• 대한수학회보
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• 제48권1호
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• pp.169-182
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• 2011

The main object of this paper is to introduce and investigate new subclasses of normalized analytic functions in the open unit disc $\mathbb{U}$, which generalize the familiar class of k-starlike functions. The various properties and characteristics for functions belonging to these classes derived here include (for example) coefficient inequalities, distortion theorems involving fractional calculus, extreme points, integral operators and integral means inequalities.

• Bulletin of the Korean Chemical Society
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• 제31권12호
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• pp.3632-3638
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• 2010

2-Iminopyrimidines (1a-e) and 2-thioxopyrimidine (2) were synthesized using the Biginelli three component cyclocondensation reaction of an appropriate $\beta$-diketone, arylaldehyde, and guanidine (for 1a-e) or thiourea (for 2). The electrochemical properties of the novel systems were investigated by CV and DPV. Moreover, B3LYP/6-31G(d,p) method was applied to the present structures in order to gather some structural and physicochemical data.

• 디지털콘텐츠
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• 6호통권133호
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• pp.123-127
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• 2004

1989년 배트맨(Batman), 2000년 엑스맨(X-man), 2002년 스파이더맨(Spider-man), 2003년 헐크(Hulk). 21세기 들어 매년 전세계 극장가는‘맨(Man)’의 바람으로 한차례 술렁인다. 이 영화들의 메인 캐릭터는 모두 인간보다 우월한 호모슈피리얼(homosuperial)들이다. 폭풍과도 같은‘맨’류 영화의 공통점은 무엇일까. 우선 미국의 만화 출판사의 양대 산맥인‘마블(Marvel)’과‘DC코믹스’의 스테디셀러라는 점이다. 둘째로 2004년의 시점에서도 끊임없이 후속 영화를 기획하고 연출한다는 점이고, 셋째로 게임시장에서 다양한 형태로 활용된다는 점을 들 수 있다. 그리고 마지막으로 캐릭터 상품으로 이어진다는 점이다. 원 소스 멀티 유즈(One Source Multi Use)를 최고의 가치로 여기는 21세기 문화시장에 있어서 이들은 그야말로 모범답안이요 보증수표라 할 만 하다. 이 모범답안을 적극 활용하기 위해서는 표면의 흥행요소뿐만 아니라, 심층의 이야기 확장 가능성을 짚어볼 필요가 있다.

• 대한수학회논문집
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• 제37권3호
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• pp.939-955
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• 2022

In this paper, we study a first-order non-linear singularly perturbed Volterra integro-differential equation (SPVIDE). We discretize the problem by a uniform difference scheme on a Bakhvalov-Shishkin mesh. The scheme is constructed by the method of integral identities with exponential basis functions and integral terms are handled with interpolating quadrature rules with remainder terms. An effective quasi-linearization technique is employed for the algorithm. We establish the error estimates and demonstrate that the scheme on Bakhvalov-Shishkin mesh is O(N^-1) uniformly convergent, where N is the mesh parameter. The numerical results on a couple of examples are also provided to confirm the theoretical analysis.

• 만화애니메이션 연구
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• 통권49호
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• pp.53-85
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• 2017

