• Title/Summary/Keyword: Bicyclo[3.1.0]hexane

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The First Synthesis of Dually Modified Southern-Mimicking Nucleoside: 4'-Methyl Branched and Bicyclo [3.1.0] Hexane Locked Nucleoside

  • Kim, Kwan-Woo;Hong, Joon-Hee
    • Bulletin of the Korean Chemical Society
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    • v.25 no.5
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    • pp.668-672
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    • 2004
  • This paper reports the stereoselective synthesis of a novel nucleoside, 4'-methyl branched and bicyclo [3.1.0] hexane locked-nucleoside 12, using a sequential [3,3]-sigmatropic rearrangement/carbene cycloaddition reaction/Curtius reaction strategy with a high stereoselectivity.