• Journal of Ginseng Research
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• v.47 no.5
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• pp.627-637
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• 2023

Background: Damage to the healthy intestinal epithelial layer and regulation of the intestinal immune system, closely interrelated, are considered pivotal parts of the curative treatment for inflammatory bowel disease (IBD). Plant-based diets and phytochemicals can support the immune microenvironment in the intestinal epithelial barrier for a balanced immune system by improving the intestinal microecological balance and may have therapeutic potential in colitis. However, there have been only a few reports on the therapeutic potential of plant-derived exosome-like nanoparticles (PENs) and the underlying mechanism in colitis. This study aimed to assess the therapeutic effect of PENs from Panax ginseng, ginseng-derived exosome-like nanoparticles (GENs), in a mouse model of IBD, with a focus on the intestinal immune microenvironment. Method: To evaluate the anti-inflammatory effect of GENs on acute colitis, we treated GENs in Caco2 and lipopolysaccharide (LPS) -induced RAW 264.7 macrophages and analyzed the gene expression of proinflammatory cytokines and anti-inflammatory cytokines such as TNF-α, IL-6, and IL-10 by real-time PCR (RT-PCR). Furthermore, we further examined bacterial DNA from feces and determined the alteration of gut microbiota composition in DSS-induced colitis mice after administration of GENs through 16S rRNA gene sequencing analysis. Result: GENs with low toxicity showed a long-lasting intestinal retention effect for 48 h, which could lead to effective suppression of pro-inflammatory cytokines such as TNF-α and IL-6 production through inhibition of NF-κB in DSS-induced colitis. As a result, it showed longer colon length and suppressed thickening of the colon wall in the mice treated with GENs. Due to the amelioration of the progression of DSS-induced colitis with GENs treatment, the prolonged survival rate was observed for 17 days compared to 9 days in the PBS-treated group. In the gut microbiota analysis, the ratio of Firmicutes/Bacteroidota was decreased, which means GENs have therapeutic effectiveness against IBD. Ingesting GENs would be expected to slow colitis progression, strengthen the gut microbiota, and maintain gut homeostasis by preventing bacterial dysbiosis. Conclusion: GENs have a therapeutic effect on colitis through modulation of the intestinal microbiota and immune microenvironment. GENs not only ameliorate the inflammation in the damaged intestine by downregulating pro-inflammatory cytokines but also help balance the microbiota on the intestinal barrier and thereby improve the digestive system.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.27 no.4
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• pp.296-313
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• 1982

At a time when world population and food supply are in a delicate balance, it is essential that we look at factors to improve this balance. We can alter the environment to better fit the plant's needs, or we can alter the plant to better fit the environment. Improved technology has allowed us to increase the yield level. For moderately detrimental weather events technology has generally decreased the yield variation, yet for major weather disasters the variation has increased. We have raised the upper level, but zero is still the bottom level. As we concentrate the production of particular crops into limited areas where the environment is closest to optimum, we may be increasing the risk of a major weather related disaster. We need to evaluate the degree of variability of different crops, and how weather and technology can interact to affect it. The natural limits of crop production are imposed by important ecological factors. Production is a function of the climate, the soil, and the crop and all activities related to them. In looking at the environment of a crop we must recognize these are individuals, populations and ecosystems. Under intensive agriculture we try to limit the competition to one desired species. The environment is made up of a complex of factors; radiation, moisture, temperature and wind, among others. Plant response to the environment is due to the interaction of all of these factors, yet in attempting to understand them we often examine each factor individually. Variation in crop yields is primarily a function of limiting environmental parameters. Various weather parameters will be discussed, with emphasis placed on how they impact on crop production. Although solar radiation is a driving force in crop production, it often shows little relationship to yield variation. Water may enter into crop production as both a limiting and excessive factor. The effects of moisture deficiency have received much more attention than moisture excess. In many areas of the world, a very significant portion of yield variation is due to variation in the moisture factor. Temperature imposes limits on where crops can be grown, and the type of crop that can be grown in an area. High temperature effects are often combined with deficient moisture effects. Cool temperatures determine the limits in which crops can be grown. Growing degree units, or heat accumulations, have often been used as a means of explaining many temperature effects. Methods for explaining chilling effects are more limited.

