• 한국광학회지
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• 제14권2호
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• pp.161-165
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• 2003

Master laser(ML)의 직접 변조로 생성된 여러 개의 side-bands 중 두 개의 target band게 두 개의 Slave laser(SL)가 각각 lock이 되도록 하는 side-band injection-locking 방법을 이용하여 광학적 60㎓의 밀리미터파 신호를 구현하였다 ML에 lock이 된 두 SL의 output들은 photo detection시 서로 beating하여 안정적이고 매우 깨끗한 60㎓ 신호를 생성하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1997년도 하계학술대회 논문집 E
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• pp.1859-1860
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• 1997

다전극 DFB(distributed feedback) 레이저서, 레이징모드간 비팅을 통하여 초고속으로 자려펄스열을 발생시킬 수 있음을 제안한다. 이러한 자려펄스생성을 수정된 시영역 동적 모델(large signal time-domain dynamic model)을 이용하여 조사하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제25권2호
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• pp.159-166
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• 2021

Nicotinamide adenine dinucleotide phosphate oxidases (NOXs) are the major enzymatic source of reactive oxygen species (ROS). NOX2 and NOX4 are expressed in the heart but its role in hypoxia-induced atrial natriuretic peptide (ANP) secretion is unclear. This study investigated the effect of NOX on ANP secretion induced by hypoxia in isolated beating rat atria. The results showed that hypoxia significantly upregulated NOX4 but not NOX2 expression, which was completely abolished by endothelin-1 (ET-1) type A and B receptor antagonists BQ123 (0.3 μM) and BQ788 (0.3 μM). ET-1-upregulated NOX4 expression was also blocked by antagonists of secreted phospholipase A2 (sPLA2; varespladib, 5.0 μM) and cytosolic PLA2 (cPLA2; CAY10650, 120.0 nM), and ET-1-induced cPLA2 expression was inhibited by varespladib under normoxia. Moreover, hypoxia-increased ANP secretion was evidently attenuated by the NOX4 antagonist GLX351322 (35.0 μM) and inhibitor of ROS N-Acetyl-D-cysteine (NAC, 15.0 mM), and hypoxia-increased production of ROS was blocked by GLX351322. In addition, hypoxia markedly upregulated Src expression, which was blocked by ET receptors, NOX4, and ROS antagonists. ET-1-increased Src expression was also inhibited by NAC under normoxia. Furthermore, hypoxia-activated extracellular signal-regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) were completely abolished by Src inhibitor 1 (1.0 μM), and hypoxia-increased GATA4 was inhibited by the ERK1/2 and Akt antagonists PD98059 (10.0 μM) and LY294002 (10.0 μM), respectively. However, hypoxia-induced ANP secretion was substantially inhibited by Src inhibitor. These results indicate that NOX4/Src modulated by ET-1 regulates ANP secretion by activating ERK1/2 and Akt/GATA4 signaling in isolated beating rat hypoxic atria.

• 한국정보통신학회논문지
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• 제7권5호
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• pp.1076-1081
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• 2003

본 논문에서는 반도체레이저를 이용한 밀리미터파 대역의 신호를 생성하는 방법에 대해 제안하였다. 광대역에서의 밀리미터파 신호를 얻기 위해서는 윈하는 공진 주파수대역의 신호를 얻기 위해는 서브 하모닉의 좁은 신호 성분의 하모닉 신호인 다중의 신호를 서로 beating하여 원하는 주파수 대역의 신호를 얻을 수 있다. 따라서 본 논문에서는 반도체레이저를 사용한 광주입 방법을 통하여 실제적으로 원하는 주파수 대역의 신호를 얻기 위해 실험적으로 고찰하였으며, 신호 성분의 성능을 구하기 위해 phase noise 성분을 측정하였다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2000년도 춘계학술대회논문집
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• pp.263-268
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• 2000

