• Journal of Korean Medicine Rehabilitation
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• v.26 no.3
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• pp.67-77
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• 2016

Objectives To evaluate the evidence supporting the effectiveness of Bee Venom therapy for traumatic injury. Methods We conducted search across 3 electronic databases (Pubmed, CAJ and Oasis) to find clinical trials that used Bee Venom therapy as treatment for traumatic injury. The methodological quality of RCTs (Randomized controlled clinical trials) were assessed using the Cochrane Risk of Bias (RoB) tool, while NRCTs (Non-Randomized controlled clinical trials) were assessed using the Cochrane Risk of Bias Assessment tool for Non-randomized Study (RoBANS) tool. Results Among 87 articles that were searched, 10 RCTs and 19 NRCTs were finally selected. Among 19 selected studies, all studies showed that Bee Venom therapy has significant effect on traumatic injury. Conclusions Our systematic review found encouraging but limited evidence of Bee Venom therapy for traumatic injury. We recommend clinical trials which compare the effectiveness of Bee Venom therapy with other pharmacopuncture therapies to clarify the effectiveness of Bee Venom therapy from other pharmacopuncture therapies.

• Journal of Acupuncture Research
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• v.36 no.4
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• pp.220-229
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• 2019

Background: The therapeutic potential of Bee Venom Pharmacopuncture (BVP) on acute ischemic cerebral infraction was determined in mice in vivo and in vitro. Methods: Analysis of acute ischemic cerebral infraction was performed using 7 week old male ICR mice (n = 20) and microglial BV-2 cells. Bee venom ($5{\mu}g/kg$) was injected into the caudal vein of middle cerebral artery occlusion (MCAo) mice (1 hour after reperfusion, 3 hours after MCAo probe insertion), and also used to treat LPS-stimulated microglial BV-2 cells (1, 2, $5{\mu}g/mL$). Markers of inflammation were monitored. Results: NO declined statistically significantly in BVP treated MCAo mice compared to the untreated MCAo group (p < 0.05). Compared to the MCAo group, the BVP-treated MCAo group showed a decreased production volume of malondialdehyde, but an increased glutathione/oxidized glutathione ratio. Compared to the untreated MCAo group, the BVP treated MCAo group showed a statistically significant decline in TNF and $IL-1{\beta}$ levels (p < 0.05). BVP inhibited the levels of p65, p50, $p-I{\kappa}B-{\alpha}$, and levels of p-ERK1/2, p-JNK2, p-P38 declined. Conclusion: BVP is effective at dampening the inflammatory response in vivo and in vitro and may supplement rt-PA treatment.

• Journal of Pharmacopuncture
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• v.4 no.3
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• pp.119-126
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• 2001

Objective : In order to report the process of treatment of Aplastic anemia by herbal acupuncture Methods: This case was diagnosed as deficiency of Yang of spleen and kidneys, deficiency of Ki and blood, and fevescence from the deficiency of Urn. Hominis Placenta herbal acupuncture and Bee-venom acupuncture were choosen as the method to treat the case. Results: 1. The nocturnal fevescence and indigestion was decreased during the times when Hominis Placenta herbal acupuncture was used once a day. 2. The mobility of the joints was improved and the inflamation on the joints was decreased during the times when Bee-venom acupuncture was used every other day. 3. The interval between the transfusion was extended during the times when Hominis Placenta herbal acupuncture and Bee-venom acupuncture were used by turns. Conclution : Hominis Placenta herbal acupuncture and Bee-venom acupuncture sucessfully imporved the symtoms of patient with Aplastic anemia

• Journal of Pharmacopuncture
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• v.8 no.3
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• pp.99-105
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• 2005

Objectives : The purpose of this study is to analyze the functional and clinical improvement effect on temporomandibular disorder by additional Hominis Placenta and bee venom herbal acupuncture treatment. Methods : A patient was treated with Hominis Placenta, bee venom herbal acupuncture, simple acupuncture, chiropractic therapy, and herbal medicine. We evaluated the improvement by visual analogue scale(VAS) score, mouth opening range, and X-ray image. Results : The VAS score was significantly decreased and mouth opening range was increased after treatment. X-ray image showed improved change after treatments. Conclusions : We think Hominis Placenta and bee venom herbal acupuncture treatment mainly contributed to the improvement of temporomandibular disorders. Further study is needed for the confirmation of this effect of on temporomandibular disorders.