• Textile Coloration and Finishing
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• v.24 no.4
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• pp.253-259
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• 2012

In this work, the natural indigo production process from Polygonum tinctorium was balanced based on the traditional Niram method in Korea. A standard procedure was determined considering the conditions of indican extraction from plant material, the amount of alkali for precipitation, storage of extract, etc. The effect of experimental conditions on the yield of crude dye was investigated. The contents of indigo and indirubin of the crude dyes were analyzed by HPLC. Increase of the amount of crude dye was observed within 1-2.5 days of extraction time. Longer extraction beyond 2.5 days resulted in a slight decrease in the amount of crude dye. There was no consistency in terms of indigo content depending on extraction pH. We found that the storage of extract or harvested plants affected adversely to dye yield and dye quality. Based on the lab scale extraction, large scale extraction was performed for 2-2.5 days in water and 2.0-2.5 g/L of $Ca(OH)_2$ was applied for precipitation of indigo dye. We obtained natural indigo dye containing about 15% of pure indigo in scale-up production using whole plant except root.

• Korean Journal of Plant Resources
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• v.27 no.6
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• pp.593-600
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• 2014

Osteoporosis is a progressive bone disease characterized by low bone mass which is caused by disturbance in the balance between the activities of osteoblasts and osteoclasts. Postmenopausal osteoporosis is one of the most common disorders in women after menopause, which is linked to an estrogen deficiency and characterized by an excessive loss of trabecular bone. Rubus coreanus has been used for their various pharmacological properties in Asia as a traditional medicine. To investigate the effect of unripe fruits of R. coreanus 30% ethanol extract (RCE) on osteoblast-like cells (MG63) differentiation, we examined the effects of RCE on in vitro osteoblastic differentiation markers, alkaline phosphatase (ALP) activity and receptor activator of nuclear factor ${\kappa}$-B ligand (RANKL) and osteoprotegerin (OPG) expression. The high concentration (50 and $100{\mu}g/mL$) of RCE markedly increased ALP activity, whereas decreased the RANKL/OPG. We also investigated the effect of RCE on M-CSF plus RANKL-induced differentiation of pre-osteoclast cells (RAW 264.7). RCE treatment remarkably inhibited M-CSF/RANKL-induced formation of osteoclast-like multinuclear cells from RAW 264.7 cells. Moreover, the inhibitory effect of RCE was reduced by selective estrogen receptor-${\alpha}$ antagonist. Our research suggests that suggested that unripe fruits of R. coreanus may act beneficial effects on bone mass by regulating both osteoblast and osteoclast.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2003.10b
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• pp.46-46
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• 2003

An important function of pollen aperture is believed to be regulating the water balance of the pollen when subjected to changes in humidity (Shukla, et al. 1998). It has been reported that mature barley pollen rapidly swells upon hydration and pollen tube emerges in a few minutes of germination (Anthony and Harlan, 1920). Although, there could be other factors responsible for rapid hydration of pollen. However, K is widely known for its rapid action as an osmotic regulator (Heslop-Harrison and Heslop-Harrison, 1996). In the present study, changes in K distrbution were traced during different stages of pollen maturation in barley. The existence of K at the aperture area of matured pollen may possibly play other import physiological roles. For example, K is reported to be an essential constituent of pollen germination and even required in higher concentration for pollen tube growth(Fan et al., 2001). These results suggest that there could be a possible relationship between K, located at the aperture area and rapid uptake of water by pollen.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.27 no.4
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• pp.314-339
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• 1982

Fluctuating climate is still most important environmental constrain, although improved modem agricultural technology has succeeded to increase crop production in the world. To stabilize the food production under fluctuating weather conditions, it is very needed to obain the quantitative information of interactions between crops and climate. The main purpose of this paper is three hold. Using the JIBP-data, the dry matter accumulation of rice crops is studied in relation to weather indexes (\SigmaTa and \SigmaSt). Temperature dependence of the yield index of rice is analyzed as to air temperature and water temperature. \SigmaT$_{10}$ -fluctuations are studied using meteorological data at various stations. The possible shift of \SigmaT$_{10}$ -isopleths due to climate fluctuation is evaluated. The second interest is in the plant climate of rice crops. Using results of canopy photosynthesis, it is pointed that the canopy structure has most important implication in plant climate. Leaf-air, stomatal, and mesophyll resistances of rice crops are described in relation to weather conditions. The change in light condition and aerodynamical property of rice crops with the growth is illustrated. The energy partition is also studied at different growing stages. Third point is to show in more detail effective countermeasures against cold irrigation water and cool summer. Heat balance of warming pond and polyethylene tube as a heat exchanger is studied to make nomo-grams for evaluating the necessary area and necessary length. Effects of windbreak net on rice crops are illustrated by using experimental and simulation results.lts.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1993.10a
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• pp.584-590
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• 1993

