• 대한간호
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• 제32권4호
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• pp.48-62
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• 1993

This study was done for the purpose of analyzing the job-satisfaction and its depressive factors in human relation of operating room nurses of university hospital. Therfore, it makes an offer the basic data to help the resolution and prevention of the problems in operating room nurses. Furthermore, this study was conducted in order to find out some kinds of scientific data for the better control of depressive factors of job-satisfaction expressed by the operating room nurses. The structred questionaire reports of 246 operating room nurses who were employed in 5 different university hospitals which have over 1, 000 beds located in Seoul, Korea were used, which wer collected from August 24th to August 30th of 1992. The author visited supervisors of operating room in each university hospital and explained the aim of this study. The most of them(90.0%) answered to the questionaires. Analysis of the collected data were done by mean, standard deviation, percentage, t-test, F-test, Q-test, correlation analysis, one-way ANOVA.and stepwise multiple regression analysis. Major findings of this study were as follows: 1. The job of the operating room nurses were remarkably related with the satisfaction in human relation, which was defined as the behavioral job with thoughtful action rather than with mechanical action. However, the degree of satisfaction in human relation with personnel in other departments was found to be the lowest and its the main depressive factors were appeared due to the absence of interaction and uncooperative attitudes. Therefore, it was required that the members of other job need more cooperative attitude to the actual works in the operating room nurses. 2. The depressive factors in the satisfaction degree of human relation with offical seniors wer significantly related with their irresponsibility and partialness. Moreover, the job attitude of the operating room nurses is abundantly required to be improved, 3. The depressive factors in the satisfaction of human relation with medical doctors were significantly related with their insincerity and the class-consciousness. It is clearly suggested that the medical doctors do more cooperative behaviors for the jobs of the operating room without the suggested that the medical doctors do more cooperative behaviors for the jobs of the operating room without the superiority feeling of class-consciousness. 4. There was a significantly positive association between the satisfaction degree of human relation of the nurses with the following charateristics. (1) The registered nurses which had a tendency to be satisfied about the registered nurses' job. (2) The registered nurses which had a tendency to be a technique-aptitued in the motivation of the registered nurses'job. (3) The registered nurses which had a tendency to be satisfied about the total hospital working carrier and the aspects of old ages. Finally, these findings indicated that the operating room nurses should require the professional education courses associated with a high-development techniques and setisfaction in their jobs.

• Journal of Nutrition and Health
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• 제46권1호
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• pp.15-25
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• 2013

The purpose of this study is to investigate the proportion and associated risk factors of hypertriglyceridemia in rural Vietnamese women. Research data were collected as part of the Korean Genome and Epidemiology Study (KoGES). A cross-sectional study of 957 Vietnamese women in their 20 to 30s was conducted in rural areas of Bavi, Vietnam. Subjects were classified as hypertriglyceridemic (serum TG ${\geq}$ 150 mg/dL). Demographic, socio-economic details, anthro-pometric measurements, and blood profiles were recorded. The proportion of hypertriglyceridemic subjects was 22.0%, and the mean age of hypertriglyceridemics subjects was older than that of normo-triglyceridemic subjects (p < 0.05). In hypertriglyceridemic subjects, height, HDL-cholesterol, and LDL-cholesterol were significantly lower, compared to subjects with normo-triglyceridemia, while weight, body mass index, waist hip ratio, body fat %, blood pressure, fasting blood sugar, total cholesterol, and atherogenic index were higher, compared to those with normo-triglyceridemia. Intake of cereal and cereal products, total plant food, and cereal/potato fiber in subjects with hypertriglyceridemia was significantly higher, compared to normo-triglyceridemic subjects. Hypertriglyceridemic subjects had a significantly lower intake of animal calcium and retinol than normo-triglyceridemic subjects. Significant positive relationships were observed between the prevalence of hypertriglyceridemia and consumption of total plant food [OR (95% CI) for the highest tertile, compared to the lowest: 1.764 (1.131-2.750); p for trend = 0.008] and crude fiber [OR (95% CI) for the highest tertile compared to the lowest: 1.651 (1.092-2.497); p for trend = 0.027]. In addition, a significant inverse relationship was observed between the prevalence of hypertriglyceridemia and cholesterol intake [OR (95% CI) for the highest tertile, compared to the lowest: 0.601 (0.400-0.901); p for trend = 0.012]. These findings may provide basic data for use by policymakers and dieticians in future development of nutrition and health programs to encourage healthier eating habits, and to prevent hypertriglyceridemia advancing cardiovascular disease in rural Vietnamese women.

