• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.1
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• pp.1-7
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• 2021

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common dose-limiting side effects of neurotoxic chemotherapeutic agents that lead to decreased quality of life and dose reduction, delay or even cessation of treatment. The purpose of this systematic review is to evaluate the effect and the underlying mechanisms of bee venom (BV) pharmacopuncture therapy for CIPN in animal models. We searched for the available experimental literature using BV for CIPN through the Pubmed databases. Ten experimental studies were finally included in this review. In the oxaliplatin or paclitaxel-induced CIPN animal model, BV significantly relieved pain caused both mechanical and cold stimulation. It was suggested that the effect of BV is mediated by the stimulation effect of spinal α1- and α2-adrenergic receptors as a potential mechanism. In the future, more experimental studies are needed.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.2 no.1
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• pp.59-67
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• 2007

Objective : Poly neuropathy is disease that reveals musle relaxation or sensory disorder, and Myopathy is disease that reveals musle weakness, wasting, pain. These diseases occur in the lower or upper limbs. This is the clinical report about Poly neuropathy or Myopathy estimated patients. Method : Patients were treated by acupuncture, herb medicine, bee venom herbal-acupuncture, moxibustion. We evaluated the improvement of symptoms with ROM(Range of Motion) and MCR(Medical Research Council) standard. Result : Symptoms that patients have at admission improved and disappered gradually with oriental medicine therapy. Observing the change of ROM and MCR standard, they indicated us improvement of disease. Conclusion : We achived a desirable result from treatment of peripheral neuropathy or myopathy estimated patients. However, further studies are required to prove the effect of oriental medicine treatment.

• Journal of Acupuncture Research
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• v.34 no.1
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• pp.39-48
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• 2017

Objectives : This study examined the effects of Korean medicine treatment in three patients following rotator cuff repair. Methods : Patients were treated with acupuncture, bee venom, moxibustion, and herbal medicine. Treatments were performed for an average of 3 weeks. A numeric rating scale (NRS) and range of motion (ROM) were used for evaluation of treatment effects. Results : The NRS score decreased and the ROM increased after treatment. In Case 1, the NRS score decreased from 10 to 6; flexion increased from $25^{\circ}$ to $180^{\circ}$ and abduction increased from $35^{\circ}$ to $180^{\circ}$. In Case 2, the NRS score decreased from 10 to 7; flexion increased from $30^{\circ}$ to $125^{\circ}$ and abduction increased from $15^{\circ}$ to $100^{\circ}$. In Case 3, the NRS score decreased from 10 to 3; flexion increased from $40^{\circ}$ to $120^{\circ}$ and abduction increased from $60^{\circ}$ to $95^{\circ}$. Conclusion : Korean medicine treatment following rotator cuff repair was effective in decreasing the NRS score and increasing ROM. Although the study only involved 3 cases, Korean medicine treatment may reduce the duration of rehabilitation.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.4
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• pp.62-73
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• 2015

Objectives : The aim of this study is to propose the treatment of Peripheral Facial paralysis using Korean medical treatment methods as acupuncture, Phmacopuncture, medicine and etc.Methods : Papers were searched in internet sites such as Nation Digital Science Library, Koreanstudies Information Service System, Research Information Sharing Service and The National Assembly Library with title and abstract ʻBellʼs palsyʼ or ʻFacial paralysisʼ and ʻphamacopunctureʼ or ʻbee venomʼ orʻhominis placentaʼetc.Results : 18 papers using phamacopuncture were selected. Most of all is used Bee Vemon Phamcopuncure and all of them used Acupuncture and Medicine therapies. And Groups used Phamacopuncture such as ʻBee Venomʼ,ʻHominis Placentaʼ, ʻSoyeomʼ, ʻBUMʼ,ʻJungsongoulhyulʼetc are statistically improved compared to unused Groups.Conclusions : Acupuncture and Phamacopuncture are useful methods to improve the Peripheral Facial Paralysis, but further researchs are needed.

• Korean Journal of Acupuncture
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• v.36 no.1
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• pp.92-92
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• 2019

• Journal of Acupuncture Research
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• v.26 no.4
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• pp.49-58
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• 2009

목적 : 파킨슨 병은 기저핵 흑질의 치밀부에서 도파민성 신경세포의 퇴행으로 인하여 발생하는 질병으로 신경 염증이 주요 병인으로 밝혀져 있다. 이 연구는 MPTP 유발 파킨슨 병 동물 모델에서 신수혈($BL_{23}$)에 대한 봉독 약침의 항염증 효과 및 그 기전을 확인하기 위해 시행되었다. 방법 : $C57_{BL}$/6쥐를 무처치군, MPTP+saline군, MPTP+BVA(0.06mg/kg)군, MPTP+BVA(0.6mg/kg)군의 4군으로 나눈 뒤 무처치군을 제외한 모든 그룹에 총 8시간 동안 2시간 간격으로 MPTP-HCl(20mg/kg per dose$\times$4)을 복강내로 주입하였다. MPTP+BVA 군에서 봉독약침은 마지막 MPTP 주입 2시간 후부터 48시간 간격으로 신수혈($BL_{23}$)에 양측으로 각 20${\mu}\ell$씩 주입하였고 MPTP+saline군에서는 봉독약침 대신 Saline을 주입하였다. 마지막 MPTP 주입 후 7일째에 쥐의 뇌를 적출한 후 면역조직화학법을 시행하였다. 결과 : MPTP 유발 파킨슨 병 동물 모델에서 신수혈에 대한 봉독약침은 농도 의존적으로 TH-Immunoreactivity neuron의 감소와 microglial activation을 억제하였다. HSP70-IR neuron은 모든 군에서 나타나지 않았다. 결론 : 봉독약침이 용량의존적으로 microglial activation을 억제하는 효과를 통해 도파민성 신경세포의 파괴를 억제함으로써 항염 효과를 나타냄을 알 수 있었다. 이 결과는 봉독약침이 microglial activation 억제를 통해 임상적으로 파킨슨 병과 같은 신경 퇴행성 질병에 있어 유용한 치료수단이 될 수 있음을 시사한다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.6
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• pp.842-848
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• 2012

