• Title/Summary/Keyword: Bias Quantification

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Uncertainty Analysis of Quantitative Radar Rainfall Estimation Using the Maximum Entropy (Maximum Entropy를 이용한 정량적 레이더 강우추정 불확실성 분석)

  • Lee, Jae-Kyoung
    • Atmosphere
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    • v.25 no.3
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    • pp.511-520
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    • 2015
  • Existing studies on radar rainfall uncertainties were performed to reduce the uncertainty for each stage by using bias correction during the quantitative radar rainfall estimation process. However, the studies do not provide quantitative comparison with the uncertainties for all stages. Consequently, this study proposes a suitable approach that can quantify the uncertainties at each stage of the quantitative radar rainfall estimation process. First, the new approach can present initial and final uncertainties, increasing or decreasing the uncertainty, and the uncertainty percentage at each stage. Furthermore, Maximum Entropy (ME) was applied to quantify the uncertainty in the entire process. Second, for the uncertainty quantification of radar rainfall estimation at each stage, this study used two quality control algorithms, two rainfall estimation relations, and two bias correction techniques as post-processing and progressed through all stages of the radar rainfall estimation. For the proposed approach, the final uncertainty (ME = 3.81) from the ME of the bias correction stage was the smallest while the uncertainty of the rainfall estimation stage was higher because of the use of an unsuitable relation. Additionally, the ME of the quality control was at 4.28 (112.34%), while that of the rainfall estimation was at 4.53 (118.90%), and that of the bias correction at 3.81 (100%). However, this study also determined that selecting the appropriate method for each stage would gradually reduce the uncertainty at each stage. Finally, the uncertainty due to natural variability was 93.70% of the final uncertainty. Thus, the results indicate that this new approach can contribute significantly to the field of uncertainty estimation and help with estimating more accurate radar rainfall.

Feasibility of the Threshold-Based Quantification of Myocardial Fibrosis on Cardiac CT as a Prognostic Marker in Nonischemic Dilated Cardiomyopathy

  • Na Young Kim;Dong Jin Im;Yoo Jin Hong;Byoung Wook Choi;Seok-Min Kang;Jong-Chan Youn;Hye-Jeong Lee
    • Korean Journal of Radiology
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    • v.25 no.6
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    • pp.540-549
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    • 2024
  • Objective: This study investigated the feasibility and prognostic relevance of threshold-based quantification of myocardial delayed enhancement (MDE) on CT in patients with nonischemic dilated cardiomyopathy (NIDCM). Materials and Methods: Forty-three patients with NIDCM (59.3 ± 17.1 years; 21 male) were included in the study and underwent cardiac CT and MRI. MDE was quantified manually and with a threshold-based quantification method using cutoffs of 2, 3, and 4 standard deviations (SDs) on three sets of CT images (100 kVp, 120 kVp, and 70 keV). Interobserver agreement in MDE quantification was assessed using the intraclass correlation coefficient (ICC). Agreement between CT and MRI was evaluated using the Bland-Altman method and the concordance correlation coefficient (CCC). Patients were followed up for the subsequent occurrence of the primary composite outcome, including cardiac death, heart transplantation, heart failure hospitalization, or appropriate use of an implantable cardioverter-defibrillator. The Kaplan-Meier method was used to estimate event-free survival according to MDE levels. Results: Late gadolinium enhancement (LGE) was observed in 29 patients (67%, 29/43), and the mean LGE found with the 5-SD threshold was 4.1% ± 3.6%. The 4-SD threshold on 70-keV CT showed excellent interobserver agreement (ICC = 0.810) and the highest concordance with MRI (CCC = 0.803). This method also yielded the smallest bias with the narrowest range of 95% limits of agreement compared to MRI (bias, -0.119%; 95% limits of agreement, -4.216% to 3.978%). During a median follow-up of 1625 days (interquartile range, 712-1430 days), 10 patients (23%, 10/43) experienced the primary composite outcome. Event-free survival significantly differed between risk subgroups divided by the optimal MDE cutoff of 4.3% (log-rank P = 0.005). Conclusion: The 4-SD threshold on 70-keV monochromatic CT yielded results comparable to those of MRI for quantifying MDE as a marker of myocardial fibrosis, which showed prognostic value in patients with NIDCM.