The constructed closed recycling system discussed in this technical report will be economically viable in future for the production of fish and vegetable in earth, space station and space colony, further, it will contribute a lot in the prevention of pollution in the world's ecological system. To make combined system, water management (Nitrification) is required, and it took 45 days to breed microorganism which facilitates this process. After this period , the recycle was confirmed to be working .Using derived equations, the expected nutrient characteristics of waste water were determined and it was found that the resulting nutrient balance was almost same as that in hydroponic solution when KOH was added to maintain pH level. Reverse osmosis (RO) system could solve the problem of the low nutrient concentration . It was found that plants grow well in fish waste water which was produced using RO system. RO system could combine fish and plant production through the advantageous use of separated high concentration water for plant and permeated water for fish in integrated combined system.

• New & Renewable Energy
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• v.6 no.3
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• pp.22-29
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• 2010

The concept of Ocean Thermal Energy Conversion (OTEC) is simple and various types of OTEC have been proposed and tried. However the location of OTEC is limited because OTEC requires $20^{\circ}C$ of temperature difference as a minimum, so most of OTEC plants were constructed and experimented in tropical oceans. To solve this we proposed the modified OTEC which uses condenser discharged thermal energy of existing fossil or nuclear power plants. We call this system CTEC (Condenser Thermal Energy Conversion) as this system directly uses $32^{\circ}C$ partially saturated steam in condenser instead of $20{\sim}25^{\circ}C$ surface sea water as heat source. Increased temperature difference can improve thermal efficiency of Rankine cycle, but CTEC should be located near existing plant condenser and the length of cold water pipe between CTEC and deep cold sea water also increase. So friction loss also increases. Calculated result shows the change of efficiency, pumping power, net power and other parameters of modeled 7.9 MW CTEC at given condition. The calculated efficiency of CTEC is little larger than that of typical OTEC as expected. By proper location and optimization, CTEC could be considered another competitive renewable energy system.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.23 no.7
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• pp.67-74
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• 2009

This paper describes the speed control functions of the typical steam turbine speed controllers and the test results of generator load rejection simulations. The goal of the test is to verify the speed controller's ability to limit the steam turbine's peak speed within a predetermined level in the event of generator load loss. During normal operations, the balance between the driving force of the steam turbine and the braking force of the generator load is maintained and the speed of the turbine-generator is constant. Upon the generator's load loss, in other word, the load rejection, the turbine speed would rapidly increase up to the peak speed at a fast acceleration rate. It is required that the speed controller has the ability to limit the peak speed below the overspeed trip point, which is typically 110[%] of rated speed. If an actual load rejection occurs, a substantial amount of stresses will be applied to the turbine as well as other equipments, In order to avoid this unwanted situation, not an actual test but the other method is necessary. We are currently developing the turbine control system for another nuclear power plant and have plan to do the simulation suggested in this paper.

• Journal of Mechanical Science and Technology
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• v.17 no.5
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• pp.654-667
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• 2003

This paper presents a consequence of the systematic approach to identify the aerodynamic parameters of an unmanned aerial vehicle (UAV) equipped with the automatic flight control system. A 3-2-1-1 excitation is applied for the longitudinal mode while a multi-step input is applied for lateral/directional excitation. Optimal time step for excitation is sought to provide the broad input bandwidth. A fully automated programmed flight test method provides high-quality flight data for system identification using the flight control computer with longitudinal and lateral/directional autopilots, which enable the separation of each motion during the flight test. The accuracy of the longitudinal system identification is improved by an additional use of the closed-loop flight test data. A constrained optimization scheme is applied to estimate the aerodynamic coefficients that best describe the time response of the vehicle. An appropriate weighting function is introduced to balance the flight modes. As a result, concurrent system models are obtained for a wide envelope of both longitudinal and lateral/directional flight maneuvers while maintaining the physical meanings of each parameter.