본 연구는 애니메이션 시장의 새로운 윈도우를 활성화시키기 위해 DC 코믹스(DC Comics)의 슈퍼히어로 만화를 원작으로 하는 워너 브러더스(Warner Bros)사의 슈퍼히어로 애니메이션 제작 시스템을 분석했다. 이는 국내의 미디어 환경에서 DVD용으로 제작되는 과정을 적용할 수 있는 윈도우로 IPTV를 고려할 수 있게 되었기 때문이다. 각 작품의 엔딩 크레딧을 분석하는 일종의 텍스트 분석으로서 제작 관여 인력의 역할과 인원을 분석 대상으로 했다. 총 애니메이션 28편을 분석한 결과 다음과 같이 나타났다. 제작 시스템에서 나타나는 특징은 첫째 제작자 혹은 감독의 역할을 복수에 걸쳐 하는 인물들이 있다는 점이고, 둘째 개인이 아닌 복수의 인물에 의한 집단 제작 시스템을 활용한다는 점이며, 셋째 감독과 제작자의 역할을 모두 담당하는 인물 활용이라는 점이다. 외주 시스템에서 나타나는 특징으로는 첫째 한국과 일본의 기업만이 외주에 참여하고 있고, 둘째 한 해에 제작되는 작품을 한 기업이 모두 전담하기보다는 2개 정도의 기업에 분산되고 있으며, 셋째 편당 참여인력 면에서는 일본의 인력이 한국의 인력보다 많다는 점이다. 넷째, <배트맨: 고담 나이트> (Batman: Gotham Knight)는 완성형 제작방식에 조금 더 근접했고, 다섯째 일본 기업이 한국 기업에게 업무를 주는 재하청의 모습도 나타나고 있으며, 여섯째 한국 업체의 투입인력의 역할은 주요 집중 업무가 key 제작으로 변화가 조금 있다. 한국 애니메이션 제작 시스템에 대한 적용하기 위한 핵심도 제작 시스템 운영방식과 외주 제작 시스템이라는 특성에 따라 제시할 수 있다. 제작 시스템 운영 부분에서는 첫째 제작 시스템의 집단화에 대한 고려가 필요하다는 점이고, 둘째 유니버스형 스토리텔링 개발이 필요하다는 점이다. 외주 시스템 부분에서는 첫째 2D 애니메이션 분야에 대한 교육을 지속해야 한다는 점과, 둘째 글로벌 외주 사업에 대한 적극적 참여라는 점이다. 이러한 적용을 통해 제작자의 역할을 강화하고 제작 경험을 축적하면서 IPTV와 같은 다른 윈도우를 이용할 수 있는 애니메이션의 지속적 제작을 유도할 수 있을 것으로 본다. 이러한 캐릭터 중심의 세계관에 대한 연구가 후속 연구로서 두 가지 차원에서 제시될 필요가 있다. 하나는 세계관의 구축으로 가능한 기존의 이야기 자원에 대한 개발에 관한 것이다. 기존의 역사 속에서 세계관 구축이 가능한 캐릭터를 개발하는 것은 고대 게르만족의 신화인 토르가 그 예라고 할 수 있다. 다른 하나는 세계관 구축을 전제로 하는 작품의 개발에 대한 것이다. 현재 영화 등에서 자주 활용되고 웹툰의 캐릭터를 세계관 구축이 가능한 형태로 확장시키는 것은 스토리 기반 콘텐츠들 간의 연계를 강화하는 동시에 애니메이션 작품의 양산을 유도할 수 있다는 장점이 있으므로 이에 대한 연구가 필요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3461-3463
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• 2013

Background: Non-Hodgkin lymphoma (NHL) is a solid tumour of lymphocytes, important elements in the immune system. According to 2006 data, in Turkey the incidence was 6.5 per 100,000 in males, and 4.4 in females. The relationship between the use of pesticides and development of NHL has been extensively investigated in many studies, and it has been demonstrated that the risk of NHL is increased by exposure to such compounds. Antalya is a region of intensive agricultural activity. In this study, the relationship between the incidence of lymphoma in Antalya and the amount of pesticides employed was investigated. Materials and Methods: The study used data from 1995 to 2010 on the patients from the databank of TR Ministry of Health, Antalya Provincial Health Directorate, Cancer Registration Center and the patients who were histopathologically diagnosed with NHL during these years. Results: The relationship between the amount of pesticide used and the incidence was studied with the Spearman correlation analysis and the p value was found as 0.05. The correlation coefficient was 0.497. An increase in the NHL incidence over the years was identified, with a 2.42-fold increment found from 1995 to 2005 and a 2.77 fold elevation from 1995 to 2010. The use of pesticides increased 1.89 fold over the same period. Conclusions: Our study investigated the relationship of the pesticides used with NHL patients diagnosed during the same year. Since the time elapsing after exposure to pesticides until the development of cancer is not clear, no comparison can be made at present. We believe that the increase in use of pesticides since 1995 may be associated with the increase in the incidence of NHLand therefore that further studies on the issue including measurements of serum pesticide levels, are required.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1041-1045
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• 2015