• 여성건강간호학회지
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• 제2권2호
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• pp.230-252
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• 1996

Over one million cases of the induced abortion have been conducted annually in Korea. Among those cases, most of all were illegally done, but this has not been addressed in the literature. While Korean Nurse Association Code of Ethics presents the respect for life as one of the basic ideology, it was not dealt enough in nursing education. The purposes of the study were to activate the debate on the issues related to an induced abortion ; to introduce the related ethical theories ; and to seek the solution of the ethical problems, which will eventually result in establishing the morality of nursing practice. The ethical theories of an induced abortion have traditionally addressed two extreme perspectives ; the conservatives who emphasize the sanctity of human life and the right of life that will never ethically allow the killing fetus ; and the liberalists who insist the right to choice for women to control their body. Since these extreme theories has not been helpful to solve the ethical problems, the recent trend is leading to the modified theories both from conservative and liberal perspectives. The examples of the theories are the potentiality of fetus(Singer, 1993), the obligation of women to serve their body to fetus(Held, 1987), the Replacement theory (Callahan, 1987), and the Principle of Caring (Gilligan, 1982). The study conducted the indepth interviews with 17 women who experienced the induced abortion and the 6 cases were selected to be analyzed. The cases were analyzed and interpreted by using an integrated case method which was combined of the New Casuisty(Jonsen & Toulmin, 1988 ; Jonsen, 1991) and the Specified Principlism (Richardson, 1990 ; Degrazia, 1992). The result of analysis revealed three types of ethical problems ; (1) the responsibility of taking care of the baby to be born (2) the fear for the condition of the fetus, and (3) the choice of induced abortion as the method of birth control. The findings also revealed the related ethical principles for various situations ; the principle of caring was used for choosing an induced abortion by the subjects ; the principles of the potentiality of fetus and the obligation of women to serve their body were for the consideration for the life of fetus ; and the principle of replacement was utilized for the right to choice for women. The ethical principles related to an induced abortion introduced in the study provided the way to solve the moral problems by applying to the clinical situations for nurses. The study also revealed the possibility of modifying the current ethical theories from the method of applying the principles to the various situation in the study. The modified theories would be more useful to guide the clinical practice with similar ethical problems.

• Asian-Australasian Journal of Animal Sciences
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• 제16권1호
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• pp.77-82
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• 2003

