• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4291-4295
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• 2015

Background: Chemokines and their receptors influence carcinogenesis and cysteine-cysteine chemokine receptor 5 (CCR5) directs spread of cancer to other tissues. A 32 base pair deletion in the coding region of CCR5 that might alter the expression or function of the protein has been implicated in a variety of immune-mediated diseases. The action of antiviral drugs being proposed as adjuvant therapy in cancer is dependent on CCR5 wild type status. In the present study, distribution of CCR5${\Delta}32$ polymorphism was assessed in North Indian esophageal cancer patients to explore the potential of using chemokine receptors antagonists as adjuvant therapy. Materials and Methods: DNA samples of 175 sporadic esophageal cancer patients (69 males and 106 females) and 175 unrelated healthy control individuals (69 males and 106 females) were screened for the CCR5${\Delta}32$ polymorphism by direct polymerase chain reaction (PCR). Results: The frequencies of wild type homozygous (CCR5/CCR5), heterozygous (CCR5/${\Delta}32$) and homozygous mutant (${\Delta}32/{\Delta}32$) genotypes were 96.0 vs 97.72%, 4.0 vs 1.71% and 0 vs 0.57% in patients and controls respectively. There was no difference in the genotype and allele frequencies of CCR5${\Delta}32$ polymorphism in esophageal cancer patients and control group. Conclusions: The CCR5${\Delta}32$ polymorphism is not associated with esophageal cancer in North Indians. As the majority of patients express the wild type allele, there is potential of using antiviral drug therapy as adjuvant therapy.

• Journal of Korea Multimedia Society
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• v.13 no.5
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• pp.730-739
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• 2010

One of core technology in Web 2.0 is tagging, which is applied to multimedia data such as web document of blog, image and video etc widely. But unlike expectation that the tags will be reused in information retrieval and then maximize the retrieval efficiency, unacceptable retrieval results appear owing to toot limitation of tag. In this paper, in the base of preceding research about image retrieval through tag clustering, we design and implement a topic map generation system which is a semantic knowledge system. Finally, tag information in cluster were generated automatically with topics of topic map. The generated topics of topic map are endowed with mean relationship by use of WordNet. Also the topics are endowed with occurrence information suitable for topic pair, and then a topic map with semantic knowledge system can be generated. As the result, the topic map preposed in this paper can be used in not only user's information retrieval demand with semantic navigation but alse convenient and abundant information service.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.6
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• pp.1091-1098
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• 2009

In this paper, we designed the authentication system for home network service and applied it to actual sensor nodes. The pair-wise pre-distribution key skim is applied for prevention of authentication key from sniffing on the wireless sensor networks. The authentication key and data are encrypted by using the CBC mode RC5 algorithm based on the SPINS. The experimental environment consists of a base station (BS)and sensor nodes and each sensor node sends both sensing data and the encrypted authentication key to the BS. For simulations we set up some what-if scenarios of security menaces in home network service.Slightly modified the TOS_Msg data arrays of TinyOS is suggested to store 8-byte authentication key which can enable data encryption and authentication at the each sensor node. As a result, malfunction caused by communication between BS and nodes of other groups of added nodes having malicious purpose can be protected. Also, we confirmed that a critical data of home networking service like vital signal can be transmitted securely through this system by encryption technique.

• BMB Reports
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• v.41 no.5
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• pp.388-393
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• 2008

The Pphsc70 (heat shock cognate 70) gene was isolated from the endoparasitoid Pteromalus puparum and then characterized. The full-length cDNA was 2204 base pair (bp) and contained a single 1968 bp ORF that encoded a polypeptide of 656 amino acids with a predicted molecular mass of 71.28 kDa. Phylogenetic analysis based on Hsc70 amino acid sequences from fifteen insect species agreed with the present phylogeny. In addition, genomic DNA confirmed the presence of three introns located at the coding region as well as the 5'UTR. A significant elevation of Pphsc70 expression was observed following heat treatment, however, continued exposure to heat shock or recovery caused the expression of induced mRNA to gradually decline to levels that were significantly lower than those of control pupae (P < 0.05). In addition, a significant increase was observed in the emergence rate of pupae that were preheated at $40^{\circ}C$ and then exposed to $50^{\circ}C$ for 1 h when compared with the pupae that were not preheated, but instead directly exposed to $50^{\circ}C$. Taken together, these results revealed that exposure to gradually increasing temperatures can enhance an insects thermo-tolerance.