본 논문에서는 고조파 소음을 내는 시스템의기본 주파수 추정을 통한 새로운 피드백 능동소음제어 방법을 제안한다. 기존신호를 측정하기 어려운 상황에서 종래의 다중 정현파 소음의 능동제어 방법은 기준신호를 측정하는 대신 추정된 주파수를 이용하여 기준신호를 만들어낸다. 그러나 비팅현상(beating phenomenon)이 존재할 때는 순간적으로 특정 주파수 성분이 사라지게 되므로 적응 주파수 추정이 어렵게 되어 비팅현상에 의한 주파수 추정에서의 혼돈을 만들어진 기준신호를 쓸모없게 만든다. 제안된 알고리즘은 두 가지 부분으로 구성된다. 첫째는 기본주파수 추정을 이용한 기준신호 발생기이고 둘째는 기존의 피드포워드 제어부분이다. 제안된 결정 규칙을 이용한 기본주파수 추정알고리즘은 비팅현상에 둔감할 뿐 아니라 기존의 직렬형 적응노치필터 방법에 비해 좋은 추종성능과 적은 주파수 추정 오차의 분산을 갖는다. 더욱이 신호대잡음비가 좋지 않아 기존의 주파수 검증하기 위해서 실측한 선박의 객실 소음과 자동차의 시변하는 엔진부밍소음에 대해서 모의 실험을 수해한다.

• Journal of Veterinary Science
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• 제22권4호
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• pp.54.1-54.13
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• 2021

Background: Hypoxia causes oxidative stress and affects cardiovascular function and the programming of cardiovascular disease. Melatonin promotes antioxidant enzymes such as superoxide dismutase, glutathione reductase, glutathione peroxidase, and catalase. Objectives: This study aims to investigate the correlation between melatonin and hypoxia induction in cardiomyocytes differentiation. Methods: Mouse embryonic stem cells (mESCs) were induced to myocardial differentiation. To demonstrate the influence of melatonin under hypoxia, mESC was pretreated with melatonin and then cultured in hypoxic condition. The cardiac beating ratio of the mESC-derived cardiomyocytes, mRNA and protein expression levels were investigated. Results: Under hypoxic condition, the mRNA expression of cardiac-lineage markers (Brachyury, Tbx20, and cTn1) and melatonin receptor (Mtnr1a) was reduced. The mRNA expression of cTn1 and the beating ratio of mESCs increased when melatonin was treated simultaneously with hypoxia, compared to when only exposed to hypoxia. Hypoxia-inducible factor (HIF)-1α protein decreased with melatonin treatment under hypoxia, and Mtnr1a mRNA expression increased. When the cells were exposed to hypoxia with melatonin treatment, the protein expressions of phospho-extracellular signal-related kinase (p-ERK) and Bcl-2-associated X proteins (Bax) decreased, however, the levels of phospho-protein kinase B (p-Akt), phosphatidylinositol 3-kinase (PI3K), B-cell lymphoma 2 (Bcl-2) proteins, and antioxidant enzymes including Cu/Zn-SOD, Mn-SOD, and catalase were increased. Competitive melatonin receptor antagonist luzindole blocked the melatonin-induced effects. Conclusions: This study demonstrates that hypoxia inhibits cardiomyocytes differentiation and melatonin partially mitigates the adverse effect of hypoxia in myocardial differentiation by regulating apoptosis and oxidative stress through the p-AKT and PI3K pathway.

• The Korean Journal of Physiology and Pharmacology
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• 제21권3호
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• pp.293-300
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• 2017

