• 혜화의학회지
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• 제8권1호
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• pp.403-424
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• 1999

To evaluate the antitumor activity, antimetastatic and radioprotective effects of Kamisasammaekmundongtang(KSMT), studies were done experimentally. The results were obtained as follows: 1. In cytotoxicity against P388, A549 and B16-F10, KSMT was not showed satisfiable cytotoxicity as compared with control. 2. In Inhibitory effect on activity of DNA topoisomerase I, KSMT has strong inhibitory effect. 3. The inhibitory effect on adhesion of A549 to complex extracellular matrix was significantly increased at 0.5mg/ml, 1mg/ml of KSMT. 4. The T/C% was 122 in KSMT treated group in S-180 bearing ICR mice. 5. In antiangiogenetic effect on CAM assay, inhibitory rate was 33% in KSMT treated group. 6. In pulmonary colonization assay, a number of colonies in the lungs were decreased significantly in KSMT treated group as compared with control group. 7. By FACS analysis of splenic leukocyte after exposure to radiation by linear accelerator, T-helper cell, B cell and macrophage in KSMT treated group were significantly increased while splenocytes were decreased in control group. 8. In histological changes of jejunum of $Bald{\setminus}C$ mice after exposure to radiation by linear accelerator, exclusion and fusion of villi were decreased as compared with control group. But in duodenum and ileum, exclusion and fusion of villi were not decreased as compared with control group. 9. WBC, PLT were increased in KSMT treated group as compared with control group after exposure to radiation by linear accelerator, but the increasing effect was not significant. Above results suggest that KSMT may be useful in prevention of cancer metastasis and protection from damage by radiotherapy. But the further study of KSMT would be demanded.

• 한국해양공학회지
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• 제32권5호
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• pp.324-332
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• 2018

It is known that damages to the subsea cables used for electric power transmission between islands and countries, including renewable energy from offshore wind power, current, tides, etc., cost much to restore, which causes social and economic losses. Various types of fishing rigs and anchors have been reported to be the greatest hazards to subsea cables. It is possible to design and construct a suitable protection facility for a subsea cable by precisely estimating the underwater behavior of such hazardous apparatuses. In this study, numerical simulations of the underwater behaviors of various hazardous apparatuses were carried out using fluid-structure interaction (FSI) analysis as a basic study to simulate the actual behavior phenomena of hazardous apparatuses in relation to a subsea cable. In addition, the underwater drop characteristics according to the types of hazardous apparatuses were compared. In order to verify the accuracy of the FSI analysis method used in this study, we compared the test results for underwater drops of a steel ball bearing. Stock anchors, stockless anchors, and rocket piles, which were actually reported to be the cases of damage to subsea cables along the southwest coast of Korea, were considered as the hazardous apparatuses for the numerical simulations. Each hazardous apparatus was generated by a Lagrangian model and coupled with the fluid domain idealized by the Eulerian equation to construct the three-dimensional FSI analysis model. The accuracy of the numerical simulation results was verified by comparing them with the analytical solutions, and the underwater drop characteristics according to the types of hazard apparatuses were compared.

• 정보저장시스템학회논문집
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• 제2권2호
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• pp.130-137
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• 2006

The HDD(hard disk drive) using Load/unload(L/UL) technology includes the benefits which are increased areal density, reduced power consumption and improved shock resistance than those of contact-start-stop(CSS). It has been widely used in portable hard disk drive and will become the key technology for developing the small form factor hard disk drive. The main objects of L/UL are no slider-disk contact or no media damage. For realizing those, we must consider many design parameters in L/UL system. In this paper, we focus on lift-off force. The 'lift-off' force, defined as the minimum air bearing force, is another very important indicator of unloading performance. A large amplitude of lift-off force increases the ramp force, the unloading time, the slider oscillation and contact-possibility. To minimize 'lift-off' force we optimizes the slider and suspension using the integrated optimization frame, which automatically integrates the analysis with the optimization and effectively implements the repetitive works between them. In particular, this study is carried out the optimal design considering the process of modes tracking through the entire optimization processes. As a result, we yield the equation which can easily find a lift-off force and structural optimization for suspension.

