• 한방재활의학과학회지
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• 제25권1호
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• pp.1-15
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• 2015

Objectives The aim of this study was to investigate the effects of Cannabis Fructus on exercise capacity and cognitive function in chronic hypoperfusion induced vascular dementia rat model. Methods Vascular dementia rat models were induced by chronic cerebral hypoperfusion through bilateral common carotid arteries occlusion (BCCAO). All rats were randomly divided into 4 groups: normal group; control group; CF I group (feeding Cannabis Fructus 100 mg/kg); CF II group (feeding Cannabis Fructus 300 mg/kg). In order to study the effects of oral administration of Cannabis Fructus on vascular dementia rat models, corner turn test, hole board test, radial arm maze test, passive avoidance test were taken and Acetylcholine (ACh) activity, Acetylcholinesterase (AChE) activity, serum of Vascular endothelial growth factor (VEGF) protein level were measured. Also histological findings of the liver, kidney, brain and the change of Tau immunoreactive neurons in hippocampus were observed. Results CF I and CF II showed significant improvement in corner turn test, hole board test, radial arm maze test, passive avoidance test, Acetylcholine (ACh) activity, Acetylcholinesterase (AChE) activity, the serum of Vascular endothelial growth factor (VEGF) protein level and the change of Tau immunoreactive neurons in hippocampus. CF I showed more significant effect than CF II in these tests. However in histological observations of the liver and kidney both CF I and CF II showed glomerular injury and hepatotoxicity. Conclusions These results suggest that Cannabis Fructus was helpful in improving exercise capacity and cognitive function on Chronic hypoperfusion induced Vascular Dementia rats. However Cannabis Fructus affects the liver and kidney, therefore suggest that this is an area for further study.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 춘계학술대회
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• pp.91-93
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• 2016

2차원 영상으로부터 3차원 정보를 추출하는 과정은 매우 중요한 단계로서 하나의 카메라를 이용하는 단안시법과 두 개의 카메라를 이용하는 양안 시법이 있는 후자를 일반적으로"스테레오 비전"이라고 한다. 요즘 많이 CCTV나 여러 매체에서 사용되고 있는 자동 물체추적 시스템에서 인간의 두 눈을 모방한 스테레오 카메라를 이용하여 현장의 상황이나 작업 전개를 보다 명확하게 알 수 있어 회피/제어 기동 및 여러 작업의 효율을 극대화할 수 있다. 기존의 2D 영상에서의 물체 추적시스템은 거리를 인식할 수 없어 전이를 인식할 수 없었으나 스테레오 영상의 시차를 이용하고 객체를 표시하여 관측자가 보다 효과적으로 제어할 수 있을 것이다.

• 대한기계학회논문집B
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• 제35권11호
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• pp.1199-1204
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• 2011

본 연구에서는 원격촉진 시스템을 위한 양방향 원격조작 제어 전략개발의 일환으로, 작업환경의 실시간 파라미터 추정기법을 제안한다. 명시적 환경모델과 파라미터 추정은 원격제어에 있어 투명성의 개선과 작업환경의 경도정보를 제공할 수 있다. 본 연구는 기존의 환경모델이 갖는 문제점들을 개선하고 빠르고 안정된 알고리즘을 개발하기 위해, 연속체 역학 기반의 유한요소 모델과 확장 칼만필터를 이용한 추정 알고리즘을 포함하는 원격제어 기법을 제안한다. 이를 통해 사용자는 실시간으로 구현되는 환경 모델과 상호작용하며, 조작성의 향상 과 진단 및 분석을 위한 재료의 고유한 물성정보를 획득할 수 있다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제40권
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• pp.36.1-36.5
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• 2018