This investigation was conducted to study the effect of dietary formic acid (FA) and propionic acid (PA) mixture on inhibitory effect of Salmonella pullorum in layer chicks. Nine groups of one day-old layer chicks in addition to positive and negative controls, were fed with acids treated feed containing mixture of different acids concentrations, from 0.5% and 0.5% up to 1.5% and 1.5% FA and PA, respectively. Positive and negative controls were fed untreated feed. Groups except the negative control were challenged orally on day three with $10^4$ cfu/ml S. pullorum. Cloacal swabs were taken at three successive days and at 7, 14 and 21 days of challenge. After 1, 2 and 3 weeks after challenge, 4 chicks from each group were sacrificed and crop and cecal contents were examined for S. pullorum and pH. The numbers of S. pullorum positive culture from the excretion of all treated groups except groups treated with mixture of 0.5% and 0.5%, 1% and 0.5%, 0.5% and 1% FA and PA decreased significantly (p<0.05) as compared with the positive control. The mortality rates of all treated groups except the group treated with 0.5% FA and 0.5% PA were decreased significantly (p<0.05) as compared with the positive control. The treatment significantly (p<0.05) lowered the pH of the crop and cecal contents in all groups except the group treated with 0.5% FA and 0.5% PA as compared with the control. Also, the treatment significantly (p<0.05) lowered the pH of the crop and cecal contents in all groups after three weeks of treatment compared to the first and second weeks. The treatments significantly (p<0.05) lowered the frequency of S. pullorum recovery from crop and cecal contents in six groups treated with 1.5 and 0.5, 1 and 1, 1.5 and 1, 0.5 and 1.5, 1 and 1.5, 1.5% and 1.5% FA and PA respectively. These results indicate that addition of FA and PA mixture in a total concentration of 2 % or more to the diet of newly hatched infected layer chicks significantly decreases the crop and cecal colonization by S. pullorum and significantly decreases S. pullorum fecal excretion and reduced the chick mortality rate.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2527-2532
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• 2012

Objectives: The aim of the present study was to explore mechanisms underlying the effects of down-regulating ${\beta}$-catenin expression on esophageal carcinoma (EC) cells. Methods: Cell cycle distribution and apoptosis were determined using flow cytometry and annexin V apoptosis assay, respectively. Transmission electron microscopy (TEM) was used to examine changes in ultrastructure, while expression of cyclin D1 protein and mRNA was detected by western blot and real-time PCR. Proliferating cell nuclear antigen (PCNA) and extracellular signal-regulated kinase (ERK) 1-2 were evaluated by Western blot analysis. PCNA labeling index (LI) was determined by immunocytochemistry. Results: Compared with pGen-3-con transfected and Eca-109 cells, the percentage of G0/G1-phase pGen-3-CTNNB1 transfected cells was obviously increased (P<0.05), with no significant difference among the three groups with regard to apoptosis (P>0.05). pGen-3-CTNNB1 transfected cells exhibited obvious decrease in cyclin D1 mRNA and protein expression (P<0.05) and the ultrastructure of Eca-109 cells underwent a significant change after being transfected with pGen-3-CTNNB1, suggesting that down-regulating ${\beta}$-catenin expression can promote the differentiation and maturation. The expression of PCNA and the ERKI/2 phosphorylation state were also down-regulated in pGen-3-CTNNB1 transfected cells (P<0.05). At the same time, the PCNA labeling index was decreased accordingly (P<0.05). Conclusion: Inhibition of EC Eca-109 cellproliferation by down-regulating ${\beta}$-catenin expression could improve cell ultrastructure by mediating blockade in G0/G1 through inhibiting cyclin D1, PCNA and the MAPK pathway (p-ERK1/2).

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.49-54
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• 2014

Background: Hydrogels are a class of polymers that can absorb water or biological fluids and swell to several times their dry volume, dependent on changes in the external environment. In recent years, hydrogels and hydrogel nanocomposites have found a variety of biomedical applications, including drug delivery and cancer treatment. The incorporation of nanoparticulates into a hydrogel matrix can result in unique material characteristics such as enhanced mechanical properties, swelling response, and capability of remote controlled actuation. Materials and Methods: In this work, synthesis of hydrogel nanocomposites containing magnetic nanoparticles are studied. At first, magnetic nanoparticles ($Fe_3O_4$) with an average size 10 nm were prepared. At second approach, thermo and pH-sensitive poly (N-isopropylacrylamide -co-methacrylic acid-co-vinyl pyrrolidone) (NIPAAm-MAA-VP) were prepared. Swelling behavior of co-polymer was studied in buffer solutions with different pH values (pH=5.8, pH=7.4) at $37^{\circ}C$. Magnetic iron oxide nanoparticles ($Fe_3O_4$) and doxorubicin were incorporated into copolymer and drug loading was studied. The release of drug, carried out at different pH and temperatures. Finally, chemical composition, magnetic properties and morphology of doxorubicin-loaded magnetic hydrogel nanocomposites were analyzed by FT- IR, vibrating sample magnetometry (VSM), scanning electron microscopy (SEM). Results: The results indicated that drug loading efficiency was increased by increasing the drug ratio to polymer. Doxorubicin was released more at $40^{\circ}C$ and in acidic pH compared to that $37^{\circ}C$ and basic pH. Conclusions: This study suggested that the poly (NIPAAm-MAA-VP) magnetic hydrogel nanocomposite could be an effective carrier for targeting drug delivery systems of anti-cancer drugs due to its temperature sensitive properties.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1441-1446
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• 2014