• 비파괴검사학회지
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• 제24권4호
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• pp.348-353
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• 2004

이 연구는 터빈베어링의 신뢰성을 평가하기 위하여 초음파 C-Scan 방법을 적용한 기술이다. 수침법에 관한 연구는 실험실과 현장검사 적용에 광범위하게 사용되는 기술이다. 여기에서는 C-Scan 방법을 이용하여 베어링의 모재와 Babbitt 금속간 경계부의 상태를 평가하였다. 수침법 C-Scan 방법에 의한 초음파 영상은 베어링 경계부의 상태를 확인하는데 효과적인 방법으로 사용될 수 있었다. 초음파 영상의 분해능을 높이기 위하여 집속형 탐촉자를 사용하고, Babbitt 금속과 베어링 모재간의 접합경계면에서 발생하는 초음파 음압 반사율을 측정하여 결함의 검출과 면적을 추정할 수 있었다. 초음파 수침법은 베어링 접합부의 박리위치와 박리면적의 경계면을 결정하여 크기를 계산하는데 아주 유용하게 사용될 수 있는 기술이며, 이 연구에서 개발된 기술은 화력발전소에서 사용되고 있는 터빈베어링의 건전성을 확보하는데 적용되었다.

• 한국식품영양과학회지
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• 제22권2호
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• pp.138-143
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• 1993

초산납을 투여한 rat에 양파즙을 투여하여 양파의 납해독 능력 유무를 알아보기 위한 본 연구에서 다음 결론을 얻었다. 납만 투여한 P군은 28일간에 대조군보다 30.2% 낮은 체중 증가를 보이나 납과 함께 양파즙을 투여한 OP군은 P군보다 증가율이 약 3% 향상되었다. 외관과 해부소견상 P군은 3~4주째 OP군 보다 뚜렷한 납중독 현상 즉 경련 탈진 간변색 위점막 염증 등을 보였다. P군에서 혈청 GPT, cholesterol, blood urea nitrogen, alkaline phosphatase 값이 대조군 보다 각각 57.0, 50.3, 70.5, 71.7% 증가했다. 반면 OP군에서는 이들 측정치가 36.7, 38.5, 48.1, 37.4%로 증가하여 P군 보다 비교적 낮은 증가를 보여 양파즙에 의한 납해독 영향으로 보였다. P군의 hemoglobin 함량 9.7g/dl도 대조군 보다 37.4% 감소되나 OP군은 12.6g/dl로 개선되었다. 간의 납함량도 P군의 0.29mg/100g보다 양파즙 투여군(OP)에서 개선되어 0.1g/100g을 보였다. 28일이 경과한 P군의 다수 rat에서 간세포 변성 과 증식된 kuffer cell 내 많은량의 색소 침착과 모세혈관 주위의 출혈과 일부세포의 necrosis를 보이고 sinus 공간도 확장되었다. 그러나 OP군에서는 간세포 변성을 보이나 kuffer cell내 담흑색소량의 증가는 현저하지 않았다. 따라서 납에 중독된 rat(lead 100mg/kg rat)에 사료의 2%에 해당된 양파를 투여하므로서 납 중독의 예방 내지 중독증상을 경감할 수 있음이 나타났다.

• 한국터널지하공간학회 논문집
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• 제13권4호
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• pp.305-317
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• 2011

본 연구는 기존 모형말뚝에 인접하여 터널을 굴착하는 경우 발생하는 모형말뚝에 대한 거동연구로 이를 규명하기 위해 모형실험과 수치해석을 수행하였다. 해석 결과, 모형터널의 굴착 정도인 지반손실에 따라 수직하중을 받고 있던 모형 말뚝에 수직 및 수평변위가 동시에 발생하였으며, 이로 인해 모형말뚝이 기울어지는 현상이 발생하였다. 이러한 모형말뚝의 기울기 정도는 터널굴착으로 인한 지반손실, 터널중심으로부터 말뚝 선단부까지의 이격거리와 말뚝 선단부의 지지층 조건에 따라 크게 영향을 받는 것을 확인할 수 있었다. 따라서 도심지 터널굴착을 계획함에 있어 인접한 기존 말뚝의 위치에 따른 지반거동뿐만 아니라 말뚝 자체의 거동도 반드시 분석하여 상부구조물의 손상을 최소화해야 한다.

• 한국기계가공학회지
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• 제20권9호
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• pp.1-10
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• 2021

Recently, the repair and recycling of damaged mechanical parts via metal additive manufacturing processes have been industrial points of interest. This is because the repair and recycling of damaged mechanical parts can reduce energy and resource consumption. The directed energy deposition(DED) process has various advantages such as the possibility of selective deposition, large building space, and a small heat-affected zone. Hence, it is a suitable process for repairing damaged mechanical parts. The shaft is a core component of various mechanical systems. Although there is a high demand for the repair of the shaft, it is difficult to repair with traditional welding processes because of the thermal deformation problem. The objective of this study is to propose a repair procedure for a damaged shaft using the DED process and discuss its applications. Three types of cases, including a small shaft with a damaged surface, a medium-size shaft with a worn bearing joint, and a large shaft with serious damage, were repaired using the proposed procedure. The microstructure and hardness were examined to discuss the characteristics of the repaired component. The efficiency of the repair of the damaged shaft is also discussed.

