• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.323-333
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• 2016

Background: Ovarian cancer remains a major worldwide health care issue due to the lack of satisfactory diagnostic methods for early detection of the disease. Prior studies on the role of serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in detecting ovarian cancer presented conflicting results. New tools to improve the accuracy of identifying malignancy are urgently needed. We here aimed to evaluate the diagnostic utility of tissue CA125 and HE4 gene expression in comparison to serum CA125 and HE4 in discriminating benign from malignant pelvic masses. Materials and Methods: One-hundred Egyptian women were enrolled in this study, including 60 epithelial ovarian cancer (EOC) patients and 20 benign ovarian tumor patients, as well as 20 apparently healthy women. Preoperative serum levels of CA125 and HE4 were measured by immunoassays. Tissue expression levels of genes encoding CA125 and HE4 were determined by quantitative real time polymerase chain reaction (qRT-PCR). The diagnostic performance of CA125 and HE4, measured either as mRNA or protein levels, was evaluated by receiver operating characteristic (ROC) curves. Results: The serum CA125+HE4 combination and serum HE4, with area under the curve (AUC) values of 0.935 and 0.932, respectively, performed significantly better than serum CA125 (AUC=0.592; P<0.001). Tissue CA125 and HE4 (AUC=1) performed significantly better than serum CA125 (P<0.001), serum HE4 (P=0.016) and the serum CA125+HE4 combination (P=0.018). Conclusions: Measurement of tissue CA125 and HE4 gene expression not only improves discriminatory performance, but also broadens the range of differential diagnostic possibilities in distinguishing EOC from benign ovarian tumors.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5811-5814
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• 2014

Background: To investigate abnormal cervical histopathology (ACH) from hysterectomy specimens with normal preoperative Papanicolaou (Pap) smears. Materials and Methods: Medical records from May 2009 to April 2012 were retrospectively reviewed of subjects from whom hysterectomy specimens were taken in Thammasat University Hospital. All had normal preoperative Pap smears. ACH was the primary outcome. A p-value less than 0.05 was considered significant. A total of 483 subjects with an average age of 50.5 years were recruited. Benign cases of enlarged uterus and pelvic mass were present in 94% (430/483). Endometrial and ovarian cancer were found at 6.2 and 4.7%, respectively. In hysterectomy specimens there were 19 (4%) cases of ACH. Silent ACH with benign disease, endometrial and ovarian cancers were 1.2% (5/430), 33.3% (10/30) and 17.4% (4/23), respectively. The negative predictive value (NPV) and false negative rate of Pap smears were 96 and 4%, respectively. ACH in malignant cases were 27.9% (12/43) and 20% (2/10) in adequate (APS) and inadequate (IPS) Pap collection groups, respectively. ACH in benign condition were 0.68% (2/292) and 2.2% (3/138) in APS and IPS, respectively. ACH was more often found in hysterectomy specimens with indication of malignancy than benign conditions with statistical significance. One third of preoperative stage I endometrial cancer cases had cervical involvement. Conclusions: Silent ACH in normal preoperative Pap smear was 4 %. Inadequate Pap smear collection is still the major problem in this study. Reducing inadequate Pap smear collection could reduce the false negative rate.

• 대한후두음성언어의학회지
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• 제26권1호
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• pp.34-39
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• 2015

후두 미세 수술을 받은 환자에서 수술 전과 후 전체적인 음성 장애 지수를 비교했을 때 모두 호전이 있는 것으로 나타났다. 영역별로는 기능적, 물리적 영역에서는 남녀간의 차이가 없었으나 감성적 영역에서는 여자보다 남자에서 수술 후 만족도가 큰 것으로 나타났다. 이번 연구를 통해 음성 장애 지수가 음성의 상태를 모두 대변할 수는 없지만 객관적인 음향, 공기역학적 검사로 평가할 수 없었던 음성 장애에 대한 환자의 인식 정도를 정량화하여 평가할 수 있는 편리한 도구임을 확인 할 수 있었다.