Squamous cell/adenosquamous carcinoma (SC/ASC) of the gallbladder are rare tumors and there are few clinical reports in the literature. Herein we report our clinical experience with 46 patients with SC/ASC and 80 with adenocarcinoma (AC). Expression of EphB1 and Ephrin-B in each tumor was determined using immunohistochemical methods for determination of correlations with prognosis. There was no difference in EphB1 and Ephrin-B expression between SC/ASC and AC tumors (P>0.05), but greater expression in those less than 3 cm in diameter, stage I or II (TNM stage), with no lymph node metastases, with no local invasion and treated with radical resection was apparent. Expression of EphB1 (P<0.05) and Ephrin-B (P<0.01) was higher in well differentiated than in poorly differentiated AC tumors. Kaplan-Meier survival analysis indicated that degree of differentiation, tumor diameter, lymph node metastases, local invasion, surgical approach and expression rate of EphB1 and Ephrin-B were closely related to the survival of SC/ASC (P<0.05) and AC patients (P<0.01). Patients with tumors that positive expressed EphB1 and Ephrin-B, whether it is SC/ASC ($P_{SC/ASC}$ =0.000) or AC ($P_{AC}$ =0.000 or $P_{AC}$ =0.002) had longer survival than those negative expression. Cox multivariate analysis indicated a negative correlation between expression of EphB1 or Ephrin-B and overall survival. Hence, EphB1 and Ephrin-B could be regarded as independent good prognostic factorsand important biological markers for SC/ASC and AC of gallbladder.

• 한국정보통신학회논문지
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• 제5권1호
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• pp.89-101
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• 2001

한의학에서 진단과 치료의 기본 대상인 경혈.경락의 혈위 식별을 위한 방법으로 기존의 방식은 직류를 인체 피부에 자극하여 저정항 양도점을 식별하고 있다. 그러나 직류를 인체에 인가하면 시간에 따라 전류가 감소하는 현상이 있어서 반복 측정 시에 식별율 및 재현성이 감소되는 식별데이터의 신뢰성이 충분하지 못한 단점이 있으며 세포에 분극현상을 일으켜서 인체의 생리적 상태에 영향을 준다. 또한 직류방식은 식별계측에 시간이 다소 길게 소요되며 전류감쇠현상으로 낮아진 측정 전류량을 얻기 위해서는 전극의 압력이 증가하게 되며 그 전극누름 압력에 의한 통증을 유발시킨다. 이를 개선하기 위하여 전류의 시간적 감소현상과 인체 영향력을 최소화할 수 있는 경혈자극 패턴의 최적 파라메터를 추출하고, 이를 적용한 SPAC(Single Power Alternative Current) 자극방식을 제안하였다. 이는 주파수를 1.28V의 4kHz로 결정하고, 듀티비가 40%인 구형파에 가까운 파형을 추출하였다. 또한 피부 상태에 관계없이 식별이 어려군 부위에서도 식별이 용이하도록 피부 전류량의 절대값과 상대값을 레벨메터에 동시에 표시하고, 측정 전류량을 그래프로 연속 표시하여 식별에 유리한 알고리즘을 제안하였다. 추출된 최적 파라메터와 알고리즘을 적용한 식별시스템을 구현하여 성능을 기존의 직류방식과 비교 검토한 결과, 식별율(경혈과 비경혈의 상대차)은 19.6%, 재현성은 15.1%, 인체영향력은 11.2%, 고전 경혈점과의 부합율은 18.4% 향상되었음을 확인하였다.

