• Journal of Yeungnam Medical Science
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• 제34권2호
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• pp.298-302
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• 2017

Glandular papilloma of the lung is one of three histologic types of solitary endobronchial papillomas. It is known as an uncommon benign neoplasm. No malignant glandular papillomas have been reported. Herein, the first case of granular papilloma with malignant transformation is reported. A 74-year-old man with huge right lung mass extended upper and lower lobe was admitted to the hospital complaining of progressive cough and dyspnea. An open lung biopsy was performed. Microscopically, the tumor showed papillary growth pattern with thick fibrovascular cores. The stroma of the fibrovascular cores shown the infiltration of lymphoplasmacytic cells and proliferation of capillaries. The epithelial cells surrounding the papillary fronds were cilliated columnar cells with focal cellar atypia, and frequent mitoses. Suspicious pleural invasion foci were identified. The Ki-67 labeling index was about 24.3% and p53 labeling index was about 31.7%. Glandular papilloma is known as a benign neoplasm, which is lack of atypia and mitosis. In present case, there were several indications of malignant transformation, such as cellular atypia, frequent mitosis, architectural distortion, and pleural invasion. Pathologists must be aware that glandular papilloma can have a changes of malignant transformation. Further studies about disease behavior and molecular characteristics are needed.

• Journal of Chest Surgery
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• 제30권4호
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• pp.467-470
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• 1997

동면선종(hibernoma)은 갈색지방조직에서 발생한 양성종양이다. 겨울잠을 자는 동물의 갈색지방조직이 총선과 유사한 내분비기관으로 간주되어 동면선종으로 알려졌었고 이러한 갈색지방은 동면하지 않는 동물에서도 발견되며 사람에서도 태아와 신생아기에 주로 존재하다가 점 차 황색지방으로 대치되는데 그 기능은 확실하지 않다. 1914년 Gery에 의해 명명된 동면선종은 3∼19cm정도의 크기로 아직까지 악성전환은 보고되지 않았고 피막형성이 잘되어 전적출술로서 완치가 가능하지만 수술시 남겨진 조직에서 재발된 경우는 보고되어 있다. 종양의 호발부위는 견갑간부,목뒤쪽,종격동,후복벽 등이며 흉곽내 발생은 7례에 불과하다. 조직학적 소견은 과립상 호산구성 세포질을 가지면서 여러개의 공포를 가진 세포들이 혼재해 있는 것이 특징으로 되어있다. 저자들은 좌측 후하부 흉벽과 복벽에 걸쳐 있는 동면선종을 경험하여 보고 하는 바이다.

• 대한세포병리학회지
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• 제7권2호
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• pp.111-121
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• 1996

Fine needle aspiration cytology(FNAC) is preferred because of simplicity, safety, and reliability in the evaluation of patients with thyroid nodule or hyperplasia. However, there are a few limitations such as false-negative or false-positive cases and non-diagnostic material. To evaluate the usefulness of FNAC in thyroid lesions, we reviewed 704 FNAC cases of thyroid nodules from 1988 to 1994 at Soonchunhyang University Hospital. The results are as follows. 1. Among 704 FNAC cases of thyroid gland, 571(81.1%) cases were benign, 12(1.7%) were suspicious, 71(10.1%) were malignancy, and 50(7.1%) were material insufficiency. The cytologic diagnoses of the benign lesions included 168 cases of follicular neoplasm, 139 cases of adenomatous goiter, 162 cases of follicular lesion such as follicular neoplasm or adenomatous goiter, 61 cases of Hashimoto's thyroiditis, 13 cases of subacute thyroiditis, and 28 cases of colloidal nodule or benign nodule. The malignant lesions included 68 cases of papillary carcinona, two medullary carcinomas and a case of metastatic colon cancer. 2. The average number of cytologic smear slides was $4.12{\pm}1.81$ in material insufficiency and $5.63{\pm}1.79$ in diagnostic cases. This difference was statistically significant(p<0.00001). 3. Histological assessment of 150 cases revealed 2 false negative and 1 false positive cases. The false negative cases were a case of marked sclerosis in papillary carcinoma and an occult case of papillary carcinoma. The false positive case resulted from pseudo-ground glass nuclei due to marked dry artifact. 4. Comparison between the FNAC and the histologic diagnosis revealed that FNAC had a sensitivity of 93.5%, a specificity of 99.2%, a false negative rate of 6.6%, a false positive rate of 0.8%, and an overall diagnostic accuracy of 98.0%. Therefore, FNAC of thyroid gland is a very reliable diagnostic method with excellent accuracy rate.