• 대한한의학회지
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• 제19권2호
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• pp.211-227
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• 1998

Benign Prostatic Hyperplasia(BPH) is the most common benign tumor seen in the western male, and it is found in 50% of men over 50 years of age. It is characterized by the formation of large discrete lesions in the periurethral region. As they enlarge, these nodules tend to compress the urethra and cause partial or almost complete obstruction of .urine flow. The etiology of BPH is uncertain, but the increasing incidence with advancing age suggests the possibility of an imbalance between male and female sex hormones. In the past, most patients have had multiple indications to support the decision to initiate therapy. But both the urologic surgeon and the patient must be clearly aware of the results that can be expected and the risks involved in achieving them. The aims of this study are to investigate and summarize the current trends of treatment for BPH so as to suggest the effective and available way to treat the disease. In Oriental medicine, the BPH is recognized as uroschesis and ischuria, and the etiology is mainly in stagnated blood and insufficiency of the kidneys. The point of treatment of BPH is recovery of urination, and the treatment can be approached in two ways through herb drugs and acupuncture. Some of the herb drugs have substances which reduce BPB. Acupuncture therapy stimulates the pelvic plexus and is reported to be effective for voiding. Suppository, massotherapy, rectal injection, locus injection and attachment of herb drugs to the navel or the acupoint are announced as the effective treatments. So, this study of the approach and application of these treatments on BPH would be necessary.

• Tuberculosis and Respiratory Diseases
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• 제58권6호
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• pp.614-618
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• 2005

저자들은 자궁근종으로 자궁적출술을 시행받은 과거력이 있는 35세 여자환자가 우연히 발견된 폐의 다발성 결절을 주소로 내원한 후, 폐 생검을 통하여 양성 전이성 폐 평활근종을 진단받고, 이후 개흉술을 통한 전 결절 제거술을 성공적으로 시행 받은 드문 1예를 경험하였고, 이는 국내에서는 처음 시도된 바이기에 문헌고찰과 함께 보고하는 바이다.

• 대한영상의학회지
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• 제81권5호
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• pp.1109-1120
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• 2020

흉막의 종괴는 다양한 양성과 악성 종양이 있고 종양은 아니지만 종양 같은 질환들에 의해 발생한다. 일차 흉막 종양에는 고립섬유종양, 악성중피종, 그리고 원발성 흉막 비호지킨 림프종이 있다. 흉막에 발생하는 가장 흔한 종양은 전이성 질환이며, 림프종, 백혈병, 다발성 골수종 등의 혈액 종양을 가진 환자에서 드물게 나타난다. 흉수는 주로 흉막의 악성 질환과 연관이 있다. 드물지만 흉막 종양이 만성 농흉에서 생길 수 있으며, 그중 가장 흔한 것은 비호지킨 림프종이다(농흉과 연관된 림프종). 종양이 아닌 흉막 종괴로는 다양한 양성 질환에서 보일 수 있으며, 여기에는 결핵, 석면 흉막판, 그리고 흉막 유리체가 포함된다. 이 임상화보에서 저자들은 흉막의 다양한 양성과 악성 종양 및 종양성 질환들에 대한 특징적인 전산화단층촬영 소견에 대해 알아보고자 한다.