Background: Botulinum toxin-A (BTX-A) injection into muscle reduces muscular power and may prevent post-operative complication after orthognathic surgery. The purpose of this study was (1) to evaluate BTX-A injection into the masseter muscle on the prevention of plate fracture and (2) to compare post-operative relapse between the BTX-A injection group and the no injection group. Methods: Sixteen patients were included in this study. Eight patients received BTX-A injection bilaterally, and eight patients served as control. All patients received bilateral sagittal split ramus osteotomy for the mandibular setback and additional surgery, such as LeFort I osteotomy or genioplasty. Post-operative plate fracture was recorded. SNB angle, mandibular plane angle, and gonial angle were used for post-operative relapse. Results: Total number of fractured plates in patients was 2 out of 16 plates in the BTX-A injection group and that was 8 out of 16 plates in the no treatment group (P = 0.031). However, there were no significant differences in post-operative changes in SNB angle, mandibular plane angle, and gonial angle between groups (P > 0.05). Conclusions: BTX-A injection into the masseter muscle could reduce the incidence of plate fracture.

• Journal of Periodontal and Implant Science
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• 제42권2호
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• pp.50-58
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• 2012

Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n-HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral $4{\times}{\times}4{\times}5$ mm (buccolingual width${\times}$mesiodistal width${\times}$depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.

• Molecules and Cells
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• 제27권2호
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• pp.263-268
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• 2009

Gamma knife surgery (GKS) is used for the treatment of various human brain disorders. However, the biological effects of gamma ray irradiation on both the target area, and the surrounding tissues are not well studied. The effects of gamma ray exposure to both targeted and untargeted regions were therefore evaluated by monitoring gene expression changes in the unilateral irradiated (60 Gy) and contralateral un-irradiated striata in the rat. Striata of irradiated and control brains were dissected 16 hours post-irradiation for analysis using a whole genome 44K DNA oligo microarray approach. The results revealed 230 induced and 144 repressed genes in the irradiated striatum and 432 induced and 239 repressed genes in the unirradiated striatum. Out of these altered genes 39 of the induced and 16 of the reduced genes were common to both irradiated and un-irradiated tissue. Results of semiquantitative, confirmatory RT-PCR and western blot analyses suggested that ${\gamma}$-irradiation caused cellular damage, including oxidative stress, in the striata of both hemispheres of the brains of treated animals.

• Journal of Dental Anesthesia and Pain Medicine
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• 제20권5호
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• pp.313-323
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• 2020

Background: Previous studies have investigated the effects of dexamethasone injections into the pterygomandibular space and compared them to those of controls; however, the effects of dexamethasone injections before and after lower third molar surgery on postoperative complications have not been studied. This research investigated the postoperative sequelae of dexamethasone injections before and after surgery into the pterygomandibular space. The aim of this study was to evaluate the effects of preoperative and postoperative injections of 4 mg of dexamethasone into the pterygomandibular space on postoperative pain, facial swelling, and the restriction of mouth opening following lower third molar surgical removal. Methods: Twenty-seven participants with bilateral symmetrical lower impacted third molars were included in this study. Each participant was randomly allocated to one of two groups. Group A received injections of 1 ml dexamethasone (4 mg/mL) and 1 mL placebo into the pterygomandibular space before and after surgery, respectively. Group B received the same doses of placebo before surgery and dexamethasone after surgery. Results: A significant restriction of mouth opening on the second postoperative day was observed in both groups. Nonetheless, the postoperative restriction of mouth opening, facial swelling, postoperative pain, and analgesic consumption after lower third molar surgical removal were not significantly different in the two groups. Conclusions: Regardless of the time of administration, dexamethasone injections into the pterygomandibular space resulted in satisfactory control of the postoperative sequelae of the mandibular third molar surgical removal.

• 디자인학연구
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• 제17권1호
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• pp.63-76
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• 2004