This study was performed to investigate the acupuncture & moxibustion therapy of the Wei symptom(痿證) in order to find out the clinical possibility. We investigated the acupuncture & moxibustion therapy of Wei symptom through six books published after 1993, searched sites as like 'Oasis', 'Pubmed', 'RISS', 'KISS', 'NDSL' and 'Google scholar'. Acupuncture & moxibustion prescriptions recorded in the orietal medicine literatures that were published before and after 1993 had a similar basis. Since 2000, in the clinical papers on the wei symptom searched from domestic journal, sa-am and dong's acupuncture therapy were mainly applied, but papers were confined in a case study. Since the mid-2000s, the clinical effectiveness of bee venom and electroacupuncture therapy on the wei symptom were uncovered, but the researches about the chracteristics in accordance with acupoints are more required. Since 2010, the mechanism of the bee venom and electroacupuncture on the wei symptom was revealed in animal experiments. On this basis, the systematic clinical studies beyond case paer or pilot study is(are) needed. The development of various treatment implements as like electroacupuncture, pharmacopuncture was required to access the incurable disease like wei syptom, and the efforts of providing evidence through systemic clinical trials are needed.

• Journal of Veterinary Clinics
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• v.23 no.2
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• pp.190-193
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• 2006

Two weeks of therapy with intra-articular hyaluronic acid and oral caprofen failed to improve the clinical signs of hip osteoarthritis radiologically confirmed in a dog. Then, over the period of 30 days (7 sessions at 5-day intervals), bee- venom acupuncture (BV-AP, injection of bee venom at acupoints, also called apitoxin-aquapuncture) plus Trigger Point (TP) therapy was used. Five acupoints on the affected right limb were injected each time: GB30(as local point), plus ST35, GB33, BL40 and LIV08 (as distant points). The injection mixture (0.2 ml/point; total 1 ml/session) was saline + apitoxin + 2% lidocaine, so that the injected solution contained $100{\mu}g$ apitoxin diluted in 0.2% lidocaine-saline solution/ml. The total dose of apitoxin used was, therefore, $100{\mu}g/session$, divided over the 5 acupoints. One TP in the middle of the right quadriceps muscle was injected with 2% lidocaine (0.2 ml/point) each time. BV-AP improved the clinical signs rapidly; lameness and ataxia were disappear after 7 sessions (30 days); the right hind limb muscular atrophy was much improved and the hip radiograph was almost normal two weeks after 7 sessions (44 days). The present patient was a case with canine hip osteoarthritis which showed favorable therapeutic response by BV-AP plus TP therapy.

• Journal of Korean Traditional Oncology
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• v.25 no.2
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• pp.1-11
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• 2020

Objectives: The effectiveness of acupuncture on cancer pain is relatively well established, while there have been few clinical studies on pharmacopuncture on that. This research was aimed to investigate a trend of pharmacopuncture treatment for cancer pain and to propose information for further research. Methods: Clinical studies on pharmacopuncture for cancer pain were collected from 5 Korean medical databases. And the studies were analyzed by classifications of cancer, chief complaints, interventions, treating skills, additional treatments, treatment session, outcome measures, results and adverse effects. Results: The literatures were 8 case reports and 1 randomized controlled trial. Interventions were pharmacopunctures of soyeom, mountain ginseng, Harpagophyti Radix, snake venom, Trionycis Carapax, bee venom, Aconitum Ciliare Decaisne. Treatment skills, procedures, and indications of each pharmacopuncture were different. An adverse effects of bruising, bleeding, mild chilling, sore throat and pain were mentioned on snake venom and bee venom treatment. Conclusions: An appropriate interventions and treatment skills should be selected according to the type of cancer pain. And treatment procedures to ensure safety must be developed.

• Journal of Pharmacopuncture
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• v.17 no.4
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• pp.66-69
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• 2014

Objectives: Treating complex regional pain syndrome (CRPS) is difficult because it still does not have a recommended therapy. A 29-year-old man was diagnosed with CRPS after surgery on his $4^{th}$ and $5^{th}$ left toes 7 years ago. Though he had undergone diverse pain treatment, the symptoms persisted, so he visited Dunsan Korean Medicine Hospital of Daejeon University. This case report presents results on the effect of bee venom pharmacopuncture in treating patient with CRPS. Methods: Bee venom pharmacopuncture (BVP), 0.15 to 0.4 mL dosage, was administered at GB43. The treatment was applied each week for a total 14 times. The symptoms were evaluated using a numeric rating scale (NRS) and the dosage of pain medicine. Results: On the first visit, he was taking an anticonvulsant, a trycyclic antidepressant, and an analgesic. On the NRS the worst pain in the toes received a score of 8. He also complained of severe pain and hypersensitivity when the $4^{th}$ and the $5^{th}$ toes were touched just slightly. Other complaint included dyspepsia, rash, and depression. After treatment, on the NRS, the score for toe pain was 0, and he no longer needed to take pain medication. During the 4-months follow-up period, he has remained without pain; neither have additional symptoms appeared nor adverse events occurred. Conclusion: BVP may have potential benefits for treating patients with CRPS.