• 산업경영시스템학회지
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• 제42권1호
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• pp.55-63
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• 2019

This paper develops an algorithm to determine the batch size of the batch process in real time for improving production and efficient control of production system with multiple processes and batch processes. It is so important to find the batch size of the batch process, because the variability arising from the batch process in the production system affects the capacity of the production. Specifically, batch size could change system efficiency such as throughput, WIP (Work In Process) in production system, batch formation time and so on. In order to improve the system variability and productivity, real time batch size determined by considering the preparation time and batch formation time according to the number of operation of the batch process. The purpose of the study is to control the WIP by applying CONWIP production system method in the production line and implements an algorithm for a real time batch size decision in a batch process that requires long work preparation time and affects system efficiency. In order to verify the efficiency of the developed algorithm that determine the batch size in a real time, an existed production system with fixed the batch size will be implemented first and determines that batch size in real time considering WIP in queue and average lead time in the current system. To comparing the efficiency of a system with a fixed batch size and a system that determines a batch size in real time, the results are analyzed using three evaluation indexes of lead time, throughput, and average WIP of the queue.

• 한국시뮬레이션학회논문지
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• 제5권2호
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• pp.59-72
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• 1996

The purpose of this study is to make an improvement to the batch-means method, which is a procedure to construct a confidence interval(c.i.) for the steady-state process mean of a stationary simulation output process. In the batch-means method, the data in the output process are grouped into batches. The sequence of means of the data included in individual batches is called a batch-menas process and can be treated as an independently and identically distributed set of variables if each batch includes sufficiently large number of observations. The traditional batch-means method, therefore, uses a batch size as large as possible in order to. destroy the autocovariance remaining in the batch-means process. The c.i. prodedure developed and empirically tested in this study uses a small batch size which can be well fitted by a simple ARMA model, and then utilizes the dependence structure in the fitted model to correct for bias in the variance estimator of the sample mean.

• 제어로봇시스템학회논문지
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• 제12권12호
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• pp.1163-1168
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• 2006

Manufacturing technology for the production of high value-added fine chemical products is emphasized and getting more attention as the diversified interests of customers and the demand of high quality products are getting bigger and bigger everyday. Thus, the development of advanced batch processes, which is the preferred and most appropriate way of producing these types of products, and the related technologies are becoming more important. Therefore, high-precision batch distillation is one of the important elements in the successful manufacturing of fine chemicals, and the importance of the process operation strategy with quality assurance cannot be overemphasized. Accordingly, proposing a process structure explanation and operation strategy of such processes including batch processes and batch distillation would be of great value. We investigate optimal operation strategy and production planning of multi-purpose plants consisting of batch processes and batch distillation for the manufacturing of fine chemical products. For the short-term scheduling of a sequential multi-purpose batch plant consisting of batch distillation under MPC and UIS policy, we proposed a MILP model based on a priori time slot allocation. Also, we consider that the waste product of being produced on batch distillation is recycled to the batch distillation unit for the saving of raw materials. The developed methodology will be especially useful for the design and optimal operations of multi-purpose and multiproduct plants that is suitable for fine chemical production.

• 한국초전도ㆍ저온공학회논문지
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• 제8권1호
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• pp.23-25
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• 2006

Optimization of process variables, including oxygen and water partial pressure and also an nesting temperature, was performed in batch-type process to fabricate YBCO films on LaAlO3 single crystal. In this work, YBCO oxide powder was used as a starting precursor for metal-organic deposition(MOD)method. The precursor films were fabricated in batch furnace and they were converted to the epitaxial YBCO films at the same furnace with varying the process variables. The oxygen partial pressure was varied from 100ppm to 2000ppm and the water partial pressure from 1.2% to 12.2%. The window for optimal P(O2) was narrow about 700ppm for batch-type process. YBCO films in bathc-thype MOD process were optimized at 740-770oC and P(H2O) of 2.3%-7.3%.

• Korean Chemical Engineering Research
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• 제44권5호
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• pp.425-434
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• 2006

석유화학공업으로 대표되는 공정산업의 연속공정들은 지난 20여 년간 모델예측제어를 중심으로 고급제어(APC)기법들이 도입되며 운전성 및 생산성 향상에 많은 진보를 이루었다. 이에 반하여 중합반응기를 비롯한 각종 회분공정에는 APC 기법의 도입이 아직 활발히 이루어지지 않고 있다. 이것은 회분공정의 독특한 문제점을 극복하며 원하는 성능을 보장할 수 있는 방법론이 제시되지 못한 데에 가장 큰 이유가 있다고 할 수 있다. 그러나 최근 이러한 문제점들을 극복할 수 있는 APC 기법들이 반복학습제어(ILC)에 근거하여 개발되며 회분공정 APC 환경에 큰 변화가 일어나고 있다. 본 논문에서는 이들 기법들이 다양한 실제 공정에 활발하게 적용되어 운전을 개선할 수 있기를 기대하며, ILC를 기반으로 한 최근의 회분공정 APC 연구동향을 이론과 실례를 통해 소개한다.

