• Archives of Plastic Surgery
• /
• 제47권1호
• /
• pp.62-69
• /
• 2020

Background Cryolipolysis, a preferred method for minimally invasive body contouring, involves the noninvasive cooling of adipocytes to induce lipolysis without damaging other tissues. This study aimed to evaluate the safety and efficacy of cryolipolysis for the treatment of excessive fat tissue. Methods Between May 2014 and December 2017, 231 patients with 448 areas of interest were enrolled and their records were retrospectively reviewed. We used five different vacuum applicators, and the best-fitting applicator was used for each area. One cycle of cryolipolysis was applied at a cooling intensity factor of 41.6. The efficacy was evaluated 12 weeks after treatment via review of clinical photographs, the pinch test, and ultrasonographic measurements of fat thickness. The occurrence of any complications was also assessed. Results The volume was reduced in all of the areas to which cryolipolysis was applied. The rate of reduction of the fat layer as measured via the pinch test was 19.2%, and the rate of the decrease in fat layer thickness as measured via ultrasonography was 22.8%. Fat reduction of the upper arm differed significantly from that of the abdomen and flank, but no significant difference was found between sexes. The side effects were limited to erythema, edema, bruising, and numbness at the treatment site and resolved without treatment. Conclusions Cryolipolysis, with new and better-fitting applicators, is safe, fast, and effective for the reduction of excessive fat tissue on the abdomen, back, flank, and extremities. It is a good option for treating excess adipose tissue in Asian patients.

• 대한한방내과학회지
• /
• 제24권2호
• /
• pp.283-289
• /
• 2003

Background and Purpose : Hemiplegic upper extremity is a problem frequently encountered in the rehabilitation of patients with stroke. In Korean traditional medicine, moxibustion has been used clinically in treatment of stroke patients with hemiplegia. So far, its efficacy has not been proven clinically. The purpose of this study was to evaluate the efficacy of the moxibustion in treating hemiplegic upper extremity in stroke patients. Design : Randomized Control Trial. Subjects and Methods : Forty hemiplegic stroke patients admitted to Kyunghee oriental medicine hospital were randomized into the treatment with standard physiotheraphy combined with Moxibustion-group or Control-group with standard physiotherapy alone. It took them 2-5 weeks from the onset to start this study. Moxibustion was applied at LI4(合谷), LI11(曲池), TE3(中渚), TE5(外關) in hemiplegic hand, once a day for 2weeks. The effect of treatment on hemiplegic upper extremity was assessed using Fugl-Myer motor scale, Motricity Index and Modified Barthel Index(drinking/feeding, dressing upper body, grooming) Results : These 2 groups had comparable clinical characteristics; sex, age, plegic side (Rt., Lt.), pretreatment impairment. After two weeks, patients in the moxibustion group perfomed better on Fugl-Myer test and Motricity index test. The differences were significant.(P=0.038, 0.002) But Results on the Modified Barthel Index revealed no effect.(P=0.348) Conclusion : This results suggest that moxibustion is an effective treatment for improvement of motor function of hemiplegic upper extremity.

• 한국산업융합학회 논문집
• /
• 제20권2호
• /
• pp.105-113
• /
• 2017

Recently the direct injection diesel engine is the most efficient one available for road vehicles, so this fundamental advantage suggests the compression injection diesel engine are a wise choice for future development efforts. The compression ignition diesel engine, with its bigger compression ratios if compared to the SI engine, offers a higher thermodynamic efficiency, also additionally the diesel engine with its less pumping losses due to the throttled intake charge as in a SI engine has higher fuel economy. But the largest obstacle to the success of this engine is meeting emission standards for Nitric oxides and particulate matter while maintain fuel consumption advantage over currently available engines. Thus its use should be largely promoted, however, diesel engine emits more Nitric oxides and particulate matter than other competing one. There has been a trade-off between PM and NOx, so efforts to reduce NOx have increased PM and vice versa, but trap change this situation and better possibility emerge for treating NOx emission with engine related means, such as injection timing, equivalence ratio, charge composition, and engine speed. The common rail direct injection system is able to adjust the fuel injection timing in a compression ignition engine, so this electronically controlled injection system can reduce the formation of NOx gas without increase in soot. In this study it is designed and used the engine test bed which is installed with turbocharge and intercooler. In addition to equipped using CRDI by controlling injection timing with mapping modulator, it has been tested and analyzed the engine performance, combustion characteristics, and exhaust emission as operating parameters.

