• Journal of Microbiology and Biotechnology
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• 제4권4호
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• pp.333-337
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• 1994

In order to develop the whey beverage, we examined the optimum conditions for alcohol fermentation by Kluyveromyces tragilis ATCC 46537. The optimum conditions for alcohol production by K. fragilis ATCC 46537 were as follows; pH 4.5, $30^{\cir}C$, with a supplement of 50 g/l of lactose. To develop a continuous production of alcohol from whey, we compared batch fermentation with continuous iermentation in conjunction with UF system. Batch fermentation produced 11.0 g/l of alcohol, whereas pseudocontinuous and continuous fermentation with UF system produced 8.5 g/l of alcohol. To increase the alcohol production, we added 50 g/l of lactose to both fermentations. Batch fermentation with lactose supplement produced 15.7 g/l of alcohol and continuous fermentation with lactose supplement in conjunction with UF system produced 15.0 g/l of alcohol. These results clearly demonstrate that the UF system can be used to increase the alcohol production from whey, supplemented with exogenous lactose.

• 한국산업정보학회논문지
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• 제12권4호
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• pp.107-118
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• 2007

A single-server queueing model with infinite buffer and batch arrival of customers is considered. In contrast to the standard batch arrival when a whole batch arrives into the system at one epoch, we assume that the customers of an accepted batch arrive one-by one in exponentially distributed times. Service time is exponentially distributed. Flow of batches is the stationary Poisson arrival process. Batch size distribution is geometric. The number of batches, which can be admitted into the system simultaneously, is subject of control. Analysis of the joint distribution of the number batches and customers in the system and sojourn time distribution is implemented by means of the matrix technique and method of catastrophes. Effect of control on the main performance measures of the system is demonstrated numerically.

• 한국산업경영시스템학회:학술대회논문집
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• 한국산업경영시스템학회 2002년도 춘계학술대회
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• pp.387-396
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• 2002

Batch processes are a significant class of processes in the process industry and play an important role in the production of high quality speciality materials. Examples include the production of semiconductors, chemicals, pharmaceuticals, and biochemicals. With on-line sensors connected to most batch processes, massive amounts of data are being collected routinely during the batch on easily measured process variables such as temperatures, pressures, and flowrates. In this paper, multivariate SPC charts for on-line monitoring of the progress of new batches are developed which utilize the information in the on-line measurements in real-time. We propose the formation of statistical model which describes the normal operation of a batch at each time interval during the batch operation. An on-line monitoring scheme based on the proposed method can handle both cross-correlation among process variables at any one time and auto-correlation over time. And the control limits for the monitoring charts are established from sound statistical framework unlike previous researches which use the external reference distribution. The proposed charts perform real-time, on-line monitoring to ensure that the batch is progressing in a manner that will lead to a high-quality product or to detect and indicate faults that can be corrected prior to completion of the batch. This approach is capable of tracking the progress of new batch runs, identifying the time periods in which the fault occurred and detecting underlying cause.

• 상하수도학회지
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• 제32권1호
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• pp.11-18
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• 2018

As the sequencing batch reactor process is a time-oriented system, it has advantages of the flexibility in operation for the biological nutrient removal. Because the sequencing batch reactor is operated in a batch system, respiration rate is more sensitive and obvious than in a continuous system. The variation of respiration rate in the process well represented the characteristics of biological reactions, especially nitrification. The respiration rate dropped rapidly and greatly with the completion of nitrification, and the maximum respiration rate of nitrification showed the activity of nitrifiers. This study suggested a strategy to control the aeration of the sequencing batch reactor based on respirometry. Aeration time of the optimal aerobic period required for nitrification was daily adjusted according to the dynamics of respiration rate. The aeration time was mainly correlated with influent nitrogen loadings. The anoxic period was extended through aeration control facilitating a longer endogenous denitrification reaction time. By respirometric aeration control in the sequencing batch reactor, energy saving and process performance improvement could be achieved.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 Proceedings of the Korea Automatic Control Conference, 11th (KACC); Pohang, Korea; 24-26 Oct. 1996
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• pp.303-306
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• 1996

We propose a robust tuning method of the quadratic criterion based iterative learning control(Q-ILC) algorithm for discrete-time linear batch system. First, we establish the frequency domain representation for batch systems. Next, a robust convergence condition is derived in the frequency domain. Based on this condition, we propose to optimize the weighting matrices such that the upper bound of the robustness measure is minimized. Through numerical simulation, it is shown that the designed learning filter restores robustness under significant model uncertainty.

• Environmental Engineering Research
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• 제19권1호
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• pp.91-99
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• 2014

Ordinary heterotrophic organism (OHO) active biomass plays key roles in biological wastewater treatment processes. However, due to the lack of measurement techniques, the OHO active biomass exists hypothetically within the design and simulation of biological wastewater treatment processes. This research was purposed to develop a quick and easy quantifying technique for the OHO active biomass applying a modified batch aerobic growth test. Two nitrification-denitrification activated sludge systems, with 10- and 20-day sludge ages, were operated to provide well-cultured mixed liquor to the batch tests. A steady state design model was firstly applied to quantify the "theoretical" OHO active biomass concentration of the two parent systems. The mixed liquor from the parent systems was then inoculated to a batch growth test and a batch digestion test to estimate the "measured" OHO active biomass concentration in the mixed liquor. The measured OHO active biomass concentrations with the batch growth test and the batch digestion test were compared to the theoretical concentrations of the parent system. The measured concentrations with the batch growth test were generally smaller than the theoretical concentrations. However, the measured concentrations with the batch aerobic digestion tests showed a good correlation to the theoretical concentrations. Thus, a different microbial growth condition (i.e., a higher food/biomass ratio) in the batch growth test, compared to the parent system or the batch digestion test, was found to cause underestimation of the OHO active biomass concentrations.

