• 대한약침학회지
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• 제23권1호
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• pp.30-36
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• 2020

Objectives: The objective of the study was to prepare Bauhinia variegata loaded nanoemulsion(formulation and determine the efficacy of herbal drug formulation against diabetic peripheral neuropathic pain through acupuncture technique. Methods: Nine different ba tches of nanoemulsion (NE1 NE9) of BVN was prepared by varying the S_mix ratio and the concentration of oil. BVN was characterized to determine particle size, shape, zeta potential, polydispersity index, optical transmittance, drug release profile and stora ge stability. The optimized formulation was subjected to plantar test, behavioral tests of neuropathic pain and Von Frey filament stimulation test. Diabetes was induced by intraperitoneal injection of freshly prepared solution of Streptozotocin (60 mg/kg) to the experimental rats. Animals were made diabetic divided into four groups, Group I was untreated normal control group, Group II was diabetic control group, Group III was Bauhinia variegata extract ( treated group (100 mg/kg/day, p.o) and Group IV was BVN treated groups (100 mg/kg/day, p.o) acute and chronically. Results: The prepared B. variegata loaded nanoemulsion was nanosized (124 nm), spherical, uniform and stable over the period of 180 days with no change in physiochemical properties. The bl ood glucose and body weight of animals was normalizing after four weeks of treatment that was significant with BVN in comparison to diabetic control group. The chronic administration of BVN significantly (P<0.001) decreased hind paw withdrawal latency an d attenuated mechanical allodynia as compared with diabetic rats. Conclusion: Thus, BVN may be an effective drug formulation against diabetic peripheral neuropathic pain.

• 대한지역사회영양학회지
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• 제17권4호
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• pp.390-406
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• 2012

Childhood obesity has rapidly increased worldwide and is one of the most serious health problems in this age group. In order to prevent and manage childhood obesity, we developed a nutrition education website. The website consisted of three parts. The first part was made for self-assessment with regard to obesity index, dietary habits, food frequency, dietary attitude, nutrition knowledge, nutrient intake, energy expenditure, and the stage of behavioral change, and tailored messages and advice according to the assessment results. A total of 612 real-size food photos as well as a nutrient database of 3,346 foods and 541 dishes were created to help children estimate nutrient intakes accurately. In addition, an energy expenditure database of 156 activities for children was established to calculate calorie consumption. The second part was made for setting long-term and short-term goals and keeping track of the changes in energy intake and expenditure in one's own page. The third part was made for education. Various types of nutrition information were provided; texts, pictures, calculators and games. The readability and design of the website were evaluated by 46 obese children. Usefulness, design and readability of the website were found to be desirable for children. This website is expected to be used by an obese child alone or with parents or nutrition teachers in order to control body weight through healthy dietary habits and physical activities. In addition, a non-obese child can also use this website for maintaining healthy dietary habits and preventing obesity.

• 한국인구학
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• 제26권2호
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• pp.91-110
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• 2003

고위험 음주는 개인 건강 뿐 아니라 사회에 막대한 부담을 초래한다. 본 연구는 보건복지부와 서울대학교외 건강위험요인 전국조사 자료에 중도 절단 이변량 프로빗 모형(bivariate probit model with censoring)을 활용하여 한국 사회에서 15세 이상 인구계층의 고위험 음주에 미치는 요인을 규명하였다. 연구결과에 따르면 우리나라에서 소주가 음주 주종 중 고위험 음주와 가장 관련성이 큰 주종임이 밝혀졌다. 그동안 소주의 문제점에 관해서는 대부분 인식하고 있었으나 전국 조사 자료 및 최신 통계분석방법을 적용한 연구가 전무하여 실증적인 뒷받침이 되지 않았던 사실이 밝혀진 셈이다. 또한 나이가 많은 계층, 배우자와 동거하지 않는 계층, 경제활동에 종사하는 계층, 스트레스에 취약한 계층, 다양한 주종을 소비하는 계층이 각각 상대적으로 그렇지 않는 계층에 비해 고위험 음주를 할 가능성이 높았다. 본 연구결과로써 한국 사회에서 음주로 인한 위해를 감소시키기 위해서는 주종별로 차별화된 정책과 함께 고위험 음주 가능성이 상대적으로 높은 인구계층을 대상으로 정부 및 민간 노력이 집중되어야 한다는 정책적 시사점을 도출할 수 있었다.

