• Experimental and Molecular Medicine
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• 제50권12호
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• pp.13.1-13.12
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• 2018

We aimed to explore whether changes in circulating levels of miRNAs according to type 2 diabetes mellitus (T2DM) or prediabetes status could be used as biomarkers to evaluate the risk of developing the disease. The study included 462 patients without T2DM at baseline from the CORDIOPREV trial. After a median follow-up of 60 months, 107 of the subjects developed T2DM, 30 developed prediabetes, 223 maintained prediabetes and 78 remained disease-free. Plasma levels of four miRNAs related to insulin signaling and beta-cell function were measured by RT-PCR. We analyzed the relationship between miRNAs levels and insulin signaling and release indexes at baseline and after the follow-up period. The risk of developing disease based on tertiles (T1-T2-T3) of baseline miRNAs levels was evaluated by COX analysis. Thus, we observed higher miR-150 and miR-30a-5p and lower miR-15a and miR-375 baseline levels in subjects with T2DM than in disease-free subjects. Patients with high miR-150 and miR-30a-5p baseline levels had lower disposition index (p = 0.047 and p = 0.007, respectively). The higher risk of disease was associated with high levels (T3) of miR-150 and miR-30a-5p ($HR_{T3-T1}=4.218$ and $HR_{T3-T1}=2.527$, respectively) and low levels (T1) of miR-15a and miR-375 ($HR_{T1-T3}=3.269$ and $HR_{T1-T3}=1.604$, respectively). In conclusion, our study showed that deregulated plasma levels of miR-150, miR-30a-5p, miR-15a, and miR-375 were observed years before the onset of T2DM and pre-DM and could be used to evaluate the risk of developing the disease, which may improve prediction and prevention among individuals at high risk for T2DM.

• Journal of Multimedia Information System
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• 제4권4호
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• pp.179-188
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• 2017

The Internet Video Coding (IVC) standard is due to be published by Moving Picture Experts Group (MPEG) for various Internet applications such as internet broadcast streaming. IVC aims at three things fundamentally: 1) forming IVC patents under a free of charge license, 2) reaching comparable compression performance to AVC/H.264 constrained Baseline Profile (cBP), and 3) maintaining computational complexity for feasible implementation of real-time encoding and decoding. MPEG experts have worked diligently on the intellectual property rights issues for IVC, and they reported that IVC already achieved the second goal (compression performance) and even showed comparable performance to even AVC/H.264 High Profile (HP). For the complexity issue, however, there has not been thorough analysis on IVC decoder. In this paper, we analyze the IVC decoder in view of the time complexity by evaluating running time. Through the experimental results, IVC is 3.6 times and 3.1 times more complex than AVC/H.264 cBP under constrained set (CS) 1 and CS2, respectively. Compared to AVC/H.264 HP, IVC is 2.8 times and 2.9 times slower in decoding time under CS1 and CS2, respectively. The most critical tool to be improved for lightweight IVC decoder is motion compensation process containing a resolution-adaptive interpolation filtering process.

• Fisheries and Aquatic Sciences
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• 제6권3호
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• pp.110-115
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• 2003

Expressed sequence tag (EST) analysis was conducted using a cDNA library made from the liver mRNA of olive flounder (Paralichthys olivaceus). In the survey of 421 ESTs, 362 showed significant homology to previously described genes while 59 were unidentified or novel. Comparative analysis of the identified ESTs showed that 69 $(19.0\%)$ clones were identified as homologous to the previously reported olive flounder ESTs, and 279 $(77.1\%)$ clones were identified as orthologs of known genes from other organisms. The remaining 14 $(3.9\%)$ clones were identified as orthologs of known sequences with unknown functions. These tagged cDNA clones, identified and unidentified, could provide fundamental baseline data for genomic studies of this species.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.127-132
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• 1999