• Journal of Dental Anesthesia and Pain Medicine
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• 제19권4호
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• pp.201-208
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• 2019

Background: After tooth extraction, pain due to dry socket and pain in the adjacent tooth are common. The aim of this study was to retrospectively analyze pain in the adjacent tooth after surgical extraction of the mandibular third molar. Methods: Postoperative pain due to dry socket, pain in the adjacent tooth, and pain from other causes were present. Group A included patents with dry socket alone; group B included patients with pain in the adjacent tooth alone; and group C included patients with both. The duration of symptoms was recorded. In addition, the prognosis of pain was divided into the complete improvement, improvement, maintenance, deterioration, and complete deterioration groups. Results: A total of 312 mandibular third molars were extracted from 13, 60, and 10 patients in groups A, B, and C, respectively. The mean duration of symptoms was 5 days in group A and B and 15.2 days in group C. There were statistically significant differences in the duration of symptoms between groups A and C and groups B and C. Conclusion: Pain in the adjacent tooth after third molar extraction can be caused by inflammatory reactions and pressure on this tooth. The pain caused by pressure on the periodontal ligament and alveolar bone results from the cytokines released by osteoclasts, which are responsible for bone destruction. However, pain from periodontal ligament damage caused by excessive pressure may be misunderstood as pulpal pain. Unconscious parafunctional habits, such as clenching and bruxism, could also be associated with post-extraction pain.

• BMB Reports
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• 제54권9호
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• pp.470-475
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• 2021

Low-dose metronomic chemotherapy has been introduced as a less toxic and effective strategy to inhibit tumor angiogenesis, but its anti-angiogenic mechanism on endothelial progenitor cells (EPCs) has not been fully elucidated. Here, we investigated the functional role of regulated in development and DNA damage response 1 (REDD1), an endogenous inhibitor of mTORC1, in low-dose doxorubicin (DOX)-mediated dysregulation of EPC functions. DOX treatment induced REDD1 expression in bone marrow mononuclear cells (BMMNCs) and subsequently reduced mTORC1-dependent translation of endothelial growth factor (VEGF) receptor (Vegfr)-2 mRNA, but not that of the mRNA transcripts for Vegfr-1, epidermal growth factor receptor, and insulin-like growth factor-1 receptor. This selective event was a risk factor for the inhibition of BMMNC differentiation into EPCs and their angiogenic responses to VEGF-A, but was not observed in Redd1-deficient BMMNCs. Low-dose metronomic DOX treatment reduced the mobilization of circulating EPCs in B16 melanoma-bearing wild-type but not Redd1-deficient mice. However, REDD1 overexpression inhibited the differentiation and mobilization of EPCs in both wild-type and Redd1-deficient mice. These data suggest that REDD1 is crucial for metronomic DOX-mediated EPC dysfunction through the translational repression of Vegfr-2 transcript, providing REDD1 as a potential therapeutic target for the inhibition of tumor angiogenesis and tumor progression.

• 한국전산구조공학회논문집
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• 제35권3호
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• pp.149-158
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• 2022

교량은 사용년한이 증가함에 따라 노후화로 인해 역학적인 성질과 구조적인 성능이 저하되고, 이로 인해서 강진 시에 내진성능이 저하된다. 교각과 교량받침에 대한 노후화를 몇 가지 단계로 정량화하여 해석모델에 반영하였고, 노후화된 교각과 교량받침에 대하여 부재-수준의 지진취약도를 평가하였다. 교량 시스템의 파괴 메카니즘을 직렬시스템으로 가정하여, 부재-수준의 지진취약도 해석 결과로부터 시스템-수준의 지진취약도를 평가하는 방법을 제안하였다. 노후도에 취약한 부재인 교각과 교량받침에 대하여 5가지 정량적인 노후도(0, 5, 10, 25, 40%)를 가정하여 부재-수준의 지진취약도를 평가하였고, 이 결과로부터 시스템-수준의 지진취약도 평가를 수행하였다. 시스템-수준의 지진취약도는 교량받침 보다는 교각이 지배적인 영향을 줌을 알 수 있었다. 이는 보다 취약한 구조부재의 지진취약도가 전체 교량시스템의 지진취약도에 지배적인 영향을 주는 것을 의미한다.