• 한국ITS학회 논문지
• /
• 제7권5호
• /
• pp.26-32
• /
• 2008

장애인.노약자들은 일반인에 비해 이동에 대한 제약조건이 많으며 이동시 일반인들이 생각하는 것보다 많은 어려움이 있다. 장애인.노약자뿐만 아니라 일반인들의 보행환경을 개선하기 위해 장애인.노약자를 위한 보행 지원시스템을 구성하여 장애인.노약자들의 사회활동을 장려하고 사회 구성원으로서의 역할을 할 수 있도록 도움을 줌으로서 장애인.노약자에 대한 사회문제를 해결하는 데 큰 역할을 하게 된다. 보행용 네트워크를 구성하기 위해 건설교통부에서 2005년 7월에 발간한 "지능형교통체계 표준 노드/링크 구축.운영지침 해설서"의 내용을 분석하였으며 이를 바탕으로 장애인.노약자들에게 적합한 네트워크체계를 구성하였다. 이동제약이 가장 큰 장애인.노약자를 대상으로 한 보행 네트워크이기 때문에 일반 사람들에게 적용될 수 있다. 이렇게 보행 네트워크를 구성함으로서 사회적 약자에 속하는 장애인.노약자들의 보행에 많은 도움을 줄 수 있을 뿐만 아니라 일반인들의 보행 편의성을 높이는 효과를 가져 올 수 있다. 장애인.노약자를 비롯한 사람들의 보행률을 높임으로서 에너지 절약, 교통사고율 감소 등 사회 전반적으로 긍정적인 효과를 가져 올 것으로 기대된다.

• Nuclear Engineering and Technology
• /
• 제40권1호
• /
• pp.21-36
• /
• 2008

High bum-up fuel technology has been developed through a national R&D program, which covers key technology areas such as claddings, $UO_2$ pellets, spacer grids, performance code, and fuel assembly tests. New cladding alloys were developed through alloy designs, tube fabrication, out-of-pile test and in-reactor test. The new Zr-Nb tubes are found to be much better in their corrosion resistance and creep strength than the Zircaloy-4 tube, owing to an optimized composition and heat treatment of the new Zr-Nb alloys. A new fabrication technology for large grain $UO_2$ pellets was developed using various uranium oxide seeds and a micro-doping of Al. The uranium oxide seeds, which were added to $UO_2$ powder, were prepared by oxidizing and heat-treating scrap $UO_2$ pellets. A $UO_2$ pellet containing tungsten channels was fabricated for a thermal conductivity enhancement. For the fuel performance analysis, new high burnup models were developed and implemented in a code. This code was verified by an international database and our own database. The developed spacer grid has two features of contoured contact spring and hybrid mixing vanes. Mechanical and hydraulic tests showed that the spacer grid is superior in its rodsupporting, wear resistance and CHF performance. Finally, fuel assembly test technology was also developed. Facilities for mechanical and thermal hydraulic tests were constructed and are now in operation. Several achievements are to be utilized soon by the Korea Nuclear Fuel and thereby contribute to the economy and safety of PWR fuel in Korea