• 한국초전도ㆍ저온공학회논문지
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• 제7권3호
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• pp.9-12
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• 2005

[ $Y_1Ba_2Cu_3O_{7-8}$ ] (YBCO) coated conductor has been fabricated by batch-type process using oxide-precursor-based metal-organic deposition (MOD) method. The batch-type process can be scaled up more simply to Produce long-length YBCO conductor than the reel-to-reel process. Also, it has less handling problems and is adequate to the ambient gas environment. In this work, YBCO oride powder was used as a starting precursor for MOD method. After reel-to-reel dip coating process, me ter-long-buffered metal tape was wound around a cylinder and underwent calcination and annealing processes. Annealed YBCO films showed good c-axis alignment and dense surface morphology with no cracks, but exhibited very low critical current density of $10^5\;A/cm^2$.

• Journal of Microbiology and Biotechnology
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• 제19권12호
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• pp.1695-1702
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• 2009

An animal-component-free and chemically defined fed-batch process for GS-engineered cell lines producing recombinant antibodies has been developed. The fed-batch process relied on supplying sufficient nutrients to match their consumption, simultaneously minimizing the accumulation of by-products (lactate and osmolality). The proportionalities of nutritional consumption were determined by direct analysis. The robust, metabolically responsive feeding strategy was based on the offline measurement of glucose. The fed-batch process was shown to perform equivalently in GS-CHO and GS-NS0 cultures. Compared with batch cultures, the fed-batch technology generated the greater increase in cell yields (5-fold) and final antibody concentrations (4-8-fold). The majority of the increase in final antibody concentration was a function of the increased cell density and the prolonged culture time. This generic and high-yielding fed-batch process would shorten development time, and ensure process stability, thereby facilitating the manufacture of therapeutic antibodies by GS-engineered cell lines.

• 한국산업경영시스템학회:학술대회논문집
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• 한국산업경영시스템학회 2002년도 춘계학술대회
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• pp.387-396
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• 2002

Batch processes are a significant class of processes in the process industry and play an important role in the production of high quality speciality materials. Examples include the production of semiconductors, chemicals, pharmaceuticals, and biochemicals. With on-line sensors connected to most batch processes, massive amounts of data are being collected routinely during the batch on easily measured process variables such as temperatures, pressures, and flowrates. In this paper, multivariate SPC charts for on-line monitoring of the progress of new batches are developed which utilize the information in the on-line measurements in real-time. We propose the formation of statistical model which describes the normal operation of a batch at each time interval during the batch operation. An on-line monitoring scheme based on the proposed method can handle both cross-correlation among process variables at any one time and auto-correlation over time. And the control limits for the monitoring charts are established from sound statistical framework unlike previous researches which use the external reference distribution. The proposed charts perform real-time, on-line monitoring to ensure that the batch is progressing in a manner that will lead to a high-quality product or to detect and indicate faults that can be corrected prior to completion of the batch. This approach is capable of tracking the progress of new batch runs, identifying the time periods in which the fault occurred and detecting underlying cause.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1991년도 한국자동제어학술회의논문집(국제학술편); KOEX, Seoul; 22-24 Oct. 1991
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• pp.1718-1723
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• 1991

The determination of a production sequence is an important problem in a batch process operation. In this paper a new algorithm for a near optimal production sequence of N product in an M unit serial multiproduct batch process is proposed. The basic principle is the same as that of Johnson's algorithm for two-unit UIS system. Test results on a number of selected examples exhibit the superiority over previously reported results. In addition, a tabulation technique is presented to calculate the makespan of a given sequence of production for all processing units under UIS mode.

• Journal of Microbiology and Biotechnology
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• 제11권5호
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• pp.887-889
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• 2001

The gene encoding yeast pro-carboxypeptidase Y (pro-CPY) has been cloned and expressed in Escherichia coli. Most of the expressed pro-CPY was accumulated as cytoplasmic insoluble aggregates. In our previous study, active CPY was obtained by renaturation of entirely denatured pro-CPY followed by in vitro proteolytic processing with proteinase K along with the activation process. The same refolding process was performed to produce an active CPY from pro-CPY inclusion bodies with renaturation buffers containing proteinase K at different concentrations. The refolding efficiency decreased from $25\%\;to\;2\%$ in the renaturation buffers containing proteinase K at concentrations of $60{\mu}g/ml\;and\;0.6{\mu}g/mi$, respectively. In an attempt to increase the refolding efficiency with a lesser amount of proteinase K, a novel fed-batch refolding process was developed. In a fed-batch refolding, 99 ml of the renaturation buffer containing pro-CPY was gradually added into 1 ml of the renaturation buffer containing $60{\mu}g/ml$ of proteinase K to give a final proteinase K concentration of $0.6{\mu}g/ml$. The fed-batch refolding process resulted in a refolding efficiency of $18\%$, which corresponded to a 9-fold increase over that ($2\%$) in the batch process.