• 대한세포병리학회지
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• 제15권1호
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• pp.60-64
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• 2004

The macrofollicular variant of papillary thyroid carcinoma (MVPC) is characterized by macrofollicles occupying more than half of the tumor and demonstrating nuclear features of classic papillary carcinoma. It is difficult to recognize on fine needle aspiration (FNA) cytology due to the paucity of aspirated neoplastic cell clusters, especially when the tumor is associated with extensive areas of hemorrhage. Case: A 34-year-old female presented with a well-demarcated nodule in the thyroid gland, diagnosed as a benign nodule on ultrasonography and computed tomography. FNA cytology smear revealed a few small aggregates of follicular cells with morphological features suspicious for papillary carcinoma, set in a background of hemorrhage, inflammatory cells, and hemosiderin-laden macrophages. Intraoperative frozen section revealed macrofollicular nests filled with hemorrhage and composed of follicular cells demonstrating nuclear clearing and grooves. Conclusion: MVPC is a rare but distinctive variant of papillary carcinoma, which is easily mistaken for adenomatous goiter or benign macrofollicular neoplasm on radiologic findings. The cytopathologist should alert oneself on encountering benign radiologic findings and any smear composed of scant numbers of follicular cells with nuclear features suspicious for papillary carcinoma despite the bland-looking background of hemorrhage and hemosiderin-laden macrophages, and recommend intraoperative frozen sections for a definite diagnosis.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2171-2174
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• 2012

Background: Pancreatic cancer is a distressing disease with a miserable prospects and early recognition remains a challenge due to ubiquitous symptomatic presentation, deep anatomical location, and aggressive etiology. False positives and problems in distinguishing pancreatitis from adenocarcinoma limit the use of CA 19-9 as both disorders can present with similar symptoms and share radiographic physiognomies. This study aimed to assess the relative increase in accuracy of diagnosing the patients with chronic pancreatitis, benign neoplasm of pancreas and adenocarcinomas with CA 19-9, haptoglobin, and serum amyloid A in comparison to CA 19-9 alone. Materials and Methods: This hospital based case control study was carried out in the Departments of Medicine and Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal, between $1^{st}$ January 2010 and $31^{st}$ December 2011. The variables assessed were age, gender, serum CA19-9, serum haptoglobulin, serum Amyloid A. The data were analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results: Out of 197 cases of pancreatic disease, maximum number of assumed cases were of adenocarcinoma of pancreas (95). Number of males (59) were more than females (36) in assumed cases of adenocarcinoma of pancreas. The mean values of CA19-9 raised considerably in cases of chronic pancreatitis, benign neoplasm and adenocarcinoma of pancreas when compared to controls. The highest augmention in CA19-9 values were in cases of adenocarcinoma of pancreas. The p-value indicates that in cases of chronic pancreatitis, there was not significant increase in precision of diagnosis. Conclusions: These statistics established that haptoglobin and SAA are useful in discriminating cancer from benign conditions as well as healthy controls.

