were investigated. The structural information combined with the data for the larval growth inhibition of C. elegans provided meaningful structural insights in the search for new anthelminthic drugs.

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• 제5권2호
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• pp.60-67
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• 2024

Hitchhiker insect species from international vessels entering Korea in 2022 were monitored. A total of 947 samples of hitchhiker insects were collected using a simple collection method by hand. Among them, 856 individuals were classified as 374 species of 86 families in 10 orders through integrative analysis with DNA barcoding and morphological examination. The rest 91 individuals were identified only to the family level. As a result of examining the distribution of the 374 species (856 individuals), 38 species (71 individuals) were confirmed as not-distributed species in Korea, including six species (11 individuals) as 'regulated species' listed by the Korean Animal and Plant Quarantine Agency. Of 38 not-distributed species, 10 species were detected multiple times (at least twice). Accordingly, it is necessary to strengthen monitoring of the area around the port of entry along with continuous surveillance to prevent invasion of species detected multiple times. For monitoring alien hitchhiker insect species, this study provided detection information and biological data for alien species.

• 한국정밀공학회지
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• 제26권12호
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• pp.138-145
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• 2009

Custom medical treatment is being widely adapted to lots of medical applications. A technology for 3D modeling is strongly required to fabricate medical implants for individual patient. Needs on true 3D CAD data of a patient is strongly required for tissue engineering and human body simulations. Medical imaging devices show human inner section and 3D volume rendering images of human organs. CT or MRI is one of the popular imaging devices for that use. However, those image data is not sufficient to use for medical fabrication or simulation. This paper mainly deals how to generate 3D geometry data from those medical images. A new image processing technology is introduced to reconstruct 3D geometry of a human body vacancy from the medical images. Then a surface geometry data is reconstructed by using Marching cube algorithm. Resulting CAD data is a custom 3D geometry data of human vacancy. This paper introduces a novel 3D reconstruction process and shows some typical examples with implemented software.

• 전자공학회논문지
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• 제51권1호
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• pp.233-240
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• 2014

최근 노인인구의 증가하는 추세에 따라 만성질환자의 수도 증가하고 있으며 건강 관리문제가 중요하게 대두되고 있다. 본 논문에서는 만성질환자의 건강관리를 위한 유헬스케어 시스템을 구현하고자 한다. 제안한 만성 질환자 관리 시스템은 생체 계측 시스템과 모바일 게이트웨이 그리고 의료정보 관리 서버 그리고 클라이언트로 구성되면 생체 신호는 심전도, 혈압, 혈당, 산소포화도 등의 모듈로 구성하였다. 혈당체크는 이동성을 고려하여 생체계측 시스템으로 전송하는 방법과 게이트웨이로 전송하는 방법 중 선택할 수 있도록 구현하였다. 제안한 생체 계측 시스템과 모바일 게이트웨이는 블루투스 통신을 이용하여 전송한다. 전송된 생체 데이터는 모바일 게이트웨이에서 건강상태를 감시하거나 네트워크 서버로 전송하고 클라이언트을 이용하여 검색 할 수 있도록 하였다. 만성질환자의 생체신호 감시 시스템을 구현함으로서 측정되어진 생체 데이터를 모니터링하여 현재의 건강상태를 확인할 수 있었으며 모바일 환경에서 다양한 생체신호를 전송하였다.

• BMB Reports
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• 제43권12호
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• pp.801-806
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• 2010

The existence of glycine residues in long-chain scorpion toxins has been well documented. However, their role as analgesics has not been evaluated. To address this issue, we investigated the functional role of glycines in the C-terminal end of Chinese-scorpion toxin from Buthus martensii Karsch (BmK AGP-SYPU2) using site-directed mutagenesis and analgesic activity assays. Recombinant BmK AGP-SYPU2 and its mutants were efficiently expressed in E. coli and purified to homogeneity using immobilized metal ion affinity chromatography (IMAC) and cation exchange chromatography. The mouse-twisting test was used to detect the analgesic activity of BmK AGP-SYPU2 and its mutants. As a result, we identified glycines at the C-terminal end that, when altered, significantly affected analgesic activity. Also, Mut6566 was significantly decreased compared to BmK AGP-SYPU2. These data indicate that the glycines at the C-terminal end are important for the analgesic activity of BmK AGP-SYPU2.