• 콘크리트학회논문집
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• 제23권1호
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• pp.67-75
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• 2011

이 연구에서는 UHPCC에서 강섬유 혼입률이 압축거동에 미치는 영향에 관한 연구를 수행하였으며, 그 결과로부터 UHPCC에 적용가능한 압축거동 모델을 제시하고자 하였다. 섬유혼입률 0~5 vol.%에 대해 실험을 수행한 결과, 섬유혼입률이 증가함에 따라 압축강도 및 그 때의 극한변형률 및 탄성계수가 증가하는 경향을 확인할 수 있었다. 이와 같은 결과는 100 MPa 이하의 강섬유보강 콘크리트에 대한 기존 연구 결과들과 비교했을 때, 압축강도는 섬유보강효과가 거의 동일한 경향을 나타내는 반면, 극한변형률과 탄성계수에 대한 섬유보강효과는 상대적으로 훨씬 적게 나타났다. 섬유혼입률이 증가함에 따른 UHPCC의 압축강도, 극한변형률 및 탄성계수의 변화를 섬유보강지수(RI)를 이용한 선형관계식으로 표현하였다. UHPCC의 압축거동에 대한 섬유보강효과는 거동의 형상에 전혀 영향을 미치지 않으며, 다만 압축강도와 그 때의 극한변형률 및 탄성계수에 영향을 미치는 점을 고려하여 UHPCC의 압축응력-변형률 관계를 제시하였다.

• 대한간호학회지
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• 제46권1호
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• pp.140-148
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• 2016

Purpose: This study was performed to determine the physical and psychological effects of an urban forest-walking program for office workers. For many workers, sedentary lifestyles can lead to low levels of physical activity causing various health problems despite an increased interest in health promotion. Methods: Fifty four office workers participated in this study. They were assigned to two groups (experimental group and control group) in random order and the experimental group performed 5 weeks of walking exercise based on Information-Motivation-Behavioral skills Model. The data were collected from October to November 2014. SPSS 21.0 was used for the statistical analysis. Results: The results showed that the urban forest walking program had positive effects on the physical activity level (U=65.00, p <.001), health promotion behavior (t= - 2.20, p =.033), and quality of life (t= - 2.42, p =.020). However, there were no statistical differences in depression, waist size, body mass index, blood pressure, or bone density between the groups. Conclusion: The current findings of the study suggest the forest-walking program may have positive effects on improving physical activity, health promotion behavior, and quality of life. The program can be used as an effective and efficient strategy for physical and psychological health promotion for office workers.

• 대한간호학회지
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• 제38권6호
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• pp.866-873
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• 2008

Purpose: The study was done to compare quality of life by gender, and to identify factors which explain quality of life in individuals with coronary artery disease. Methods: For the survey, 91 individuals (53 men and 38 women) agreed to participate in the study. Cardiovascular risk factors, systolic blood pressure, body mass index, total cholesterol, triglyceride, high density lipoprotein-cholesterol, and low density lipoprotein-cholesterol, health behavior as well as quality of life, were measured. Descriptive statistics, t-test, correlation and hierarchical multiple regression with SPSS WIN 12.0 were used to analyze the data. Results: Significant gender differences were found for education, smoking status, chronic disease, perceived health status, and quality of life within sub-dimensions. Hierarchical regression analysis showed gender (men), age, perceived health status, cardiovascular risk scores, and health behaviors together explained 40.2% (adjusted $R^2$) of variance in quality of life. Conclusion: As the factors explaining quality of me in individuals with coronary artery disease have been identified as gender (men), age, perceived health status, and health behaviors, health promotion programs designed for this population should focus on these factors for effective behavioral modification, and consequent improvement in quality of life.

• 아동학회지
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• 제34권3호
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• pp.1-19
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• 2013

The purpose of this study was to investigate the relationship between parents' behavior during picture-book reading and home literacy environment and their effects on toddlers' vocabulary. The subjects of the study were 46 toddlers and their parents. The MCDI-K(Im, 2002), Lee and Kim(2004)'s categories of Verbal Behaviors, the categories of Nonverbal Behavioral Analysis(Kim, 2005), and the Home Literacy Environment Index(Han, 2006) were used. The analysis of the collected data was guided by the research questions and involved the use of descriptive statistics, t-test and an analysis of relevant correlations. The results of this study were as follows; First, the toddlers' receptive vocabulary score was 1.2 times higher than the toddler's expressive vocabulary score. Second, the father's book reading behaviors and mother's book reading behaviors were quite similar, the most frequent types of behavior being the use of 'feedback', 'explanation', 'questioning' and 'pointing'. On the other hand, there was a significant difference between the reading behavior of the mother and father as regards the categories of 'linguistic attention ventilation', 'suggesting', 'directing(instructing)', 'expanding feedback', 'pointing' and 'gesture'. Mothers performed more of these behaviors than the fathers. Third, toddler's vocabulary scores were positively correlated with the mother's 'linguistic attention ventilation'. However, the mother's use of 'restriction' was negatively correlated with the toddler's vocabulary level. Toddler's vocabulary scores were positively correlated with the father's 'description', 'reasoning/predicting', 'questioning about function or action', 'demanding feedback' and 'pointing'. The toddler's vocabulary scores were also positively correlated with the relative abundance of home environment materials and the amount of time spent on parent-child home literacy activity.