• KIPS Transactions on Computer and Communication Systems
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• v.4 no.1
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• pp.5-10
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• 2015

D2D (Device-to-Device) communication underlaying LTE-advanced networks is a promising technology to improve the system capacity and spectral efficiency. By sharing the same radio resources with cellular user equipments, D2D communications can significantly enhance the overall spectral efficiency. However, it may cause interference between D2D link and cellular link. Careful resource allocation and interference coordination between cellular and D2D communications are very important and need to be properly handled. This paper proposes a radio resource allocation scheme based on FFFR (Flexible Fractional Frequency Reuse) for D2D communication underlaying cellular networks. The base station selects randomly resource blocks assigned to cellular users, and reuses them for a D2D pair. Through simulations, we have confirmed that the proposed scheme improves the system throughput, reduces the computational complexity, and mitigates the interference of D2D link and cellular link.

• Journal of KIISE:Software and Applications
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• v.41 no.8
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• pp.598-604
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• 2014

In this paper, we develop stepwise regression data envelopment model to select important variables. We formulate null hypothesis to understand the importance of each variable and use Kruskal-Wallis test for this purpose. If the Kruskal-Wallis test does reject the null hypothesis this will imply there is significant fluctuation in the efficiency score relative to base model. And therefore we have to further check the pair of variables that causes the fluctuation in order to determine its importance using Conover-Inman test. The proposed models helps understand the extent of misclassification decision making units as efficient/inefficient when variables are retained or discarded alongside provides useful managerial prescription to make improvement strategies.

• KIPS Transactions on Software and Data Engineering
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• v.9 no.8
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• pp.243-250
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• 2020

Knowledge graph-based question answering not only requires deep understanding of the given natural language questions, but it also needs effective reasoning to find the correct answers on a large knowledge graph. In this paper, we propose a deep neural network model for effective reasoning on a knowledge graph, which can find correct answers to complex questions requiring multi-hop inference. The proposed model makes use of highly expressive bilinear graph neural network (BGNN), which can utilize context information between a pair of neighboring nodes, as well as allows bidirectional feature propagation between each entity node and one of its neighboring nodes on a knowledge graph. Performing experiments with an open-domain knowledge base (Freebase) and two natural-language question answering benchmark datasets(WebQuestionsSP and MetaQA), we demonstrate the effectiveness and performance of the proposed model.

• Journal of the Institute of Convergence Signal Processing
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• v.2 no.2
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• pp.20-27
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• 2001

3D image coding and transmission technologies are essential for transmitting 3D image information through the limited transmission channel, and very important in the area of information and telecommunication services using 3D image media. In this paper, we propose the 3D image coding and transmission methods welch use disparity information and MPEG-2's scalability. Left and Fight image sequences are coded in base layer and enhancement layer, respectively. The enhancement layer contains the disparity and prediction informations. In order to reduce searching time for disparity information, we propose a method in which the disparity information of previous image paid is used in the next image pair, and we adopt the bit rate control method proposed in MPEG-2 TM6. An experimental result showed that the proposed searching method considerably reduced the entire encoding time and reached the desired bit rates.

• Journal of Microbiology and Biotechnology
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• v.26 no.12
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• pp.2192-2198
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• 2016

The myeloid-specific IgA Fc receptor ($Fc{\alpha}R$) is a cell surface molecule on immunocytes that provides a fundamental connection between humoral and cellular immunity. In this study, the full-length cDNA sequence of swine $Fc{\alpha}RI$ ($swFc{\alpha}RI$) was isolated and characterized and found to contain a 792-base-pair open reading frame, encoding a 264-amino-acid transmembrane glycoprotein with a predicted molecular mass of 29.4 kDa. The $swFc{\alpha}RI$ shares high amino acid sequence homology (>50%) with its counterparts from cattle, seal, and horse. Rosetting analysis confirmed that COS-7 cells transfected with an $swFc{\alpha}RI$ expression plasmid was able to combine with chicken erythrocytes sensitized with porcine IgA, but not IgG.

• Journal of Microbiology and Biotechnology
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• v.14 no.1
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• pp.116-120
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• 2004

The medicinal properties of Ganoderma lucidum have been recognized in China for many centuries. Active pharmaceutical components include triterpenes. To elucidate the molecular regulation of triterpene biosynthesis in this mushroom, a 57-base pair DNA fragment encoding the fourth conserved domain SQ-4 (SMGLFLQKTNIIRDYNEDL) of squalene synthase was synthesized and cloned into the expression vector pET-32a(＋). The recombinant fusion protein induced by IPTG (isopropyl-$\beta$-D-thiogalactopyranoside) was overexpressed in the Escherichia coli. Using the purified recombinant fusion protein of 20.9 kDa, a specific polyclonal antibody was obtained from immunized rabbit. Expression of squalene synthase at different development stages of Ganoderma lucidum was analyzed.