• Restorative Dentistry and Endodontics
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• 제48권2호
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• pp.21.1-21.15
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• 2023

Objectives: This study evaluated the effects of Biodentine (BD), Bio-C Repair (BCR), and mineral trioxide aggregate (MTA) plug on the fracture resistance of simulated immature teeth with replacement root resorption (RRR) and in vitro-induced osteoclastogenesis. Materials and Methods: Sixty bovine incisors simulating immature teeth and RRR were divided into 5 groups: BD and BCR groups, with samples completely filled with the respective materials; MTA group, which utilized a 3-mm apical MTA plug; RRR group, which received no root canal filling; and normal periodontal ligament (PL) group, which had no RRR and no root canal filling. All the teeth underwent cycling loading, and compression strength testing was performed using a universal testing machine. RAW 264.7 macrophages were treated with 1:16 extracts of BD, BCR, and MTA containing receptor activator of nuclear factor-kappa B ligand (RANKL) for 5 days. RANKL-induced osteoclast differentiation was assessed by staining with tartrate-resistant acid phosphatase. The fracture load and osteoclast number were analyzed using 1-way ANOVA and Tukey's test (α = 0.05). Results: No significant difference in fracture resistance was observed among the groups (p > 0.05). All materials similarly inhibited osteoclastogenesis (p > 0.05), except for BCR, which led to a lower percentage of osteoclasts than did MTA (p < 0.0001). Conclusions: The treatment options for non-vital immature teeth with RRR did not strengthen the teeth and promoted a similar resistance to fractures in all cases. BD, MTA, and BCR showed inhibitory effects on osteoclast differentiation, with BCR yielding improved results compared to the other materials.

• Journal of Animal Science and Technology
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• 제64권6호
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• pp.1117-1131
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• 2022

Previous studies reported that Bifidobacterium animalis ssp. lactis HY8002 (HY8002) improved intestinal integrity and had immunomodulatory effects. Lactobacillus plantarum HY7717 (HY7717) was screened in vitro from among 21 other lactic acid bacteria (LAB) and demonstrated nitric oxide (NO) production. The aims of this study were to investigate the individual and combined ex vivo and in vivo effects of LAB strains HY8002 and HY7717 at immunostimulating mice that have been challenged with an immunosuppressant drug. The combination of HY8002 and HY7717 increased the secretion of cytokines such as interferon (IFN)-γ, interleukin (IL)-12, and tumor necrosis factor (TNF)-α in splenocytes. In a cyclophosphamide (CTX)-induced immunosuppression model, administration of the foregoing LAB combination improved the splenic and hematological indices, activated natural killer (NK) cells, and up-regulated plasma immunoglobulins and cytokines. Moreover, this combination treatment increased Toll-like receptor 2 (TLR2) expression. The ability of the combination treatment to upregulate IFN-γ and TNF-α in the splenocytes was inhibited by anti-TLR2 antibody. Hence, the immune responses stimulated by the combination of HY8002 and HY7717 are associated with TLR2 activation. The preceding findings suggest that the combination of the HY8002 and HY7717 LAB strains could prove to be a beneficial and efficacious immunostimulant probiotic supplement. The combination of the two probiotic strains will be applied on the dairy foods including yogurt and cheese.

• 대한조현병학회지
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• 제21권2호
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• pp.43-50
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• 2018

Objectives : Genome-wide association studies (GWASs) and meta-analyses indicate that single-nucleotide polymorphisms (SNPs) in the a-1C subunit of the L-type voltage-dependent calcium channel (CACNA1C) gene increase the risk for schizophrenia and bipolar disorders (BDs). We investigated the association between the genetic variants on CACNA1C and schizophrenia and/or BDs in the Korean population. Methods : A total of 582 patients with schizophrenia, 336 patients with BDs consisting of 179 bipolar I disorder (BD-I) and 157 bipolar II disorder (BD-II), and 502 healthy controls were recruited. Based on previous results from other populations, three SNPs (rs10848635, rs1006737, and rs4765905) were selected and genotype-wise association was evaluated using logistic regression analysis under additive, dominant and recessive genetic models. Results : rs10848635 showed a significant association with schizophrenia (p=0.010), the combined schizophrenia and BD group (p=0.018), and the combined schizophrenia and BD-I group (p=0.011). The best fit model was dominant model for all of these phenotypes. The association remained significant after correction for multiple testing in schizophrenia and the combined schizophrenia and BD-I group. Conclusion : We identified a possible role of CACNA1C in the common susceptibility of schizophrenia and BD-I. However no association trend was observed for BD-II. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.