Errors in Isotope Dilution Caused by Matrix-induced Mass Bias Effect in Quadrupole Inductively Coupled Plasma-Mass Spectrometry

  • Pak, Yong-Nam
    • Bulletin of the Korean Chemical Society
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    • v.35 no.12
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    • pp.3482-3488
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    • 2014
  • Matrix-induced mass bias and its effect on the accuracy of isotope ratio measurements have been examined for a quadrupole-based inductively coupled plasma-mass spectrometer (Q ICP-MS). Matrix-induced mass bias effect was directly proportional to % mass difference, and its magnitude varied for element and nebulizer flow rate. For a given element and conditions in a day, the effect was consistent. The isotope ratio of Cd106/Cd114 under $200{\mu}g\;g^{-1}$ U matrix deviated from the natural value significantly by 3.5%. When Cd 111 and Cd114 were used for the quantification of Cd with isotope dilution (ID) method, the average of differences between the calculated and measured concentrations was -0.034% for samples without matrix ($0.076{\mu}g\;g^{-1}$ to $0.21{\mu}g\;g^{-1}$ for the period of 6 months). However, the error was as large as 1.5% for samples with $200{\mu}g\;g^{-1}$ U. The error in ID caused by matrix could be larger when larger mass difference isotopes are used.

Quantification of Acoustic Pressure Estimation Error due to Sensor and Position Mismatch in Planar Acoustic Holography (평면 음향 홀로그래피에서 센서간 특성 차이와 측정 위치의 부정확성에 의한 음압 추정 오차의 정량화)

  • 남경욱;김양한
    • Journal of KSNVE
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    • v.8 no.6
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    • pp.1023-1029
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    • 1998
  • When one attempts to construct a hologram. one finds that there are many sources of measurement errors. These errors are even amplified if one predicts the pressures close to the sources. The pressure estimation errors depend on the following parameters: the measurement spacing on the hologram plane. the prediction spacing on the prediction plane. and the distance between the hologram and the prediction plane. This raper analyzes quantitatively the errors when these are distributed irregularly on the hologram plane The sensor mismatch and inaccurate measurement location. position mismatch. are mainly addressed. In these cases. one can assume that the measurement is a sample of many measurement events. The bias and random error are derived theoretically. Then the relationship between the random error amplification ratio and the parameters mentioned above is examined quantitatively in terms of energy.

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The Selection of Sample Injection Modes and Its Effect on the Calibration Bias in S Gas Detection by Gas Chromatography (GC의 주입방식 차에 따른 고농도 악취황 성분의 검량오차 연구 : 주입부피의 고정방식 대비 주입농도의 고정방식 간 비교연구)

  • Kim Ki-Hyun;Choi YJ
    • Journal of Korean Society for Atmospheric Environment
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    • v.21 no.2
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    • pp.269-274
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    • 2005
  • In this work, analytical bias arising from the gas chromatographic determination of sulfur compounds was evaluated by the application of direct loop injection method to the GC/PFPD detection of four sulfur compounds including H$_{2}$S, CH$_{3}$SH, DMS, and DMDS. For the proper evaluation of analytical uncertainties involved in GC calibration, we employed two comparative techniques of calibration at fxed concentration injection (CFCI) vs calibration at fixed volume injection (CFVI) method. The results of our study indicate that CFCI method exhibits very poor sensitivity due to the matrix effect with varying injection volumes. On the other hand, as CFVI method overcomes such limitation, it can be used to obtain very accurate quantification of S compounds at their high concentration levels above a few to a few tens ppb.

