• Korean Journal of Clinical Pharmacy
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• v.29 no.4
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• pp.223-230
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• 2019

Background: Small-molecule tyrosine kinase inhibitors (TKIs) have had major impacts on anticancer therapy by targeting the catalytic activities of dysregulated tyrosine kinases. TKIs have not presented traditional toxicities; however, some serious adverse effects, including hepatotoxicity, have been documented in clinical trials and post-marketing surveillance. Although TKI-induced hepatotoxicity can cause severe clinical complications in patients, the underlying mechanism is still unclear. Methods: Studies on TKI-induced hepatotoxicity were identified by Pubmed search, and relevant articles were reviewed. Results: Immunoallergic reaction, cytochrome P (CYP) 450 polymorphisms, and formation of reactive metabolites are under consideration as mechanisms of TKI-induced hepatotoxicity. Host protein-drug metabolite conjugates are recognized as antigens by class II major histocompatibility complexes and are believed to cause liver injuries. Polymorphisms in CYP, which influences TKI metabolism, can slow TKI metabolism and may induce development of hepatotoxicity. The formation of reactive metabolites during drug metabolism can induce hepatotoxicity by directly causing cytotoxicity, leading to cell dysfunction, and indirect toxicity by mediating secondary immune reactions. Concurrent use of various medications with TKI can also cause hepatotoxicity by affecting drug transporter or enzyme activities. Conclusion: Periodic monitoring of patients taking TKIs and risk/benefit reassessments though post marketing surveillance are necessary to prevent hepatotoxicity.

• Journal of ILASS-Korea
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• v.10 no.2
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• pp.18-31
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• 2005

This study was performed to explore the liquid breakup and atomization characteristics for the classification of drop formation mode and background of uniform droplets generation in electrohydrodynmaic atomization according to the change of experimental parameters such as nozzle material (stainless steel. teflon). fluid flow rate, applied electrical field and intensity, and frequency. In results, from the classification map of drop formation modes according to the variation of applied AC voltage and frequency at a stainless nozzle, the droplet size was smaller than the outer diameter of the nozzle tip relatively in the spindle mode. The transition points became clearly to be moved toward the high applied voltage by rising the applied AC frequency beyond 450Hz. Also the droplet radius can be observed quite small in the frequency bandwidth of $350{\sim}450Hz$. The droplet radiuses decrease as the applied voltage increases for a fixed applied AC frequency within the range from 50Hz to 400Hz Over 400Hz, the relation between the power intensity and the droplet size was not consistent with a continuous mechanism of liquid breakup. Thus, it is showed that the droplet size distribution using the teflon nozzle was analogous to the results of stainless steel, but the droplet size was bigger than that of stainless steel relatively in case of a teflon nozzle.

• Safety and Health at Work
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• v.12 no.3
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• pp.403-415
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• 2021

Background: This study aimed to assess the possibility of benzene exposure in workers of a Korean semiconductor manufacturing company by reviewing the issued patents. Methods: A systematic patent search was conducted with the Google "Advanced Patent Search" engine using the keywords "semiconductor" and "benzene" combined with all of the words accessed on January 24, 2016. Results: As a result of the search, we reviewed 75 patent documents filed by a Korean semiconductor manufacturing company from 1994 to 2010. From 22 patents, we found that benzene could have been used as one of the carbon sources in chemical vapor deposition for capacitor; as diamond-like carbon for solar cell, graphene formation, or etching for transition metal thin film; and as a solvent for dielectric film, silicon oxide layer, nanomaterials, photoresist, rise for immersion lithography, electrophotography, and quantum dot ink. Conclusion: Considering the date of patent filing, it is possible that workers in the chemical vapor deposition, immersion lithography, and graphene formation processes could be exposed to benzene from 1996 to 2010.