• 약학회지
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• 제56권5호
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• pp.309-313
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• 2012

Antiobesity, hypotriglyceridemic and antihypertensive activities of isoflavone-free peptide mixture (black soybean peptide, BSP) were reported in our previous experiments. In the present study, angiotensin converting enzyme inhibitory (ACEi) activity was decreased in the aorta tissues of spontaneously hypertensive rats (SHRs) treated with BSP (1% in drink water) for 4 weeks, but not in serum. BSP administration significantly decreased ACE activity by 17.5% (from $33.2{\pm}4.5$ to $27.4{\pm}1.96$ mUnit/mg, p=0.0013) in aorta tissue hydrolysate. BSP treatment also decreased significantly mean blood pressure (BP) (from $213.0{\pm}16.96$ to $184.0{\pm}6.53$ mmHg, p<0.0001) as expected. These results indicate that BSP has antihypertensive activity as well as ACEi activity.

• Journal of Welding and Joining
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• 제32권2호
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• pp.18-21
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• 2014

Cold cracking of weldment is one of the most serious welding problems. A sufficient quantity of diffusible hydrogen, a residual stress, and a sensitive microstructure are the causes of cold cracking. Removal of any one of these factors can be used to prevent cold cracking. Application of flux cored arc welding process is increasing due to high productivity and easiness of welding. In addition, to prevent cold cracking in the HAZ or weldment, preheat temperature and interpass temperature have to be controlled. In this study, the effect of preheat temperature on the levels of diffusible hydrogen in the weld metal deposited using flux cored wire was examined. The levels of preheat temperature of base metal specimen were ambient temperature, 50, 100 and $150^{\circ}C$ respectively. The result showed that the increase of preheat temperature was a linear relationship with reduction of diffusible hydrogen content in weldment.

• Journal of Welding and Joining
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• 제32권4호
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• pp.10-14
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• 2014

Laser aided Direct Metal Tooling(DMT) process is a kind of Additive Manufacturing processes (or 3D-Printing processes), which is developed for using various commercial steel powders such as P20, P21, SUS420, H13, D2 and other non-ferrous metal powders, aluminum alloys, titanium alloys, copper alloys and so on. The DMT process is a versatile process which can be applied to various fields like the mold industry, the medical industry, and the defense industry. Among of them, the application of DMT process to the mold industry is one of the most attractive and practical applications since the conformal cooling channel core of injection molds can be fabricated at the slightly expensive cost by using the hybrid fabrication method of DMT technology compared to the part fabricated with the machining technology. The main objectives of this study are to provide various characteristics of the parts made by DMT process compared to the same parts machined from bulk materials and prove the performance of the injection mold equipped with the conformal cooling channel core which is fabricated by the hybrid method of DMT process.

• 한국자동차공학회논문집
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• 제15권6호
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• pp.137-143
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• 2007

An object of this study is to understand the application characteristics in accordance with changes of EGR rate, applying BD20 reformed by ultrasonic energy irradiation to common-rail diesel engine. BD containing about 10% oxygen has attracted attention due to soaring crude oil prices and environmental pollution. This oxygen decreases soot by promoting combustion, but it also increases NOx. To make up for this problem, an EGR system is applied so that NOx might be decreased. In that case, engine power is lowered and exhaust gas is raised. However, the reformed fuel by ultrasonic energy irradiation is changed physically and chemically, promotes combustion, and thus solves such a problem. As the results of the experimemt, we could identify the optimum EGR rate by investigating the engine performance and the characteristics of exhaust materials in accordance with the EGR rate after ultrasonic energy irradiation to BD20 and applying it to common-rail diesel engine. The optimum EGR rate that can satisfy both engine performance and characteristics of exhaust materials was in the range of 15%.