• 대한임상독성학회지
• /
• 제6권2호
• /
• pp.134-137
• /
• 2008

Methylene blue is the first choice for treating methemoglobinemia, any increase in normal methemoglobin levels. Methemoglobin is an abnormal hemoglobin in which the iron has been oxidized to the ferric(+3) state, making it incapable of oxygen transport. Methemoglobinemia most commonly results from exposure to oxidizing chemicals, but may also arise form genetic, dietary, or even idiopathic etiologies. Patients with low methemoglobin levels are asymptomatic, but high methemoglobin levels can lead to headaches or even death. Methylene blue, the first-line treatment for methemoglobinemia, can also produce hemolytic anemia. Jaundice or dark urine during methylene blue treatment may indicate hemolytic anemia. A 47-year-old female patient with a history of depressive mood disorder developed significant methemoglobinemia after ingesting a Propanil overdose. Twenty-two hours after ingestion, methemoglobin levels in the blood were 73.2%. She was treated with intravenous methylene blue in the therapeutic range (1 mg/kg every 4 h for 3days). The 2nd day after methylene blue use, methemoglobin levels in the blood were 33%, and the 5th day decreased to 10% with better general condition. The patient had hyperbilirubinemia after hemolytic anemia, but she recovered completely.

• 대한한방내과학회지
• /
• 제40권3호
• /
• pp.343-355
• /
• 2019

Objectives: Traditional oriental medicine is used in treating breast cancer-related lymphedema to alleviate symptoms. Upper limb lymphedema is a symptom that is frequently observed in patients with breast cancer, and it impairs their quality of life. This systematic review aimed to summarize the current available evidence to evaluate the effect of traditional oriental medicine on upper limb lymphedema in breast cancer patients. Methods: The review evaluated randomized controlled trials (RCTs) measuring the effect of herbal medicine, acupuncture, and moxibustion on upper limb lymphedema in breast cancer patients within four electronic databases. The Cochrane risk of bias (ROB) tool was used to assess the quality of the RCTs. Results: In total, 23 RCTs met the inclusion criteria. Among them, 22 studies reported that the rate of severity of lymphedema improved after treatment in the traditional treatment group using herbal medicine, acupuncture, or moxibustion better than in the conventional medicine group. The methodological quality of the RCTs was insufficient with an unclear and high ROB. Conclusions: Traditional oriental medicine may have a potential to improve lymphedema in patients with breast cancer. To confirm the clinical recommendation, further research with a rigorous study design is required to support the effects of traditional oriental medicine.

• 대한한방내과학회지
• /
• 제40권1호
• /
• pp.70-88
• /
• 2019

Objective: This study investigated the trends in pancreatic cancer research on Korean medicine in order to establish a direction for further study. Methods: Pancreatic cancer research on Korean medicine was reviewed using databases such as OASIS, KoreanTK, KISS, RISS, KISTI, and NDSL. The search terms were "pancreatic cancer" "Korean medicine," and "herbal medicine." There was no restriction on publication dates, and the reviewed studies were analyzed according to the type of research. Results: Nineteen studies were reviewed. The numbers and types of research were as follows: 9 clinical studies including case reports, 2 review studies, and 8 in vitro studies; there was no in vivo study. Among the clinical research were 3 descriptive studies and 6 case reports. The baseline characteristics and quality of life of pancreatic cancer patients were analyzed in the descriptive studies. In the case reports, interventions such as herbal medicine, pharmacopuncture, and acupuncture were used. Research articles on the review of pancreatic cancer were titled "Preliminary Study for Development of Korean Medicine Clinical Practice Guideline for Pancreatic Cancer" and "Systemic Review on the Tumor Dormancy Therapy." Cell lines such as PANC-1, MIA PaCa-2, and AsPC-1 were used for in vitro studies. These studies have reported decreased cell viability, induced apoptosis, and changes in cancer-related gene expression. Conclusion: Through this review, we found that using Korean medicine for treating pancreatic cancer is applicable. However, due to overall limited the number of study, the benefit of Korean medicine for pancreatic cancer may be substantiated to a limited degree. Better methodological quality and large controlled trials are expected to further quantify the therapeutic effect of Korean medicine.