• KSBB Journal
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• 제15권5호
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• pp.489-496
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• 2000

고농도 유전자 재조합 대장균을 이용하여 pyruvate dehy-drogenase complex-E2 특이성 인간 모노클론 항체의 Fab 부분을 효율적으로 생산하기 위해 회분식, 이단 연속식, 반 유 가식, two-stage cyclic fed-batch 동 여러 가지 배양 방법이 조사되었다. 먼저 플라스미드 안정성 문제를 극복하기 위해 growth stage와 production stage를 분리하는 two-phase 회분식 배양과 이단 연속식 시스템을 시도하였다 그 결과 two-phase 회분식 배양보다는 이단 연속식 배양에서의 세포농도와 항체 생산성이 우수하였다 또한 이단 연속식 배양에서의 세포 성 장과 항처l 생산성은 용존산소를 제어한 경우가 그렇지 않은 경우보다 월등하게 높았다. 그리고 plasmid 안정성에 있어서 는 실험기간 내에 거의 100%를 유지하여 높은 안정도를 보 여주었다. 유가식 공정에 적합한 공급 배지로 변형된 M9 배 지가 최적배지로 선정되었고 이 배지 중 최적의 CjN 비율을 조사한 결파 2:3으로 결정되었다. 반 유가식 시스템에서 constant feeding 전략을 사용할 경우 최적 공급속도는 $0.6g/\ell/hr$이었다. 또한 pulse에 의해 공급배지를 공급할 경우에는 총 공급 량이 같을 경우 소량으로 자주 공급해 주는 것이 공급배지를 한꺼번에 많은 양을 공급해주는 것 보다 바람직하였다. 여러 가지 feeding 전략을 조사해 본 결과 linear feeding 방법이 가장 효과적이었다. 하지만 linear feeding 방법마저도 고농도 세포배양에 한계가 있었기 때문에 pH-stat 방법을 이용한 two-stage cyclic fed-batch 시스템을 시도하여 $54 g/\ell$의 세포 를 얻을 수 있었다. 따라서 이 방법이 일단 생산성 향상을 위한 세포의 고농도 배양에는 조사한 여러 배양 시스템 중에 가장 효율적인 시스템임올 알 수 있었다 하지만 이 시스템 에서 포도당을 낮은 level로 유지할 수 있었으나, 초산의 과도한 축적으로 항체 생산성의 향상은 예상에 비해 크지 않았다.

• Environmental Engineering Research
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• 제11권2호
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• pp.63-76
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• 2006

Multivariate analysis and batch monitoring on a pilot-scale sequencing batch reactor (SBR) are described for integrated wastewater treatment management system, where a batchwise multiway independent component analysis method (MICA) are used to extract meaningful hidden information from non-Gaussian wastewater treatment data. Three-way batch data of SBR are unfolded batch-wisely, and then a non-Gaussian multivariate monitoring method is used to capture the non-Gaussian characteristics of normal batches in biological wastewater treatment plant. It is successfully applied to an 80L SBR for biological wastewater treatment, which is characterized by a variety of error sources with non-Gaussian characteristics. The batchwise multivariate monitoring results of a pilot-scale SBR for integrated wastewater treatment management system showed more powerful monitoring performance on a WWTP application than the conventional method since it can extract non-Gaussian source signals which are independent and cross-correlation of variables.

• 대한산업공학회지
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• 제38권2호
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• pp.89-97
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• 2012

This paper considers a manufacturer with a two-station make-to-stock and make-to-order serial production system. The MTS facility produces a single type of component and provides components for the MTO facility that produces customized products. In addition to the internal demand from the MTO facility, the MTS facility faces demands from the spot market with the option of to accept or reject each incoming demand. This paper addresses a joint component inventory rationing and batch production control which maximizes the manufacturer's profit. Using the Markov decision process model, we investigate the structural properties of the optimal inventory rationing and batch production policy, and present two types of heuristics. We implement a numerical experiment to compare the performance of the optimal and heuristic policies and a simulation study to examine the impact of the stochastic process variability on the inventory rationing and batch production control.

• 산업경영시스템학회지
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• 제17권32호
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• pp.177-186
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• 1994

Economic Lot size decision is studied on this thesis foe the muti-product small batch production system. Even though economic lot size decision has been studied for the MRP system. this could be applied at the industry under the multi-product small batch production system because of very complicate and manager's lack of understand. Therefore, this technique is applied at the industry in order to minimize ordering cosy based on optimal quantity and period, and holding cost according to optimize inventory level under the muti-product small batch production system. After that, lot size decision technique is compared with lot size decision technique which has been used for analyzing and emphasizing productivity