• Proceedings of the KSME Conference
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• 2003.04a
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• pp.899-904
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• 2003

Microarrayer makes DNA chip and microarray that contain hundreds to thousands of immobilized DNA probes on surface of a microscope slide. This paper shows the development results for a printing type of microarrayer. It realizes a typical, low-cost and efficient microarrayer for generating low density microarray. The microarrayer is developed by using a robot of three-axes perpendicular type. It is composed of a computer-controlled three-axes robot and a pen tip assembly. The key component of the arrayer is the print-head containing the tips to immobilize cDNA, genomic DNA or similar biological material on glass surface. The robot is designed to automatically collect probes from two 96-well plates with up to 32 tips at the same time. To prove the performance of the developed microarrayer, the general water types of inks such as black, blue and red. The inks are distributed at proper positions of 96 well plates and the three color inks are immobilized on the slide glass under the operation procedure. As the result of the test, it can be shown that it has sufficient performance for the production of low integrated DNA chip consisted of 96 spots within 1 $cm^2$ area.

• Journal of Information Processing Systems
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• v.3 no.1
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• pp.16-20
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• 2007

This paper describes the development of the sensor interface and driver program for a point of care (POC) device. The proposed pac device comprises an ARM9 embedded processor and eight-channel sensor input to measure various bio-signals. It features a user-friendly interface using a full-color TFT-LCD and touch-screen, and a bluetooth wireless communication module. The proposed device is based on the system on a programmable chip (SOPC). We use Altera's Excalibur device, which has an ARM9 and FPGA area on a chip, as a test bed for the development of interface hardware and driver software.

• Microbiology and Biotechnology Letters
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• v.14 no.2
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• pp.199-203
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• 1986

A tubular tormentor was prepared by packing the wood chips and pumping the yeast solution of Saccharomyces formosensis in a tubular column. Investigations to characterize the ethanol fermentation in the immobilized cell tubular fermentor and to compare such a fermentors with other type fermentors were undertaken. Ethanol productivity of 24.4g EtOH/$\ell$.hr has been obtained from glucose substrate. This productivity is higher or compared favourably with that reported in immobilized bio-reactors.

• Journal of Biomedical Engineering Research
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• v.30 no.2
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• pp.103-112
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• 2009

Neuron-on-a-Chip technology is based on advanced neuronal culture technique, surface micropatterning, microelectrode array technology, and multi-dimensional data analysis techniques. The combination of these techniques allowed us to design and analyze live biological neural networks in vitro using real neurons. In this review article, two underlying technologies are reviewed: Microelectrode array technology and Neuronal patterning technology. There are new opportunities in the fusion of these technologies to apply them in neurobiology, neuroscience, neural prostheses, and cell-based biosensor areas.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.3
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• pp.265-268
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• 2009

We present the experimental study to realize a DNA separation chip using asymmetrically-switched nonuniform electric fields. The DNA separation chip redistributes DNA molecules within a specific area based on the size- and field-dependent nonlinearity of DNA drift velocity. The present chip is composed of a width variable channel to distribute nonuniform electric field, a DNA loading slit and a pair of electrodes to apply electric field. We focus on the design of DNA separation chips with identifying the nonlinearity of DNA drift velocity using three different DNA molecules (11.1kbp, 15.6kbp, and 48.5kbp) in the chips. It is demonstrated that different size of DNA shows different net migration in different direction under the asymmetrically-switched nonuniform electric field.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.53 no.8
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• pp.578-584
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• 2004

The CSVM(Current Support Vector Machine) that is a digital architecture performing all phases of recognition process including kernel computing, learning, and recall of SVM(Support Vector Machine) on a chip is proposed. Concurrent operation by parallel architecture of elements generates high speed and throughput. The classification problems of bio data having high dimension are solved fast and easily using the CSVM. Quadratic programming in original SVM learning algorithm is not suitable for hardware implementation, due to its complexity and large memory consumption. Hardware-friendly SVM learning algorithms, kernel adatron and kernel perceptron, are embedded on a chip. Experiments on fixed-point algorithm having quantization error are performed and their results are compared with floating-point algorithm. CSVM implemented on FPGA chip generates fast and accurate results on high dimensional cancer data.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.6
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• pp.157-162
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• 2023

A highly sensitive refractive index bio-sensor based on grating-assisted strip directional coupler (GASDC) is proposed. The sensor is designed using two asymmetric strip waveguides with a top-loaded grating structure in one of the waveguides. Maximum light couples from one waveguide to the other at the resonance wavelength satisfying phase-matching condition (PMC), and it shows that the change in phase-matching condition with the change in refractive index of the analyte medium in the cover region can be used as a measure of the sensitivity. The proposed sensor will be an on-chip device with a high refractive index sensitivity, and the sensor configuration offers a low propagation loss, thereby enhancing the sensitivity. Furthermore, variation of the sensitivity with the waveguide parameters of sensor is evaluated to optimize the design.

• BMB Reports
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• v.46 no.6
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• pp.305-309
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• 2013

The determination of relatedness between individuals in a family is crucial in analysis of common complex diseases. We present a method to infer close inter-familial relationships based on SNP genotyping data and provide the relationship coefficient of kinship in Korean families. We obtained blood samples from 43 Korean individuals in two families. SNP data was obtained using the Affymetrix Genome-wide Human SNP array 6.0 and the Illumina Human 1M-Duo chip. To measure the kinship coefficient with the SNP genotyping data, we considered all possible pairs of individuals in each family. The genetic distance between two individuals in a pair was determined using the allele sharing distance method. The results show that genetic distance is proportional to the kinship coefficient and that a close degree of kinship can be confirmed with SNP genotyping data. This study represents the first attempt to identify the genetic distance between very closely related individuals.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.11a
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• pp.301-302
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• 2008

• BT NEWS
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• v.11 no.2
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• pp.35-40
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• 2004

‘바이오칩(biochip)’ 이란 컴퓨터 칩(computer chip)에서 유래되어 바이오(bio)와 관련된 어떤 집적회로의 요소와 관련된 용어로 지칭되어 왔으나, 최근 몇년 동안 기술개발이 구체으로 이루어 지면서, DNA를 포함한 생체분자(biomolecule)에 대하여 생화학적 분석에 사용되는 프로브(probe)를 정렬(array)시킨 물질 및 장치라고 정의되고있다.(중략)