• Journal of Chest Surgery
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• 제37권3호
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• pp.228-234
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• 2004

원발성 심종양은 비특이적 증상을 호소하고 매우 드물게 발생하는 질환이다. 악성 종양과 양성 종양으로 구분되며 외과적 절제술과 부가적인 치료를 필요로 한다. 1995년 3월부터 2003년 3월까지 원발성 심종양으로 진단받은 21예의 환자들을 대상으로 하였다. 이 환자들을 대상으로 수술 전후의 여러 가지 인자들과 수술 후 조기 및 만기 성적에 대한 후향적 연구를 진행하였다. 6예는 남자, 15예는 여자였으며 그들의 평균 연령은 45.44$\pm$18.76세였다. 병리학적 검사 결과 21예 중에서 18예는 양성(14예의 점액종, 2예의 섬유탄력종, 1예의 혈관종, 1예의 부신경절종), 3예는 악성(1예의 혈관 육종, 1예의 중피종, 1예 점액섬유육종)종양이었다. 1예의 수술 사망이 관찰되었고, 혈관종, 중피종과 혈관육종의 경우 근치적인 수술이 불가능한 상태에서 술 후 부가적인 치료와 외래 추적 중에 사망하였다. 원발성 심종양의 치료에 있어서 수술적 치료가 중요하며 경우에 따라서 부가적인 치료도 중요하지만 악성의 결과 예후는 불량하다.

• 대한두경부종양학회지
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• 제31권1호
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• pp.34-38
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• 2015

Progressive transformation of germinal centers(PTGC) is a rare benign lymph node enlargement characterized by chronic lymphadenopathy and the presence of germinal centers with fused and expanded mantles within a lymph node that are 3-5 times the size of a typical reactive follicle. Although PTGC is reported in 3.5-10% of chronic lymphadenopathy, head and neck surgeons do not often experience this condition and its clinical implications. Althoug PTGC is benign disease, it could not be excluded the association with other malignant lymphoid diseases. Therefore, periodic follow up of PTGC patient could be required. We report two cases at this study ; a 16 years old man who visited out-patient clinic due to palpable mass of right cervical area, several months ago, and a 35 years old man who visited out-patient clinic for evaluating right cervical mass. Both of two patients were diagnosed with PTGC. In this study, we focus on the clinic-pathologic features of this uncommon disease along with other literature reviews.

• Journal of Chest Surgery
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• 제39권5호
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• pp.419-422
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• 2006

양성 대칭성 지방종증은 주로 음주를 하는 중년 남성에게 드물게 발생하며 아직 발생기전은 명확하게 알려져 있지 않은 질환이다. 63세 남자가 내원 2개월 전부터 갑작스럽게 증가하는 양쪽 어깨의 종 물을 주소로 내원하였다. 미용적인 문제 이외에 특별한 증상은 없었고, 혈액검사에서도 이상소견은 발견되지 않았으며 방사선학적 검사에서 과도한 지방의 축적이 관찰되었다. 조직검사에서 지방종으로 진단되었고 임상적으로 양성 대칭성 지방종증으로 진단되었다. 특별한 증상의 호소 없이 현재 외래 추적 관찰 중이다.

• Journal of Chest Surgery
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• 제13권2호
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• pp.149-153
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• 1980

Von Recklinghausen's disease is a systemic hereditary disorder with varied manifestations in bone, soft tissue, nervous system, and skin, the most common of which is the developement of multiple, small, cutaneous tumors with a characteristic histologic picture. Tumors develop after birth and before puberty in most cases, and they increase in number until old age. Malignant neoplasms that complicate multiple neurofibromatosis include gliomas of the optic nerve, astrocytomaas of the cerebral and cerebellar hemispheres, and sarcomas of peripheral nerves (femoral, tibial and intercostal nerves) and somatic soft tissues. Little attention has been paid to the presence of cystic lung disease in association with neurofibromatosis. Currently, most think of thoracic involvement in neurofibromatosis in terms of posterior mediastinal neuroma, pheochrocytoma, meningocele or, less commonly parenchymal pulmonary neurofibromas. Author have experienced 2 cases of Von Recklinghausen's disease. One case developed a hyge malignant Schwannoma in the parietal pleura of left 4th intercostal space and multiple benign neurofibromas (two in intercostal spacees and one in the neck) , and the other has several episodes of pneumothorax resulting from diffuse cystic lung disease which required closed thoracotomy drainage.