• Journal of the Korean Society of Food Culture
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• v.34 no.2
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• pp.93-111
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• 2019

This paper provides a comprehensive description of previous studies of making and developing kimchi in terms of the origins of kimchi and the changes in the history of kimchi, along with newly discovered data, including the collection of works in Joseon Dynasty as well as old cookbooks discovered after the year 2000, and latest research in related disciplines, e.g., ancient history studies, archeology, and linguistics. Because new ruins and relics, such as the Liao-ho Civilization in the Northeast Asia continent, which was closely related to Dongyi tribes, have been discovered and studied, it is important to determine how to reflect the outcome of archeological studies on the origin of preserved vegetables. In addition, to describe the background and changes in the independent formation of making Korean kimchi chronologically, they were divided into the following: development from jjanji to singunji; formation of the basis for seokbakji dressed with fermented fish sauce; settlement of seokbakji culture for dressing seokbakji with fermented fish sauce and spices, including chili varieties when they were introduced; and establishment of the method for making whole cabbage kimchi, which is currently typical kimchi made by adding the seokbakji as the stuffing of the cabbage kimchi, to examine the time and specific details of the change.

• Journal of Ecology and Environment
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• v.46 no.3
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• pp.243-249
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• 2022

Background: Mixed breeding herb Viola collina Besser, which produces both chasmogamous and cleistogamous flower, has limited habitats under closed canopy and short and early flowering timing, making it relatively more vulnerable to climate change. To better understand the effect of light and nutrient on the flower formation and vegetative growth of V. collina, a mesocosm experiment was conducted. Two-by-two factorial treatments of two light conditions (100% and 60% of natural light) and two fertilizer treatment conditions (fertilized and not fertilized) were applied in the mesocosm experiment. Results: The number of flowers, including chamogamous and cleistogamous flowers, was highest (5.65/pot) under 60% light and fertilized condition and lowest (1.41/pot) under 100% light and not-fertilized condition. However, above ground vegetative growth was highest (2.89 g/pot) under 100% light and fertilized condition and lowest (2.38 g/pot) under 60% light and not-fertilized condition. Above ground biomass to belowground biomass ratio was highest (1.50) under 60% light and fertilized condition and lowest (1.26) under 100% light and fertilized condition. Conclusions: This study showed that high light and nutrient are responsible for the vegetative growth, though the effect of fertilizer was reduced due to allocation and retainment of nutrients. In addition, the low light is necessary to make flowers, especially chasmogamous flowers.

• Journal of dental hygiene science
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• v.24 no.2
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• pp.84-96
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• 2024

Background: Recent studies have elucidated the quorum-sensing mechanisms, biofilm formation, inter-pathogen interactions, and genes related to oral pathogens. This review aims to explore the recent expansion of drug targets against oral pathogens and summarize the current research on novel antibiotic substances derived from marine organisms that target oral pathogens. Methods: A comprehensive literature review summarized the novel mechanisms pertaining to quorum-sensing signal transmission systems, biofilm formation, and metabolite exchange in oral pathogens. The amino acid sequences of the 16 proteins identified as potential drug targets were systematically classified and compared across various oral microorganisms. Results: Through a literature review, we identified nine studies researching quorum sensing signaling inhibitors targeting oral pathogens. A comparison of the amino acid sequences of 16 potential drug targets in oral microorganisms revealed significant differences between oral pathogens and beneficial oral symbiotic microorganisms. These findings imply that it is possible to design drugs that can bind more selectively to oral pathogens. Conclusion: By summarizing the results of recent research on the signaling mechanisms that cause pathogenicity, new drug targets against oral pathogens were proposed. Additionally, the current status of developing new antibiotics for oral pathogens using recently developed quorum sensing inhibitors and natural products derived from marine organisms was introduced. Consequently, marine natural products can be used to develop drugs targeting new proteins in oral pathogens.

• Journal of the Korean earth science society
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• v.30 no.1
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• pp.69-80
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• 2009

We investigate the dependence of star formation rate and Active Galaxy Nuclei (AGN) frequency on the bar properties, especially the bar strength, using SDSS DR6. To better represent the bar strength, we divided the bars into 6 classes according to their length and axial ratios. There seems to be a fairly good correlation between the star formation rate derived from $H{\alpha}$ emission lines and the bar strength, whereas there is no apparent correlation between the AGN activity and the bar strength. We interpret that the former correlation is due to the dependence of bar-driven gas inflow on the strength of bar. The lack of correlation between AGN and bar properties suggests that the accretion of gas onto a supermassive black hole (SMBH) is regulated by the interplay between the bar and SMBH. The frequency of AGN seems to be dependent on the background density but the star formation rate does not. It suggests that star formation is a localized phenomenon that is mostly determined by the gas density in a galaxy, while AGN activity is more closely related to the host property such as mass and luminosity that are thought to be dependent on the environment through the density-luminosity relation.