• 한국산학기술학회논문지
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• 제19권4호
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• pp.423-432
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• 2018

이 연구는 40-59세의 중년들이 갖고 있는 여러 가지 건강행태 중에서 고밀도지단백(HDL) 콜레스테롤에 영향을 명확히 미치는 건강행태를 파악함으로써 한국 중년의 건강증진에 도움이 되는 기초자료를 제공되고자 한다. 국민건강영양조사의 제4기 3차년도(2009), 제5기의 1차년도(2010), 2차년도(2011), 3차년도(2012), 제6기의 1차년도(2013) 등 총 5개년의 원시데이터를 합하여 사용하여 7,406명을 최종분석 대상자로 선정하였다. 고밀도지단백 콜레스테롤을 40mg/dl 미만과 40mg/dl 이상으로 두 집단으로 구분했다. 다중 로지스틱 회귀분석을 시행한 결과, 여자보다 남자일 경우 OR=3.916배, 비만 유병이 저체중에서 정상일 경우 OR=3.439배, 비만일 경우 OR=7.336배, 음주자일 때 OR=1.629배, 흡연자일 때 OR=1.498배, 중등도 신체활동 미실천일 시 OR=1.426배, 걷기 미실천일 시 OR=1.264배, 탄수화물을 과소 섭취할 때보다 적정 섭취할 때 OR=1.510배, 과다 섭취할 때 OR=1.787배 고밀도지단백(HDL) 콜레스테롤이 40mg/dl 이상에서 40mg/dl 미만으로 될 확률이 증가하였다. 한국 중년의 고밀도지단백(HDL) 콜레스테롤 수치를 높여 적절한 건강을 유지하기 위해서는 유산소 운동, 금연, 절절한 음주, 비만 해소, 건강한 식습관과 건강한 식품 선택으로 인한 외식이 이루어져야 한다. 이를 위해서는 지역사회 내에서 지속적인 홍보와 교육이 필요하며, 건강행태를 생활 속에서 실천할 수 있도록 하는 사회적 환경이 구축되어야 할 것이다.

• 융합정보논문지
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• 제8권1호
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• pp.9-14
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• 2018

본 연구는 맨발 보행과 운동화 착용 보행에서 보행주기의 차이를 비교하여 보행역학에 따른 신발 개발에 기초자료를 제공하고자 한다. 발의 변형과 이상이 없는 정상 성인 여성 30명을 대상으로 보행 주기를 측정하였다. 먼저 운동화를 착용하고 보행하여 주기를 측정한 후, 맨발로 보행하여 주기를 측정하여 데이터를 얻었다. 이후 두 데이터를 대응표본 T-test를 이용하여 비교하였다. 실험 결과 맨발 보행에서 입각기 좌측(p<.001), 우측(p<.005), 체중부하기 좌측(p<.009), 우측(p<.002), 전유각기 좌측(p<.002), 우측(p<.011), 양하지 지지기(p<.004)가 증가하였고, 중간 입각기 좌측(p<.016), 우측(p<.001), 유각기 좌측(p<.001)이 감소하였다. 이는 맨발 보행이 다양한 발의 감각의 입력을 증가시켜 보행안정성이 높은 보행이 가능해 졌다고 보여 지며, 향후 보행 주기에 의거하여 맨발보행과 가까운 신발 개량이 필요하다고 사료된다. 향후 신발의 개량을 위해 신발 종류에 따른 보행주기 연구가 필요할 것이다.