• Journal of Korean Neurosurgical Society
• /
• 제62권4호
• /
• pp.467-475
• /
• 2019

Objective : There is a lack of knowledge regarding whether decompression is necessary in treating patients with epidural spinal cord compression (ESCC) grade 2. The purpose of this study was to compare the outcomes of minimally invasive surgery (MIS) without decompression and conventional open surgery (palliative laminectomy) for patients with hepatocellular carcinoma (HCC) spinal metastasis of ESCC grade 2. Methods : Patients with HCC spinal metastasis requiring surgery were retrospectively reviewed. Patients with ESCC grade 2, medically intractable mechanical back pain, a Nurick grade better than 3, 3-6 months of life expectancy, Tomita score ${\geq}5$, and Spinal Instability Neoplastic Score ${\geq}7$ were included. Patients with neurological deficits, other systemic illnesses and less than 1 month of life expectancy were excluded. Thirty patients were included in the study, including 17 in the open surgery group (until 2008) and 13 in the MIS group (since 2009). Results : The MIS group had a significantly shorter operative time ($94.2{\pm}48.2minutes$ vs. $162.9{\pm}52.3minutes$, p=0.001), less blood loss ($140.0{\pm}182.9mL$ vs. $1534.4{\pm}1484.2mL$, p=0.002), and less post-operative intensive care unit transfer (one patient vs. eight patients, p=0.042) than the open surgery group. The visual analogue scale for back pain at 3 months post-operation was significantly improved in the MIS group than in the open surgery group ($3.0{\pm}1.2$ vs. $4.3{\pm}1.2$, p=0.042). The MIS group had longer ambulation time ($183{\pm}33days$ vs. $166{\pm}36days$) and survival time ($216{\pm}38days$ vs. $204{\pm}43days$) than the open surgery group without significant difference (p=0.814 and 0.959, respectively). Conclusion : MIS without decompression would be a good choice for patients with HCC spinal metastasis of ESCC grade 2, especially those with limited prognosis, mechanical instability and no neurologic deficit.

• Tuberculosis and Respiratory Diseases
• /
• 제82권2호
• /
• pp.158-165
• /
• 2019

Background: A recent study reported that mesenchymal stem cells possess potential cellular therapeutic properties for treating patients with chronic obstructive pulmonary disease, which is characterized by emphysema. We examined the potential therapeutic effect of Wharton's Jelly-derived mesenchymal stem cells (WJMSCs), following pretreatment with pioglitazone, in lung regeneration mouse emphysema models. Methods: We used two mouse emphysema models, an elastase-induced model and a cigarette smoke-induced model. We intravenously injected WJMSCs ($1{\times}10^4/mouse$) to mice, pretreated or not, with pioglitazone for 7 days. We measured the emphysema severity by mean linear intercepts (MLI) analysis using lung histology. Results: Pioglitazone pretreated WJMSCs (pioWJMSCs) were associated with greater lung regeneration than non-augmented WJMSCs in the two mouse emphysema models. In the elastase-induced emphysema model, the MLIs were $59.02{\pm}2.42{\mu}m$ (n=6), $72.80{\pm}2.87{\mu}m$ (n=6), for pioWJMSCs injected mice, and non-augmented WJMSCs injected mice, respectively (p<0.01). Both pioWJMSCs and non-augmented WJMSCs showed regenerative effects in the cigarette smoke emphysema model (MLIs were $41.25{\pm}0.98$ [n=6] for WJMSCs and $38.97{\pm}0.61{\mu}m$ [n=6] for pioWJMSCs) compared to smoking control mice ($51.65{\pm}1.36{\mu}m$, n=6). The mean improvement of MLI appeared numerically better in pioWJMSCs than in non-augmented WJMSCs injected mice, but the difference did not reach the level of statistical significance (p=0.071). Conclusion: PioWJMSCs may produce greater lung regeneration, compared to non-augmented WJMSCs, in a mouse emphysema model.