정보디자인 원리는 1970년대의 출판디자인을 포함한 그래픽디자인 분야에서 비롯되었으나, 리처드 솔 워먼(Richard Saul Wurman)이 인터넷 환경에서 정보디자인과 그것의 실질적인 적용에 관한 문제를 탐구하면서부터 현재와 같이 정보디자인이 멀티미디어디자인 영역에서 매우 중요한 위치를 차지하기에 이르렀다. 그러나 아직까지도 멀티미디어디자인상에서 정보디자인 개념의 정체성 확보를 위한 이렇다할만한 연구가 부족한 실정이며, 경우에 따라선 과거 그래픽디자인 분야에서 정의되었던 ‘정보의 재현 및 시각화’라는 측면으로 대단히 협의적 관점에서 정보디자인을 조망하는 경향이 나타나고 있다. 이와 같은 맥락에서 본 연구는 과거의 전통적 정보디자인과 대비되는 상대적 관점으로 현재의 멀티미디어디자인에서 정보디자인 특성을 고찰하였다. 연구결과로서 멀티미디어디자인에서 정보디자인 특성은 '컨텍스트 제공과 정보 위계 발견', '통합적 사고에 의한 접근과 정보 통제권 공유', '다차원 매체 활용과 컨텐트 중심', '정보 질 보장과 통합적 정보 의미 해석', '쌍방향 정보 표출과 사용자 지식 확장'의 크게 5가지 측면으로 제시하였다. 본 연구를 토대로 향후에는 인터페이스디자인, 상호작용디자인, 경험디자인과 같은 정보디자인 인접분야와의 상호 의존적 또는 배타적 특성에 대한 담론이 제시될 수 있기를 기대한다.

• 한국임상수의학회지
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• 제30권2호
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• pp.100-106
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• 2013

A clinical trial was performed to assess clinical efficacy and/or reduction in relapses by gold-bead implantation into acupuncture points in dogs with canine chronic recurrent otitis externa (CCROE). Forty dog-patients randomly divided into two groups were diagnosed as suffering CCROE, having intact tympanic membranes and a history of recurrences. Treatments were: control group (CG), treated with commercially available antimicrobial otic droplets, dosed twice daily for 7 days; and experimental group (GBI- gold bead implants), treated as for CG plus the insertion of 13 gold-bead implants under light anesthesia. Overall per cent assessment of composite clinical progression and progression of individual clinical signs were recorded. Bilateral chronic external otitis was diagnosed in 60% of the cases and left or right otitis in 20% of the cases each. Logistic model for repeated measures analysis showed that GBI induced a better clinical recovery as far as lesion score of some clinical signs is concerned. The overall percent cures of each group showed statistically significant difference. A McNemar analysis revealed that higher number of relapses was observed in CG patients as compared to the GBI (P < 0.05). In particular during these days, lesion on the pinna showed in odd ratios analysis a 7:1 ratio (recurrence CG:GBI) and ear wax/pus (4:1) from D42 to D365. It is concluded that gold-bead implantation into acupuncture points improves resolution of some clinical signs and greatly reduce relapses in CCROE affected dogs after 1 year follow-up (98.75%).

• 대한두개안면성형외과학회지
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• 제22권5호
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• pp.239-246
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• 2021

Background: Bone grafts can provide an optimal environment for permanent tooth to erupt and enhance the stability of the alveolar maxilla. Although autologous bone is an optimal source for osteogenesis, its inevitable donor site morbidity has led to active research on bone substitutes. This study was designed to evaluate the safety and feasibility of using biphasic calcium phosphate (BCP; Osteon) as a bone substitute in dogs. Methods: Bilateral third and fourth premolars of four 15-week-old mongrel dogs were used. All teeth were extracted except the third premolar of the right mandible, which was used as a control. After extraction of the premolars, each dog was administered BCP (Osteon), demineralized bone matrix (DBM; DBX), and no graft in the hollow sockets of the right fourth premolar, left fourth premolar, and left third premolar, respectively. Radiographs were taken at 2-week intervals to check for tooth eruption. After 8 weeks, each dog was sacrificed, and tooth and bone biopsies were performed to check for the presence of tooth and bone substitute particle remnants. Results: Four weeks after the operation, permanent tooth eruptions had started at all the extraction sites in each dog. Eight weeks after the operation, all teeth had normally erupted, and histological examination revealed BCP particles at the right fourth premolar. Conclusion: In all four dogs, no delay in the eruption of the teeth or shape disfigurement of permanent teeth was observed on gross inspection and radiologic evaluation. On histological examination, most of the BCP and DBM were replaced by new bone. Bone substitutes can be used as graft materials in patients with alveolar clefts.