Bias-corrected Hp(10)-to-Organ-Absorbed Dose Conversion Coefficients for the Epidemiological Study of Korean Radiation Workers

  • Jeong, Areum;Kwon, Tae-Eun;Lee, Wonho;Park, Sunhoo
    • Journal of Radiation Protection and Research
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    • v.47 no.3
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    • pp.158-166
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    • 2022
  • Background: The effects of radiation on the health of radiation workers who are constantly susceptible to occupational exposure must be assessed based on an accurate and reliable reconstruction of organ-absorbed doses that can be calculated using personal dosimeter readings measured as Hp(10) and dose conversion coefficients. However, the data used in the dose reconstruction contain significant biases arising from the lack of reality and could result in an inaccurate measure of organ-absorbed doses. Therefore, this study quantified the biases involved in organ dose reconstruction and calculated the bias-corrected Hp(10)-to-organ-absorbed dose coefficients for the use in epidemiological studies of Korean radiation workers. Materials and Methods: Two major biases were considered: (a) the bias in Hp(10) arising from the difference between the dosimeter calibration geometry and the actual exposure geometry, and (b) the bias in air kerma-to-Hp(10) conversion coefficients resulting from geometric differences between the human body and slab phantom. The biases were quantified by implementing personal dosimeters on the slab and human phantoms coupled with a Monte Carlo method and considered to calculate the bias-corrected Hp(10)-to-organ-absorbed dose conversion coefficients. Results and Discussion: The bias in Hp(10) was significant for large incident angles and low energies (e.g., 0.32 for right lateral at 218 keV), whereas the bias in dose coefficients was significant for the posteroanterior (PA) geometry only (e.g., 0.79 at 218 keV). The bias-corrected Hp(10)-to-organ-absorbed dose conversion coefficients derived in this study were up to 3.09- fold greater than those from the International Commission on Radiological Protection publications without considering the biases. Conclusion: The obtained results will aid future studies in assessing the health effects of occupational exposure of Korean radiation workers. The bias-corrected dose coefficients of this study can be used to calculate organ doses for Korean radiation workers based on personal dose records.

A study on quantification of α-quartz, cristobalite, kaolinite mixture in respirable dust using by FTIR (FTIR를 이용한 호흡성 분진중 α-quartz, cristobalite, kaolinite 혼합물 정량 분석 연구)

  • Eun Cheol Choi;Seung Ho Lee
    • Analytical Science and Technology
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    • v.36 no.6
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    • pp.315-323
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    • 2023
  • This study is to quantify α-quartz, cristobalite and kaolinite using by FTIR in respirable dust generated in the mining workplace. Various minerals in mines can interfere with peaks when quantifying respirable crystalline silica by FTIR. Therefore, for accurate quantification, it is necessary to remove interfering substances or correct the peaks that cause interference. To confirm the peaks occurring in α-quartz, cristobalite and kaolinite, each standard material was diluted with KBr and scanned in the range of 400 cm-1 to 4000 cm-1 using by FTIR. As a result of scanning the analytes, it was decided to use the peaks of 797.66 cm-1 and 695.25 cm-1 for α-quartz, 621.58 cm-1 for cristobalite, and 3696.47 cm-1 for kaolinite. When the above materials are mixed, interference occurs at the peak for quantification, which is corrected by the calculation formula. The analysis of the mixture of α-quartz and cristobalite shows the average bias (%) of 2.64 (corrected) at α-quartz (797.66 cm-1), 5.61 (uncorrected) at α-quartz (695.25 cm-1) and 1.51 (uncorrected) at cristobalite (621.58 cm-1). The analysis of the mixture of α-quartz and kaolinite shows the average bias(%) of 1.79(corrected) at α-quartz (797.66 cm-1), 3.92 (corrected) at α-quartz (695.25 cm-1) and 2.58 (uncorrected) at kaolinite (3696.47 cm-1). The analysis of the mixture of cristobalite and kaolinite shows the average bias (%) of 2.15 (corrected) at cristobalite (621.58 cm-1), 4.32 (uncorrected) at kaolinite (3696.47 cm-1). The analysis of the mixture of αquartz and cristobalite and kaolinite shows the average bias (%) of 1.93(corrected) at α-quartz (797.66 cm-1), 6.47 (corrected) at α-quartz (695.25 cm-1) and 1.77 (corrected) at cristobalite (621.58 cm-1) and 2.61 (uncorrected) at kaolinite (3696.47 cm-1). The experimental results showed that the deviation caused by peak interference by two or three substances could be corrected to less than 6 % of the average deviation. This study showed the possibility of correcting and quantifying when various interfering substances that are difficult to remove are mixed.