Cardiovascular, respiratory and electrodermal responses to acute stress episodes modeled by combined presentation of intense white noise and performance of word recognition task with noise background were studied in 15 college students. Experimental procedure consisted in sessions with white noise, word recognition task presentation with noise background and test with noise background. Recorded physiological variables were analyzed in terms of their sensitivity to detect activation of sympathetic and parasympathetic branches of autonomic nervous system and thus reflect autonomic arousal level during shout-term stress-inducing experimental manipulations. It was shown that performance of effortful mental task with noise background elicited significant physiological responses typical for active coping behavior, namely electrodermal arousal and increased cardiovascular activity. this response profile was more profound as compared to white noise only or attending task in noise background. However, all physiological responses were mostly phasic, without long-term tonic changes, since almost all variables recovered to their initial baseline levels, suggesting that dominant autonomic mechanisms in transient acute stress episodes were of parasympathetic nature (withdrawal in stress with subsequent activation in restoration period), while sympathetic contribution was not long-lasting. Nevertheless, increased number of stressors and their longer exposure may result in higher profile of tonic sympathetic arousal and reduced functional role of vagal mechanisms in autonomic balance regulation.

• Advances in aircraft and spacecraft science
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• 제2권3호
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• pp.329-343
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• 2015

This study aimed to observe the effect of a novel concept (referred to as the flap extension) implemented on the leading edge of the flap of a three element high lift device. The high lift device, consisting of a flap, main element and slat is designed around an Airbus research profile for sufficient take off and landing performance of a large commercial aircraft. The concept is realised on the profile and numerically optimised to achieve an optimum geometry. Two different optimisation approaches based on Genetic Algorithm optimisations are used: a zero order approach which makes simplifying assumptions to achieve an optimised solution: as well as a direct approach which employs an optimisation in ANSYS DesignXplorer using RANS calculations. Both methods converge to different optimised solutions due to simplifying assumptions. The solution to the zero order optimisation showed a decreased stall angle and decreased maximum lift coefficient against angle of attack due to early stall onset at the flap. The DesignXplorer optimised solution matched that of the baseline solution very closely. The concept was seen to increase lift locally at the flap for both optimisation methods.

• Investigative and Clinical Urology
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• 제59권6호
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• pp.399-409
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• 2018

Purpose: To analyze data from an observational, prospective, cumulative registry study in 805 hypogonadal men stratified by mild or moderate-to-severe lower urinary tract symptoms (LUTS) according to International Prostate Symptom Score. Materials and Methods: A total of 412 men underwent testosterone therapy (TTh) with injectable testosterone undecanoate, 393 men served as untreated controls. Measures of urinary function, anthropometric and metabolic parameters were performed at least twice per year. Results: Data from 615 men with mild LUTS (253 treated, 362 untreated) and 190 with moderate-to-severe LUTS (159 treated, 31 untreated) were available. During a follow-up period of 8 years a significant improvement of LUTS was noted for all TTh-patients whereas the control-groups showed deterioration or fluctuation around initial values. Despite advancing age, TTh fully prevented worsening of symptoms. In parallel, a considerable improvement of anthropometric parameters, lipids and glycemic control, blood pressure, C-reactive protein, and quality of life was found. Moderate-to-severe LUTS was associated with worse cardiometabolic risk profile at baseline as well as worse cardiovascular outcomes during follow-up in comparison to mild LUTS. Effect size of TTh was more pronounced in men with moderate-to-severe than with mild LUTS. Conclusions: Correcting hypogonadism by TTh is highly effective and safe for improving LUTS in hypogonadal men. TTh may also improve cardiometabolic risk and major adverse cardiovascular events.

• Nutrition Research and Practice
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• 제11권6호
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• pp.479-486
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• 2017

BACKGROUND/OBJECTIVES: Timing of almond intake during a day may result differently in the perspectives of body composition and changes of lipid profile. The current study was conducted to compare the effects of daily almond intake as a preload versus as a snack on body composition, blood lipid profile, and oxidative and inflammation indicators among young Korean adults aged 20-39 years old. SUBJECTS/METHODS: Participants were randomly assigned to one of three groups: a pre-meal almond group (PM), a snack almond group (SN) in which participants were instructed to consume 56 g of almonds either as a preload before meals or as a snack between meals, respectively, and a control group (CL) in which participants were provided high-carbohydrate iso-caloric control food. Measurements were performed at baseline, weeks 8 and 16. RESULTS: A total of 169 (M 77 / F 92) out of the 227 participants completed the study between June 2014 and June 2015 (n = 58 for PM; 55 for SN; and 56 for CL). A significant decrease in body fat mass was observed in the PM group at both weeks 8 and 16 compared with the CL. There were significant intervention effects on changes of body fat mass (P = 0.025), body fat percentages (P = 0.019), and visceral fat levels (P < 0.001). Consuming almonds as a daily snack reduced the levels of total cholesterol (P = 0.043) and low-density lipoprotein (LDL) cholesterol (P = 0.011) without changing high-density lipoprotein (HDL) cholesterol compared with the CL. CONCLUSION: Almond consumption as a preload modified body fat percentages, whereas snacking on almonds between meals improved blood lipid profiles. This trial was registered at ClinicalTrials.gov as NCT03014531.

