• Title/Summary/Keyword: Bhopal

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POSITIVE SOLUTIONS FOR A NONLINEAR MATRIX EQUATION USING FIXED POINT RESULTS IN EXTENDED BRANCIARI b-DISTANCE SPACES

  • Reena, Jain;Hemant Kumar, Nashine;J.K., Kim
    • Nonlinear Functional Analysis and Applications
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    • v.27 no.4
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    • pp.709-730
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    • 2022
  • We consider the nonlinear matrix equation (NMEs) of the form 𝓤 = 𝓠 + Σki=1 𝓐*iℏ(𝓤)𝓐i, where 𝓠 is n × n Hermitian positive definite matrices (HPDS), 𝓐1, 𝓐2, . . . , 𝓐m are n × n matrices, and ~ is a nonlinear self-mappings of the set of all Hermitian matrices which are continuous in the trace norm. We discuss a sufficient condition ensuring the existence of a unique positive definite solution of a given NME and demonstrate this sufficient condition for a NME 𝓤 = 𝓠 + 𝓐*1(𝓤2/900)𝓐1 + 𝓐*2(𝓤2/900)𝓐2 + 𝓐*3(𝓤2/900)𝓐3. In order to do this, we define 𝓕𝓖w-contractive conditions and derive fixed points results based on aforesaid contractive condition for a mapping in extended Branciari b-metric distance followed by two suitable examples. In addition, we introduce weak well-posed property, weak limit shadowing property and generalized Ulam-Hyers stability in the underlying space and related results.

Innovation and Creativity in Business Practices

  • Venkatesh, Bharti;Qureshi, Shazia
    • Journal of Distribution Science
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    • v.10 no.4
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    • pp.7-11
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    • 2012
  • "Great things in business are never done by one person; they're done by a team of people." By Steve Jobs, 2003. As define by Linda Naiam - Creativity is the act of turning new and imaginative ideas into reality. Creativity involves two processes: thinking, then producing. Innovation is the production or implementation of an idea. If you have ideas, but don't act on them, you are imaginative but not creative. So in order to maintain the pace with the changing business scenario and coping with the competition Innovation and Creativity is considered a mandatory tool for a business to exist and grow in market. Whether a company is Employee centric or Business centric Innovation and creativity has to have its space in order to keep a business ahead of others in the Market. Also it's not just the competition which has led to the Innovation and Creativity in Business practices it's also the demanding chunk of consumers and customers who are aware and prefer maximum choices before making a final deal. Another reason as to why there is a change in business practices is the globalization of businesses where you need to rope in the Innovative ideas to launch and sustain in new market. There had been tremendous shift in business practices but to give a room to innovative ideas and implement that creativity need ample to space and vision along with an attitude where in you can resist for getting an immediate results from innovative business practices. Corporate Creativity is characterized by the ability to perceive the world in new ways, to find hidden patterns, to make connections between seemingly unrelated phenomena, and to generate solutions. Generating fresh solutions to problems, and the ability to create new products, processes or services for a changing market, are part of the intellectual capital that give a company its competitive edge. Creativity is a crucial part of the innovation equation. The innovation and creativity is not limited to any area of business, it can start from your waiting lounge to your board room meeting depending upon how the things are perceived and implemented for the betterment of people and business. The purpose of this research is to understand the latest creative business approaches and practices that organizations are following to be different from their competitors. Also this shift from generic business practices to the Innovative and Creative approach seems to take the business into new world. This approaches means starting from the bottom of the Pyramid and finally touching the pinnacles in Innovation and creativity. The paper will discuss on the various areas of business where in innovative approaches can be roped in and sets new bench mark altogether in the business arena.

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폭주반응에 의한 사고사례 고찰

  • 안형환
    • Bulletin of the Korean Institute for Industrial Safety
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    • v.1 no.1
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    • pp.7-10
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    • 2001
  • 화학공장에서 발생되는 중대산업사고(major industrial accident)는 그 영향이 공장내부에만 국한되지 않고 인근 지역의 주민들과 환경에까지 치명적인 영향을 미친다. 이러한 중대산업사고의 원인은 여러 가지가 있을 수 있으나 발열화학 반응공정에서 발생될 수 있는 폭주반응도 그 중 하나이다. 폭주반응에 의한 중대산업사고(major industrial accident)의 대표적인 사례로는 인도의 보팔(Bhopal)에서 methylisocyanate 누출사고와 이탈리아의 세베소(Seveso) 폭발사고를 들 수 있으며 보팔 사고의 경우 사망자수가 2,000명 이상이었고, 20,000명 이상이 부상하였으며, 세베소 사고의 경우 막대한 환경피해를 입혔다.(중략)