• 한국지능시스템학회논문지
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• 제15권3호
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• pp.349-354
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• 2005

본 논문에서는 휴대용 개인정보 단말기를 이용하여 개인의 생체신호를 보다 쉽게 취득 하고 분석하는 시스템을 제안한다. 바쁘게 사는 현대인들이나, 거동이 불편한 환자들에게 병원을 직접 내원하여 검사를 받거나 진단을 받는 일은 큰 부담이 아닐 수 없다. 이에 본 연구에서는 원격지에서의 병원이나 타 의료장치에서 취득된 생체신호를 유비쿼터스 환경에서 블루투스로 전송하고 이 데이타를 블루투스가 내장된 PDA에서 획득하여 화면상에 다양한 표현방법으로 표현하는 생체신호 획득 시스템 구현을 목표로 한다. 이와 같은 시스템을 구현함으로서 이전의 생체신호와 현재의 생체신호를 쉽게 비교하고 분석할 수 있으며, 자신의 건강상태를 자가 점검하거나 의료기관의 의사에게 보내어짐으로서 검진 받을 수 있는 원격진료가 가능하다.

• Journal of Crop Science and Biotechnology
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• 제10권2호
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• pp.98-105
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• 2007

Phylogenetic relationships in Korean watermelons were evaluated by genetic similarity coefficients using 15 SSR(simple sequence repeat), 14 SCAR(sequence characterized amplified region) and 14 CAPS(sequence characterized amplified region) markers. The SSR markers were selected from previously reported melon and watermelon SSRs through testing polymorphisms within a set of commercial $F_1$ varieties. The SCAR and CAPS markers were developed from polymorphic AFLP(amplified fragment length polymorphism) markers between inbred lines 'BN4001' and 'BN4002'. From the AFLP analysis, 105 polymorphic fragments were identified between the inbred lines using 1,440 primer combinations of EcoRI+CNNN and XbaI+ANNN. Based on the sequencing data of these polymorphic fragments, we synthesized sequence specific primer pairs and detected clear and reliable polymorphisms in 27 primer pairs by indels(insertion/deletion) or RFLP(restriction fragment length polymorphism). A total of 43 sequence-based PCR markers were obtained and polymorphic information content(PIC) was analyzed to measure the informativeness of each marker in watermelon varieties. The average PIC value of SCAR markers was 0.41, which was similar to that of SSR markers. Genetic diversity was also estimated by using these markers to assess the phylogenetic relationships among commercial varieties of watermelon. These markers differentiated 26 Korean watermelon varieties into two major phylogenetic groups, but this grouping was not significantly correlated with their morphological and physiological characteristics. The mean genetic similarity was 66% within the complete set of 26 commercial varieties. In addition, these sequence-based PCR markers were reliable and useful to identify cultivars and genotypes of watermelon.

• The Journal of Asian Finance, Economics and Business
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• 제8권12호
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• pp.211-222
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• 2021

Green economy, also known as sustainable economy, is a current development trend in which consumers prefer products that are wholly or partly derived from materials of biological origin since they have become more concerned about their health and the environment in which they live. This study aims to examine consumer behavior toward bio-based products with three key goals in mind. First, it helps to understand the perception of consumers toward Bio-based products. Second, it properly helps consumers be aware of products derived from materials of biological origin so that the consumer can make purchasing decisions to protect their health and contribute to the protection of the environment. Third, the study on consumer behavior towards bio-based products will provide a more accurate view and assessment to companies looking to develop Bio-based products. Based on that, the research is carried out through surveying, collecting data from consumers, and then using the deductive approach, descriptive statistics, and quantitative method analysis. The results demonstrated that a positive relationship and a direct impact are established between the variables of Attitude and Social Norms and the Purchase Intention toward Bio-based products. Furthermore, the findings reveal that customers have positive feelings towards bio-based products in terms of trust, knowledge, and the environment.