• Journal of Pharmacopuncture
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• v.5 no.2
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• pp.109-115
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• 2002

Objective : This study was performed to evaluate the treatment of Acupuncture therapy including Herbal Acupuncture theraphy and Korean Bee Venom Theraphy in Klippel-Trenaunay-Weber Syndrome. Methods : We treated 1 case of Klippel-Trenaunay-Weber Syndrome patient with mainly Korean Bee Venom Theraphy, and herbal Acupuncture, acupuncture theraphy from 27th August, 2001 to February, 2003. Results : After 3 weeks of Korean Bee Venom Theraphy, and herbal Acupuncture, acupuncture theraphy, a remarkable improvement was made for Klippel-Trenaunay-Weber Syndrome. Conclusions : Korean Bee Venom Theraphy and other acupuncture therapies were effective in reducing the symptoms. We think that it need the further study and clinical trial for Klippel-Trenaunay-Weber Syndrome.

• Journal of Pharmacopuncture
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• v.6 no.2
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• pp.119-125
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• 2003

Objective : The purpose of this study is to show that there was a significant result in prescribing Herb remedy and Korean-Bee-Venom acupuncture and acupuncture & moxibustion therapy to Urinary incontinence patients due to Neurologic Bladder caused by Cauda equina syndrome after having an vertebrae lumbale operation. Method : The methods used in this study was observe the patient's subjective improvement, valuation of the bladder function and the change of the sensibility drop when Herb remedy and Korean-Bee-Venom acupuncture and acupuncture was applied. Results : When acupuncture and Korean-Bee-Venom acupuncture was both applied the function of Bladder changed from score 10 to 0 and the Grade of Urinary Incontinence changed from Grade III to 0 also with the sensibility drop. Conclusion : The results show that when using Umnungchon(SP9), Yangnungchon (GB34), Taedon(LR1), Kokkol(CV2) there was an effect to some degree to the Urinary incontinence patients but when Korean-Bee-Venom was acupunctured to Kwanwon(CV4) and Kihae(CV6) the effect increased. Further studies and examples for evidence are required.

• Journal of Pharmacopuncture
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• v.7 no.1 s.12
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• pp.101-106
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• 2004

Objective : The purpose of this study is to report the effect of Bee Venom Acua-Acupuncture Therapy to the patient of Pes Anserine Bursitis by using DITI. Patient & Methods : The patient was 60-year-old woman who complained severe knee pain. She was treated by bee venom acuaacupuncture therapy. To estimate the efficacy of tratment, we used DITI, visual analog scale, knee joint check(ROM). Results : In this case, we treated patient of Pes Anserine Bursitis for 28 days. bee venom acua-acupuncture therapy efficiently relieved patient's pain and improved ROM. DITI and Visual analog scale also showed significantly valuable changes.

• Journal of Pharmacopuncture
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• v.17 no.4
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• pp.66-69
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• 2014