• Journal of Chest Surgery
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• 제41권6호
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• pp.777-781
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• 2008

양성 전이성 평활근종은 조직학적으로 양성 종양의 소견을 보이나 임상적으로 폐나 다른 장기로 전이하는 매우 드문 질환이다. 저자들은 2개월간 지속된 기침을 주소로 입윈한 53세의 여자환자에서 좌우 다발성으로 퍼져 있는 폐결절들을 가진 전이성 평활근종 1예를 경험하였다. 증례는 과거력상 13년전 자궁근종으로 전자궁적출술을 받았으며, 자궁근종은 병리조직 검사상 평활근종으로 진단되었었다. 환자는 전이성 폐암 의심 하에 흉강경 폐 조직검사를 실시하였다. 폐 결절들은 낮은 세포 분열을 보이는 양성 종양의 소견을 보이며, 평활근 세포의 다발성 결절들로 이루어져 병리학적으로 양성 전이성 평활근종과 일치하는 소견을 보였다. 환자는 현재 별다른 치료 없이 추적 관찰 중이다.

• Journal of Chest Surgery
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• 제30권3호
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• pp.353-353
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• 1997

흉막에 발생하는국소성 섬유성 종양은 드문 질환으로 대부분의 경우 단순흉부촬영상 우연히 발견되며 특징적 인 임상상 및 조직병 리학적 소견을 보인다. 본 논문에서는 증상없는 저혈당을 동반한 악성 국소성 섬유성 종양 1례 및 양성 국소성 섬유성 종양 2례를 보고하고자 한다. 악성의 예에서는 개흉술을 통해 종양을 절제해 내었고 수술직후 저혈당의 소실을 관찰할 수 있었으며 양성 2예에서는 비디고 흉강경을 이용하여 종양을 절제할 수 있었다.

• Journal of Chest Surgery
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• 제30권3호
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• pp.253.2-356
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• 1997

흉막에 발생하는국소성 섬유성 종양은 드문 질환으로 대부분의 경우 단순흉부촬영상 우연히 발견되며 특징적 인 임상상 및 조직병 리학적 소견을 보인다. 본 논문에서는 증상없는 저혈당을 동반한 악성 국소성 섬유성 종양 1례 및 양성 국소성 섬유성 종양 2례를 보고하고자 한다. 악성의 예에서는 개흉술을 통해 종양을 절제해 내었고 수술직후 저혈당의 소실을 관찰할 수 있었으며 양성 2예에서는 비디고 흉강경을 이용하여 종양을 절제할 수 있었다.

• 대한두개안면성형외과학회지
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• 제17권3호
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• pp.176-179
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• 2016

Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. The lesion was considered to be benign, and the initial treatment was simple excision with a 3-mm margin. However, histologic examination revealed the diagnosis of PCMC, and the patient underwent re-excision of the tumor site with an additional 3-mm margin from the initial scar. Histologic study of this second margin was free of any malignant cells. The patient experienced no postoperative complication or recurrence after 2 years. In our case, the skin lesion had benign morphologic findings and was strongly suspected to be a benign mass. Physicians should be aware of this tumor and be able to differentiate it from benign cystic or solid eyelid lesions.

• Korean Journal of Radiology
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• 제24권1호
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• pp.62-78
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• 2023

As the majority of incidentally detected lesions in the anterior mediastinum is small nodules with soft tissue appearance, the differential diagnosis has typically included thymic neoplasm and prevascular lymph node, with benign cyst. Overestimation or misinterpretation of these lesions can lead to unnecessary surgery for ultimately benign conditions. Diagnosing mediastinal cysts using MRI serves as a problem-solving modality in distinguishing between surgical and nonsurgical anterior mediastinal lesions. The pitfalls of MRI evaluation for anterior mediastinal cystic lesions are as follows: first, we acknowledge the limitation of T2-weighted images for evaluating benign cystic lesions. Due to variable contents within benign cystic lesions, such as hemorrhage, T2 signal intensity may be variable. Second, owing to extensive necrosis and cystic changes, the T2 shine-through effect may be seen on diffusion-weighted images (DWI), and small solid portions might be missed on enhanced images. Therefore, both enhancement and DWI with apparent diffusion coefficient values should be considered. An algorithm will be suggested for the diagnostic evaluation of anterior mediastinal cystic lesions, and finally, a management strategy based on MRI features will be suggested.