• 방송공학회논문지
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• 제21권4호
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• pp.578-591
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• 2016

본 논문에서는 HEVC 부호화기의 속도를 향상시키기 위하여, 움직임 벡터의 군집화를 통한 코딩 블록의 최대 분할 깊이를 결정하는 방법을 제안한다. 현재 HEVC (High Efficiency Video Coding)의 참조 소프트웨어 HM은 최적의 코딩 블록 구조를 찾기 위해 다양한 코딩 블록의 깊이들에 대한 율-왜곡 최적화 (RDO: Rate-Distortion Optimization)를 수행한다. 하지만 이는 부호화기의 높은 복잡도를 차지하는 요소 중 하나로 보고된다. 본 논문에서는 최적의 코딩 블록 구조를 움직임 벡터의 군집화 된 결과에 따라 결정함으로써, 부호화 과정에서 코딩 블록 구조를 찾기 위한 RDO의 복잡도를 줄임으로써 부호화기의 속도를 향상시키는 방법을 제안한다. 제안하는 방법은 전처리 과정으로부터 원본 영상에 대한 움직임 벡터 계산, 이를 통한 계층적 군집화를 수행하여, 군집화된 경향을 기반으로 코딩 블록의 최대 깊이를 결정한다. 본 논문의 제안하는 방법은 HEVC 참조 소프트웨어 대비 평균 1.45% BD-rate 손실이 있었으며 평균 16%의 부호화 속도 향상을 보였다. 또한, 기존의 고속화 방법과 함께 적용한 경우 1.84% BD-rate 손실과 45.13%의 평균 부호화 속도 향상을 나타냈다.

• 한국의류산업학회지
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• 제21권3호
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• pp.318-325
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• 2019

This study analyzes current self-nail tips and nail-tip satisfaction. The study method selected from 3 domestic and 3 overseas companies analyzed current self-nail tips based on brand recognition and sales rate. A questionnaire was conducted on 261 adult women in their 20s and 50s about the satisfaction of nail care and self-nail tips. The results are as follows. As a result to analyze the current nail tips, there were products that did not contain the type of nail tip or the composition and ingredients of the glue. An online survey of the sizes of the current nail tips indicated differences in the sizing system method and that the presented sizes are different. The response rate was the highest for the survey results on why self-nail tips were preferred for respondents who prefer self-nail tips because the price was cheap. The reason why they did not prefer self-nail tips was that the degree of completeness was lower and the fitness was not good. In addition, it showed a high response rate in that the adhesive strength was poor and the size did not fit the nails. Therefore, it is necessary to develop a size for nail types by ergonomic design and develop a self-nail tip that can reduce nail damage.

• 한국ITS학회 논문지
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• 제21권1호
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• pp.91-104
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• 2022

Level 3 자율주행차의 상용화가 가시화됨에 따라 자율주행차의 운행설계영역(ODD)이 고속도로 외 도심도로로 확대될 필요가 있다. 본 연구는 도심도로 내 인프라-자율차 간 협력주행 기반의 자율주행차 서비스에 대한 교통운영효율성 및 안전성 측면의 효과평가를 통해 도심도로 자율협력주행 서비스의 실효성을 분석하였다. 도심도로 자율협력주행 서비스의 구현 및 효과평가는 미시교통시뮬레이션모델을 활용하였으며, 각 서비스별 중점관리목표에 따른 개별적인 효과평가 지표를 선정하여 효과 분석에 활용하였다. 분석 결과, V2X 통신 기반의 자율협력주행 서비스를 통해 자율주행차량의 교통운영 효율성과 안전성이 향상됨을 확인하였고, 그 효과는 자율주행차의 시장점유율이 증가할수록 커지는 것으로 분석되었다. 본 연구는 단속류인 도심도로를 대상으로 V2X 통신 기반의 자율협력주행 서비스의 효과를 도출해낸 것에 의의가 있으며, 향후 자율협력주행 서비스 검증 기반이 마련되는데 기초자료로 활용될 수 있을 것으로 기대된다.