• 동의생리병리학회지
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• 제35권1호
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• pp.15-21
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• 2021

Donggwaja (Benincasae Semen), the seed of Benincasa hispida (Thunb.) Cogn., has been used in Korean traditional medicine to control the body heat and water retention caused by various diseases. Both the symptoms targeted by the herbal medicine in clinic and studies with disease mouse models support the potential anti-inflammatory effect of Donggwaja. However, it is less understood how Donggwaja exerts its possible anti-inflammatory effect. Here, we present evidence that Donggwaja suppresses macrophage inflammatory reactions via expressing tumor necrosis factor a-induced protein 3 (TNFAIP3 or A20) and suppressing NF-kB activity. The ethanol extract of Donggwaja (EED) showed no toxicity when added to RAW 264.7 cells less than 100mg/ml. When treating the cells for 16 h, EED significantly suppressed the nuclear localization of NF-kB, suggesting that EED suppresses NF-kB activity. Concordantly, a semi-quantitative RT-PCR analysis showed that EED decreased the expression of prototypic pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-a, IL(interleukin)-6, and IL-1b. EED induced in RAW 264.7 cells the expression of A20, a ubiquitin modulator that suppresses inflammatory signaling cascades initiated from TLR4 and TNF and IL-1 receptors, while not affecting the induction of Nrf2, an anti-inflammatory factor that could suppress the effect of NF-kB. These results suggest that EED exerts its suppressive effect on inflammation, at least in part, by expressing anti-inflammatory factor A20 and suppressing pro-inflammatory factor NF-kB activity.

• 대한본초학회지
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• 제25권4호
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• pp.161-169
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• 2010

Objectives & Methods : To compare the medicinal herbs between Ayurvedic medicine and traditional Korean medicine(TKM), we took reference of major publications related to Ayurvedic medicinal herbs such as Indian Herbal Remedies, Prime Ayurvedic Plant Drugs, with those of TKM. We selected most widely used 130 herbal species of Ayurvedic medicine and compared the similarities and differences with TKM. Comparative factors were the origin, habitation, synonyms, usage, medicinal parts, and precautions. Results : 1. The medicinal herbs Resinatum Lignum(沈香), Arecae Pericarpium(大腹皮), Arecae Semen(檳榔), Carthami Flos (紅花), Camphorum(樟腦), Crotonis Semen(巴豆), Curculiginis Rhizoma(仙茅) used in TKM did exactly correlate in their origins with those of Ayurvedic medicine. 2. Varieties of allied species were found in their origins. Benincasae Pericarpium(冬瓜皮), and Benincasae Semen(冬瓜子) derive from the same plant Benincasa hispida Cogn. for both Ayurvedic medicine and TKM. Interestingly, B. cerifera Savi. is also claimed for same uses in Ayurvedic medicine. This broadened use of allied species is found in various Ayurvedic herbal medicine such as Cannabis Semen(火麻仁) using Cannabis indica Lam., and Curcuma Longae Rhizoma(薑黃) using Curcuma domestica Valeton. This suggests the possibility of their usage also in TKM. 3. Myrrha(沒藥), and Curculiginis Rhizoma concorded their usage with TKM. While Arecae Pericarpium(大腹皮), Arecae Semen(檳榔), Aquilariae Resinatum Lignum(沈香), Pericarpium(冬瓜皮), Benincasae Semen(冬瓜子), Cannabis Semen(火麻仁), Carthami Flos(紅花), Camphorum(樟腦), Crotonis Semen(巴豆), Curcumae Radix(鬱金), Curcuma Longae Rhizoma(薑黃) and Zedoariae Rhizoma(莪朮) revealed varied efficacies according to their part used or usage forms. Conclusion : Both Ayurvedic medicine and TKM reflect the traditional medicine of its regions where is founded. Mutual understanding improves the capability of coping of diverse ailments of present days and also replacing some plants in the days of increasing threat to our environment. Abundant external applications of various plants found in Ayurvedic medicine were particularly useful for TKM to complement its strength in herbal intake.

• 한국식품과학회지
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• 제29권4호
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• pp.671-679
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• 1997

국내에서 재배, 유통되고 있는 약초 일반성분 및 무기질 함량을 분석하였다. 건물기준으로 조회분은 오가피, 쇠비름, 사상자가 각각 22.4, 20.6, 15.0%로 다량 함유하고 있었고, 조단백은 산조인, 택사, 정력자, 결명자가 각각 39.9, 30.6, 28.8, 27.5%로 다량 함유하고 있었다. 조지방은 산조인, 창이자, 소자, 동과자 순으로 각각 27.9, 24.0, 22.8, 22.4%, 조섬유는 만형자, 영지, 송절, 접골목 순으로 각각 59.5, 53.9, 46.4, 41.2% 그리고 가용성 무질소물은 복령, 천마, 초용담, 지황이 각각 91.2, 87.9, 86.3, 86.0%로 다량 함유하고 있는 것으로 분석되었다. 인은 상기생, 동규자, 연자육이 각각 100 g당 1,485.9, 1,149.5, 985.0 mg로 다량 함유한 것으로 분석되었고, 마그네슘은 삼백초, 단삼, 칡이 각각 728.0, 582.0, 464.9 mg로 다량 함유하였다. 칼슘은 승마, 오가피, 건칠이 각각 8,506.6, 7,106.5, 3,010.2 mg로 측정되었으며, 칼륨은 송이, 어성초, 우슬이 각각 5,613.5, 5,353.5, 4,665.7 mg였다. 또한 나트륨의 경우 육종용, 두충, 매실이 각각 2,064.5, 595.3, 291.4 mg, 철은 대계근, 초용담, 속단이 각각 307.4, 233.0, 207.6 mg로 나타났다.

• 수산해양교육연구
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• 제28권6호
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• pp.1715-1723
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• 2016

복합 생약재 열수추출물(6종 혼합)을 농도별 기간별로 사료에 흡습시켜 12주 동안 넙치에 급여 후 비특이적 면역 및 질병저항성에 대한 효과를 조사하였다. 복합 생약재 열수추출물의 첨가는 어류 성장에는 아무런 영향을 미치지 않았으며 혈액생화학적인, 결과도 넙치의 생리에는 아무런 영향을 미치지 않았다. 라이소자임 활성은 0.01%의 복합 생약재 열수추출물 농도로 흡습시킨 사료 그룹에서 라이소자임 활성이 증가됨을 알 수 있었다. 복합 생약재 열수추출물의 투여에 따른 넙치 장기의 병리조직에 영향이 없음을 알 수 있었다. 에드와드균의 인위감염에 의한 질병저항성은 0.01% 복합 생약재 열수추출물 농도에서 상대생존율이 높게 나타났다. 이상의 결과를 종합하여 볼 때 넙치에 복합 생약재 열수추출물을 투여시에는 어류의 비특이적 면역력 증강 및 질병 저항성 증강을 나타내는 것으로 사료되었다.