• The Journal of the Korea Contents Association
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• v.13 no.11
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• pp.167-175
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• 2013

This paper studied the resolving the regional conflict method through the community capital formation. For this purpose, the theoretical background about the social capital, function of the social capital and component, and regional conflict factor were organized. In addition, it analyze empitically through the survey. First, in order to resolve the frequency analysis result regional conflict, the social capital formation was exposed to be important. Next, the regression analysis result, the factor of social capital and the local egoism, the local participation, and the problem of local areas, each, it was expressed as the coefficient of determination 5.1%, 5.5%, 1.6%, and F value showed up as 4.030, 4.3,51, 1.194. This demonstrates that it is decreased the regional conflict as the social capital formation is high. That is, the social capital formation was proved at the resolving the regional conflict that there was lots of the correlation. The community and penis organizationThe local residents should cooperate together and it should try. Particularly, the 20 generations and 30 generations in which the social capital is weak, the social capital formation strategy about the 20 generations and 30 generations should be studied.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.39
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• pp.8.1-8.8
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• 2017

Background: For an effective bone graft for reconstruction of the maxillofacial region, an adequate vascular network will be required to supply blood, osteoprogenitor cells, and growth factors. We previously reported that the secretomes of bone marrow-derived mesenchymal stem cells (MSC-CM) contain numerous growth factors such as insulin-like growth factor (IGF)-1, transforming growth factor $(TGF)-{\beta}1$, and vascular endothelial growth factor (VEGF), which can affect the cellular characteristics and behavior of regenerating bone cells. We hypothesized that angiogenesis is an important step for bone regeneration, and VEGF is one of the crucial factors in MSC-CM that would enhance its osteogenic potential. In the present study, we focused on VEGF in MSC-CM and evaluated the angiogenic and osteogenic potentials of MSC-CM for bone regeneration. Methods: Cytokines in MSC-CM were measured by enzyme-linked immunosorbent assay (ELISA). Human umbilical vein endothelial cells (HUVECs) were cultured with MSC-CM or MSC-CM with anti-VEGF antibody (MSC-CM + anti-VEGF) for neutralization, and tube formation was evaluated. For the evaluation of bone and blood vessel formation with micro-computed tomography (micro-CT) and for the histological and immunohistochemical analyses, a rat calvarial bone defect model was used. Results: The concentrations of IGF-1, VEGF, and $TGF-{\beta}1$ in MSC-CM were $1515.6{\pm}211.8pg/mL$, $465.8{\pm}108.8pg/mL$, and $339.8{\pm}14.4pg/mL$, respectively. Tube formation of HUVECs, bone formation, and blood vessel formation were increased in the MSC-CM group but decreased in the MSC-CM + anti-VEGF group. Histological findings suggested that new bone formation in the entire defect was observed in the MSC-CM group although it was decreased in the MSC-CM + anti-VEGF group. Immunohistochemistry indicated that angiogenesis and migration of endogenous stem cells were much more abundant in the MSC-CM group than in the MSC-CM + anti-VEGF group. Conclusions: VEGF is considered a crucial factor in MSC-CM, and MSC-CM is proposed to be an adequate therapeutic agent for bone regeneration with angiogenesis.

• Journal of Christian Education in Korea
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• v.70
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• pp.239-265
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• 2022

The purpose of this paper is to examine the Christian educational understanding of habit formation through the practical field of Christianity called worship. In the Cultural Liturgy series, James Smith criticized the intellectualistic Christian education so far and opened up a completely different level of possibility for Christian education through a unique study on habit formation. He focuses on education through actions, not education through the mind, and deals in depth with the relationship between habits and the body, between habits and knowledge, between habits and meaning systems, and between habits and human formation. Among them, it is emphasized that worship is a major liturgy that forms the identity of the participants through habits. Accepting Smith's position positively, this thesis first deals with the concept and understanding of major thinkers about habit. Second, we will look at habitual knowledge through the body. And lastly, it deals with Christian educational understanding of worship as a place of habit formation. Worship is not a one-time event, but an inseparable relationship with habit in terms of regular body practice. In particular, when we look at worship from the point of view of habits, it can be seen that the accumulation of experiences through bodily activities plays an important role in forming the horizon and background for understanding the world of the worshiper. Therefore, this thesis is meaningful in seeking and reconfirming the Christian educational possibility of worship as a habit formation.