Objectives: Treating complex regional pain syndrome (CRPS) is difficult because it still does not have a recommended therapy. A 29-year-old man was diagnosed with CRPS after surgery on his $4^{th}$ and $5^{th}$ left toes 7 years ago. Though he had undergone diverse pain treatment, the symptoms persisted, so he visited Dunsan Korean Medicine Hospital of Daejeon University. This case report presents results on the effect of bee venom pharmacopuncture in treating patient with CRPS. Methods: Bee venom pharmacopuncture (BVP), 0.15 to 0.4 mL dosage, was administered at GB43. The treatment was applied each week for a total 14 times. The symptoms were evaluated using a numeric rating scale (NRS) and the dosage of pain medicine. Results: On the first visit, he was taking an anticonvulsant, a trycyclic antidepressant, and an analgesic. On the NRS the worst pain in the toes received a score of 8. He also complained of severe pain and hypersensitivity when the $4^{th}$ and the $5^{th}$ toes were touched just slightly. Other complaint included dyspepsia, rash, and depression. After treatment, on the NRS, the score for toe pain was 0, and he no longer needed to take pain medication. During the 4-months follow-up period, he has remained without pain; neither have additional symptoms appeared nor adverse events occurred. Conclusion: BVP may have potential benefits for treating patients with CRPS.

• Journal of Korean Traditional Oncology
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• v.25 no.2
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• pp.1-11
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• 2020

Objectives: The effectiveness of acupuncture on cancer pain is relatively well established, while there have been few clinical studies on pharmacopuncture on that. This research was aimed to investigate a trend of pharmacopuncture treatment for cancer pain and to propose information for further research. Methods: Clinical studies on pharmacopuncture for cancer pain were collected from 5 Korean medical databases. And the studies were analyzed by classifications of cancer, chief complaints, interventions, treating skills, additional treatments, treatment session, outcome measures, results and adverse effects. Results: The literatures were 8 case reports and 1 randomized controlled trial. Interventions were pharmacopunctures of soyeom, mountain ginseng, Harpagophyti Radix, snake venom, Trionycis Carapax, bee venom, Aconitum Ciliare Decaisne. Treatment skills, procedures, and indications of each pharmacopuncture were different. An adverse effects of bruising, bleeding, mild chilling, sore throat and pain were mentioned on snake venom and bee venom treatment. Conclusions: An appropriate interventions and treatment skills should be selected according to the type of cancer pain. And treatment procedures to ensure safety must be developed.

• Journal of Pharmacopuncture
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• v.4 no.2
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• pp.5-15
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• 2001

This study was carried out for production of neutral antibody to bee venom $(anti-phospholipase\;A_2IgY)$. Hen layings were injected repeatedly with bee venom and phospholipase $A_2$ with Freund's adjuvant. Specific antibody in egg yolk from immunized hen laying was separated, and purified, also immunological characteristics of anti phospholipase $A_2\;IgY$ was invested. The results were summarized as follows: 1. Phospholipase $A_2$ was showed single band at molecular weight 17,000 in SDS-PAGE and bee venom was showed two band at molecular weight 17,000 and under molecular weight 6,500 in SDS-PAGE. 2. During 70 days after hen immunized with bee venom and phospholipase $A_2$, antibodies(anti-bee venom IgY) to bee venom were showed poor ELISA value in egg yolk, but antibodies$(anti-Phospholipase\;A_2IgY)$ to phospholipase $A_2$ in egg yolk were increased ELISA value from 8 days or 15 days and found maximum ELISA value at 42 days. Also after booster at 49 days, ELISA value of anti Phospholipase $A_2\;IgY$ in egg yolk was supported at optical density(O.D) 1.0 level, continuously. 3. Titer of phospholipase $A_2\;IgY$ was showed 1: 32,000. 4. In double immunodiffusion test to phospholipase $A_2$ after double dilution of anti-phospholipase $A_2\;IgY$, only precipitation line was made in 1:1 dilution well of anti-Phospholipase $A_2\;IgY$. But In immunodiffusion test to anti-phospholipase $A_2\;IgY$ after double dilution of phospholipase $A_2$, Precipitation line to 250ul/ml well of phospholipase $A_2$ was showed. In double immunodiffusion test to bee venom(1mg/ml) after double dilution anti-phospholipase $A_2\;IgY$, all well without 1:32 dilution well were showed strong precipitation line. 5. In dot bloting test to anti-phospholipase $A_2\;IgY$ after diluting bee venom(0.5mg/ml), dot bloting color was showed clearly to $1/100(5{\mu}g/ml)$ in bee venom.