Quantification of Pancreas Surface Lobularity on CT: A Feasibility Study in the Normal Pancreas

  • Riccardo Sartoris;Alberto Calandra;Kyung Jin Lee;Tobias Gauss;Valerie Vilgrain;Maxime Ronot
    • Korean Journal of Radiology
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    • v.22 no.8
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    • pp.1300-1309
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    • 2021
  • Objective: To assess the feasibility and reproducibility of pancreatic surface lobularity (PSL) quantification derived from abdominal computed tomography (CT) in a population of patients free from pancreatic disease. Materials and Methods: This retrospective study included 265 patients free from pancreatic disease who underwent contrast-enhanced abdominal CT between 2017 and 2019. A maximum of 11 individual PSL measurements were performed by two abdominal radiologists (head [5 measurements], body, and tail [3 measurements each]) using dedicated software. The influence of age, body mass index (BMI), and sex on PSL was assessed using the Pearson correlation and repeated measurements. Inter-reader agreement was assessed using the intraclass correlation coefficient (ICC) and Bland Altman (BA) plots. Results: CT images of 15 (6%) patients could not be analyzed. A total of 2750 measurements were performed in the remaining 250 patients (143 male [57%], mean age 45 years [range, 18-91]), and 2237 (81%) values were obtained in the head 951/1250 (76%), body 609/750 (81%), and tail 677/750 (90%). The mean ± standard deviation PSL was 6.53 ± 1.37. The mean PSL was significantly higher in male than in female (6.89 ± 1.30 vs. 6.06 ± 1.31, respectively, p < 0.001). PSL gradually increased with age (r = 0.32, p < 0.001) and BMI (r = 0.32, p < 0.001). Inter-reader agreement was excellent (ICC 0.82 [95% confidence interval 0.72-0.85], with a BA bias of 0.30 and 95% limits of agreement of -1.29 and 1.89). Conclusion: CT-based PSL quantification is feasible with a high success rate and inter-reader agreement in subjects free from pancreatic disease. Significant variations were observed according to sex, age, and BMI. This study provides a reference for future studies.

Quantification of Acoustic Pressure Estimation Error due to Sensor Position Mismatch in Spherical Acoustic Holography (구형 음향 홀로그래피에서 측정위치 부정확성에 의한 음압 추정 오차의 정량화)

  • Lee, Seung-Ha;Kim, Yang-Hann
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2007.11a
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    • pp.1325-1328
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    • 2007
  • When we visualize the sound field radiated from a spherical sound source, spherical acoustic holography is proper among acoustic holography methods. However, there are measurement errors due to sensor position mismatch, sensor mismatch, directivity of sensor, and background noise. These errors are amplified if one predicts the pressures close to the sources: backward prediction. The goal of this paper is to quantitatively examine the effects of the error due to sensor position mismatch on acoustic pressure estimation. This paper deals with the cases of which the measurement deviations are distributed irregularly on the hologram plane. In such cases, one can assume that the measurement is a sample of many measurement events, and the cause of the measurement error is white noise on the hologram plane. Then the bias and random error are derived mathematically. In the results, it is found that the random error is important in the backward prediction. The relationship between the random error amplification ratio and the measurement parameters is derived quantitatively in terms of their energies.

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On using computational versus data-driven methods for uncertainty propagation of isotopic uncertainties

  • Radaideh, Majdi I.;Price, Dean;Kozlowski, Tomasz
    • Nuclear Engineering and Technology
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    • v.52 no.6
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    • pp.1148-1155
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    • 2020
  • This work presents two different methods for quantifying and propagating the uncertainty associated with fuel composition at end of life for cask criticality calculations. The first approach, the computational approach uses parametric uncertainty including those associated with nuclear data, fuel geometry, material composition, and plant operation to perform forward depletion on Monte-Carlo sampled inputs. These uncertainties are based on experimental and prior experience in criticality safety. The second approach, the data-driven approach relies on using radiochemcial assay data to derive code bias information. The code bias data is used to perturb the isotopic inventory in the data-driven approach. For both approaches, the uncertainty in keff for the cask is propagated by performing forward criticality calculations on sampled inputs using the distributions obtained from each approach. It is found that the data driven approach yielded a higher uncertainty than the computational approach by about 500 pcm. An exploration is also done to see if considering correlation between isotopes at end of life affects keff uncertainty, and the results demonstrate an effect of about 100 pcm.