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In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas-Tragedy survivors

  • Khan, Inbesat;Senthilkumar, Chinnu Sugavanam;Upadhyay, Nisha;Singh, Hemant;Sachdeva, Meenu;Jatawa, Suresh Kumar;Tiwari, Archana
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.17
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    • pp.7663-7670
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    • 2015
  • DNA methyltransferase 1 (DNMT1) is a relatively large protein family responsible for maintenance of normal methylation, cell growth and survival in mammals. Toxic industrial chemical exposure associated methylation misregulation has been shown to have epigenetic influence. Such misregulation could effectively contribute to cancer development and progression. Methyl isocyanate (MIC) is a noxious industrial chemical used extensively in the production of carbamate pesticides. We here applied an in silico molecular docking approach to study the interaction of MIC with diverse domains of DNMT1, to predict cancer risk in the Bhopal population exposed to MIC during 1984. For the first time, we investigated the interaction of MIC and its hydrolytic product (1,3-dimethylurea) with DNMT1 interacting (such as DMAP1, RFTS, and CXXC) and catalytic (SAM, SAH, and Sinefungin) domains using computer simulations. The results of the present study showed a potential interaction of MIC and 1,3-dimethylurea with these domains. Obviously, strong binding of MIC with DNMT1 interrupting normal methylation will lead to epigenetic alterations in the exposed humans. We suggest therefore that the MIC-exposed individuals surviving after 1984 disaster have excess risk of cancer, which can be attributed to alterations in their epigenome. Our findings will help in better understanding the underlying epigenetic mechanisms in humans exposed to MIC.

Unusual chromosomal features in a child with gradual disappearance of right ulna (mono ostolic osteolysis)

  • Goswami, Hit K.;Shrivastava, Nirhhay;Gopal, Shiv Kumar;Sharna, Sanjay;Chandorkar, Manoj;Lee, In-Hwan;Chang, Sung-Ik
    • Journal of Genetic Medicine
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    • v.1 no.1
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    • pp.11-16
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    • 1997
  • A nine month old male child presenting degenerating right ulna (massive osteolysis) has been followed up for two years. The bone completely disappeared due to abscesses on the right forearm and without orthopedic or haematological complications. Repeated lymphocyte cultures showed somatic pairing (mostly chromosome pair 5), end to end association involving chromosome 14, 21, 21 and 16, and satellite enlargement in a high proportion of cells with an otherwise normal 46,XY karyotype. These observations are compared with 13 other types of orthopaedic patients, and we opine that cumulative picture of chromosomal aberrations appears to correspond with the present rare anomaly "Mono Ostolic Osteolysis" involving right ulna. None of the controls or any other orthopaedic anomaly studied hereunder exhibits this chromosomal picture.

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CONTROL FUNCTION BASED COUPLED AND COMMON COUPLED FIXED POINT THEOREMS IN PARTIAL METRIC SPACES

  • H. K. Nashine;G. S. Saluja;G. V. V. Jagannadha Rao;W. H. Lim
    • Nonlinear Functional Analysis and Applications
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    • v.29 no.2
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    • pp.559-580
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    • 2024
  • In this paper, we aim to prove coupled and common coupled fixed point theorems for contractive type conditions in the context of partial metric spaces by means of a control function, and to provide some corollaries of the established results. This paper presents a number of results that generalize and extend previous work in the field. In order to better illustrate the process, we provide examples.

Methyl Isocyanate and Carcinogenesis: Bridgeable Gaps in Scientific Knowledge

  • Senthilkumar, Chinnu Sugavanam;Sah, Nand Kishore;Ganesh, Narayanan
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.6
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    • pp.2429-2435
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    • 2012
  • Methyl isocyanate may have a role in cancer etiology, although the link is unclear. There is evidence in the literature that it can induce cancer in animals but the carcinogenic potency is weak. Pheochromocytoma of adrenal medulla and acinar cell tumors of pancreas have been observed in methyl isocyanate exposed animals. Conversely, emerging data from population-based epidemiological studies are contradictory since there is no evidence of such cancers in methyl isocyanate exposed humans. Recently, we reported a high prevalence of breast and lung cancers in such a population in Bhopal. In vitro findings appearing in the latest scientific literature suggest that genomic instability is caused by methyl isocyanate analogs in lung, colon, kidney, ovary epithelial cells, and that hepatocytes may undergo oncogenic transformation, have obvious implications. The conflicting information prompted us to present this update over the last three decades on methyl isocyanate-induced cancers after an extensive literature search using PubMed. While the pertinent literature remains limited, with a scarcity of strong laboratory analyses and field-epidemiological investigations, our succinct review of animal and human epidemiological data including in vitro evidences, should hopefully provide more insight to researchers, toxicologists, and public health professionals concerned with validation of the carcinogenicity of methyl isocyanate in humans.