• Journal of Community Nutrition
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• 제2권2호
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• pp.119-128
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• 2000

Lifestyle and dietary behavior intervention as the primary prevention of lipid disorder seems safe and compatible with other treatments of cardiovascular diseases. Cross-sectional associations between lifestyle factors and dietary behavioral factors with plasma lipid and lipoprotein levels were analyzed in 189 middle-aged men in Suwon, Korea. Overnight fasting plasma levels of total cholesterol, high-density lipoprotein(HDL)-cholesterol, triacylglycerol and glucose were analyzed. Blood pressure and anthropometric data were also measured. Lifestyle factors such as smoking status, alcohol consumption and frequency of physical exercise were evaluated by a self-administered questionnaire. Questions regarding dietary behavior were also asked. The subjects were 43.8%${\pm}$7.9 years old, and 23.8%${\pm}$2.6kg/m$^2$. From stepwise regression analyses, significant correlates with total cholesterol level were body mass index(BMI), alcohol intake(negative), age and coffee drinking(model R$^2$=14.3%). BMI, breakfast-skipping, age, and sleeping hours were significant for triacylglycerol level(model R$^2$=15.8%). BMI, alcohol drinking(negative), age, and coffee drinking were significant for low-density lipoprotein(LDL)(model R$^2$=11.7%). Age(negative), BMI(negative), alcohol drinking, stress level(negative), physical exercise, and cigarette smoking(negative) were significant for high-density lipoprotein(HDL)(model R$^2$=12.1%). From stepwise regression analyses, excluding BMI and age as factors in the model, alcohol intake(negative) and coffee drinking were significantly correlated with total cholesterol level(model R$^2$=4.4%) : breakfast-skipping with triacylglycerol(model R$^2$=3.2%) : alcohol intake (negative) with LDL level(model R$^2$=3.4%) : alcohol intake, physical exercise and stress level(negative) with HDL level(model R$^2$=6.3%). The findings suggest that a healthy daily lifestyle and dietary behavior may have an anti-atherogenic effect by altering plasma lipid and lipoprotein levels in middle-aged Korean men. (J Community Nutrition 2(2) : 119∼128, 2000)

• 한국보건간호학회지
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• 제26권1호
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• pp.147-157
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• 2012

Purpose: The purpose of this study was to identify the related factors of change affecting the stages of change for exercise, on the assumption that there are various stages of change in the exercise behavior of women in nursing college. Methods: The subjects were 496 female college students in D city. The research instruments were stages of change for exercise behavior, the process of change, decisional balance, and self-efficacy. The dates were analyzed by descriptive statistics, ANOVA, and stepwise multiple regression using the SPSS 18.0 program. Results: The distribution of the subjects across the stages was: pre-contemplation, 17.7%; contemplation, 58.7%; preparation, 19.0%; action, 2.8%; maintenance, 1.8%. Analysis of variance showed that cognitive process (F=17.26, p<0.01), behavioral process (F=27.05, p<0.01), the pros of decisional-balance (F=7.07, p<0.01), the cons of decision-balance (F=5.82, p<0.01), and self efficacy (F=17.79, p<0.01) were significantly associated with the change of exercise behavior stages. The related factors of change affecting the change of exercise behavior stage were the cons of decision-making, counter conditioning, self re-evaluation, and body mass index, including 28.4% R-square. Conclusion: The transtheoretical model would be applicable to explain the exercise behavior of some women in nursing college. So, this study will be useful information for developing effective exercise behavior programs considering female students' stages of change.

• The Korean Journal of Physiology and Pharmacology
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• 제13권2호
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• pp.71-78
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• 2009

(S)-Carbamic acid 2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-1-phenyl-ethyl ester hydrochloride (YKP1447) is a novel "atypical" antipsychotic drug which selectively binds to serotonin (5-$HT_{2A}$, Ki=0.61 nM, 5-$HT_{2C}$, Ki=20.7 nM) and dopamine ($D_2$, Ki=45.9 nM, $D_3$, Ki=42.1 nM) receptors with over $10\sim100$-fold selectivity over the various receptors which exist in the brain. In the behavioral studies using mice, YKP1447 antagonized the apomorphine-induced cage climbing ($ED_{50}$=0.93 mg/kg) and DOI-induced head twitch ($ED_{50}$=0.18 mg/kg) behavior. In the dextroamphetamine-induced hyperactivity and conditioned avoidance response (CAR) paradigm in rats, YKP1447 inhibited the hyperactivity induced by amphetamine ($ED_{50}$=0.54 mg/kg) and the avoidance response ($ED_{50}$=0.48 mg/kg); however, unlike other antipsychotic drugs, catalepsy was observed only at much higher dose ($ED_{50}$=68.6 mg/kg). Based on the CAR and catalepsy results, the therapeutic index (TI) value for YKP1447 is over 100 (i.p.). These results indicate that YKP1447 has an atypical profile and less undesirable side effects than currently available drugs.