Background: Paget's disease (PD) is a rare form of intraepithelial adenocarcinoma that involves breast and extramammarian tissues. It is often associated with ductal carcinoma in situ and/or invasive ductal cancer. Molecular pathways that play a role in development of Paget's disease are stil unclear. Expression patterns of Cox-2 and bcl-2 were therefore assessed. Materials and Methods: Patients with a histopathological diagnosis of Paget's disease were included in this study. Patient files were analysed retrospectively. Results: Invasive cancer was diagnosed in 35 (76.1%) of the patients, 7 (15.2%) had ductal carcinoma in situ and 4 (8.7%) patients had no associated neoplasm. Twenty four (52.2%) patients showed COX-2 expression in Paget cells whereas no expression was seen in 22 (47.8%) patients. No relation was found between COX-2 expression and the lesion underlying Paget's disease (p=0.518). Bcl-2 expression in Paget cells was found positive in 12 (26.1%) and negative in 27 (58,7%) cases. There was no relation between Bcl-2 expression and the lesion accompanying Paget's disease (p=0.412). No relation was observed between COX-2 expression and Bcl-2 expression (p=0.389). Conclusions: In breast cancer, COX-2 expression is associated with poor prognostic factors. As COX-2 expression increases the tendency to metastasize also increases. In our study we found a significantly high COX-2 expression in Paget's disease of the breast. We suggest that COX-2 expression and inflammatory processes may play a role in pathogenesis of the Paget's disease of the breast.

• Safety and Health at Work
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• 제13권2호
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• pp.180-186
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• 2022

Background: In occupational studies, it is a known situation that technical and organizational attempts are used to prevent occupational accidents. Especially in the mining sector, if these attempts cannot prevent occupational accidents, personal protective equipment (PPE) becomes a necessity. Thus, in this study, the main objective is to examine the effects of the variables on the use of PPE and identify important factors. Methods: A questionnaire was implemented and structural equation modeling was conducted to ascertain the significant factors affecting the PPE use of mining employees. The model includes the factors that ergonomics, the efficiency of PPE and employee training, and PPE usage habit. Results: The results indicate that ergonomics and employee training have no significant effect (p > 0.05) on the use of PPE. The efficiency of PPE has a statistically meaningful effect (p < 0.05) on the use of PPE. Various variables have been evaluated in previous studies. However, none of them examined the variables simultaneously. Conclusion: The developed model in the study enables to better focus on ergonomics and employee training in the PPE usage. The effectiveness of a PPE makes its use unavoidable. Emphasizing PPE effectiveness in OHS training and even showing them in practice will increase employees' PPE usage. The fact that a PPE with high effectiveness is also ergonomic means that it will be used at high rates by the employee.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6669-6671
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• 2014

Background: We here examined the awareness of female health employees (doctors, nurses, midwives) working in primary health care service about cervical cancer and its risk factors. Additionally attitude and behavior for gynecologic examination and pap smear screening wwere researched. Materials and Methods: This cross-sectional, descriptive study con cerned female health employees working at primary health care services in two southern cities of Turkey, over a four month period in 2013. Participants were recently or previously sexually active research was explained and verbal informed consent was obtained face to face. The questionnaire consisted of two parts; socio-demographic characteristics and level of knowledge about cervical cancer and its risk factors. Results: The average age of the participants (midwives 43.7%, n=143; nurses 40.4%, n=132; doctors 6.4%, n=21; emergency medical technicians and others, 9.5%, n=31; total, n=327) was $30.9{\pm}6.41$ years. 64.2% (n=210) were working in Diyarbakir and 35.8% (n=117) in Batman. A large proportion reported low knowledge and inadequate screening practice Conclusions: Health employees should be better informed about the importance of screening for cancers, given their preventive roles for the general population.

• BMB Reports
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• 제53권3호
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• pp.154-159
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• 2020

We investigated the effects of physalin A, B, D, and F on osteoclastogenesis induced by receptor activator of nuclear factor κB ligand (RANKL). The biological functions of different physalins were first predicted using an in silico bioinformatic tool (BATMAN-TCM). Afterwards, we tested cell viability and cell apoptosis rate to analyze the cytotoxicity of different physalins. We analyzed the inhibitory effects of physalins on RANKL-induced osteoclastogenesis from mouse bone-marrow macrophages (BMMs) using a tartrate-resistant acid phosphatase (TRAP) stain. We found that physalin D has the best selectivity index (SI) among all analyzed physalins. We then confirmed the inhibitory effects of physalin D on osteoclast maturation and function by immunostaining of F-actin and a pit-formation assay. On the molecular level, physalin D attenuated RANKL-evoked intracellular calcium ([Ca(2+)](i)) oscillation by inhibiting phosphorylation of phospholipase Cγ2 (PLCγ2) and thus blocked the downstream activation of Ca2+/calmodulin-dependent protein kinases (CaMK)IV and cAMP-responsive element-binding protein (CREB). An animal study showed that physalin D treatment rescues bone microarchitecture, prevents bone loss, and restores bone strength in a model of rapid bone loss induced by soluble RANKL. Taken together, these results suggest that physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via suppressing the PLCγ2-CaMK-CREB pathway.