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http://dx.doi.org/10.15188/kjopp.2021.02.35.1.1

Review of Experimental Researches on Bee Venom Pharmacopuncture Therapy for Chemotherapy-induced Peripheral Neuropathy  

Kwon, Bo In (Department of Pathology, College of Korean Medicine, Sangji University)
Woo, Yeonju (Department of Physiology, College of Korean Medicine, Sangji University)
Kim, Joo-Hee (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.35, no.1, 2021 , pp. 1-7 More about this Journal
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common dose-limiting side effects of neurotoxic chemotherapeutic agents that lead to decreased quality of life and dose reduction, delay or even cessation of treatment. The purpose of this systematic review is to evaluate the effect and the underlying mechanisms of bee venom (BV) pharmacopuncture therapy for CIPN in animal models. We searched for the available experimental literature using BV for CIPN through the Pubmed databases. Ten experimental studies were finally included in this review. In the oxaliplatin or paclitaxel-induced CIPN animal model, BV significantly relieved pain caused both mechanical and cold stimulation. It was suggested that the effect of BV is mediated by the stimulation effect of spinal α1- and α2-adrenergic receptors as a potential mechanism. In the future, more experimental studies are needed.
Keywords
Chemotherapy-induced peripheral neuropathy; Bee venom; Pharmacopuncture; Experimental research; Review;
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