Prostaglandin $D_2$ ($PGD_2$) may act against myocardial ischemia-reperfusion (I/R) injury and play an anti-inflammatory role in the heart. Although the effect of $PGD_2$ in regulation of ANP secretion of the atrium was reported, the mechanisms involved are not clearly identified. The aim of the present study was to investigate whether $PGD_2$ can regulate ANP secretion in the isolated perfused beating rat atrium, and its underlying mechanisms. $PGD_2$ (0.1 to $10{\mu}M$) significantly increased atrial ANP secretion concomitantly with positive inotropy in a dose-dependent manner. Effects of $PGD_2$ on atrial ANP secretion and mechanical dynamics were abolished by AH-6809 ($1.0{\mu}M$) and AL-8810 ($1.0{\mu}M$), $PGD_2$ and prostaglandin $F2{\alpha}$ ($PGF2{\alpha}$) receptor antagonists, respectively. Moreover, $PGD_2$ clearly upregulated atrial peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$) and the $PGD_2$ metabolite 15-deoxy-${\Delta}12$, 14-$PGJ_2$ (15d-$PGJ_2$, $0.1{\mu}M$) dramatically increased atrial ANP secretion. Increased ANP secretions induced by $PGD_2$ and 15d-$PGJ_2$ were completely blocked by the $PPAR{\gamma}$ antagonist GW9662 ($0.1{\mu}M$). PD98059 ($10.0{\mu}M$) and LY294002 ($1.0{\mu}M$), antagonists of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling, respectively, significantly attenuated the increase of atrial ANP secretion by $PGD_2$. These results indicated that $PGD_2$ stimulated atrial ANP secretion and promoted positive inotropy by activating $PPAR{\gamma}$ in beating rat atria. MAPK/ERK and PI3K/Akt signaling pathways were each partially involved in regulating $PGD_2$-induced atrial ANP secretion.

• 한국임상수의학회지
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• 제23권3호
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• pp.258-262
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• 2006

This study was performed to evaluate the usefulness of gray-scale and power Doppler ultrasonography, and to compare with radiography for detection of the repairing in experimentally induced bone defects in dogs. In 4 adult beagle dogs bilateral bone defects were created in 8 canine femurs as sized as 5 mm diameter. Mean detection time of the ultrasonographic endosteal callus formations(mean $14.25{\pm}2.31$ days) was significantly shorter than that of the radiographic opacity chanees(mean $23.50{\pm}2.27$ days) in the defected region. Mean time of the neovascularizd flow signal(mean $6.00{\pm}3.59$ days) from the power Doppler ultrasonographic examination was significantly shorter than that of gray-scale ultrasonographic findings. With these results, gray-scale ultransonography and power Doppler ultrasonography can be used for an early detection modality for bone healing.

• 한국멀티미디어학회논문지
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• 제19권3호
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• pp.557-566
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• 2016

Heart sounds generated by the beating heart and blood flow reflect the turbulence created when the heart valves snap shut. Cardiac diagnosis is typically started by an auscultation using a stethoscope, from which a medical doctor, depending on his hearing capabilities and training, listens and interprets the acoustic signal. This method of diagnostic is uncertain, mostly due to the fact that human ear loses the acoustic frequency sensitivity through the years. Even though an auscultation has some weaknesses like uncertainty, it is considered as a primary tool due to its simplicity. In this paper, heart murmur detection algorithm is proposed using time and frequency characteristics of heart sound. The propose heart murmur detection method adapted conventional primary heart sound detection method in time domain and modified spectral flatness method in frequency domain for detecting heart murmurs. From experimental results, it is confirmed that the proposed algorithm detect the heart murmurs efficiently.

• 센서학회지
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• 제22권4호
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• pp.292-296
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• 2013

The ultrasonic wind sensor that pass through the air, beating the delivery of ultrasonic wind speed increases or decreases by the physical characteristics of the wind speed and the direction of the sensor, the transmission and reception of ultrasonic time difference measured by a two-axis vector wind and wind speed measured by calculating a device that converts the digital signal is Anemometer and wind direction meteorological facilities management, management of the ship sail used for various purposes, including, but used the existing 3-cup (mechanical) anemometer wind rotor caused by mechanical wear parts replacement due to the short-term, the reliability of the product is low, parts replacement, and according to the characteristics caused the car, there is a problem in high maintenance costs. In addition, because the bearings use of the marine environment and the cryogenic environment was constrained. In this study, the excellent long-term reliability, using ultrasonic-type environment that is not constrained to produce wind anemometer located $90^{\circ}$ conformal road using four piezoelectric sensors were fabricated structures, the piezoelectric oscillator circuit produces a rash and receiving transmit and receive speeds the car through the two-axis vector calculation to measure wind velocity processor firmware programming, and its characteristics were tested.