Factors Influencing Youngsters' Consumption Behavior on High-End Cosmetics in China

  • GILITWALA, Bhumiphat;NAG, Amit Kumar
    • The Journal of Asian Finance, Economics and Business
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    • v.8 no.1
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    • pp.443-450
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    • 2021
  • The paper investigates the factors that affect the decision of young Chinese consumers to buy high-end cosmetics. The study is based on the responses obtained by questionnaires from 400 respondents in Guangzhou, China. The information was collected and classified on the basis of gender, occupation, age and education in order to understand the main characteristics of the sample in a better way. The purposive, convenient and quota sampling techniques of non-probability sampling method were used. Besides this, the predictive test was carried out with 30 respondents to ensure the reliability and validity of the questionnaires. The data was put to descriptive statistical analysis and multiple regression analysis in order to verify the hypotheses. The data revealed that, while brand awareness does not affect the consumer attitude about the high-end cosmetics, other factors like product involvement, perceived quality, subjective norm, and word-of-mouth have significant effect on consumer's attitude and consumers' intention about high-end cosmetics. The findings of the study show that subjective norm, perceived value, word-of-mouth, and consumer attitude of cosmetic products highly affect consumers purchase intention of high-end cosmetic products. The research paper helps to form concrete and effective marketing strategy based on various aspects of consumer behavior for high-end cosmetics in China.

A Model Approach to Calculate Cancer Prevalence From 5 Year Survival Data for Selected Cancer Sites in India

  • Takiar, Ramnath;Jayant, Kasturi
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6899-6903
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    • 2013
  • Background: Prevalence is a statistic of primary interest in public health. In the absence of good follow-up facilities, it is difficult to assess the complete prevalence of cancer for a given registry area. Objective: An attempt was here made to arrive at complete prevalence including limited duration prevalence with respect to selected sites of cancer for India by fitting appropriate models to 1, 3 and 5 years cancer survival data available for selected population-based registries. Materials and Methods: Survival data, available for the registries of Bhopal, Chennai, Karunagappally, and Mumbai was pooled to generate survival for breast, cervix, ovary, lung, stomach and mouth cancers. With the available data on survival for 1, 3 and 5 years, a model was fitted and the survival curve was extended beyond 5 years (up to 35 years) for each of the selected sites. This helped in generation of survival proportions by single year and thereby survival of cancer cases. With the help of survival proportions available year-wise and the incidence, prevalence figures were arrived for selected cancer sites and for selected periods. Results: The prevalence to incidence ratio (PI ratio) stabilized after a certain duration for all the cancer sites showing that from the knowledge of incidence, the prevalence can be calculated. The stabilized P/I ratios for the cancer sites of breast, cervix, ovary, stomach, lung, mouth and for life time was observed to be 4.90, 5.33, 2.75, 1.40, 1.37, 4.04 and 3.42 respectively. Conclusions: The validity of the model approach to calculate prevalence could be demonstrated with the help of survival data of Barshi registry for cervix cancer, available for the period 1988-2006.

Additive Properties of Crude, Age Specific and Age Adjusted Rates for Cancer Incidence and Mortality

  • Takiar, Ramnath;Shrivastava, Atul
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.13
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    • pp.5407-5409
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    • 2014
  • Background: In National Cancer Registry Programme (NCRP) reports, various rates are routinely provided for 50 cancer sites of males and 54 cancer sites of females. Very often, depending on our interest, we wish to see these rates for group of cancers like head and neck cancers, oral cancers, and reproductive cancers. In such a situation, the desired rates are calculated independently from the actual data and reported. The question is can we derive the rates for groups of cancers from the published reports when the data is provided only for the individual sites? Objective: In the present paper, an attempt is made to explore the mathematical properties of various rates to derive them directly for the group of cancer sites from the published data when the rates are provided only for the individual sites. Source of data: The cancer incidence data collected by two urban Population Based Cancer Registries (PBCRs), under the network of NCRP for the period of 2006-08 was considered for the study purposes. The Registries included were: Bangalore and Bhopal. Results: In the present communication, we have shown that the crude rate (CR), age specific rates and age-adjuste rates (AAR) all possess additive properties. This means, given the above rates for individual sites, the above rates can be calculated for groups of sites by simply adding them. In terms of formula it can be stated that CR(Site1+Site2+++ SiteN) = CR(Site1)+CR(Site2) +++ CR(SiteN). This formula holds good for age specific rates as well as for AAR. This property facilitates the calculation of various rates for defined groups of cancers by simply adding the above rates for individual sites from which they are made up.