• Nutrition Research and Practice
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• 제10권3호
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• pp.313-320
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• 2016

BACKGROUND/OBJECTIVES: This study was conducted to compare the overall changes in dietary intake and metabolic syndrome risk parameters in Vietnamese marriage-based female immigrants over time. SUBJECTS/METHODS: The subjects of this study were 581 Vietnamese marriage-based female immigrants, who were recruited from local clinical centers in Korea. Baseline data were collected from 2006-2011 and the follow-up data were collected from 2012-2014. Dietary food intake was assessed by a 1-day 24-hour recall method. RESULTS: Compared to the baseline, the mean body weight, body mass index, waist circumference, high density lipoprotein (HDL)-cholesterol, systolic blood pressure and diastolic blood pressure increased while the fasting blood sugar, triglycerides and low density lipoprotein-cholesterol decreased at follow-up. The total consumption of foods such as vegetables/fruits/seaweeds/mushrooms, oil and fat, and eggs decreased during the follow-up period, whereas the consumption of sugars, beverages and meats increased. Partial correlation between the rate of change [(Follow-up - Baseline) / Baseline ${\times}100$] in metabolic syndrome risk parameters and food intake after controlling for confounding factors showed that the waist circumference was positively correlated with either the total plant food intake (r = 0.1042, P = 0.0129) or the total food intake (r = 0.0880, P = 0.0359). The plasma levels of total cholesterol (r = -0.1918, P = 0.0289) and HDL-cholesterol (r = -0.1424, P = 0.0007) were negatively correlated with the percentage of total intake from plant food, and HDL-cholesterol levels were positively correlated with the intake of total animal food (r = 0.0980, P = 0.0217). The serum C-reactive protein levels were positively correlated with the total intake of animal food (r = 0.2374, P < 0.0001) or the percentage of total intake from animal food (r = 0.1346, P = 0.0016). CONCLUSIONS: These results suggest that the change rate of dietary intake such as total plant food or animal food is associated with the change rates of metabolic syndrome risk parameters.

• ETRI Journal
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• 제27권5호
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• pp.491-496
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• 2005

An application specific processor for an H.264 decoder with a configurable embedded processor is designed in this research. The motion compensation, inverse integer transform, inverse quantization, and entropy decoding algorithm of H.264 decoder software are optimized. We improved the performance of the processor with instruction-level hardware optimization, which is tailored to configurable embedded processor architecture. The optimized instructions for video processing can be used in other video compression standards such as MPEG 1, 2, and 4. A significant performance improvement is achieved with high flexibility. Experimental results show that we could achieve 300% performance for the H.264 baseline profile level 2 decoder.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2005년도 추계종합학술대회
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• pp.39-42
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• 2005

H.264, a recently proposed international video coding standard, has adopted context-based adaptive variable length coding (CAVLC) as the entropy coding tool in the baseline profile. By combining an adaptive variable length coding technique with context modeling, we can achieve a high degree of redundancy reduction. However, CAVLC in H.264 has weakness that the correct prediction rate of the variable length coding (VLC) table is low in a complex area, such as the boundary of an object. In this paper, we propose a VLC table prediction scheme considering multiple reference blocks; the same position block of the previous frame and the neighboring blocks of the current frame. The proposed algorithm obtains the new weighting values considering correctness of the VLC table for each reference block. Using this method, we can enhance the prediction rate of the VLC table and reduce the bit-rate.